TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 409.399 | Formula: C21H22F3NO4
H donors: 1 H acceptors: 2 LogP: 3.85 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)c1cc(ccc1N1CC[C@@H](C1)OCCOCc1ccccc1)C(F)(F)F
InChi: 1S/C21H22F3NO4/c22-21(23,24)16-6-7-19(18(12-16)20(26)27)25-9-8-17(13-25)29-11-10-28-14-15-4-2-1-3-5-15/h1-7,12,17H,8-11,13-14H2,(H,26,27)/t17-/m0/s1
InChiKey: AAPFSKSRMZARSC-KRWDZBQOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lipase, endothelial	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	tyrosin kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0118	0	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0403	0.706	1
Toxoplasma gondii	protein kinase	0.0118	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0118	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0403	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0118	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0118	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0403	0.706	0.706
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Echinococcus granulosus	anosmin 1	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus multilocularis	Netrin receptor DCC	0.0403	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Brugia malayi	hypothetical protein	0.0403	0.706	1
Giardia lamblia	Kinase	0.0118	0	0.5
Echinococcus multilocularis	Netrin receptor DCC	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	hypothetical protein	0.0118	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0403	0.706	1
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0118	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0403	0.706	0.706
Giardia lamblia	Kinase, NEK	0.0118	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0118	0	0.5
Echinococcus granulosus	nephrin	0.0403	0.706	0.706
Loa Loa (eye worm)	myotactin form A	0.0403	0.706	1
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0403	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Brugia malayi	SPRY domain containing protein	0.0403	0.706	1
Brugia malayi	hypothetical protein	0.0403	0.706	1
Plasmodium falciparum	protein kinase, putative	0.0118	0	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0403	0.706	1
Giardia lamblia	Protein 21.1	0.0118	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0403	0.706	1
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0403	0.706	0.706
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	anosmin 1	0.0403	0.706	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0403	0.706	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0118	0	0.5
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0403	0.706	0.706
Entamoeba histolytica	tyrosin kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0403	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	Netrin receptor DCC	0.0403	0.706	0.706
Brugia malayi	Fibronectin type III domain containing protein	0.0403	0.706	1
Echinococcus granulosus	Netrin receptor DCC	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0403	0.706	0.706
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0118	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Schistosoma mansoni	neuroglian	0.0403	0.706	0.706
Entamoeba histolytica	hypothetical protein, conserved	0.0118	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	UNCoordinated family member	0.0403	0.706	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0403	0.706	1
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Schistosoma mansoni	cell adhesion molecule	0.0403	0.706	0.706
Leishmania major	hypothetical protein, conserved	0.0403	0.706	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0118	0	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0118	0	0.5
Echinococcus multilocularis	titin	0.0403	0.706	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0403	0.706	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0403	0.706	1
Echinococcus multilocularis	anosmin 1	0.0403	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0118	0	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0403	0.706	0.706
Entamoeba histolytica	hypothetical protein	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	cell adhesion molecule	0.0403	0.706	0.706
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0118	0	0.5
Onchocerca volvulus		0.0403	0.706	1
Brugia malayi	Fibronectin type III domain containing protein	0.0403	0.706	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Echinococcus multilocularis	neuroglian	0.0403	0.706	0.706
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0403	0.706	0.706
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Echinococcus multilocularis	Fibronectin, type III	0.0403	0.706	0.706
Loa Loa (eye worm)	lethal protein 805	0.0403	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	hypothetical protein	0.0118	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0403	0.706	1
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0118	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0118	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Schistosoma mansoni	nephrin	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0118	0	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Brugia malayi	Lethal protein 805	0.0403	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Echinococcus multilocularis	roundabout 2	0.0403	0.706	0.706
Schistosoma mansoni	cell adhesion molecule	0.0403	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0403	0.706	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0403	0.706	0.706
Onchocerca volvulus		0.0403	0.706	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0403	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Schistosoma mansoni	hypothetical protein	0.0403	0.706	0.706
Brugia malayi	myotactin form A	0.0403	0.706	1
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0403	0.706	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0403	0.706	1
Echinococcus multilocularis	titin	0.0403	0.706	0.706
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus multilocularis	roundabout 2	0.0403	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Onchocerca volvulus		0.0403	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Plasmodium falciparum	protein kinase, putative	0.0118	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Giardia lamblia	Kinase, NEK	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	roundabout 2	0.0403	0.706	0.706
Brugia malayi	myotactin form B	0.0403	0.706	1
Echinococcus multilocularis	roundabout 2	0.0403	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Schistosoma mansoni	hypothetical protein	0.0403	0.706	0.706
Echinococcus granulosus	contactin	0.0403	0.706	0.706
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0403	0.706	0.706
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0118	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Loa Loa (eye worm)	CAMK protein kinase	0.0403	0.706	1
Schistosoma mansoni	factor for adipocyte differentiation	0.0403	0.706	0.706
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Entamoeba histolytica	cysteine surface protein, putative	0.0118	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0403	0.706	1
Entamoeba histolytica	tyrosin kinase, putative	0.0118	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0403	0.706	0.706
Schistosoma mansoni	factor for adipocyte differentiation	0.0403	0.706	0.706
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0403	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0403	0.706	1
Schistosoma mansoni	nephrin	0.0403	0.706	0.706
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0	0.5
Onchocerca volvulus		0.0403	0.706	1
Schistosoma mansoni	cell adhesion molecule	0.0403	0.706	0.706
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0403	0.706	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Onchocerca volvulus		0.0403	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0118	0	0.5
Plasmodium vivax	protein kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0403	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0403	0.706	0.706
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0403	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0403	0.706	0.706
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0403	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	roundabout 2	0.0403	0.706	0.706
Brugia malayi	Fibronectin type III domain containing protein	0.0403	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Echinococcus granulosus	titin	0.0403	0.706	0.706
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0118	0	0.5
Echinococcus multilocularis	anosmin 1	0.0403	0.706	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0403	0.706	1
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0118	0	0.5
Echinococcus multilocularis	cell adhesion molecule	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0118	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Onchocerca volvulus		0.0403	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Echinococcus granulosus	EG95	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Schistosoma mansoni	titin	0.0403	0.706	0.706
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0118	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0403	0.706	0.706
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0522	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0403	0.706	0.706
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Schistosoma mansoni	titin	0.0403	0.706	0.706
Brugia malayi	Fibronectin type III domain containing protein	0.0403	0.706	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0403	0.706	1
Schistosoma mansoni	factor for adipocyte differentiation	0.0403	0.706	0.706
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0403	0.706	0.706
Schistosoma mansoni	hemicentin	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Entamoeba histolytica	hypothetical protein	0.0118	0	0.5
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0403	0.706	0.706
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0118	0	0.5
Onchocerca volvulus		0.0403	0.706	1
Echinococcus granulosus	titin	0.0403	0.706	0.706
Schistosoma mansoni	protein tyrosine phosphatase	0.0403	0.706	0.706
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Echinococcus granulosus	Fibronectin type III	0.0403	0.706	0.706
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Onchocerca volvulus		0.0403	0.706	1
Schistosoma mansoni	myosin-binding protein-related	0.0403	0.706	0.706
Schistosoma mansoni	titin	0.0403	0.706	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0403	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Brugia malayi	protein unc-22	0.0403	0.706	1
Onchocerca volvulus		0.0403	0.706	1
Entamoeba histolytica	hypothetical protein	0.0118	0	0.5
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0403	0.706	1
Entamoeba histolytica	hypothetical protein	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Echinococcus multilocularis	transfer RNA-Phe	0.0403	0.706	0.706
Onchocerca volvulus		0.0403	0.706	1
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0403	0.706	0.706
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Schistosoma mansoni	ephrin receptor	0.0522	1	1
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Echinococcus granulosus	usherin	0.0403	0.706	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0403	0.706	1
Onchocerca volvulus		0.0403	0.706	1
Echinococcus granulosus	neuroglian	0.0403	0.706	0.706
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0403	0.706	0.706
Onchocerca volvulus		0.0403	0.706	1
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0403	0.706	1
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Entamoeba histolytica	hypothetical protein	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0118	0	0.5
Echinococcus granulosus	G1Y162 protein	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0118	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0118	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Trichomonas vaginalis	STE family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	projectin	0.0403	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0403	0.706	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0403	0.706	1
Schistosoma mansoni	cell adhesion molecule	0.0403	0.706	0.706
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0403	0.706	1
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0403	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Entamoeba histolytica	hypothetical protein	0.0118	0	0.5
Entamoeba histolytica	hypothetical protein	0.0118	0	0.5
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Toxoplasma gondii	STE kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	roundabout 2	0.0403	0.706	0.706
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0118	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Echinococcus multilocularis	anosmin 1	0.0403	0.706	0.706
Brugia malayi	Protein-tyrosine phosphatase	0.0403	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	hypothetical protein	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Onchocerca volvulus		0.0403	0.706	1
Onchocerca volvulus		0.0403	0.706	1
Entamoeba histolytica	hypothetical protein	0.0118	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0118	0	0.5
Trichomonas vaginalis	TK family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0403	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Brugia malayi	Lethal protein 805	0.0403	0.706	1
Schistosoma mansoni	cell adhesion molecule	0.0403	0.706	0.706
Echinococcus granulosus	anosmin 1	0.0403	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0118	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0118	0	0.5
Schistosoma mansoni	hypothetical protein	0.0403	0.706	0.706
Entamoeba histolytica	serine/threonine kinase, putative	0.0118	0	0.5
Echinococcus multilocularis	usherin	0.0403	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0118	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Schistosoma mansoni	tripartite motif protein trim9	0.0403	0.706	0.706
Entamoeba histolytica	receptor protein kinase, putative	0.0118	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0118	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of recombinant human hepatic lipase using bis-BODIPY-FL C11-PC as substrate preincubated for 30 mins followed by substrate addition by FELA method	ChEMBL.	24211162
IC50 (binding)	= 0.088 uM	Inhibition of recombinant human endothelial lipase using bis-BODIPY-FL C11-PC as substrate preincubated for 30 mins followed by substrate addition by FELA method	ChEMBL.	24211162
IC50 (binding)	> 33 uM	Inhibition of recombinant human lipoprotein lipase using bis-BODIPY-FL C11-PC as substrate preincubated for 30 mins followed by substrate addition by FELA method	ChEMBL.	24211162

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3093396

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1828385