TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 272.749 | Formula: C15H9ClOS
H donors: 0 H acceptors: 0 LogP: 4.77 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)c1cc2ccccc2c(=S)o1
InChi: 1S/C15H9ClOS/c16-12-7-5-10(6-8-12)14-9-11-3-1-2-4-13(11)15(18)17-14/h1-9H
InChiKey: AXJHXSINKKEXCU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	tubulin alpha chain	0.0036	0.0485	0.0649
Onchocerca volvulus		0.0085	0.3268	0.6703
Plasmodium vivax	tubulin alpha chain, putative	0.0036	0.0485	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0106	0.4418	0.5707
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.013	0.5791	0.64
Loa Loa (eye worm)	hypothetical protein	0.0118	0.514	0.6873
Brugia malayi	protein unc-22	0.0106	0.4418	0.5707
Echinococcus multilocularis	Immunoglobulin	0.0074	0.2617	0.2241
Echinococcus granulosus	nephrin	0.0106	0.4418	0.4134
Loa Loa (eye worm)	hypothetical protein	0.013	0.5791	0.7744
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0106	0.4418	0.4134
Entamoeba histolytica	tubulin alpha chain, putative	0.0036	0.0485	0.5
Onchocerca volvulus		0.0085	0.3268	0.6703
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0352	0.0471
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0036	0.0485	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.093	0.1244
Schistosoma mansoni	cell adhesion molecule	0.0044	0.093	0.068
Brugia malayi	Fibronectin type III domain containing protein	0.0085	0.3268	0.4093
Brugia malayi	hypothetical protein	0.0159	0.7478	1
Loa Loa (eye worm)	projectin	0.0106	0.4418	0.5909
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0106	0.4418	0.5707
Echinococcus multilocularis	tyrosine protein kinase otk	0.0044	0.093	0.0468
Trichomonas vaginalis	tubulin beta chain, putative	0.0036	0.0485	1
Brugia malayi	Fibronectin type III domain containing protein	0.0085	0.3268	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0074	0.2617	0.35
Loa Loa (eye worm)	TK/ROR protein kinase	0.0045	0.0987	0.132
Schistosoma mansoni	titin	0.0106	0.4418	0.4785
Echinococcus granulosus	Netrin receptor DCC	0.0085	0.3268	0.2925
Echinococcus granulosus	anosmin 1	0.0085	0.3268	0.2925
Loa Loa (eye worm)	tubulin alpha chain	0.0036	0.0485	0.0649
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0085	0.3268	1
Onchocerca volvulus		0.0085	0.3268	0.6703
Schistosoma mansoni	factor for adipocyte differentiation	0.0085	0.3268	0.3432
Schistosoma mansoni	tubulin subunit alpha	0.0036	0.0485	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0098	0.399	0.5335
Leishmania major	hypothetical protein, conserved	0.0085	0.3268	1
Echinococcus granulosus	Netrin receptor DCC	0.0085	0.3268	0.2925
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3268	0.4371
Schistosoma mansoni	septate junction protein	0.0044	0.093	0.068
Brugia malayi	myotactin form B	0.0085	0.3268	0.4093
Brugia malayi	Lethal protein 805	0.0085	0.3268	0.4093
Schistosoma mansoni	hypothetical protein	0.0106	0.4418	0.4785
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0123	0.5419	0.7246
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3268	0.4371
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0106	0.4418	0.5909
Echinococcus granulosus	anosmin 1	0.0085	0.3268	0.2925
Echinococcus multilocularis	hemicentin 1	0.0044	0.093	0.0468
Brugia malayi	Immunoglobulin I-set domain containing protein	0.013	0.5791	0.7632
Echinococcus multilocularis	peroxidasin	0.0044	0.093	0.0468
Echinococcus multilocularis	titin	0.0085	0.3268	0.2925
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.011	0.4641	0.4367
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0036	0.0485	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0036	0.0485	1
Echinococcus multilocularis	transfer RNA-Phe	0.0106	0.4418	0.4134
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0044	0.093	0.1244
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.1252	0.1674
Brugia malayi	myotactin form A	0.0085	0.3268	0.4093
Brugia malayi	Peroxidasin	0.0044	0.093	0.0811
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.013	0.5791	0.5576
Schistosoma mansoni	tubulin subunit alpha	0.0036	0.0485	0.0157
Echinococcus multilocularis	anosmin 1	0.0085	0.3268	0.2925
Onchocerca volvulus		0.0106	0.4418	1
Echinococcus granulosus	twitchin	0.0094	0.3767	0.3449
Echinococcus granulosus	titin	0.0106	0.4418	0.4134
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.013	0.5791	0.7744
Schistosoma mansoni	nephrin	0.013	0.5791	0.64
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.1252	0.1263
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0085	0.3268	0.3432
Echinococcus multilocularis	Netrin receptor DCC	0.0085	0.3268	0.2925
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3268	0.4371
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0085	0.3268	0.4093
Brugia malayi	tubulin alpha chain - mouse	0.0036	0.0485	0.0187
Schistosoma mansoni	titin	0.0106	0.4418	0.4785
Onchocerca volvulus		0.0085	0.3268	0.6703
Echinococcus multilocularis	roundabout 2	0.013	0.5791	0.5576
Brugia malayi	Fibronectin type III domain containing protein	0.0085	0.3268	0.4093
Loa Loa (eye worm)	CAMK protein kinase	0.0106	0.4418	0.5909
Schistosoma mansoni	nephrin	0.018	0.8628	0.9738
Echinococcus granulosus	anosmin 1	0.0085	0.3268	0.2925
Schistosoma mansoni	septate junction protein	0.0044	0.093	0.068
Loa Loa (eye worm)	alpha-tubulin	0.0036	0.0485	0.0649
Brugia malayi	Lethal protein 805	0.0085	0.3268	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0118	0.514	0.6873
Schistosoma mansoni	cell adhesion molecule	0.0183	0.885	1
Echinococcus granulosus	cell adhesion molecule	0.0085	0.3268	0.2925
Schistosoma mansoni	titin	0.0085	0.3268	0.3432
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0111	0.4698	0.4427
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0044	0.093	0.1244
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0085	0.3268	0.3432
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3268	0.4371
Schistosoma mansoni	hemicentin	0.0106	0.4418	0.4785
Loa Loa (eye worm)	alpha-tubulin	0.0036	0.0485	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3268	0.4371
Schistosoma mansoni	protein tyrosine phosphatase	0.0085	0.3268	0.3432
Trichomonas vaginalis	tubulin beta chain, putative	0.0036	0.0485	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0045	0.0987	0.0163
Echinococcus multilocularis	titin	0.0106	0.4418	0.4134
Loa Loa (eye worm)	hypothetical protein	0.0044	0.093	0.1244
Plasmodium vivax	tubulin alpha chain, putative	0.0036	0.0485	0.5
Echinococcus multilocularis	neuroglian	0.0094	0.3767	0.3449
Loa Loa (eye worm)	hypothetical protein	0.0044	0.093	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3268	0.4371
Brugia malayi	Immunoglobulin I-set domain containing protein	0.011	0.4641	0.6019
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0044	0.093	0.0811
Schistosoma mansoni	alpha tubulin	0.0036	0.0485	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0074	0.2617	0.35
Schistosoma mansoni	ephrin receptor	0.0111	0.4698	0.5114
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0106	0.4418	0.5707
Schistosoma mansoni	roundabout	0.0044	0.093	0.068
Loa Loa (eye worm)	hypothetical protein	0.0044	0.093	0.1244
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0106	0.4418	0.5909
Loa Loa (eye worm)	TK protein kinase	0.0045	0.0987	0.132
Brugia malayi	SPRY domain containing protein	0.0085	0.3268	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0159	0.7478	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.011	0.4641	0.6206
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0074	0.2617	0.2666
Brugia malayi	hypothetical protein	0.0085	0.3268	0.4093
Echinococcus multilocularis	roundabout 2	0.0204	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0106	0.4418	0.5707
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.013	0.5791	0.5576
Schistosoma mansoni	hypothetical protein	0.0085	0.3268	0.3432
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3268	0.4371
Schistosoma mansoni	titin	0.0044	0.093	0.068
Brugia malayi	Tubulin alpha-2 chain	0.0036	0.0485	0.0187
Loa Loa (eye worm)	myotactin form A	0.0085	0.3268	0.4371
Echinococcus granulosus	usherin	0.0085	0.3268	0.2925
Brugia malayi	Fibronectin type III domain containing protein	0.0085	0.3268	0.4093
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0085	0.3268	0.2925
Toxoplasma gondii	alpha tubulin TUBA1	0.0036	0.0485	0.5
Echinococcus granulosus	titin	0.0106	0.4418	0.4134
Schistosoma mansoni	factor for adipocyte differentiation	0.0085	0.3268	0.3432
Echinococcus multilocularis	Netrin receptor DCC	0.0085	0.3268	0.2925
Loa Loa (eye worm)	hypothetical protein	0.0044	0.093	0.1244
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0085	0.3268	0.4371
Schistosoma mansoni	alpha tubulin	0.0036	0.0485	0.0157
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0085	0.3268	1
Brugia malayi	Fibronectin type III domain containing protein	0.0085	0.3268	0.4093
Plasmodium falciparum	alpha tubulin 1	0.0036	0.0485	0.5
Giardia lamblia	Alpha-tubulin	0.0036	0.0485	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0045	0.0987	0.0891
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.013	0.5791	0.7744
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0085	0.3268	0.4093
Echinococcus granulosus	hemicentin 1	0.0044	0.093	0.0468
Schistosoma mansoni	tubulin subunit alpha	0.0036	0.0485	0.0157
Brugia malayi	Tubulin alpha chain	0.0036	0.0485	0.0187
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0085	0.3268	0.2925
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3268	0.4371
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0085	0.3268	0.2925
Echinococcus multilocularis	anosmin 1	0.0085	0.3268	0.2925
Echinococcus multilocularis	lachesin	0.0044	0.093	0.0468
Echinococcus granulosus	Immunoglobulin	0.0074	0.2617	0.2241
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0074	0.2617	0.2241
Schistosoma mansoni	tripartite motif protein trim9	0.0085	0.3268	0.3432
Loa Loa (eye worm)	hypothetical protein	0.0106	0.4418	0.5909
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0074	0.2617	0.2666
Toxoplasma gondii	alpha-tubulin I, putative	0.0036	0.0485	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0123	0.5419	0.711
Brugia malayi	Prion-like-	0.0044	0.093	0.0811
Schistosoma mansoni	cell adhesion molecule	0.013	0.5791	0.64
Loa Loa (eye worm)	hypothetical protein	0.0044	0.093	0.1244
Onchocerca volvulus		0.0085	0.3268	0.6703
Echinococcus multilocularis	neuroglian	0.013	0.5791	0.5576
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0036	0.0485	0.0649
Schistosoma mansoni	serine/threonine protein kinase	0.0106	0.4418	0.4785
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0085	0.3268	0.4371
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0085	0.3268	0.2925
Loa Loa (eye worm)	UNCoordinated family member	0.0085	0.3268	0.4371
Echinococcus granulosus	neuroglian	0.0094	0.3767	0.3449
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0111	0.4698	0.4427
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0044	0.093	0.0811
Onchocerca volvulus		0.0106	0.4418	1
Echinococcus multilocularis	cell adhesion molecule	0.0085	0.3268	0.2925
Schistosoma mansoni	tyrosine kinase	0.0069	0.2359	0.2362
Schistosoma mansoni	neuroglian	0.013	0.5791	0.64
Loa Loa (eye worm)	hypothetical protein	0.0106	0.4418	0.5909
Echinococcus granulosus	tyrosine protein kinase otk	0.0044	0.093	0.0468
Echinococcus granulosus	contactin	0.013	0.5791	0.5576
Echinococcus multilocularis	roundabout 2	0.013	0.5791	0.5576
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0085	0.3268	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0159	0.7478	1
Onchocerca volvulus		0.0085	0.3268	0.6703
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0106	0.4418	0.5909
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0045	0.0987	0.0527
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0085	0.3268	0.3432
Loa Loa (eye worm)	hypothetical protein	0.0074	0.2617	0.35
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0044	0.093	0.0811
Schistosoma mansoni	alpha tubulin	0.0036	0.0485	0.0157
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0044	0.093	0.0811
Schistosoma mansoni	factor for adipocyte differentiation	0.0085	0.3268	0.3432
Echinococcus multilocularis	Immunoglobulin	0.0074	0.2617	0.2241
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0044	0.093	0.0811
Loa Loa (eye worm)	hypothetical protein	0.005	0.1252	0.1674
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0085	0.3268	0.2925
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.011	0.4641	0.4367
Brugia malayi	Protein-tyrosine phosphatase	0.0085	0.3268	0.4093
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0085	0.3268	0.4371
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.1252	0.1263
Onchocerca volvulus		0.0085	0.3268	0.6703
Echinococcus granulosus	EG95	0.0085	0.3268	0.2925
Schistosoma mansoni	cell adhesion molecule	0.013	0.5791	0.64
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0085	0.3268	0.2925
Brugia malayi	Immunoglobulin I-set domain containing protein	0.013	0.5791	0.7632
Echinococcus granulosus	roundabout 2	0.013	0.5791	0.5576
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3268	0.4371
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0044	0.093	0.0811
Trichomonas vaginalis	tubulin beta chain, putative	0.0036	0.0485	1
Echinococcus granulosus	peroxidasin	0.0044	0.093	0.0468
Onchocerca volvulus		0.0085	0.3268	0.6703
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0044	0.093	0.0468
Entamoeba histolytica	tubulin alpha-1 chain	0.0036	0.0485	0.5
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0085	0.3268	0.2925
Loa Loa (eye worm)	hypothetical protein	0.0044	0.093	0.1244
Trichomonas vaginalis	tubulin beta chain, putative	0.0036	0.0485	1
Echinococcus multilocularis	hemicentin 1	0.0044	0.093	0.0468
Echinococcus multilocularis	anosmin 1	0.0085	0.3268	0.2925
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0085	0.3268	0.4093
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0098	0.399	0.3683
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0045	0.0987	0.0527
Schistosoma mansoni	cell adhesion molecule	0.0106	0.4418	0.4785
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0085	0.3268	0.2925
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.013	0.5791	0.5576
Echinococcus granulosus	roundabout 2	0.013	0.5791	0.5576
Echinococcus granulosus	neuroglian	0.013	0.5791	0.5576
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0085	0.3268	0.2925
Onchocerca volvulus		0.0085	0.3268	0.6703
Trichomonas vaginalis	tubulin beta chain, putative	0.0036	0.0485	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.013	0.5791	0.7632
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3268	0.4371
Loa Loa (eye worm)	hypothetical protein	0.0159	0.7478	1
Loa Loa (eye worm)	lethal protein 805	0.0085	0.3268	0.4371
Brugia malayi	Tubulin alpha-2 chain	0.0036	0.0485	0.0187
Onchocerca volvulus		0.0085	0.3268	0.6703
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3268	0.4371
Echinococcus granulosus	defective proboscis extension response	0.0074	0.2617	0.2241
Plasmodium falciparum	alpha tubulin 2	0.0036	0.0485	0.5
Brugia malayi	tubulin alpha-2 chain	0.0036	0.0485	0.0187
Trypanosoma cruzi	hypothetical protein, conserved	0.0085	0.3268	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0106	0.4418	0.5707
Echinococcus multilocularis	usherin	0.0085	0.3268	0.2925
Echinococcus granulosus	G1Y162 protein	0.0085	0.3268	0.2925
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0044	0.093	0.068
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3268	0.4371
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0036	0.0485	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0485	0.0649
Onchocerca volvulus		0.0106	0.4418	1
Schistosoma mansoni	myosin-binding protein-related	0.0106	0.4418	0.4785
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3268	0.4371
Echinococcus granulosus	lachesin	0.0044	0.093	0.0468
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.013	0.5791	0.5576
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0085	0.3268	0.2925
Onchocerca volvulus		0.0085	0.3268	0.6703
Giardia lamblia	Alpha-tubulin	0.0036	0.0485	0.5
Schistosoma mansoni	vesicular amine transporter	0.0074	0.2617	0.2666
Echinococcus multilocularis	Fibronectin, type III	0.0085	0.3268	0.2925
Brugia malayi	Fibronectin type III domain containing protein	0.0159	0.7478	1
Schistosoma mansoni	cell adhesion molecule	0.0106	0.4418	0.4785
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3268	0.4371
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0085	0.3268	0.2925
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0085	0.3268	0.3432
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3268	0.4371
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.013	0.5791	0.5576
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0106	0.4418	0.5707
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0106	0.4418	0.5707
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0085	0.3268	0.2925
Loa Loa (eye worm)	hypothetical protein	0.0159	0.7478	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0085	0.3268	0.4371
Schistosoma mansoni	hypothetical protein	0.0085	0.3268	0.3432
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0106	0.4418	0.5909
Brugia malayi	alpha-tubulin	0.0036	0.0485	0.0187
Echinococcus granulosus	Fibronectin type III	0.0085	0.3268	0.2925

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 26.4 uM	Inhibition of Bos taurus (bovine) milk lactoperoxidase-catalyzed iodination of L-tyrosine substrate by reverse phase HPLC analysis	ChEMBL.	No reference
Inhibition (binding)	= 20 %	Inhibition of Bos taurus (bovine) milk lactoperoxidase-catalyzed iodination of L-tyrosine substrate at 100 uM by reverse phase HPLC analysis	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2299194

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1796168