TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 432.214 | Formula: C20H22Cl4N2
H donors: 2 H acceptors: 0 LogP: 6.2 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(c(c1)Cl)CNC1CCCCC1NCc1ccc(cc1Cl)Cl
InChi: 1S/C20H22Cl4N2/c21-15-7-5-13(17(23)9-15)11-25-19-3-1-2-4-20(19)26-12-14-6-8-16(22)10-18(14)24/h5-10,19-20,25-26H,1-4,11-12H2
InChiKey: AHUOBESNXKKXAS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0264	0.5763	0.5694
Brugia malayi	Fibronectin type III domain containing protein	0.0167	0.3197	0.4301
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1381	0.168
Schistosoma mansoni	serine/threonine protein kinase	0.0212	0.4381	0.4877
Loa Loa (eye worm)	projectin	0.0212	0.4381	0.5803
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0167	0.3197	0.3087
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0264	0.5763	0.5694
Echinococcus granulosus	contactin	0.0264	0.5763	0.5694
Brugia malayi	Immunoglobulin domain containing protein	0.0053	0.0197	0.0265
Leishmania major	hypothetical protein, conserved	0.0167	0.3197	1
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Brugia malayi	basement membrane proteoglycan precursor	0.0053	0.0197	0.0265
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0264	0.5763	0.7702
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0167	0.3197	0.3087
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0159	0.5
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0066	0.0553	0.0455
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0051	0.0159	0.0214
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Schistosoma mansoni	basigin related	0.0053	0.0197	0.0044
Loa Loa (eye worm)	animal heme peroxidase	0.0074	0.0755	0.082
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0053	0.0197	0.0044
Onchocerca volvulus	Peroxidasin homolog	0.0074	0.0755	0.1412
Brugia malayi	Tyrosine-protein kinase abl-1	0.0051	0.0159	0.0214
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Brugia malayi	SH2 domain containing protein	0.0051	0.0159	0.0214
Brugia malayi	myotactin form B	0.0167	0.3197	0.4301
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1381	0.168
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0167	0.3197	0.4301
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0167	0.3197	0.3087
Loa Loa (eye worm)	hypothetical protein	0.0212	0.4381	0.5803
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0167	0.3197	0.4176
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0096	0.1343	0.1807
Brugia malayi	Fibronectin type III domain containing protein	0.0167	0.3197	0.4301
Brugia malayi	Animal haem peroxidase family protein	0.0074	0.0755	0.1016
Echinococcus granulosus	acetylcholinesterase	0.0066	0.0553	0.0401
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Loa Loa (eye worm)	hypothetical protein	0.0328	0.7435	1
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0159	0.5
Schistosoma mansoni	factor for adipocyte differentiation	0.0167	0.3197	0.351
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0167	0.3197	0.4176
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0053	0.0197	0.0265
Onchocerca volvulus		0.0167	0.3197	0.7196
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Loa Loa (eye worm)	hypothetical protein	0.0161	0.3053	0.3978
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Brugia malayi	Immunoglobulin domain containing protein	0.0053	0.0197	0.0265
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0167	0.3197	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0553	0.0542
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Echinococcus multilocularis	acetylcholinesterase	0.0066	0.0553	0.0401
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0159	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0167	0.3197	0.4176
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0159	0.5
Brugia malayi	hypothetical protein	0.0167	0.3197	0.4301
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0073	0.0746	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0328	0.7435	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0167	0.3197	0.351
Plasmodium falciparum	tyrosine kinase-like protein	0.0051	0.0159	0.5
Echinococcus granulosus	Immunoglobulin	0.0161	0.3053	0.2941
Echinococcus multilocularis	Fibronectin, type III	0.0167	0.3197	0.3087
Echinococcus granulosus	Netrin receptor DCC	0.0167	0.3197	0.3087
Schistosoma mansoni	tripartite motif protein trim9	0.0167	0.3197	0.351
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0051	0.0159	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0212	0.4381	0.5893
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0053	0.0197	0.0039
Schistosoma mansoni	septate junction protein	0.0053	0.0197	0.0044
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0212	0.4381	0.5803
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0053	0.0197	0.0044
Schistosoma mansoni	hypothetical protein	0.0167	0.3197	0.351
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0212	0.4381	0.5803
Echinococcus granulosus	roundabout 2	0.0264	0.5763	0.5694
Echinococcus granulosus	netrin receptor unc 5	0.0053	0.0197	0.0039
Echinococcus multilocularis	lachesin	0.0098	0.1381	0.1242
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0051	0.0159	0.5
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0167	0.3197	0.3087
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Plasmodium falciparum	protein kinase, putative	0.0051	0.0159	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0167	0.3197	0.4301
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3197	0.4176
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0328	0.7435	1
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0073	0.0746	0.1933
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0167	0.3197	0.3087
Schistosoma mansoni	cell adhesion molecule	0.0212	0.4381	0.4877
Brugia malayi	hypothetical protein	0.0051	0.0159	0.0214
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Loa Loa (eye worm)	myotactin form A	0.0167	0.3197	0.4176
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0265	0.5778	0.7771
Echinococcus multilocularis	titin	0.0212	0.4381	0.4291
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0212	0.4381	0.5893
Giardia lamblia	Protein 21.1	0.0051	0.0159	0.5
Giardia lamblia	Kinase, NEK	0.0051	0.0159	0.5
Loa Loa (eye worm)	lethal protein 805	0.0167	0.3197	0.4176
Brugia malayi	C-terminal src kinase protein 1	0.0051	0.0159	0.0214
Toxoplasma gondii	STE kinase	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Schistosoma mansoni	hypothetical protein	0.0053	0.0197	0.0044
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Schistosoma mansoni	tyrosine kinase	0.0149	0.2724	0.2963
Brugia malayi	basement membrane proteoglycan	0.0053	0.0197	0.0265
Echinococcus granulosus	Immunoglobulin subtype	0.0053	0.0197	0.0039
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0051	0.0159	0.5
Brugia malayi	SRC-1	0.0051	0.0159	0.0214
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0264	0.5763	0.7751
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0167	0.3197	0.351
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3197	0.4176
Schistosoma mansoni	hypothetical protein	0.0167	0.3197	0.351
Echinococcus granulosus	titin	0.0212	0.4381	0.4291
Schistosoma mansoni	cell adhesion molecule	0.0098	0.1381	0.1412
Echinococcus granulosus	neuroglian	0.0206	0.4237	0.4144
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0219	0.4579	0.4491
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0212	0.4381	0.5893
Echinococcus multilocularis	cell adhesion molecule:down regulated by	0.0053	0.0197	0.0039
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0053	0.0197	0.0044
Schistosoma mansoni	basigin related	0.0053	0.0197	0.0044
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0212	0.4381	0.5893
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Echinococcus granulosus	tyrosine protein kinase otk	0.0098	0.1381	0.1242
Giardia lamblia	Kinase	0.0051	0.0159	0.5
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0051	0.0159	0.0214
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0161	0.3053	0.3343
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0053	0.0197	0.0044
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0167	0.3197	0.3087
Brugia malayi	Immunoglobulin domain containing protein	0.0053	0.0197	0.0265
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0051	0.0159	0.0214
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Schistosoma mansoni	titin	0.0098	0.1381	0.1412
Schistosoma mansoni	cell adhesion molecule	0.0264	0.5763	0.6473
Loa Loa (eye worm)	TK/ROR protein kinase	0.0096	0.1343	0.1627
Schistosoma mansoni	myosin-binding protein-related	0.0212	0.4381	0.4877
Loa Loa (eye worm)	hypothetical protein	0.0264	0.5763	0.7702
Brugia malayi	hypothetical protein	0.0053	0.0197	0.0265
Echinococcus granulosus	EG95	0.0167	0.3197	0.3087
Brugia malayi	Fibronectin type III domain containing protein	0.0328	0.7435	1
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Schistosoma mansoni	hypothetical protein	0.0053	0.0197	0.0044
Giardia lamblia	Kinase, NEK	0.0051	0.0159	0.5
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0053	0.0197	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3197	0.4176
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Onchocerca volvulus		0.0167	0.3197	0.7196
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3197	0.4176
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0219	0.4579	0.6159
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3197	0.4176
Trypanosoma cruzi	hypothetical protein, conserved	0.0167	0.3197	1
Echinococcus multilocularis	peroxidasin	0.0126	0.2137	0.201
Plasmodium falciparum	protein kinase, putative	0.0051	0.0159	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0264	0.5763	0.7751
Schistosoma mansoni	hypothetical protein	0.0053	0.0197	0.0044
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0098	0.1381	0.1858
Echinococcus multilocularis	Immunoglobulin	0.0053	0.0197	0.0039
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0053	0.0197	0.0039
Onchocerca volvulus		0.0167	0.3197	0.7196
Echinococcus granulosus	peroxidasin	0.0126	0.2137	0.201
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0098	0.1381	0.1242
Echinococcus granulosus	Immunoglobulin	0.0053	0.0197	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Echinococcus multilocularis	Immunoglobulin	0.0161	0.3053	0.2941
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Echinococcus multilocularis	cell adhesion molecule	0.0167	0.3197	0.3087
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Echinococcus granulosus	anosmin 1	0.0167	0.3197	0.3087
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0073	0.0746	0.1933
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1381	0.168
Schistosoma mansoni	cell adhesion molecule	0.0053	0.0197	0.0044
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0167	0.3197	0.3087
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0197	0.0052
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Schistosoma mansoni	neuroglian	0.0264	0.5763	0.6473
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0264	0.5763	0.6473
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0159	0.5
Brugia malayi	protein-tyrosine kinase	0.0051	0.0159	0.0214
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0167	0.3197	0.3087
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0167	0.3197	0.351
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Echinococcus multilocularis	tyrosine protein kinase otk	0.0098	0.1381	0.1242
Schistosoma mansoni	peroxidasin	0.0081	0.0953	0.0917
Brugia malayi	Raf kinase	0.0051	0.0159	0.0214
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0073	0.0746	0.0807
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0096	0.1343	0.2804
Echinococcus multilocularis	carboxylesterase 5A	0.0066	0.0553	0.0401
Brugia malayi	Guanylyl cyclase protein 23	0.0051	0.0159	0.0214
Echinococcus granulosus	twitchin	0.0206	0.4237	0.4144
Echinococcus granulosus	basement membrane specific heparan sulfate	0.0053	0.0197	0.0039
Schistosoma mansoni	ephrin receptor	0.0218	0.4541	0.5061
Schistosoma mansoni	titin	0.0167	0.3197	0.351
Plasmodium vivax	protein kinase, putative	0.0051	0.0159	0.5
Echinococcus multilocularis	hemicentin 1	0.0098	0.1381	0.1242
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0098	0.1381	0.1858
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Schistosoma mansoni	cell adhesion molecule	0.0212	0.4381	0.4877
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0219	0.4579	0.6075
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0161	0.3053	0.3343
Toxoplasma gondii	protein kinase	0.0051	0.0159	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0051	0.0159	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0197	0.0052
Echinococcus granulosus	lachesin	0.0098	0.1381	0.1242
Trichomonas vaginalis	STE family protein kinase	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0197	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0159	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0167	0.3197	0.4301
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0167	0.3197	0.351
Schistosoma mansoni	hypothetical protein	0.0212	0.4381	0.4877
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0167	0.3197	1
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Echinococcus granulosus	carboxylesterase 5A	0.0066	0.0553	0.0401
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0096	0.1343	0.1203
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0212	0.4381	0.5893
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0051	0.0159	0.0214
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0098	0.1381	0.168
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0053	0.0197	0.0265
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Echinococcus granulosus	usherin	0.0167	0.3197	0.3087
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3197	0.4176
Echinococcus multilocularis	titin	0.0167	0.3197	0.3087
Brugia malayi	SPRY domain containing protein	0.0167	0.3197	0.4301
Echinococcus multilocularis	transfer RNA-Phe	0.0212	0.4381	0.4291
Loa Loa (eye worm)	carboxylesterase	0.0066	0.0553	0.0542
Echinococcus granulosus	Immunoglobulin	0.0053	0.0197	0.0039
Toxoplasma gondii	protein kinase domain-containing protein	0.0051	0.0159	0.5
Echinococcus granulosus	Fibronectin type III	0.0167	0.3197	0.3087
Schistosoma mansoni	roundabout	0.0098	0.1381	0.1412
Brugia malayi	Lethal protein 805	0.0167	0.3197	0.4301
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0218	0.4541	0.4452
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0167	0.3197	0.4176
Loa Loa (eye worm)	hypothetical protein	0.0328	0.7435	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1381	0.168
Schistosoma mansoni	hemicentin	0.0212	0.4381	0.4877
Schistosoma mansoni	vesicular amine transporter	0.0161	0.3053	0.3343
Schistosoma mansoni	hypothetical protein	0.0053	0.0197	0.0044
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Onchocerca volvulus		0.0167	0.3197	0.7196
Echinococcus granulosus	Netrin receptor DCC	0.0167	0.3197	0.3087
Echinococcus granulosus	neuroglian	0.0264	0.5763	0.5694
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0212	0.4381	0.5893
Echinococcus multilocularis	roundabout 2	0.0426	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0167	0.3197	0.3087
Schistosoma mansoni	netrin receptor unc5	0.0053	0.0197	0.0044
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Echinococcus multilocularis	leucine rich repeat containing protein 4	0.0053	0.0197	0.0039
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0098	0.1381	0.2895
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Brugia malayi	ephrin receptor 1 precursor	0.0051	0.0159	0.0214
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Onchocerca volvulus	Peroxidasin homolog	0.0074	0.0755	0.1412
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3197	0.4176
Schistosoma mansoni	nephrin related	0.0053	0.0197	0.0044
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0053	0.0197	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Schistosoma mansoni	septate junction protein	0.0053	0.0197	0.0044
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0167	0.3197	0.4301
Echinococcus granulosus	acetylcholinesterase	0.0066	0.0553	0.0401
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Brugia malayi	myotactin form A	0.0167	0.3197	0.4301
Echinococcus granulosus	anosmin 1	0.0167	0.3197	0.3087
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0167	0.3197	1
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Brugia malayi	Lethal protein 805	0.0167	0.3197	0.4301
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0197	0.0052
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Brugia malayi	Heparan sulfate	0.0053	0.0197	0.0265
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0051	0.0159	0.0214
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0073	0.0746	0.1933
Echinococcus granulosus	G1Y162 protein	0.0167	0.3197	0.3087
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3197	0.4176
Echinococcus multilocularis	roundabout 2	0.0264	0.5763	0.5694
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0098	0.1381	0.168
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0073	0.0746	0.1933
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0098	0.1381	0.1858
Brugia malayi	Carboxylesterase family protein	0.0066	0.0553	0.0744
Echinococcus multilocularis	neuroglian	0.0264	0.5763	0.5694
Schistosoma mansoni	hypothetical protein	0.0053	0.0197	0.0044
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0161	0.3053	0.2941
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0051	0.0159	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0159	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0053	0.0197	0.0265
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0264	0.5763	0.5694
Echinococcus multilocularis	Immunoglobulin subtype	0.0053	0.0197	0.0039
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0264	0.5763	0.7702
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0096	0.1343	0.1203
Schistosoma mansoni	factor for adipocyte differentiation	0.0167	0.3197	0.351
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Brugia malayi	hypothetical protein	0.0051	0.0159	0.0214
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Echinococcus multilocularis	Immunoglobulin	0.0161	0.3053	0.2941
Loa Loa (eye worm)	hypothetical protein	0.0161	0.3053	0.3978
Echinococcus granulosus	3'partial\|cell adhesion molecule:down regulated by	0.0053	0.0197	0.0039
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0098	0.1381	0.1412
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0167	0.3197	0.3087
Schistosoma mansoni	netrin receptor unc5	0.0053	0.0197	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0214	0.4434	0.5876
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Brugia malayi	hypothetical protein	0.0328	0.7435	1
Onchocerca volvulus		0.0212	0.4381	1
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Echinococcus multilocularis	anosmin 1	0.0167	0.3197	0.3087
Loa Loa (eye worm)	LAD-2 short isoform	0.0053	0.0197	0.0052
Echinococcus multilocularis	hemicentin 1	0.0098	0.1381	0.1242
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0053	0.0197	0.0039
Schistosoma mansoni	hypothetical protein	0.0053	0.0197	0.0044
Brugia malayi	Carboxylesterase family protein	0.0066	0.0553	0.0744
Brugia malayi	SH2 domain containing protein	0.0051	0.0159	0.0214
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0098	0.1381	0.1858
Echinococcus granulosus	nephrin	0.0212	0.4381	0.4291
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0214	0.4434	0.4345
Loa Loa (eye worm)	hypothetical protein	0.0161	0.3053	0.3978
Echinococcus granulosus	hemicentin 1	0.0098	0.1381	0.1242
Loa Loa (eye worm)	UNCoordinated family member	0.0167	0.3197	0.4176
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3197	0.4176
Trichomonas vaginalis	TK family protein kinase	0.0051	0.0159	0.5
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3197	0.4176
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0053	0.0197	0.0265
Schistosoma mansoni	nephrin	0.0264	0.5763	0.6473
Onchocerca volvulus		0.0212	0.4381	1
Echinococcus multilocularis	Immunoglobulin	0.0053	0.0197	0.0039
Echinococcus granulosus	cell adhesion molecule	0.0167	0.3197	0.3087
Trichomonas vaginalis	protein kinase atn1, putative	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Plasmodium falciparum	protein kinase, putative	0.0051	0.0159	0.5
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Loa Loa (eye worm)	immunoglobulin domain-containing protein	0.0053	0.0197	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0259	0.5618	0.7504
Echinococcus granulosus	defective proboscis extension response	0.0161	0.3053	0.2941
Brugia malayi	protein unc-22	0.0212	0.4381	0.5893
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0051	0.0159	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0212	0.4381	0.5803
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Schistosoma mansoni	septate junction protein	0.0098	0.1381	0.1412
Echinococcus multilocularis	acetylcholinesterase	0.0066	0.0553	0.0401
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0053	0.0197	0.0039
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0073	0.0746	0.1004
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0212	0.4381	0.4291
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3197	0.4176
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0051	0.0159	0.5
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0264	0.5763	0.7751
Schistosoma mansoni	cell adhesion molecule	0.0053	0.0197	0.0044
Echinococcus multilocularis	usherin	0.0167	0.3197	0.3087
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0218	0.4541	0.4452
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0264	0.5763	0.5694
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1381	0.168
Brugia malayi	Tyrosine-protein kinase PR2	0.0051	0.0159	0.0214
Brugia malayi	Prion-like-	0.0098	0.1381	0.1858
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Loa Loa (eye worm)	hypothetical protein	0.0212	0.4381	0.5803
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0073	0.0746	0.0678
Loa Loa (eye worm)	acetylcholinesterase 1	0.0066	0.0553	0.0542
Brugia malayi	hypothetical protein	0.0051	0.0159	0.0214
Loa Loa (eye worm)	TK protein kinase	0.0096	0.1343	0.1627
Echinococcus multilocularis	netrin receptor unc 5	0.0053	0.0197	0.0039
Echinococcus multilocularis	anosmin 1	0.0167	0.3197	0.3087
Onchocerca volvulus		0.0167	0.3197	0.7196
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0167	0.3197	0.3087
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0553	0.0542
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Brugia malayi	Fibronectin type III domain containing protein	0.0167	0.3197	0.4301
Echinococcus granulosus	titin	0.0212	0.4381	0.4291
Schistosoma mansoni	titin	0.0212	0.4381	0.4877
Brugia malayi	Fibronectin type III domain containing protein	0.0167	0.3197	0.4301
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0264	0.5763	0.5694
Echinococcus multilocularis	anosmin 1	0.0167	0.3197	0.3087
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0098	0.1381	0.1858
Brugia malayi	Receptor family ligand binding region containing protein	0.0051	0.0159	0.0214
Schistosoma mansoni	factor for adipocyte differentiation	0.0167	0.3197	0.351
Onchocerca volvulus		0.0167	0.3197	0.7196
Echinococcus multilocularis	Netrin receptor DCC	0.0167	0.3197	0.3087
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Loa Loa (eye worm)	CAMK protein kinase	0.0212	0.4381	0.5803
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0051	0.0159	0.5
Echinococcus granulosus	anosmin 1	0.0167	0.3197	0.3087
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Schistosoma mansoni	protein tyrosine phosphatase	0.0167	0.3197	0.351
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0073	0.0746	1
Onchocerca volvulus		0.0212	0.4381	1
Onchocerca volvulus		0.0167	0.3197	0.7196
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0265	0.5778	0.7723
Brugia malayi	Protein-tyrosine phosphatase	0.0167	0.3197	0.4301
Schistosoma mansoni	nephrin	0.0373	0.8619	0.9772
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0212	0.4381	0.5803
Echinococcus multilocularis	Netrin receptor DCC	0.0167	0.3197	0.3087
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0051	0.0159	0.5
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0073	0.0746	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1381	0.168
Schistosoma mansoni	cell adhesion molecule	0.0264	0.5763	0.6473
Brugia malayi	integrin-linked kinase	0.0051	0.0159	0.0214
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0167	0.3197	0.3087
Loa Loa (eye worm)	hypothetical protein	0.0126	0.2137	0.2718
Brugia malayi	Peroxidasin	0.0126	0.2137	0.2874
Echinococcus multilocularis	roundabout 2	0.0264	0.5763	0.5694
Echinococcus granulosus	roundabout 2	0.0264	0.5763	0.5694
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0212	0.4381	0.5893
Schistosoma mansoni	titin	0.0212	0.4381	0.4877
Echinococcus multilocularis	neuroglian	0.0206	0.4237	0.4144
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Onchocerca volvulus		0.0167	0.3197	0.7196
Onchocerca volvulus		0.0167	0.3197	0.7196
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3197	0.4176
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3197	0.4176
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Schistosoma mansoni	septate junction protein	0.0098	0.1381	0.1412
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0219	0.4579	0.4491
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0051	0.0159	0.0214
Onchocerca volvulus		0.0167	0.3197	0.7196
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0051	0.0159	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0197	0.0052
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0051	0.0159	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0098	0.1381	0.1858
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0051	0.0159	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3197	0.4176
Schistosoma mansoni	basigin related	0.0053	0.0197	0.0044
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0159	0.0214
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5
Loa Loa (eye worm)	hypothetical protein	0.0259	0.5618	0.7504
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3197	0.4176
Onchocerca volvulus		0.0167	0.3197	0.7196
Schistosoma mansoni	cell adhesion molecule	0.0381	0.8816	1
Trichomonas vaginalis	TKL family protein kinase	0.0051	0.0159	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1739273

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1558758