TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 349.386 | Formula: C19H19N5O2
H donors: 1 H acceptors: 2 LogP: 3.19 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CN(c1ccc(cc1)N=Nc1c(C)[nH]n(c1=O)c1ccccc1)C(=O)C
InChi: 1S/C19H19N5O2/c1-13-18(19(26)24(22-13)17-7-5-4-6-8-17)21-20-15-9-11-16(12-10-15)23(3)14(2)25/h4-12,22H,1-3H3
InChiKey: JUCNEYVZMYFXSZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Giardia intestinalis	Putative fructose-1,6-bisphosphate aldolase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Treponema pallidum	fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Giardia lamblia	Fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Mycobacterium ulcerans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	26.9 %
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.8 %
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0172	0.4125	0.5
Onchocerca volvulus		0.0155	0.3568	1
Echinococcus multilocularis	transfer RNA-Phe	0.0155	0.3568	0.706
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0155	0.3568	0.706
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0155	0.3568	0.706
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0155	0.3568	0.706
Onchocerca volvulus		0.0155	0.3568	1
Echinococcus multilocularis	roundabout 2	0.0155	0.3568	0.706
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0155	0.3568	0.706
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Loa Loa (eye worm)	projectin	0.0155	0.3568	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0155	0.3568	1
Brugia malayi	myotactin form B	0.0155	0.3568	1
Onchocerca volvulus		0.0155	0.3568	1
Echinococcus multilocularis	anosmin 1	0.0155	0.3568	0.706
Loa Loa (eye worm)	myotactin form A	0.0155	0.3568	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0201	0.5054	1
Schistosoma mansoni	titin	0.0155	0.3568	0.706
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0155	0.3568	0.706
Echinococcus granulosus	titin	0.0155	0.3568	0.706
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0046	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0046	0	0.5
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0155	0.3568	1
Onchocerca volvulus		0.0155	0.3568	1
Plasmodium vivax	protein kinase, putative	0.0046	0	0.5
Brugia malayi	hypothetical protein	0.0155	0.3568	1
Echinococcus granulosus	usherin	0.0155	0.3568	0.706
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	1	1
Onchocerca volvulus		0.0155	0.3568	1
Echinococcus multilocularis	cell adhesion molecule	0.0155	0.3568	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0155	0.3568	1
Onchocerca volvulus		0.0155	0.3568	1
Schistosoma mansoni	hypothetical protein	0.0155	0.3568	0.706
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0155	0.3568	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0155	0.3568	0.706
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Onchocerca volvulus		0.0155	0.3568	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	1	1
Echinococcus granulosus	Fibronectin type III	0.0155	0.3568	0.706
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0155	0.3568	0.706
Schistosoma mansoni	cell adhesion molecule	0.0155	0.3568	0.706
Echinococcus multilocularis	Netrin receptor DCC	0.0155	0.3568	0.706
Schistosoma mansoni	nephrin	0.0155	0.3568	0.706
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Onchocerca volvulus		0.0155	0.3568	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0155	0.3568	0.706
Schistosoma mansoni	nephrin	0.0155	0.3568	0.706
Echinococcus granulosus	Netrin receptor DCC	0.0155	0.3568	0.706
Onchocerca volvulus		0.0155	0.3568	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0046	0	0.5
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0155	0.3568	0.706
Toxoplasma gondii	protein kinase domain-containing protein	0.0046	0	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0201	0.5054	1
Echinococcus granulosus	EG95	0.0155	0.3568	0.706
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0155	0.3568	1
Leishmania major	hypothetical protein, conserved	0.0155	0.3568	1
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0155	0.3568	1
Schistosoma mansoni	titin	0.0155	0.3568	0.706
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0155	0.3568	1
Schistosoma mansoni	cell adhesion molecule	0.0155	0.3568	0.706
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0155	0.3568	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Onchocerca volvulus		0.0155	0.3568	1
Echinococcus multilocularis	anosmin 1	0.0155	0.3568	0.706
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0155	0.3568	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Toxoplasma gondii	protein kinase	0.0046	0	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0046	0	0.5
Toxoplasma gondii	STE kinase	0.0046	0	0.5
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0155	0.3568	0.706
Schistosoma mansoni	myosin-binding protein-related	0.0155	0.3568	0.706
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0155	0.3568	0.706
Echinococcus granulosus	G1Y162 protein	0.0155	0.3568	0.706
Schistosoma mansoni	tripartite motif protein trim9	0.0155	0.3568	0.706
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	1	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	1	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0046	0	0.5
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0155	0.3568	0.706
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Brugia malayi	Lethal protein 805	0.0155	0.3568	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0155	0.3568	0.706
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0155	0.3568	0.706
Echinococcus granulosus	neuroglian	0.0155	0.3568	0.706
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0155	0.3568	0.706
Brugia malayi	Fibronectin type III domain containing protein	0.0155	0.3568	1
Schistosoma mansoni	titin	0.0155	0.3568	0.706
Giardia lamblia	Fructose-bisphosphate aldolase	0.0353	1	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0155	0.3568	0.706
Echinococcus granulosus	nephrin	0.0155	0.3568	0.706
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Brugia malayi	Fibronectin type III domain containing protein	0.0155	0.3568	1
Echinococcus multilocularis	usherin	0.0155	0.3568	0.706
Loa Loa (eye worm)	CAMK protein kinase	0.0155	0.3568	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0155	0.3568	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0155	0.3568	1
Schistosoma mansoni	neuroglian	0.0155	0.3568	0.706
Echinococcus multilocularis	titin	0.0155	0.3568	0.706
Echinococcus granulosus	roundabout 2	0.0155	0.3568	0.706
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0046	0	0.5
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0155	0.3568	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0155	0.3568	0.706
Echinococcus granulosus	Netrin receptor DCC	0.0155	0.3568	0.706
Brugia malayi	myotactin form A	0.0155	0.3568	1
Onchocerca volvulus		0.0155	0.3568	1
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0155	0.3568	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0155	0.3568	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0155	0.3568	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Echinococcus granulosus	roundabout 2	0.0155	0.3568	0.706
Schistosoma mansoni	hypothetical protein	0.0155	0.3568	0.706
Echinococcus multilocularis	anosmin 1	0.0155	0.3568	0.706
Echinococcus multilocularis	neuroglian	0.0155	0.3568	0.706
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Schistosoma mansoni	hemicentin	0.0155	0.3568	0.706
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0155	0.3568	1
Loa Loa (eye worm)	lethal protein 805	0.0155	0.3568	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0155	0.3568	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0155	0.3568	0.706
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Plasmodium falciparum	protein kinase, putative	0.0046	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Schistosoma mansoni	factor for adipocyte differentiation	0.0155	0.3568	0.706
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0172	0.4125	0.5
Echinococcus granulosus	anosmin 1	0.0155	0.3568	0.706
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0155	0.3568	1
Echinococcus multilocularis	roundabout 2	0.0155	0.3568	0.706
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0046	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Echinococcus multilocularis	titin	0.0155	0.3568	0.706
Echinococcus granulosus	contactin	0.0155	0.3568	0.706
Brugia malayi	Fibronectin type III domain containing protein	0.0155	0.3568	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0046	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0155	0.3568	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0155	0.3568	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	1	1
Echinococcus multilocularis	Fibronectin, type III	0.0155	0.3568	0.706
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	1	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0155	0.3568	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0155	0.3568	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0155	0.3568	1
Echinococcus multilocularis	Netrin receptor DCC	0.0155	0.3568	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0155	0.3568	1
Brugia malayi	protein unc-22	0.0155	0.3568	1
Echinococcus granulosus	roundabout 2	0.0155	0.3568	0.706
Brugia malayi	Lethal protein 805	0.0155	0.3568	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0155	0.3568	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0155	0.3568	1
Brugia malayi	hypothetical protein	0.0155	0.3568	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0155	0.3568	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0172	0.4125	0.5
Onchocerca volvulus		0.0155	0.3568	1
Echinococcus granulosus	cell adhesion molecule	0.0155	0.3568	0.706
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0155	0.3568	1
Schistosoma mansoni	factor for adipocyte differentiation	0.0155	0.3568	0.706
Loa Loa (eye worm)	UNCoordinated family member	0.0155	0.3568	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0155	0.3568	1
Brugia malayi	Protein-tyrosine phosphatase	0.0155	0.3568	1
Onchocerca volvulus		0.0155	0.3568	1
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0155	0.3568	0.706
Schistosoma mansoni	cell adhesion molecule	0.0155	0.3568	0.706
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Echinococcus granulosus	anosmin 1	0.0155	0.3568	0.706
Echinococcus granulosus	titin	0.0155	0.3568	0.706
Schistosoma mansoni	hypothetical protein	0.0155	0.3568	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0155	0.3568	1
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0155	0.3568	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0155	0.3568	0.706
Brugia malayi	Fibronectin type III domain containing protein	0.0155	0.3568	1
Brugia malayi	Fibronectin type III domain containing protein	0.0155	0.3568	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0155	0.3568	1
Onchocerca volvulus		0.0155	0.3568	1
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0155	0.3568	0.706
Echinococcus multilocularis	roundabout 2	0.0155	0.3568	0.706
Treponema pallidum	fructose-bisphosphate aldolase	0.0353	1	0.5
Schistosoma mansoni	cell adhesion molecule	0.0155	0.3568	0.706
Schistosoma mansoni	cell adhesion molecule	0.0155	0.3568	0.706
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0155	0.3568	0.706
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0155	0.3568	0.706
Schistosoma mansoni	factor for adipocyte differentiation	0.0155	0.3568	0.706
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0155	0.3568	0.706
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	1	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3568	1
Brugia malayi	Fibronectin type III domain containing protein	0.0155	0.3568	1
Echinococcus granulosus	anosmin 1	0.0155	0.3568	0.706
Schistosoma mansoni	ephrin receptor	0.0201	0.5054	1
Plasmodium falciparum	protein kinase, putative	0.0046	0	0.5
Brugia malayi	SPRY domain containing protein	0.0155	0.3568	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0155	0.3568	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 4.4668 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ]	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3145218

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1854817