Detailed information for compound 1529773

Basic information

Technical information
  • TDR Targets ID: 1529773
  • Name: N-[(2-methoxyphenyl)methyl]-2-(phenylmethylsu lfonyl)acetamide
  • MW: 333.402 | Formula: C17H19NO4S
  • H donors: 1 H acceptors: 3 LogP: 1.91 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CNC(=O)CS(=O)(=O)Cc1ccccc1
  • InChi: 1S/C17H19NO4S/c1-22-16-10-6-5-9-15(16)11-18-17(19)13-23(20,21)12-14-7-3-2-4-8-14/h2-10H,11-13H2,1H3,(H,18,19)
  • InChiKey: SZSSIXBQPNTQQR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(benzylsulfonyl)-N-(2-methoxybenzyl)acetamide
  • N-[(2-methoxyphenyl)methyl]-2-(phenylmethylsulfonyl)ethanamide
  • STK128320
  • ZINC00620044

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2488 0.2488
Onchocerca volvulus 0.0089 0.4623 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0089 0.4623 0.477
Brugia malayi hypothetical protein 0.0089 0.4623 0.4623
Loa Loa (eye worm) myotactin form A 0.0089 0.4623 0.4623
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0089 0.4623 0.4623
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0089 0.4623 0.4623
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0089 0.4623 0.4623
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.2252 0.5
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0089 0.4623 0.4623
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0089 0.4623 0.4623
Echinococcus granulosus Fibronectin type III 0.0089 0.4623 0.477
Onchocerca volvulus 0.0089 0.4623 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.2488 0.2488
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2488 0.2488
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Schistosoma mansoni hemicentin 0.0089 0.4623 0.4623
Schistosoma mansoni nephrin 0.0089 0.4623 0.4623
Schistosoma mansoni hypothetical protein 0.0089 0.4623 0.4623
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0089 0.4623 0.4623
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0089 0.4623 0.4623
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0089 0.4623 0.4623
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.4623 0.4623
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0089 0.4623 0.4623
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.4623 0.4623
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0089 0.4623 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.2488 0.2488
Brugia malayi SPRY domain containing protein 0.0089 0.4623 0.4623
Brugia malayi Fibronectin type III domain containing protein 0.0089 0.4623 0.4623
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2488 0.2488
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Schistosoma mansoni cell adhesion molecule 0.0089 0.4623 0.4623
Leishmania major hypothetical protein, conserved 0.0089 0.4623 0.5
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0089 0.4623 0.4623
Schistosoma mansoni hypothetical protein 0.0089 0.4623 0.4623
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0089 0.4623 0.4623
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0089 0.4623 0.4623
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0089 0.4623 0.4623
Echinococcus granulosus titin 0.0089 0.4623 0.477
Schistosoma mansoni cell adhesion molecule 0.0089 0.4623 0.4623
Onchocerca volvulus 0.0089 0.4623 1
Brugia malayi Fibronectin type III domain containing protein 0.0089 0.4623 0.4623
Brugia malayi protein unc-22 0.0089 0.4623 0.4623
Echinococcus granulosus titin 0.0089 0.4623 0.477
Schistosoma mansoni titin 0.0089 0.4623 0.4623
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0089 0.4623 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.4623 0.4623
Onchocerca volvulus 0.0089 0.4623 1
Schistosoma mansoni titin 0.0089 0.4623 0.4623
Echinococcus multilocularis usherin 0.0089 0.4623 0.4623
Echinococcus granulosus Fibronectin type III domain containing protein 0.0089 0.4623 0.477
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.2252 0.2324
Loa Loa (eye worm) CAMK protein kinase 0.0089 0.4623 0.4623
Echinococcus multilocularis anosmin 1 0.0089 0.4623 0.4623
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 1 1
Echinococcus granulosus fibronectin type III domain-containing protein 0.0089 0.4623 0.477
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0089 0.4623 0.4623
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.2252 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.4623 0.4623
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.9692 1
Brugia malayi myotactin form A 0.0089 0.4623 0.4623
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0089 0.4623 0.4623
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.4623 0.4623
Onchocerca volvulus 0.0089 0.4623 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0089 0.4623 0.4623
Echinococcus multilocularis Fibronectin, type III 0.0089 0.4623 0.4623
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Echinococcus multilocularis roundabout 2 0.0089 0.4623 0.4623
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2488 0.2488
Brugia malayi Fibronectin type III domain containing protein 0.0089 0.4623 0.4623
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0089 0.4623 0.4623
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0089 0.4623 0.4623
Schistosoma mansoni protein tyrosine phosphatase 0.0089 0.4623 0.4623
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0089 0.4623 0.477
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Echinococcus multilocularis Netrin receptor DCC 0.0089 0.4623 0.4623
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0089 0.4623 0.477
Echinococcus multilocularis Netrin receptor DCC 0.0089 0.4623 0.4623
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.4623 0.4623
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.4623 0.4623
Brugia malayi Lethal protein 805 0.0089 0.4623 0.4623
Echinococcus multilocularis roundabout 2 0.0089 0.4623 0.4623
Schistosoma mansoni nephrin 0.0089 0.4623 0.4623
Echinococcus granulosus anosmin 1 0.0089 0.4623 0.477
Brugia malayi Fibronectin type III domain containing protein 0.0089 0.4623 0.4623
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0089 0.4623 0.477
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0089 0.4623 0.4623
Schistosoma mansoni titin 0.0089 0.4623 0.4623
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2488 0.2568
Echinococcus granulosus neuroglian 0.0089 0.4623 0.477
Schistosoma mansoni factor for adipocyte differentiation 0.0089 0.4623 0.4623
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0089 0.4623 0.4623
Echinococcus granulosus roundabout 2 0.0089 0.4623 0.477
Echinococcus granulosus EG95 0.0089 0.4623 0.477
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0089 0.4623 0.4623
Schistosoma mansoni tripartite motif protein trim9 0.0089 0.4623 0.4623
Loa Loa (eye worm) acetyltransferase 0.0175 1 1
Echinococcus multilocularis anosmin 1 0.0089 0.4623 0.4623
Schistosoma mansoni neuroglian 0.0089 0.4623 0.4623
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.4623 0.4623
Schistosoma mansoni cell adhesion molecule 0.0089 0.4623 0.4623
Echinococcus granulosus anosmin 1 0.0089 0.4623 0.477
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.4623 0.4623
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.4623 0.4623
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.1983 0.5
Schistosoma mansoni ephrin receptor 0.0089 0.4623 0.4623
Brugia malayi myotactin form B 0.0089 0.4623 0.4623
Loa Loa (eye worm) projectin 0.0089 0.4623 0.4623
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0089 0.4623 0.4623
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.4623 0.4623
Echinococcus granulosus cell adhesion molecule 0.0089 0.4623 0.477
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.4623 0.4623
Echinococcus granulosus roundabout 2 0.0089 0.4623 0.477
Loa Loa (eye worm) lethal protein 805 0.0089 0.4623 0.4623
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0452 0.0452
Brugia malayi Cytochrome P450 family protein 0.0023 0.0452 0.0452
Onchocerca volvulus 0.0089 0.4623 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0089 0.4623 0.4623
Onchocerca volvulus 0.0089 0.4623 1
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0089 0.4623 0.4623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2488 0.2488
Echinococcus granulosus G1Y162 protein 0.0089 0.4623 0.477
Schistosoma mansoni myosin-binding protein-related 0.0089 0.4623 0.4623
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.1983 0.5
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0089 0.4623 0.477
Echinococcus multilocularis cell adhesion molecule 0.0089 0.4623 0.4623
Onchocerca volvulus 0.0089 0.4623 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.2252 0.5
Loa Loa (eye worm) UNCoordinated family member 0.0089 0.4623 0.4623
Brugia malayi hypothetical protein 0.0089 0.4623 0.4623
Onchocerca volvulus 0.0089 0.4623 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Schistosoma mansoni cell adhesion molecule 0.0089 0.4623 0.4623
Schistosoma mansoni factor for adipocyte differentiation 0.0089 0.4623 0.4623
Echinococcus granulosus roundabout 2 0.0089 0.4623 0.477
Echinococcus multilocularis titin 0.0089 0.4623 0.4623
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0089 0.4623 0.4623
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2488 0.2568
Echinococcus granulosus Netrin receptor DCC 0.0089 0.4623 0.477
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0089 0.4623 0.4623
Schistosoma mansoni cell adhesion molecule 0.0089 0.4623 0.4623
Schistosoma mansoni hypothetical protein 0.0089 0.4623 0.4623
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.4623 0.4623
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0089 0.4623 0.4623
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Echinococcus granulosus anosmin 1 0.0089 0.4623 0.477
Echinococcus multilocularis roundabout 2 0.0089 0.4623 0.4623
Brugia malayi Lethal protein 805 0.0089 0.4623 0.4623
Echinococcus granulosus usherin 0.0089 0.4623 0.477
Schistosoma mansoni factor for adipocyte differentiation 0.0089 0.4623 0.4623
Echinococcus granulosus nephrin 0.0089 0.4623 0.477
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0089 0.4623 0.4623
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0089 0.4623 0.477
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0089 0.4623 0.4623
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0089 0.4623 0.4623
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0089 0.4623 0.4623
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.2252 0.5
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0089 0.4623 0.477
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.1983 0.5
Onchocerca volvulus 0.0089 0.4623 1
Onchocerca volvulus 0.0089 0.4623 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Echinococcus granulosus Netrin receptor DCC 0.0089 0.4623 0.477
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.4623 0.5
Brugia malayi Fibronectin type III domain containing protein 0.0089 0.4623 0.4623
Echinococcus multilocularis transfer RNA-Phe 0.0089 0.4623 0.4623
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Onchocerca volvulus 0.0089 0.4623 1
Echinococcus multilocularis titin 0.0089 0.4623 0.4623
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.2252 0.5
Onchocerca volvulus 0.0089 0.4623 1
Echinococcus granulosus contactin 0.0089 0.4623 0.477
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Loa Loa (eye worm) hypothetical protein 0.0089 0.4623 0.4623
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0089 0.4623 0.477
Echinococcus multilocularis neuroglian 0.0089 0.4623 0.4623
Echinococcus multilocularis anosmin 1 0.0089 0.4623 0.4623
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0089 0.4623 0.5
Brugia malayi Protein-tyrosine phosphatase 0.0089 0.4623 0.4623
Brugia malayi Fibronectin type III domain containing protein 0.0089 0.4623 0.4623
Onchocerca volvulus 0.0089 0.4623 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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