Detailed information for compound 1387428

Basic information

Technical information
  • TDR Targets ID: 1387428
  • Name: 2,3-dihydro-1,4-benzodioxin-7-yl-[4-(2,3-dime thylphenyl)piperazin-1-yl]methanone
  • MW: 352.427 | Formula: C21H24N2O3
  • H donors: 0 H acceptors: 1 LogP: 3.42 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc2c(c1)OCCO2)N1CCN(CC1)c1cccc(c1C)C
  • InChi: 1S/C21H24N2O3/c1-15-4-3-5-18(16(15)2)22-8-10-23(11-9-22)21(24)17-6-7-19-20(14-17)26-13-12-25-19/h3-7,14H,8-13H2,1-2H3
  • InChiKey: BOZOIIBAEOEPJS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,3-dihydro-1,4-benzodioxin-7-yl-[4-(2,3-dimethylphenyl)-1-piperazinyl]methanone
  • IVK/1268004
  • ZINC01459090
  • Oprea1_566774
  • MLS001018924
  • SMR000385413

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0216 0.3372 0.4556
Brugia malayi Immunoglobulin I-set domain containing protein 0.0272 0.4658 0.6294
Brugia malayi TAR-binding protein 0.0076 0.0227 0.0306
Onchocerca volvulus 0.0216 0.3372 0.7239
Schistosoma mansoni roundabout 0.0115 0.1095 0.1257
Onchocerca volvulus 0.0216 0.3372 0.7239
Echinococcus granulosus G1Y162 protein 0.0216 0.3372 0.3372
Echinococcus multilocularis Netrin receptor DCC 0.0216 0.3372 0.3372
Schistosoma mansoni tyrosine kinase 0.0069 0.0054 0.0062
Loa Loa (eye worm) myotactin form A 0.0216 0.3372 0.4556
Brugia malayi Immunoglobulin I-set domain containing protein 0.0394 0.7401 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0066 0 0.5
Brugia malayi Fibronectin type III domain containing protein 0.0216 0.3372 0.4556
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0069 0.0054 0.0054
Schistosoma mansoni tyrosine kinase 0.0069 0.0054 0.0062
Echinococcus multilocularis Immunoglobulin 0.0178 0.2524 0.2524
Onchocerca volvulus 0.0216 0.3372 0.7239
Echinococcus multilocularis roundabout 2 0.033 0.5971 0.5971
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.033 0.5971 0.5971
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.033 0.5971 0.5971
Schistosoma mansoni factor for adipocyte differentiation 0.0216 0.3372 0.387
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0272 0.4658 0.6294
Onchocerca volvulus Tyrosine kinase homolog 0.0121 0.1231 0.2643
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0236 0.3838 0.3838
Loa Loa (eye worm) hypothetical protein 0.0216 0.3372 0.4556
Loa Loa (eye worm) hypothetical protein 0.033 0.5971 0.8069
Echinococcus granulosus c src tyrosine kinase 0.0069 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0216 0.3372 0.4556
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0227 0.026
Loa Loa (eye worm) hypothetical protein 0.0115 0.1095 0.148
Schistosoma mansoni hypothetical protein 0.0216 0.3372 0.387
Loa Loa (eye worm) hypothetical protein 0.0115 0.1095 0.148
Echinococcus multilocularis anosmin 1 0.0216 0.3372 0.3372
Onchocerca volvulus 0.0216 0.3372 0.7239
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0227 0.0306
Echinococcus granulosus usherin 0.0216 0.3372 0.3372
Brugia malayi Immunoglobulin I-set domain containing protein 0.0272 0.4658 0.6294
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0216 0.3372 0.4556
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0216 0.3372 0.4556
Brugia malayi Fibronectin type III domain containing protein 0.0394 0.7401 1
Echinococcus multilocularis contactin neuroglian septate junction protein 0.033 0.5971 0.5971
Echinococcus multilocularis usherin 0.0216 0.3372 0.3372
Loa Loa (eye worm) hypothetical protein 0.0272 0.4658 0.6294
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0272 0.4658 0.6294
Echinococcus granulosus tar DNA binding protein 0.0076 0.0227 0.0227
Echinococcus multilocularis anosmin 1 0.0216 0.3372 0.3372
Schistosoma mansoni factor for adipocyte differentiation 0.0216 0.3372 0.387
Brugia malayi Protein-tyrosine phosphatase 0.0216 0.3372 0.4556
Loa Loa (eye worm) hypothetical protein 0.0216 0.3372 0.4556
Onchocerca volvulus 0.0216 0.3372 0.7239
Schistosoma mansoni hemicentin 0.0272 0.4658 0.5345
Brugia malayi hypothetical protein 0.0394 0.7401 1
Echinococcus multilocularis Netrin receptor DCC 0.0216 0.3372 0.3372
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0197 0.2963 0.2963
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0272 0.4658 0.6294
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0069 0.0054 0.0054
Schistosoma mansoni nephrin 0.033 0.5971 0.6853
Loa Loa (eye worm) hypothetical protein 0.0115 0.1095 0.148
Loa Loa (eye worm) hypothetical protein 0.0216 0.3372 0.4556
Brugia malayi Immunoglobulin I-set domain containing protein 0.0272 0.4658 0.6294
Brugia malayi Immunoglobulin I-set domain containing protein 0.0121 0.1231 0.1663
Schistosoma mansoni titin 0.0272 0.4658 0.5345
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0115 0.1095 0.1095
Echinococcus granulosus fibronectin type III domain-containing protein 0.0216 0.3372 0.3372
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0178 0.2524 0.2897
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.033 0.5971 0.8069
Echinococcus granulosus roundabout 2 0.033 0.5971 0.5971
Echinococcus granulosus tyrosine protein kinase otk 0.0115 0.1095 0.1095
Echinococcus granulosus titin 0.0272 0.4658 0.4658
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0216 0.3372 0.4556
Loa Loa (eye worm) hypothetical protein 0.0394 0.7401 1
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0216 0.3372 0.3372
Schistosoma mansoni vesicular amine transporter 0.0178 0.2524 0.2897
Loa Loa (eye worm) hypothetical protein 0.0216 0.3372 0.4556
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.033 0.5971 0.5971
Brugia malayi Prion-like- 0.0115 0.1095 0.148
Echinococcus multilocularis neuroglian 0.0235 0.3811 0.3811
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.028 0.4821 0.4821
Loa Loa (eye worm) hypothetical protein 0.0216 0.3372 0.4556
Onchocerca volvulus 0.0216 0.3372 0.7239
Onchocerca volvulus 0.0216 0.3372 0.7239
Schistosoma mansoni titin 0.0272 0.4658 0.5345
Brugia malayi Immunoglobulin I-set domain containing protein 0.0272 0.4658 0.6294
Echinococcus granulosus tyrosine protein kinase Lyn 0.0069 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0216 0.3372 0.4556
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0216 0.3372 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0227 0.026
Brugia malayi Immunoglobulin I-set domain containing protein 0.0115 0.1095 0.148
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0216 0.3372 0.4556
Echinococcus granulosus tyrosine protein kinase Fyn 0.0069 0.0054 0.0054
Echinococcus granulosus neuroglian 0.033 0.5971 0.5971
Echinococcus granulosus contactin 0.033 0.5971 0.5971
Loa Loa (eye worm) UNCoordinated family member 0.0216 0.3372 0.4556
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0115 0.1095 0.148
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0227 0.026
Echinococcus multilocularis peroxidasin 0.0115 0.1095 0.1095
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0216 0.3372 0.3372
Onchocerca volvulus 0.0216 0.3372 0.7239
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0178 0.2524 0.2897
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0216 0.3372 0.387
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0216 0.3372 0.3372
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0274 0.4685 0.6331
Schistosoma mansoni cell adhesion molecule 0.033 0.5971 0.6853
Brugia malayi Fibronectin type III domain containing protein 0.0216 0.3372 0.4556
Echinococcus multilocularis lachesin 0.0115 0.1095 0.1095
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0069 0.0054 0.0054
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0216 0.3372 0.387
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0121 0.1231 0.1231
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0115 0.1095 0.2351
Schistosoma mansoni tyrosine kinase 0.0179 0.2544 0.292
Schistosoma mansoni factor for adipocyte differentiation 0.0216 0.3372 0.387
Brugia malayi Fibronectin type III domain containing protein 0.0216 0.3372 0.4556
Brugia malayi Lethal protein 805 0.0216 0.3372 0.4556
Loa Loa (eye worm) hypothetical protein 0.0216 0.3372 0.4556
Loa Loa (eye worm) lethal protein 805 0.0216 0.3372 0.4556
Loa Loa (eye worm) hypothetical protein 0.0115 0.1095 0.148
Brugia malayi myotactin form B 0.0216 0.3372 0.4556
Loa Loa (eye worm) CAMK protein kinase 0.0272 0.4658 0.6294
Brugia malayi SRC-1 0.0069 0.0054 0.0073
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0178 0.2524 0.2524
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0274 0.4685 0.4685
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0216 0.3372 0.3372
Loa Loa (eye worm) hypothetical protein 0.0394 0.7401 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0115 0.1095 0.148
Onchocerca volvulus 0.0272 0.4658 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0069 0.0054 0.0054
Schistosoma mansoni septate junction protein 0.0115 0.1095 0.1257
Brugia malayi Fibronectin type III domain containing protein 0.0216 0.3372 0.4556
Loa Loa (eye worm) hypothetical protein 0.0216 0.3372 0.4556
Schistosoma mansoni cell adhesion molecule 0.033 0.5971 0.6853
Schistosoma mansoni serine/threonine protein kinase 0.0272 0.4658 0.5345
Echinococcus multilocularis roundabout 2 0.0508 1 1
Schistosoma mansoni tripartite motif protein trim9 0.0216 0.3372 0.387
Echinococcus multilocularis cell adhesion molecule 0.0216 0.3372 0.3372
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0274 0.4685 0.4685
Echinococcus granulosus lachesin 0.0115 0.1095 0.1095
Echinococcus granulosus twitchin 0.0235 0.3811 0.3811
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0069 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0115 0.1095 0.148
Brugia malayi Peroxidasin 0.0115 0.1095 0.148
Loa Loa (eye worm) hypothetical protein 0.0272 0.4658 0.6294
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0069 0.0054 0.0054
Echinococcus granulosus insulin growth factor 1 receptor beta 0.028 0.4821 0.4821
Loa Loa (eye worm) hypothetical protein 0.0178 0.2524 0.3411
Schistosoma mansoni cell adhesion molecule 0.0115 0.1095 0.1257
Schistosoma mansoni septate junction protein 0.0115 0.1095 0.1257
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0272 0.4658 0.4658
Loa Loa (eye worm) TK protein kinase 0.0121 0.1231 0.1663
Schistosoma mansoni tyrosine kinase 0.0069 0.0054 0.0062
Loa Loa (eye worm) hypothetical protein 0.0216 0.3372 0.4556
Leishmania major hypothetical protein, conserved 0.0216 0.3372 0.5
Onchocerca volvulus 0.0216 0.3372 0.7239
Echinococcus multilocularis tyrosine protein kinase Abl 0.0069 0.0054 0.0054
Onchocerca volvulus 0.0272 0.4658 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.033 0.5971 0.8069
Echinococcus multilocularis hemicentin 1 0.0115 0.1095 0.1095
Loa Loa (eye worm) TK/KIN16 protein kinase 0.03 0.5287 0.7144
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0069 0.0054 0.0054
Echinococcus granulosus defective proboscis extension response 0.0178 0.2524 0.2524
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0069 0.0054 0.0054
Schistosoma mansoni neuroglian 0.033 0.5971 0.6853
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0216 0.3372 0.4556
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0115 0.1095 0.1257
Schistosoma mansoni tyrosine kinase 0.0195 0.2909 0.3339
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0197 0.2963 0.2963
Echinococcus multilocularis hemicentin 1 0.0115 0.1095 0.1095
Schistosoma mansoni cell adhesion molecule 0.0272 0.4658 0.5345
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0216 0.3372 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0069 0.0054 0.0054
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0115 0.1095 0.148
Echinococcus granulosus Netrin receptor DCC 0.0216 0.3372 0.3372
Loa Loa (eye worm) hypothetical protein 0.0216 0.3372 0.4556
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0216 0.3372 0.4556
Onchocerca volvulus 0.0216 0.3372 0.7239
Loa Loa (eye worm) hypothetical protein 0.0216 0.3372 0.4556
Echinococcus granulosus tyrosine protein kinase Fyn 0.0069 0.0054 0.0054
Schistosoma mansoni tyrosine kinase 0.0069 0.0054 0.0062
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0216 0.3372 0.3372
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0121 0.1231 0.1231
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.033 0.5971 0.5971
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0227 0.026
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0227 0.0306
Echinococcus granulosus cell adhesion molecule 0.0216 0.3372 0.3372
Brugia malayi hypothetical protein 0.0216 0.3372 0.4556
Echinococcus multilocularis Fibronectin, type III 0.0216 0.3372 0.3372
Brugia malayi Immunoglobulin I-set domain containing protein 0.0274 0.4685 0.6331
Brugia malayi Immunoglobulin I-set domain containing protein 0.033 0.5971 0.8069
Brugia malayi Immunoglobulin I-set domain containing protein 0.0115 0.1095 0.148
Brugia malayi Immunoglobulin I-set domain containing protein 0.0115 0.1095 0.148
Echinococcus granulosus hemicentin 1 0.0115 0.1095 0.1095
Brugia malayi Immunoglobulin I-set domain containing protein 0.0272 0.4658 0.6294
Brugia malayi RNA binding protein 0.0076 0.0227 0.0306
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0069 0.0054 0.0054
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0216 0.3372 0.3372
Loa Loa (eye worm) hypothetical protein 0.0236 0.3838 0.5186
Echinococcus granulosus tyrosine protein kinase Src64B 0.0069 0.0054 0.0054
Schistosoma mansoni protein tyrosine phosphatase 0.0216 0.3372 0.387
Echinococcus multilocularis anosmin 1 0.0216 0.3372 0.3372
Brugia malayi Fibronectin type III domain containing protein 0.0216 0.3372 0.4556
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0069 0.0054 0.0062
Echinococcus granulosus anosmin 1 0.0216 0.3372 0.3372
Echinococcus multilocularis titin 0.0272 0.4658 0.4658
Onchocerca volvulus 0.0216 0.3372 0.7239
Echinococcus granulosus Fibronectin type III 0.0216 0.3372 0.3372
Brugia malayi Immunoglobulin I-set domain containing protein 0.03 0.5287 0.7144
Schistosoma mansoni hypothetical protein 0.0272 0.4658 0.5345
Brugia malayi SPRY domain containing protein 0.0216 0.3372 0.4556
Loa Loa (eye worm) hypothetical protein 0.0115 0.1095 0.148
Loa Loa (eye worm) hypothetical protein 0.0216 0.3372 0.4556
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0216 0.3372 0.387
Brugia malayi Tyrosine-protein kinase abl-1 0.0069 0.0054 0.0073
Echinococcus multilocularis tyrosine protein kinase otk 0.0115 0.1095 0.1095
Echinococcus granulosus titin 0.0272 0.4658 0.4658
Loa Loa (eye worm) hypothetical protein 0.0394 0.7401 1
Brugia malayi protein unc-22 0.0272 0.4658 0.6294
Schistosoma mansoni hypothetical protein 0.0216 0.3372 0.387
Loa Loa (eye worm) SRC-1 0.0069 0.0054 0.0073
Echinococcus granulosus peroxidasin 0.0115 0.1095 0.1095
Schistosoma mansoni titin 0.0216 0.3372 0.387
Echinococcus granulosus anosmin 1 0.0216 0.3372 0.3372
Onchocerca volvulus 0.0272 0.4658 1
Loa Loa (eye worm) hypothetical protein 0.0178 0.2524 0.3411
Loa Loa (eye worm) TK/ROR protein kinase 0.0121 0.1231 0.1663
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0216 0.3372 0.4556
Loa Loa (eye worm) hypothetical protein 0.0293 0.5124 0.6924
Brugia malayi Immunoglobulin I-set domain containing protein 0.033 0.5971 0.8069
Loa Loa (eye worm) projectin 0.0272 0.4658 0.6294
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0069 0.0054 0.0054
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0216 0.3372 0.3372
Echinococcus multilocularis c src tyrosine kinase 0.0069 0.0054 0.0054
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0227 0.0227
Brugia malayi Immunoglobulin I-set domain containing protein 0.0115 0.1095 0.148
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0069 0.0054 0.0054
Echinococcus multilocularis transfer RNA-Phe 0.0272 0.4658 0.4658
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0227 0.026
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0216 0.3372 0.3372
Echinococcus multilocularis neuroglian 0.033 0.5971 0.5971
Echinococcus granulosus Immunoglobulin 0.0178 0.2524 0.2524
Schistosoma mansoni cell adhesion molecule 0.0272 0.4658 0.5345
Brugia malayi Immunoglobulin I-set domain containing protein 0.0272 0.4658 0.6294
Trypanosoma cruzi hypothetical protein, conserved 0.0216 0.3372 0.5
Schistosoma mansoni titin 0.0115 0.1095 0.1257
Schistosoma mansoni ephrin receptor 0.028 0.4821 0.5533
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0216 0.3372 0.387
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0069 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0115 0.1095 0.148
Echinococcus granulosus Netrin receptor DCC 0.0216 0.3372 0.3372
Echinococcus granulosus Fibronectin type III domain containing protein 0.0216 0.3372 0.3372
Schistosoma mansoni cell adhesion molecule 0.0452 0.8714 1
Loa Loa (eye worm) hypothetical protein 0.0293 0.5124 0.6924
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0216 0.3372 0.3372
Loa Loa (eye worm) RNA binding protein 0.0076 0.0227 0.0306
Echinococcus granulosus nephrin 0.0272 0.4658 0.4658
Brugia malayi Lethal protein 805 0.0216 0.3372 0.4556
Echinococcus granulosus anosmin 1 0.0216 0.3372 0.3372
Schistosoma mansoni nephrin 0.045 0.8687 0.9969
Schistosoma mansoni myosin-binding protein-related 0.0272 0.4658 0.5345
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0216 0.3372 0.3372
Brugia malayi Immunoglobulin I-set domain containing protein 0.033 0.5971 0.8069
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0227 0.0306
Brugia malayi Immunoglobulin I-set domain containing protein 0.0115 0.1095 0.148
Echinococcus granulosus roundabout 2 0.033 0.5971 0.5971
Brugia malayi myotactin form A 0.0216 0.3372 0.4556
Loa Loa (eye worm) hypothetical protein 0.0178 0.2524 0.3411
Loa Loa (eye worm) hypothetical protein 0.0216 0.3372 0.4556
Echinococcus multilocularis titin 0.0216 0.3372 0.3372
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0216 0.3372 0.5
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.033 0.5971 0.6853
Echinococcus multilocularis Immunoglobulin 0.0178 0.2524 0.2524
Echinococcus multilocularis roundabout 2 0.033 0.5971 0.5971
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0272 0.4658 0.6294
Echinococcus granulosus neuroglian 0.0235 0.3811 0.3811
Brugia malayi Immunoglobulin I-set domain containing protein 0.0272 0.4658 0.6294
Echinococcus granulosus EG95 0.0216 0.3372 0.3372

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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