Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | myotactin form B | 0.0414 | 0.6115 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | anosmin 1 | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | titin | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0222 | 0 | 0.5 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0414 | 0.6115 | 0.6115 |
Leishmania major | hypothetical protein, conserved | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | fibronectin type III domain-containing protein | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | hemicentin | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | titin | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | nephrin | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | transfer RNA-Phe | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | Phosphotidylinositol phosphatase PTPRQ | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | myotactin form A | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | Fibronectin, type III | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0414 | 0.6115 | 1 |
Brugia malayi | protein unc-22 | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | Down syndrome cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | Fibronectin type III | 0.0414 | 0.6115 | 0.6115 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0222 | 0 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0414 | 0.6115 | 1 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | titin | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0536 | 1 | 1 |
Echinococcus granulosus | titin | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | myosin-binding protein-related | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | roundabout 2 | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | EG95 | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | projectin | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | factor for adipocyte differentiation | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | factor for adipocyte differentiation | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | usherin | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | G1Y162 protein | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | titin | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | neuroglian | 0.0414 | 0.6115 | 0.6115 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0222 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | anosmin 1 | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | Netrin receptor DCC | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | lethal protein 805 | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0222 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Brugia malayi | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | Phosphotidylinositol phosphatase PTPRQ | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 30. | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | UNCoordinated family member | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | nephrin | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | titin | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | anosmin 1 | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Schistosoma mansoni | ephrin receptor | 0.0536 | 1 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | neuroglian | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | fibronectin type III domain-containing protein | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Echinococcus granulosus | Netrin receptor DCC | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | titin | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | protein-tyrosine phosphatase Lar-like precursor, putative | 0.0414 | 0.6115 | 1 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Trypanosoma brucei | Fibronectin type III domain containing protein, putative | 0.0414 | 0.6115 | 1 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Echinococcus granulosus | anosmin 1 | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | contactin | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 32 | 0.0414 | 0.6115 | 1 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Lethal protein 805 | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | myotactin form A | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | Down syndrome cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Brugia malayi | SPRY domain containing protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | neuroglian | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | Phosphotidylinositol phosphatase PTPRQ | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Echinococcus granulosus | Netrin receptor DCC | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | tripartite motif protein trim9 | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0414 | 0.6115 | 1 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | anosmin 1 | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0222 | 0 | 0.5 |
Echinococcus multilocularis | anosmin 1 | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | usherin | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | factor for adipocyte differentiation | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | Netrin receptor DCC | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | Lethal protein 805 | 0.0414 | 0.6115 | 1 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | nephrin | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0414 | 0.6115 | 0.6115 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 0 % | Phytotoxicity against directly seeded Oryza sativa (rice) seedlings assessed as phytotoxic activity ratings (0- no effect to 5-complete killing rating scale) at 100 g/a measured after 3 weeks post compound treatment under green house conditions | ChEMBL. | 27393589 |
Activity (ADMET) | = 99 % | Effect on Oryza sativa (rice) assessed as growth rate at 1 uM relative to control | ChEMBL. | 27393060 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.