TDR Targets

Basic information

Technical information

TDR Targets ID: 1496475
Name: 1-[amino-(3-methylphenoxy)phosphoryl]oxy-3-me thylbenzene
MW: 277.256 | Formula: C14H16NO3P
H donors: 1 H acceptors: 1 LogP: 3.08 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(c1)OP(=O)(Oc1cccc(c1)C)N
InChi: 1S/C14H16NO3P/c1-11-5-3-7-13(9-11)17-19(15,16)18-14-8-4-6-12(2)10-14/h3-10H,1-2H3,(H2,15,16)
InChiKey: MHXKRLDJPWTMDD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[amino-(3-methylphenoxy)phosphoryl]oxy-3-methyl-benzene
bis(3-methylphenoxy)phosphorylamine
74178-24-8
MLS001049257
Phosphoramidic acid di-m-tolyl ester
SMR000427627
STOCK1S-94256
NSC202812
ZINC01737262

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0039	0.3299	0.3895
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0039	0.3299	0.3181
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0032	0.227	0.2133
Onchocerca volvulus		0.0039	0.3299	0.3895
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0071	0.8198	0.8166
Onchocerca volvulus		0.0039	0.3299	0.3895
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0032	0.227	0.2133
Schistosoma mansoni	neuroglian	0.0071	0.8198	0.9055
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0032	0.227	0.2612
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.1982	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Echinococcus multilocularis	anosmin 1	0.0039	0.3299	0.3181
Echinococcus multilocularis	titin	0.0032	0.227	0.2133
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0039	0.3299	0.3527
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0071	0.8198	0.8198
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Schistosoma mansoni	factor for adipocyte differentiation	0.0039	0.3299	0.3527
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.8198	1
Brugia malayi	hypothetical protein	0.0039	0.3299	0.4024
Brugia malayi	Prion-like-	0.0032	0.227	0.2768
Schistosoma mansoni	roundabout	0.0032	0.227	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Echinococcus granulosus	leucine rich repeats and immunoglobulin	0.0032	0.227	0.2133
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0039	0.3299	0.3299
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Schistosoma mansoni	hypothetical protein	0.0039	0.3299	0.3527
Brugia malayi	Peroxidasin	0.0032	0.227	0.2768
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Onchocerca volvulus		0.0071	0.8198	1
Schistosoma mansoni	subfamily M23B non-peptidase homologue (M23 family)	0.0032	0.227	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Schistosoma mansoni	septate junction protein	0.0032	0.227	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Brugia malayi	metabotropic glutamate receptor type 2	0.0033	0.2371	0.2892
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0039	0.3299	0.3181
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0071	0.8198	0.8198
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Echinococcus granulosus	contactin	0.0071	0.8198	0.8166
Onchocerca volvulus	Peroxidasin homolog	0.0032	0.227	0.2612
Schistosoma mansoni	ephrin receptor	0.0051	0.5137	0.5601
Schistosoma mansoni	septate junction protein	0.0032	0.227	0.2365
Echinococcus multilocularis	Netrin receptor DCC	0.0039	0.3299	0.3181
Schistosoma mansoni	cell adhesion molecule	0.0032	0.227	0.2365
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0039	0.3299	0.3181
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0071	0.8198	0.8198
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0032	0.227	0.2768
Brugia malayi	Guanylyl cyclase protein 23	0.0019	0.0173	0.0212
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0039	0.3299	0.3299
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.8198	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0032	0.227	0.227
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Echinococcus multilocularis	leucine rich repeats and immunoglobulin	0.0032	0.227	0.2133
Schistosoma mansoni	cell adhesion molecule	0.0071	0.8198	0.9055
Echinococcus granulosus	Fibronectin type III	0.0039	0.3299	0.3181
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0039	0.3299	0.3181
Brugia malayi	protein unc-22	0.0071	0.8198	1
Echinococcus granulosus	Netrin receptor DCC	0.0039	0.3299	0.3181
Loa Loa (eye worm)	myotactin form A	0.0039	0.3299	0.3299
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0068	0.7629	0.9306
Echinococcus granulosus	titin	0.0032	0.227	0.2133
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0032	0.227	0.2365
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0039	0.3299	0.3181
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Echinococcus granulosus	usherin	0.0039	0.3299	0.3181
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0071	0.8198	0.8166
Loa Loa (eye worm)	projectin	0.0071	0.8198	0.8198
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0039	0.3299	0.4024
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Echinococcus granulosus	titin	0.0071	0.8198	0.8166
Onchocerca volvulus		0.0039	0.3299	0.3895
Onchocerca volvulus		0.0071	0.8198	1
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0057	0.5964	0.5893
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0039	0.3299	0.3299
Echinococcus granulosus	anosmin 1	0.0039	0.3299	0.3181
Echinococcus granulosus	cell adhesion molecule	0.0039	0.3299	0.3181
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0044	0.4108	0.5011
Brugia malayi	Fibronectin type III domain containing protein	0.0039	0.3299	0.4024
Echinococcus granulosus	Netrin receptor DCC	0.0039	0.3299	0.3181
Loa Loa (eye worm)	CAMK protein kinase	0.0071	0.8198	0.8198
Schistosoma mansoni	hypothetical protein	0.0032	0.227	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0071	0.8198	0.8166
Schistosoma mansoni	titin	0.0032	0.227	0.2365
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0032	0.227	0.227
Brugia malayi	Prion-like-	0.0032	0.227	0.2768
Loa Loa (eye worm)	animal heme peroxidase	0.0032	0.227	0.227
Schistosoma mansoni	titin	0.0071	0.8198	0.9055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0051	0.5137	0.5051
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Loa Loa (eye worm)	glutamate receptor	0.0068	0.7629	0.7629
Echinococcus multilocularis	anosmin 1	0.0039	0.3299	0.3181
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0032	0.227	0.2133
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0039	0.3299	0.3181
Onchocerca volvulus	Putative titin	0.0032	0.227	0.2612
Onchocerca volvulus		0.0039	0.3299	0.3895
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Onchocerca volvulus		0.0039	0.3299	0.3895
Schistosoma mansoni	nephrin	0.0071	0.8198	0.9055
Echinococcus multilocularis	cell adhesion molecule	0.0039	0.3299	0.3181
Schistosoma mansoni	hypothetical protein	0.0032	0.227	0.2365
Schistosoma mansoni	hypothetical protein	0.0032	0.227	0.2365
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0039	0.3299	0.3527
Echinococcus granulosus	lachesin	0.0032	0.227	0.2133
Schistosoma mansoni	titin	0.0032	0.227	0.2365
Brugia malayi	myotactin form A	0.0039	0.3299	0.4024
Echinococcus granulosus	roundabout 2	0.0071	0.8198	0.8166
Echinococcus granulosus	nephrin	0.0071	0.8198	0.8166
Brugia malayi	Leucine Rich Repeat family protein	0.0032	0.227	0.2768
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.8198	1
Brugia malayi	Animal haem peroxidase family protein	0.0032	0.227	0.2768
Loa Loa (eye worm)	TK/ROR protein kinase	0.0044	0.4108	0.4108
Echinococcus multilocularis	transfer RNA-Phe	0.0071	0.8198	0.8166
Echinococcus multilocularis	Fibronectin, type III	0.0039	0.3299	0.3181
Echinococcus granulosus	insulin growth factor binding	0.0032	0.227	0.2133
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0071	0.8198	0.8198
Onchocerca volvulus		0.0039	0.3299	0.3895
Schistosoma mansoni	titin	0.0032	0.227	0.2365
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.1982	0.5
Echinococcus granulosus	EG95	0.0039	0.3299	0.3181
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Brugia malayi	kettin	0.0032	0.227	0.2768
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Echinococcus multilocularis	Netrin receptor DCC	0.0039	0.3299	0.3181
Onchocerca volvulus		0.0032	0.227	0.2612
Brugia malayi	hypothetical protein	0.0039	0.3299	0.4024
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Schistosoma mansoni	hypothetical protein	0.0039	0.3299	0.3527
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0071	0.8198	0.8198
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Echinococcus granulosus	Opioid binding protein:cell adhesion molecule	0.0032	0.227	0.2133
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0019	0.0173	0.0173
Echinococcus granulosus	titin	0.0032	0.227	0.2133
Onchocerca volvulus	Netrin receptor homolog	0.0032	0.227	0.2612
Brugia malayi	Protein-tyrosine phosphatase	0.0039	0.3299	0.4024
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0083	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.3299	0.4024
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0071	0.8198	0.9055
Echinococcus multilocularis	lachesin	0.0032	0.227	0.2133
Echinococcus multilocularis	neuroglian	0.0071	0.8198	0.8166
Brugia malayi	SPRY domain containing protein	0.0039	0.3299	0.4024
Onchocerca volvulus		0.0039	0.3299	0.3895
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0032	0.227	0.227
Echinococcus multilocularis	roundabout 2	0.0071	0.8198	0.8166
Brugia malayi	Lethal protein 805	0.0039	0.3299	0.4024
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0077	0.9035	1
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0039	0.3299	1
Schistosoma mansoni	hemicentin	0.0071	0.8198	0.9055
Brugia malayi	myotactin form B	0.0039	0.3299	0.4024
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Echinococcus multilocularis	tyrosine protein kinase otk	0.0032	0.227	0.2133
Brugia malayi	Wrapper/rega-1/klingon homolog protein 1	0.0032	0.227	0.2768
Echinococcus granulosus	roundabout 2	0.0071	0.8198	0.8166
Loa Loa (eye worm)	UNCoordinated family member	0.0039	0.3299	0.3299
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0039	0.3299	0.3181
Schistosoma mansoni	cell adhesion molecule	0.0039	0.3299	0.3527
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0061	0.6665	0.813
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0039	0.3299	0.3181
Echinococcus multilocularis	roundabout 2	0.0071	0.8198	0.8166
Schistosoma mansoni	nephrin	0.0071	0.8198	0.9055
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Onchocerca volvulus		0.0071	0.8198	1
Echinococcus multilocularis	twitchin	0.0032	0.227	0.2133
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0039	0.3299	0.3299
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Schistosoma mansoni	titin	0.0071	0.8198	0.9055
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.8198	1
Onchocerca volvulus		0.0032	0.227	0.2612
Echinococcus multilocularis	hemicentin 1	0.0032	0.227	0.2133
Schistosoma mansoni	metabotropic glutamate receptor	0.0057	0.5964	0.6534
Onchocerca volvulus		0.0032	0.227	0.2612
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0044	0.4108	0.4004
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0039	0.3299	0.4024
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0032	0.227	0.227
Onchocerca volvulus		0.0039	0.3299	0.3895
Schistosoma mansoni	titin	0.0032	0.227	0.2365
Brugia malayi	Fibronectin type III domain containing protein	0.0039	0.3299	0.4024
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0039	0.3299	0.3527
Schistosoma mansoni	tyrosine kinase	0.0044	0.4108	0.444
Brugia malayi	Receptor family ligand binding region containing protein	0.0019	0.0173	0.0212
Loa Loa (eye worm)	lethal protein 805	0.0039	0.3299	0.3299
Loa Loa (eye worm)	hypothetical protein	0.003	0.1982	0.1982
Brugia malayi	Fibronectin type III domain containing protein	0.0039	0.3299	0.4024
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0039	0.3299	0.4024
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0071	0.8198	0.8166
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0039	0.3299	0.3181
Echinococcus granulosus	titin	0.0071	0.8198	0.8166
Onchocerca volvulus	Peroxidasin homolog	0.0032	0.227	0.2612
Echinococcus multilocularis	insulin growth factor binding	0.0032	0.227	0.2133
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0051	0.5137	0.5051
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0032	0.227	0.227
Echinococcus granulosus	tyrosine protein kinase otk	0.0032	0.227	0.2133
Onchocerca volvulus		0.0032	0.227	0.2612
Echinococcus granulosus	leucine rich repeat containing protein 4	0.0032	0.227	0.2133
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0057	0.5964	0.5893
Loa Loa (eye worm)	hypothetical protein	0.0071	0.8198	0.8198
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.1982	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.3299	0.4024
Echinococcus granulosus	twitchin	0.0032	0.227	0.2133
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.3299	1
Schistosoma mansoni	tripartite motif protein trim9	0.0039	0.3299	0.3527
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0039	0.3299	0.3527
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0071	0.8198	0.8166
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Schistosoma mansoni	metabotropic glutamate receptor	0.0033	0.2371	0.2479
Echinococcus granulosus	neuroglian	0.0071	0.8198	0.8166
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0039	0.3299	0.3181
Schistosoma mansoni	slit	0.0032	0.227	0.2365
Schistosoma mansoni	hypothetical protein	0.0032	0.227	0.2365
Schistosoma mansoni	myosin-binding protein-related	0.0071	0.8198	0.9055
Loa Loa (eye worm)	TK protein kinase	0.0044	0.4108	0.4108
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Onchocerca volvulus	Tyrosine kinase homolog	0.0044	0.4108	0.4903
Echinococcus multilocularis	titin	0.0032	0.227	0.2133
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.1982	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.8198	1
Onchocerca volvulus		0.0032	0.227	0.2612
Echinococcus multilocularis	hemicentin 1	0.0032	0.227	0.2133
Echinococcus granulosus	titin	0.0032	0.227	0.2133
Schistosoma mansoni	cell adhesion molecule	0.0071	0.8198	0.9055
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0044	0.4108	0.4004
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0039	0.3299	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Loa Loa (eye worm)	hypothetical protein	0.0071	0.8198	0.8198
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0019	0.0173	0.0173
Brugia malayi	Fibronectin type III domain containing protein	0.0039	0.3299	0.4024
Schistosoma mansoni	nephrin related	0.0032	0.227	0.2365
Echinococcus multilocularis		0.0032	0.227	0.2133
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0032	0.227	0.227
Echinococcus granulosus	roundabout 2	0.0071	0.8198	0.8166
Loa Loa (eye worm)	hypothetical protein	0.0071	0.8198	0.8198
Echinococcus granulosus	G1Y162 protein	0.0039	0.3299	0.3181
Onchocerca volvulus		0.0032	0.227	0.2612
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Echinococcus multilocularis	neuroglian	0.0032	0.227	0.2133
Brugia malayi	Fibronectin type III domain containing protein	0.0039	0.3299	0.4024
Schistosoma mansoni	titin	0.0032	0.227	0.2365
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0039	0.3299	0.3181
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Schistosoma mansoni	cell adhesion molecule	0.0071	0.8198	0.9055
Schistosoma mansoni	protein tyrosine phosphatase	0.0039	0.3299	0.3527
Schistosoma mansoni	cell adhesion molecule	0.0032	0.227	0.2365
Schistosoma mansoni	hypothetical protein	0.0032	0.227	0.2365
Echinococcus granulosus	peroxidasin	0.0032	0.227	0.2133
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0039	0.3299	0.3181
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0019	0.0173	0.0173
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Onchocerca volvulus		0.0039	0.3299	0.3895
Schistosoma mansoni	factor for adipocyte differentiation	0.0039	0.3299	0.3527
Onchocerca volvulus		0.0039	0.3299	0.3895
Loa Loa (eye worm)	glutamate receptor	0.0027	0.1406	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Brugia malayi	Prion-like-	0.0032	0.227	0.2768
Echinococcus granulosus	down syndrome cell adhesion	0.0032	0.227	0.2133
Echinococcus multilocularis	anosmin 1	0.0039	0.3299	0.3181
Echinococcus multilocularis	peroxidasin	0.0032	0.227	0.2133
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0032	0.227	0.227
Echinococcus multilocularis	titin	0.0071	0.8198	0.8166
Echinococcus granulosus	hemicentin 1	0.0032	0.227	0.2133
Schistosoma mansoni	titin	0.0039	0.3299	0.3527
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0039	0.3299	1
Echinococcus multilocularis	Opioid binding protein:cell adhesion molecule	0.0032	0.227	0.2133
Brugia malayi	Fibronectin type III domain containing protein	0.0039	0.3299	0.4024
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0039	0.3299	0.3299
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0039	0.3299	0.3181
Onchocerca volvulus		0.0032	0.227	0.2612
Brugia malayi	hypothetical protein	0.002	0.0348	0.0424
Brugia malayi	Lethal protein 805	0.0039	0.3299	0.4024
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.8198	1
Schistosoma mansoni	titin	0.0032	0.227	0.2365
Echinococcus multilocularis	down syndrome cell adhesion	0.0032	0.227	0.2133
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Loa Loa (eye worm)	one IG domain family member	0.0032	0.227	0.227
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0071	0.8198	0.8166
Schistosoma mansoni	cell adhesion molecule	0.0071	0.8198	0.9055
Echinococcus granulosus	anosmin 1	0.0039	0.3299	0.3181
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0071	0.8198	0.8198
Echinococcus granulosus	neuroglian	0.0032	0.227	0.2133
Onchocerca volvulus		0.0032	0.227	0.2612
Loa Loa (eye worm)	hypothetical protein	0.0083	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.8198	1
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.227	0.2365
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0039	0.3299	0.3181
Echinococcus granulosus	anosmin 1	0.0039	0.3299	0.3181
Schistosoma mansoni	factor for adipocyte differentiation	0.0039	0.3299	0.3527
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.8198	1
Loa Loa (eye worm)	disorganized muscle protein 1	0.0032	0.227	0.227
Echinococcus multilocularis	usherin	0.0039	0.3299	0.3181
Schistosoma mansoni	hypothetical protein	0.0071	0.8198	0.9055
Brugia malayi	hypothetical protein	0.003	0.1982	0.2418
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.8198	0.9055
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0173	0.0173
Leishmania major	hypothetical protein, conserved	0.0039	0.3299	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.227	0.2768
Echinococcus multilocularis	titin	0.0032	0.227	0.2133
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.8198	1
Brugia malayi	Disorganized muscle protein 1	0.0032	0.227	0.2768
Brugia malayi	Prion-like-	0.0032	0.227	0.2768
Echinococcus multilocularis	roundabout 2	0.0071	0.8198	0.8166
Echinococcus multilocularis	titin	0.0039	0.3299	0.3181
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.8198	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.227	0.227
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3299	0.3299
Schistosoma mansoni	hypothetical protein	0.0032	0.227	0.2365

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0267 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.9285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	1.1689 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1699007

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1496475