Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | projectin | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0536 | 1 | 1 |
Echinococcus granulosus | titin | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | myosin-binding protein-related | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | EG95 | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | roundabout 2 | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | anosmin 1 | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | Netrin receptor DCC | 0.0414 | 0.6115 | 0.6115 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0222 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | lethal protein 805 | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Brugia malayi | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0222 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | UNCoordinated family member | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | Phosphotidylinositol phosphatase PTPRQ | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 30. | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | factor for adipocyte differentiation | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | factor for adipocyte differentiation | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | usherin | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | titin | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | neuroglian | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | G1Y162 protein | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | transfer RNA-Phe | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | Phosphotidylinositol phosphatase PTPRQ | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | myotactin form B | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0414 | 0.6115 | 0.6115 |
Leishmania major | hypothetical protein, conserved | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | titin | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | anosmin 1 | 0.0414 | 0.6115 | 0.6115 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0222 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | fibronectin type III domain-containing protein | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | titin | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | nephrin | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | hemicentin | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | Fibronectin type III | 0.0414 | 0.6115 | 0.6115 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0222 | 0 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Echinococcus multilocularis | titin | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | myotactin form A | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Echinococcus multilocularis | Fibronectin, type III | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | hypothetical protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | protein unc-22 | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | Down syndrome cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0414 | 0.6115 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | Netrin receptor DCC | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Schistosoma mansoni | tripartite motif protein trim9 | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0414 | 0.6115 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | Netrin receptor DCC | 0.0414 | 0.6115 | 0.6115 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0414 | 0.6115 | 1 |
Brugia malayi | Lethal protein 805 | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | factor for adipocyte differentiation | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | nephrin | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | anosmin 1 | 0.0414 | 0.6115 | 0.6115 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0222 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | anosmin 1 | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | usherin | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | fibronectin type III domain-containing protein | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | titin | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | Netrin receptor DCC | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Trypanosoma brucei | Fibronectin type III domain containing protein, putative | 0.0414 | 0.6115 | 1 |
Brugia malayi | protein-tyrosine phosphatase Lar-like precursor, putative | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | nephrin | 0.0414 | 0.6115 | 0.6115 |
Echinococcus granulosus | anosmin 1 | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Schistosoma mansoni | ephrin receptor | 0.0536 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Schistosoma mansoni | titin | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0414 | 0.6115 | 0.6115 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | neuroglian | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | hypothetical protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | Down syndrome cell adhesion molecule | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | myotactin form A | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0414 | 0.6115 | 1 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Brugia malayi | SPRY domain containing protein | 0.0414 | 0.6115 | 1 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0414 | 0.6115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | neuroglian | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0414 | 0.6115 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0414 | 0.6115 | 0.6115 |
Echinococcus multilocularis | Phosphotidylinositol phosphatase PTPRQ | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Echinococcus granulosus | roundabout 2 | 0.0414 | 0.6115 | 0.6115 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | contactin | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Echinococcus granulosus | anosmin 1 | 0.0414 | 0.6115 | 0.6115 |
Onchocerca volvulus | 0.0414 | 0.6115 | 0.5 | |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 32 | 0.0414 | 0.6115 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0414 | 0.6115 | 0.6115 |
Brugia malayi | Lethal protein 805 | 0.0414 | 0.6115 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 0 % | Phytotoxicity against transplanted Oryza sativa (rice) seedlings assessed as phytotoxic activity ratings (0- no effect to 5-complete killing rating scale) at 100 g/a measured after 3 weeks post compound treatment under green house conditions | ChEMBL. | 27393589 |
Activity (ADMET) | = 100 % | Effect on Oryza sativa (rice) assessed as growth rate at 1 uM relative to control | ChEMBL. | 27393060 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.