Detailed information for compound 1530023

Basic information

Technical information
  • TDR Targets ID: 1530023
  • Name: 1-(3,5-dimethylpiperidin-1-yl)-2-([1,2,4]tria zolo[4,5-a]pyridin-3-ylsulfanyl)ethanone
  • MW: 304.411 | Formula: C15H20N4OS
  • H donors: 0 H acceptors: 3 LogP: 3.27 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CC(C)CN(C1)C(=O)CSc1nnc2n1cccc2
  • InChi: 1S/C15H20N4OS/c1-11-7-12(2)9-18(8-11)14(20)10-21-15-17-16-13-5-3-4-6-19(13)15/h3-6,11-12H,7-10H2,1-2H3
  • InChiKey: ZBFCKPROCQSUMS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3,5-dimethyl-1-piperidyl)-2-([1,2,4]triazolo[4,5-a]pyridin-3-ylsulfanyl)ethanone
  • 1-(3,5-dimethyl-1-piperidinyl)-2-([1,2,4]triazolo[4,5-a]pyridin-3-ylthio)ethanone
  • 1-(3,5-dimethyl-1-piperidyl)-2-([1,2,4]triazolo[4,5-a]pyridin-3-ylthio)ethanone
  • T0517-9309

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Fibronectin type III domain containing protein 0.0089 0.442 0.3902
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0089 0.442 0.6887
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0089 0.442 0.3487
Echinococcus granulosus anosmin 1 0.0089 0.442 0.8994
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Echinococcus granulosus Netrin receptor DCC 0.0089 0.442 0.8994
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.442 0.5
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0089 0.442 0.3487
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0089 0.442 0.8994
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.482 0.5
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.482 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0161 1 1
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0089 0.442 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.442 0.3902
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0089 0.442 0.3487
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2327 0.285
Loa Loa (eye worm) myotactin form A 0.0089 0.442 0.3487
Brugia malayi Latrophilin receptor protein 2 0.0051 0.1432 0.0637
Brugia malayi myotactin form A 0.0089 0.442 0.3902
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0089 0.442 0.8994
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0089 0.442 0.5
Echinococcus granulosus neuroglian 0.0089 0.442 0.8994
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2327 0.285
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.2286 0.4744
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.482 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.2327 0.1615
Onchocerca volvulus 0.0089 0.442 0.5
Schistosoma mansoni hypothetical protein 0.0089 0.442 0.6887
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0089 0.442 0.8994
Onchocerca volvulus 0.0089 0.442 0.5
Echinococcus granulosus roundabout 2 0.0089 0.442 0.8994
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0089 0.442 0.8994
Schistosoma mansoni tripartite motif protein trim9 0.0089 0.442 0.6887
Brugia malayi SPRY domain containing protein 0.0089 0.442 0.3902
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.1432 0.1468
Echinococcus granulosus Netrin receptor DCC 0.0089 0.442 0.8994
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0089 0.442 0.8994
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0089 0.442 0.5
Loa Loa (eye worm) RNA binding protein 0.0062 0.2327 0.1045
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.442 0.3902
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Schistosoma mansoni hypothetical protein 0.0051 0.1432 0.1124
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Onchocerca volvulus 0.0089 0.442 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.442 0.3902
Brugia malayi TAR-binding protein 0.0062 0.2327 0.1615
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0089 0.442 0.3487
Schistosoma mansoni nephrin 0.0089 0.442 0.6887
Loa Loa (eye worm) hypothetical protein 0.0161 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.442 0.3902
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.442 0.3902
Echinococcus multilocularis roundabout 2 0.0089 0.442 0.8994
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.6034 0.5666
Schistosoma mansoni titin 0.0089 0.442 0.6887
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.1432 0.1468
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0089 0.442 0.8994
Echinococcus multilocularis anosmin 1 0.0089 0.442 0.8994
Echinococcus granulosus GPCR family 2 0.0051 0.1432 0.1468
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.2286 0.5
Schistosoma mansoni myosin-binding protein-related 0.0089 0.442 0.6887
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.442 0.3902
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.482 1
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0089 0.442 0.8994
Brugia malayi Fibronectin type III domain containing protein 0.0089 0.442 0.3902
Schistosoma mansoni factor for adipocyte differentiation 0.0089 0.442 0.6887
Onchocerca volvulus 0.0089 0.442 0.5
Echinococcus multilocularis Netrin receptor DCC 0.0089 0.442 0.8994
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0089 0.442 0.3487
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0089 0.442 0.8994
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0089 0.442 0.8994
Echinococcus multilocularis Fibronectin, type III 0.0089 0.442 0.8994
Onchocerca volvulus 0.0089 0.442 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0089 0.442 0.3487
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.2327 0.1045
Onchocerca volvulus 0.0089 0.442 0.5
Schistosoma mansoni titin 0.0089 0.442 0.6887
Echinococcus multilocularis anosmin 1 0.0089 0.442 0.8994
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Echinococcus multilocularis GPCR, family 2 0.0051 0.1432 0.1468
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.482 1
Onchocerca volvulus 0.0089 0.442 0.5
Echinococcus multilocularis transfer RNA-Phe 0.0089 0.442 0.8994
Loa Loa (eye worm) hypothetical protein 0.0094 0.482 0.3953
Echinococcus granulosus tar DNA binding protein 0.0062 0.2327 0.3723
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0089 0.442 0.3487
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0089 0.442 0.3902
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0089 0.442 0.3487
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.1432 0.1468
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.2286 0.5
Echinococcus multilocularis roundabout 2 0.0089 0.442 0.8994
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0089 0.442 0.8994
Echinococcus multilocularis Netrin receptor DCC 0.0089 0.442 0.8994
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2327 0.285
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0089 0.442 0.8994
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.442 0.3902
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0089 0.442 0.8994
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0089 0.442 0.8994
Loa Loa (eye worm) CAMK protein kinase 0.0089 0.442 0.3487
Leishmania major hypothetical protein, conserved 0.0089 0.442 0.5
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.482 0.5
Onchocerca volvulus 0.0089 0.442 0.5
Schistosoma mansoni hypothetical protein 0.0051 0.1432 0.1124
Echinococcus granulosus roundabout 2 0.0089 0.442 0.8994
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.482 0.7657
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0089 0.442 0.8994
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Echinococcus granulosus Fibronectin type III domain containing protein 0.0089 0.442 0.8994
Echinococcus granulosus titin 0.0089 0.442 0.8994
Brugia malayi Lethal protein 805 0.0089 0.442 0.3902
Brugia malayi Lethal protein 805 0.0089 0.442 0.3902
Echinococcus granulosus Fibronectin type III 0.0089 0.442 0.8994
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Onchocerca volvulus 0.0089 0.442 0.5
Echinococcus multilocularis neuroglian 0.0089 0.442 0.8994
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.442 0.3902
Schistosoma mansoni cell adhesion molecule 0.0089 0.442 0.6887
Schistosoma mansoni cell adhesion molecule 0.0089 0.442 0.6887
Brugia malayi Probable ClpP-like protease 0.0094 0.482 0.4339
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.442 0.3902
Brugia malayi protein unc-22 0.0089 0.442 0.3902
Echinococcus multilocularis anosmin 1 0.0089 0.442 0.8994
Echinococcus granulosus usherin 0.0089 0.442 0.8994
Echinococcus granulosus anosmin 1 0.0089 0.442 0.8994
Echinococcus multilocularis cell adhesion molecule 0.0089 0.442 0.8994
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0089 0.442 0.8994
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0089 0.442 0.6887
Brugia malayi hypothetical protein 0.0089 0.442 0.3902
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0089 0.442 0.3487
Echinococcus granulosus fibronectin type III domain-containing protein 0.0089 0.442 0.8994
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0089 0.442 0.8994
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.442 0.6887
Brugia malayi hypothetical protein 0.0089 0.442 0.3902
Echinococcus granulosus G1Y162 protein 0.0089 0.442 0.8994
Echinococcus multilocularis tar DNA binding protein 0.0062 0.2327 0.3723
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.482 1
Entamoeba histolytica hypothetical protein 0.0043 0.0849 0.5
Loa Loa (eye worm) lethal protein 805 0.0089 0.442 0.3487
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2327 0.285
Schistosoma mansoni ephrin receptor 0.0089 0.442 0.6887
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0089 0.442 0.8994
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.482 1
Brugia malayi Fibronectin type III domain containing protein 0.0089 0.442 0.3902
Brugia malayi myotactin form B 0.0089 0.442 0.3902
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0089 0.442 0.3487
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.482 0.5
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.482 1
Onchocerca volvulus 0.0089 0.442 0.5
Schistosoma mansoni neuroglian 0.0089 0.442 0.6887
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0089 0.442 0.3902
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.442 0.3902
Schistosoma mansoni hypothetical protein 0.0089 0.442 0.6887
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.482 0.5
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2327 0.285
Echinococcus multilocularis roundabout 2 0.0089 0.442 0.8994
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0089 0.442 0.6887
Loa Loa (eye worm) UNCoordinated family member 0.0089 0.442 0.3487
Brugia malayi Fibronectin type III domain containing protein 0.0089 0.442 0.3902
Entamoeba histolytica hypothetical protein 0.0043 0.0849 0.5
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.482 1
Onchocerca volvulus 0.0089 0.442 0.5
Brugia malayi RNA binding protein 0.0062 0.2327 0.1615
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Onchocerca volvulus 0.0089 0.442 0.5
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0089 0.442 0.8994
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Schistosoma mansoni factor for adipocyte differentiation 0.0089 0.442 0.6887
Echinococcus granulosus nephrin 0.0089 0.442 0.8994
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Entamoeba histolytica hypothetical protein 0.0043 0.0849 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0089 0.442 0.3487
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.1432 0.1468
Loa Loa (eye worm) TAR-binding protein 0.0062 0.2327 0.1045
Echinococcus granulosus contactin 0.0089 0.442 0.8994
Schistosoma mansoni cell adhesion molecule 0.0089 0.442 0.6887
Onchocerca volvulus 0.0089 0.442 0.5
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.482 1
Echinococcus granulosus anosmin 1 0.0089 0.442 0.8994
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Schistosoma mansoni titin 0.0089 0.442 0.6887
Brugia malayi Protein-tyrosine phosphatase 0.0089 0.442 0.3902
Echinococcus granulosus roundabout 2 0.0089 0.442 0.8994
Entamoeba histolytica hypothetical protein 0.0043 0.0849 0.5
Schistosoma mansoni protein tyrosine phosphatase 0.0089 0.442 0.6887
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.2286 0.3619
Schistosoma mansoni hypothetical protein 0.0051 0.1432 0.1124
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0089 0.442 0.6887
Schistosoma mansoni hypothetical protein 0.0089 0.442 0.6887
Onchocerca volvulus 0.0089 0.442 0.5
Schistosoma mansoni nephrin 0.0089 0.442 0.6887
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.442 0.3902
Schistosoma mansoni factor for adipocyte differentiation 0.0089 0.442 0.6887
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0089 0.442 0.8994
Schistosoma mansoni cell adhesion molecule 0.0089 0.442 0.6887
Schistosoma mansoni hemicentin 0.0089 0.442 0.6887
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0089 0.442 0.3902
Schistosoma mansoni hypothetical protein 0.0051 0.1432 0.1124
Brugia malayi Fibronectin type III domain containing protein 0.0089 0.442 0.3902
Schistosoma mansoni hypothetical protein 0.011 0.6034 1
Echinococcus multilocularis titin 0.0089 0.442 0.8994
Loa Loa (eye worm) projectin 0.0089 0.442 0.3487
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Schistosoma mansoni cell adhesion molecule 0.0089 0.442 0.6887
Loa Loa (eye worm) hypothetical protein 0.011 0.6034 0.5371
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.2286 0.3619
Echinococcus multilocularis usherin 0.0089 0.442 0.8994
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0089 0.442 0.8994
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0089 0.442 0.6887
Echinococcus granulosus EG95 0.0089 0.442 0.8994
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.442 0.3902
Echinococcus granulosus titin 0.0089 0.442 0.8994
Echinococcus multilocularis titin 0.0089 0.442 0.8994
Brugia malayi Fibronectin type III domain containing protein 0.0089 0.442 0.3902
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0161 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.442 0.3487
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.1432 0.0637
Echinococcus granulosus cell adhesion molecule 0.0089 0.442 0.8994

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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