Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0056 | 1 | 0.5 |
Giardia lamblia | Aurora kinase | 0.0056 | 1 | 0.5 |
Echinococcus granulosus | hemicentin 1 | 0.0041 | 0.5218 | 0.1703 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 1 | 1 |
Brugia malayi | Leucine Rich Repeat family protein | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.8229 | 0.8229 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Echinococcus multilocularis | twitchin | 0.0039 | 0.4389 | 0.0263 |
Echinococcus granulosus | roundabout 2 | 0.0041 | 0.5218 | 0.1703 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Echinococcus granulosus | lachesin | 0.0041 | 0.5218 | 0.1703 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5218 | 0.5218 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0041 | 0.5218 | 0.5218 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0041 | 0.5218 | 0.5218 |
Entamoeba histolytica | protein kinase, putative | 0.0056 | 1 | 0.5 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0056 | 1 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0041 | 0.5218 | 0.1703 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0041 | 0.5218 | 0.5218 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0052 | 0.8782 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Echinococcus granulosus | roundabout 2 | 0.005 | 0.8229 | 0.6926 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Schistosoma mansoni | cell adhesion molecule | 0.0041 | 0.5218 | 0.1703 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0052 | 0.8782 | 0.8782 |
Loa Loa (eye worm) | projectin | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | AUR protein kinase | 0.0056 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase transmembrane receptor | 0.0052 | 0.8782 | 0.7886 |
Schistosoma mansoni | cell adhesion molecule | 0.0041 | 0.5218 | 0.1703 |
Leishmania major | protein kinase, putative | 0.0056 | 1 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0041 | 0.5218 | 0.5218 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0042 | 0.537 | 0.537 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Trichomonas vaginalis | AGC family protein kinase | 0.0056 | 1 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0038 | 0.4237 | 0.4237 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0056 | 1 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0041 | 0.5218 | 0.5218 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5218 | 0.5218 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0041 | 0.5218 | 0.1703 |
Echinococcus multilocularis | neuroglian | 0.0041 | 0.5218 | 0.1703 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0041 | 0.5218 | 0.2159 |
Schistosoma mansoni | roundabout | 0.0041 | 0.5218 | 0.1703 |
Echinococcus multilocularis | roundabout 2 | 0.0041 | 0.5218 | 0.1703 |
Trichomonas vaginalis | AGC family protein kinase | 0.0056 | 1 | 0.5 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0041 | 0.5218 | 0.1703 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0039 | 0.4389 | 0.4389 |
Echinococcus granulosus | roundabout 2 | 0.0041 | 0.5218 | 0.1703 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0041 | 0.5218 | 0.5218 |
Trypanosoma brucei | aurora B kinase | 0.0056 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5218 | 0.5218 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | TK protein kinase | 0.0052 | 0.8782 | 0.8782 |
Echinococcus multilocularis | roundabout 2 | 0.005 | 0.8229 | 0.6926 |
Schistosoma mansoni | neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule | 0.0041 | 0.5218 | 0.1703 |
Brugia malayi | Peroxidasin | 0.0041 | 0.5218 | 0.5218 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5218 | 0.5218 |
Echinococcus granulosus | twitchin | 0.0048 | 0.7399 | 0.5486 |
Echinococcus granulosus | peroxidasin | 0.0041 | 0.5218 | 0.1703 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Trichomonas vaginalis | AGC family protein kinase | 0.0056 | 1 | 0.5 |
Loa Loa (eye worm) | one IG domain family member | 0.0038 | 0.4237 | 0.4237 |
Brugia malayi | Animal haem peroxidase family protein | 0.0038 | 0.4237 | 0.4237 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5218 | 0.5218 |
Entamoeba histolytica | protein kinase , putative | 0.0056 | 1 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0052 | 0.8782 | 0.8782 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0039 | 0.4389 | 0.0263 |
Echinococcus granulosus | contactin | 0.0041 | 0.5218 | 0.1703 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5218 | 0.5218 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Schistosoma mansoni | tyrosine kinase | 0.0055 | 0.9763 | 0.9589 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0041 | 0.5218 | 0.5218 |
Schistosoma mansoni | neuroglian | 0.0041 | 0.5218 | 0.1703 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0038 | 0.4237 | 0.4237 |
Schistosoma mansoni | titin | 0.0041 | 0.5218 | 0.1703 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0056 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Brugia malayi | Prion-like- | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | AUR protein kinase | 0.0056 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0039 | 0.4389 | 0.4389 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0041 | 0.5218 | 0.1703 |
Onchocerca volvulus | 0.0039 | 0.4389 | 0.0333 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5218 | 0.5218 |
Brugia malayi | Disorganized muscle protein 1 | 0.0038 | 0.4237 | 0.4237 |
Brugia malayi | Prion-like- | 0.0041 | 0.5218 | 0.5218 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Echinococcus granulosus | titin | 0.0039 | 0.4389 | 0.0263 |
Brugia malayi | Prion-like- | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5218 | 0.5218 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0056 | 1 | 0.5 |
Echinococcus multilocularis | aurora kinase A | 0.0056 | 1 | 1 |
Brugia malayi | Wrapper/rega-1/klingon homolog protein 1 | 0.0038 | 0.4237 | 0.4237 |
Echinococcus granulosus | neuroglian | 0.0041 | 0.5218 | 0.1703 |
Loa Loa (eye worm) | AUR protein kinase | 0.0056 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0056 | 1 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase otk | 0.0041 | 0.5218 | 0.1703 |
Brugia malayi | Prion-like- | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Echinococcus multilocularis | hemicentin 1 | 0.0041 | 0.5218 | 0.1703 |
Brugia malayi | protein unc-22 | 0.0039 | 0.4389 | 0.4389 |
Echinococcus multilocularis | tyrosine protein kinase transmembrane receptor | 0.0052 | 0.8782 | 0.7886 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0056 | 1 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase otk | 0.0041 | 0.5218 | 0.1703 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0041 | 0.5218 | 0.5218 |
Echinococcus granulosus | neuroglian | 0.0047 | 0.7247 | 0.5223 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0039 | 0.4389 | 0.4389 |
Trichomonas vaginalis | AGC family protein kinase | 0.0056 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.8229 | 0.8229 |
Schistosoma mansoni | septate junction protein | 0.0041 | 0.5218 | 0.1703 |
Echinococcus multilocularis | neurotracting:lsamp:neurotrimin:obcam | 0.0041 | 0.5218 | 0.1703 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0056 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0041 | 0.5218 | 0.5218 |
Schistosoma mansoni | cell adhesion molecule | 0.0041 | 0.5218 | 0.1703 |
Schistosoma mansoni | nephrin | 0.0041 | 0.5218 | 0.1703 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0041 | 0.5218 | 0.5218 |
Toxoplasma gondii | aurora kinase | 0.0056 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0056 | 1 | 1 |
Echinococcus granulosus | aurora kinase A | 0.0056 | 1 | 1 |
Echinococcus multilocularis | neuroglian | 0.0047 | 0.7247 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Echinococcus multilocularis | titin | 0.0039 | 0.4389 | 0.0263 |
Brugia malayi | kettin | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0038 | 0.4237 | 0.4237 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0041 | 0.5218 | 0.1703 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0039 | 0.4389 | 0.0263 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0038 | 0.4237 | 0.4237 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0041 | 0.5218 | 0.1703 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0041 | 0.5218 | 0.1703 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Schistosoma mansoni | titin | 0.0039 | 0.4389 | 0.0263 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Echinococcus multilocularis | hemicentin 1 | 0.0041 | 0.5218 | 0.1703 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | disorganized muscle protein 1 | 0.0038 | 0.4237 | 0.4237 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Schistosoma mansoni | protein kinase | 0.0056 | 1 | 1 |
Echinococcus multilocularis | lachesin | 0.0041 | 0.5218 | 0.1703 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0041 | 0.5218 | 0.5218 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0056 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4237 | 0.4237 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0056 | 1 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0041 | 0.5218 | 0.1703 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.4237 | 0.4237 |
Schistosoma mansoni | nephrin | 0.0047 | 0.7247 | 0.5223 |
Brugia malayi | serine/threonine kinase 12 | 0.0056 | 1 | 1 |
Schistosoma mansoni | septate junction protein | 0.0041 | 0.5218 | 0.1703 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0041 | 0.5218 | 0.5218 |
Echinococcus granulosus | titin | 0.0039 | 0.4389 | 0.0263 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 uM | Inhibition of EPH receptor B2 using ELISA; ND = Not determined | ChEMBL. | 15857128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.