TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 385.288 | Formula: C15H10Cl2N2O2S2
H donors: 1 H acceptors: 3 LogP: 4.73 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)c1csc(n1)NS(=O)(=O)c1cccc(c1)Cl
InChi: 1S/C15H10Cl2N2O2S2/c16-11-6-4-10(5-7-11)14-9-22-15(18-14)19-23(20,21)13-3-1-2-12(17)8-13/h1-9H,(H,18,19)
InChiKey: TUMWYLCZDAXMOJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific demethylase 1A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_130448	All targets in OG5_130448
Schistosoma japonicum	Lysine-specific histone demethylase 1, putative	Get druggable targets OG5_130448	All targets in OG5_130448
Schistosoma japonicum	ko:K00540 amine oxidase (flavin containing) domain 2 [EC:1.-.-.-], putative	Get druggable targets OG5_130448	All targets in OG5_130448
Brugia malayi	SWIRM domain containing protein	Get druggable targets OG5_130448	All targets in OG5_130448
Schistosoma mansoni	Lysine-specific histone demethylase 1	Get druggable targets OG5_130448	All targets in OG5_130448
Echinococcus multilocularis	lysine specific histone demethylase 1A	Get druggable targets OG5_130448	All targets in OG5_130448
Echinococcus granulosus	lysine specific histone demethylase 1A	Get druggable targets OG5_130448	All targets in OG5_130448
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130448	All targets in OG5_130448
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130448	All targets in OG5_130448
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130448	All targets in OG5_130448

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0054	0	0.5
Schistosoma mansoni	neuroglian	0.0184	0.706	0.706
Brugia malayi	Fibronectin type III domain containing protein	0.0184	0.706	1
Entamoeba histolytica	hypothetical protein	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Echinococcus granulosus	titin	0.0184	0.706	0.706
Echinococcus granulosus	roundabout 2	0.0184	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.706	1
Loa Loa (eye worm)	lethal protein 805	0.0184	0.706	1
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0	0.5
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0184	0.706	0.706
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0184	0.706	0.706
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0184	0.706	1
Echinococcus granulosus	EG95	0.0184	0.706	0.706
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0083	0.1569	0.1569
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Schistosoma mansoni	hypothetical protein	0.0184	0.706	0.706
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0	0.5
Entamoeba histolytica	hypothetical protein	0.0054	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Schistosoma mansoni	myosin-binding protein-related	0.0184	0.706	0.706
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Entamoeba histolytica	hypothetical protein	0.0054	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.706	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0054	0	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0054	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Echinococcus multilocularis	roundabout 2	0.0184	0.706	0.706
Brugia malayi	SWIRM domain containing protein	0.009	0.1951	0.2763
Entamoeba histolytica	hypothetical protein, conserved	0.0054	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0054	0	0.5
Toxoplasma gondii	protein kinase	0.0054	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.706	1
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0184	0.706	0.706
Trichomonas vaginalis	STE family protein kinase	0.0054	0	0.5
Echinococcus multilocularis	roundabout 2	0.0184	0.706	0.706
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0184	0.706	0.706
Plasmodium falciparum	protein kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0054	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0184	0.706	0.706
Entamoeba histolytica	receptor protein kinase, putative	0.0054	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0	0.5
Loa Loa (eye worm)	UNCoordinated family member	0.0184	0.706	1
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Brugia malayi	Lethal protein 805	0.0184	0.706	1
Brugia malayi	protein unc-22	0.0184	0.706	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0184	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0054	0	0.5
Loa Loa (eye worm)	CAMK protein kinase	0.0184	0.706	1
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0184	0.706	0.706
Schistosoma mansoni	nephrin	0.0184	0.706	0.706
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0054	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.706	1
Echinococcus multilocularis	roundabout 2	0.0184	0.706	0.706
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1569	0.2223
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Brugia malayi	myotactin form A	0.0184	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Leishmania major	hypothetical protein, conserved	0.0184	0.706	1
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0184	0.706	0.706
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0184	0.706	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.706	1
Giardia lamblia	Kinase, NEK	0.0054	0	0.5
Trichomonas vaginalis	TK family protein kinase	0.0054	0	0.5
Schistosoma mansoni	titin	0.0184	0.706	0.706
Brugia malayi	SPRY domain containing protein	0.0184	0.706	1
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0184	0.706	1
Echinococcus multilocularis	Netrin receptor DCC	0.0184	0.706	0.706
Brugia malayi	Fibronectin type III domain containing protein	0.0184	0.706	1
Schistosoma mansoni	cell adhesion molecule	0.0184	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Echinococcus granulosus	anosmin 1	0.0184	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0054	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Schistosoma mansoni	hypothetical protein	0.0184	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0184	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0184	0.706	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0054	0	0.5
Onchocerca volvulus		0.0184	0.706	1
Echinococcus multilocularis	Netrin receptor DCC	0.0184	0.706	0.706
Plasmodium falciparum	protein kinase, putative	0.0054	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.706	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Toxoplasma gondii	STE kinase	0.0054	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0184	0.706	0.706
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Echinococcus multilocularis	neuroglian	0.0184	0.706	0.706
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0184	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0184	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.706	1
Echinococcus granulosus	Fibronectin type III	0.0184	0.706	0.706
Onchocerca volvulus		0.0184	0.706	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0054	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Echinococcus granulosus	usherin	0.0184	0.706	0.706
Giardia lamblia	Kinase	0.0054	0	0.5
Echinococcus granulosus	cell adhesion molecule	0.0184	0.706	0.706
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Entamoeba histolytica	hypothetical protein	0.0054	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0	0.5
Echinococcus granulosus	G1Y162 protein	0.0184	0.706	0.706
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0054	0	0.5
Onchocerca volvulus		0.0184	0.706	1
Echinococcus granulosus	roundabout 2	0.0184	0.706	0.706
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0184	0.706	0.706
Schistosoma mansoni	ephrin receptor	0.0238	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Schistosoma mansoni	titin	0.0184	0.706	0.706
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Echinococcus multilocularis	anosmin 1	0.0184	0.706	0.706
Loa Loa (eye worm)	hypothetical protein	0.009	0.1951	0.2763
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0184	0.706	0.706
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0184	0.706	1
Echinococcus granulosus	Netrin receptor DCC	0.0184	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Brugia malayi	hypothetical protein	0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0184	0.706	0.706
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0184	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0184	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0184	0.706	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0184	0.706	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0184	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Brugia malayi	hypothetical protein	0.0184	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Schistosoma mansoni	cell adhesion molecule	0.0184	0.706	0.706
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0054	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0184	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0054	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0184	0.706	0.706
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0184	0.706	1
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0054	0	0.5
Onchocerca volvulus		0.0184	0.706	1
Echinococcus granulosus	Netrin receptor DCC	0.0184	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0054	0	0.5
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0184	0.706	0.706
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Schistosoma mansoni	tripartite motif protein trim9	0.0184	0.706	0.706
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0184	0.706	1
Echinococcus granulosus	neuroglian	0.0184	0.706	0.706
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0083	0.1569	0.1569
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0054	0	0.5
Onchocerca volvulus		0.0184	0.706	1
Schistosoma mansoni	cell adhesion molecule	0.0184	0.706	0.706
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0184	0.706	0.706
Entamoeba histolytica	hypothetical protein	0.0054	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Echinococcus multilocularis	anosmin 1	0.0184	0.706	0.706
Onchocerca volvulus		0.0184	0.706	1
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0184	0.706	0.706
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0	0.5
Onchocerca volvulus		0.0184	0.706	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0184	0.706	0.706
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Onchocerca volvulus		0.0184	0.706	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Schistosoma mansoni	hemicentin	0.0184	0.706	0.706
Onchocerca volvulus		0.009	0.1951	0.2763
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0184	0.706	0.706
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0054	0	0.5
Echinococcus multilocularis	anosmin 1	0.0184	0.706	0.706
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0184	0.706	0.706
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Plasmodium vivax	protein kinase, putative	0.0054	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Entamoeba histolytica	hypothetical protein	0.0054	0	0.5
Echinococcus multilocularis	titin	0.0184	0.706	0.706
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0184	0.706	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Echinococcus multilocularis	cell adhesion molecule	0.0184	0.706	0.706
Echinococcus granulosus	anosmin 1	0.0184	0.706	0.706
Echinococcus multilocularis	titin	0.0184	0.706	0.706
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Onchocerca volvulus		0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Giardia lamblia	Kinase, NEK	0.0054	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Echinococcus granulosus	roundabout 2	0.0184	0.706	0.706
Entamoeba histolytica	hypothetical protein	0.0054	0	0.5
Onchocerca volvulus		0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	cysteine surface protein, putative	0.0054	0	0.5
Echinococcus granulosus	anosmin 1	0.0184	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0184	0.706	0.706
Schistosoma mansoni	protein tyrosine phosphatase	0.0184	0.706	0.706
Echinococcus multilocularis	Fibronectin, type III	0.0184	0.706	0.706
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0054	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.706	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Schistosoma mansoni	factor for adipocyte differentiation	0.0184	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Echinococcus multilocularis	transfer RNA-Phe	0.0184	0.706	0.706
Brugia malayi	Fibronectin type III domain containing protein	0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0083	0.1569	0.1569
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	hypothetical protein	0.0054	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1569	0.2223
Schistosoma mansoni	factor for adipocyte differentiation	0.0184	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Echinococcus multilocularis	usherin	0.0184	0.706	0.706
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0	0.5
Giardia lamblia	Protein 21.1	0.0054	0	0.5
Entamoeba histolytica	hypothetical protein	0.0054	0	0.5
Schistosoma mansoni	nephrin	0.0184	0.706	0.706
Entamoeba histolytica	hypothetical protein	0.0054	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0184	0.706	1
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0	0.5
Brugia malayi	myotactin form B	0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0184	0.706	0.706
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Onchocerca volvulus		0.0184	0.706	1
Schistosoma mansoni	cell adhesion molecule	0.0184	0.706	0.706
Onchocerca volvulus		0.0184	0.706	1
Schistosoma mansoni	factor for adipocyte differentiation	0.0184	0.706	0.706
Schistosoma mansoni	cell adhesion molecule	0.0184	0.706	0.706
Onchocerca volvulus		0.0184	0.706	1
Onchocerca volvulus		0.0184	0.706	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0238	1	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0	0.5
Schistosoma mansoni	titin	0.0184	0.706	0.706
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0054	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Echinococcus granulosus	titin	0.0184	0.706	0.706
Brugia malayi	Protein-tyrosine phosphatase	0.0184	0.706	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0184	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0184	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0	0.5
Echinococcus granulosus	nephrin	0.0184	0.706	0.706
Entamoeba histolytica	hypothetical protein	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Loa Loa (eye worm)	myotactin form A	0.0184	0.706	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0	0.5
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0184	0.706	1
Echinococcus granulosus	contactin	0.0184	0.706	0.706
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0	0.5
Schistosoma mansoni	hypothetical protein	0.0184	0.706	0.706
Brugia malayi	Lethal protein 805	0.0184	0.706	1
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0184	0.706	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0	0.5
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0184	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0054	0	0.5
Loa Loa (eye worm)	projectin	0.0184	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0054	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 10.3 uM	Inhibition of LSD1 (unknown origin) using histone H3 (1 to 21) K4(Me1)-biotin peptide as substrate after 30 mins by HTRF assay	ChEMBL.	No reference
IC50 (binding)	= 248 uM	Inhibition of MAO-A (unknown origin) assessed as oxidative deamination of kynuramine to 4-hydroxyquinoline after 30 mins by fluorescence assay	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3134344

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1850413