Detailed information for compound 1394121

Basic information

Technical information
  • TDR Targets ID: 1394121
  • Name: 1-methyl-4-oxo-N-[3-(2-oxopyrrolidin-1-yl)pro pyl]-1,4-dihydropyrido[1,2-a]pyrrolo[2,3-d]py rimidine-2-carboxamide
  • MW: 367.402 | Formula: C19H21N5O3
  • H donors: 1 H acceptors: 3 LogP: 0.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCCN1CCCNC(=O)c1cc2c(n1C)nc1n(c2=O)cccc1
  • InChi: 1S/C19H21N5O3/c1-22-14(18(26)20-8-5-10-23-9-4-7-16(23)25)12-13-17(22)21-15-6-2-3-11-24(15)19(13)27/h2-3,6,11-12H,4-5,7-10H2,1H3,(H,20,26)
  • InChiKey: KVIYKROGWZEIPC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • MLS000094466
  • SMR000030027
  • T5434327
  • ZINC02917083

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens caspase 1, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens caspase 7, apoptosis-related cysteine peptidase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cell death protein 3 precursor caspase 7, apoptosis-related cysteine peptidase 303 aa 256 aa 37.1 %
Echinococcus granulosus caspase 8 caspase 1, apoptosis-related cysteine peptidase 383 aa 312 aa 26.6 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus titin 0.0322 0.4001 0.4001
Loa Loa (eye worm) hypothetical protein 0.0255 0.2557 0.3611
Onchocerca volvulus 0.0255 0.2557 0.639
Schistosoma mansoni tripartite motif protein trim9 0.0255 0.2557 0.2988
Loa Loa (eye worm) TK/ROR protein kinase 0.0142 0.0135 0.0191
Schistosoma mansoni factor for adipocyte differentiation 0.0255 0.2557 0.2988
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0322 0.4001 0.565
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0255 0.2557 0.3611
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0279 0.308 0.308
Echinococcus granulosus twitchin 0.0278 0.3049 0.3049
Schistosoma mansoni caspase-7 (C14 family) 0.0141 0.0115 0.0134
Schistosoma mansoni hypothetical protein 0.0322 0.4001 0.4676
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0255 0.2557 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0391 0.5476 0.5476
Loa Loa (eye worm) hypothetical protein 0.0255 0.2557 0.3611
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0324 0.4032 0.4032
Echinococcus multilocularis roundabout 2 0.0391 0.5476 0.5476
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0391 0.5476 0.5476
Loa Loa (eye worm) hypothetical protein 0.0255 0.2557 0.3611
Echinococcus multilocularis caspase 0.0141 0.0115 0.0115
Schistosoma mansoni ephrin receptor 0.033 0.4167 0.487
Schistosoma mansoni vesicular amine transporter 0.0211 0.1605 0.1876
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0322 0.4001 0.4001
Echinococcus multilocularis Netrin receptor DCC 0.0255 0.2557 0.2557
Echinococcus granulosus roundabout 2 0.0391 0.5476 0.5476
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0255 0.2557 0.2557
Brugia malayi Immunoglobulin I-set domain containing protein 0.0466 0.7081 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0255 0.2557 0.3611
Onchocerca volvulus 0.0322 0.4001 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0141 0.0115 0.0115
Echinococcus multilocularis anosmin 1 0.0255 0.2557 0.2557
Brugia malayi hypothetical protein 0.0466 0.7081 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0324 0.4032 0.5694
Echinococcus multilocularis usherin 0.0255 0.2557 0.2557
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0255 0.2557 0.2557
Loa Loa (eye worm) hypothetical protein 0.0211 0.1605 0.2267
Trypanosoma cruzi hypothetical protein, conserved 0.0255 0.2557 0.5
Schistosoma mansoni titin 0.0322 0.4001 0.4676
Echinococcus multilocularis roundabout 2 0.0601 1 1
Schistosoma mansoni tyrosine kinase 0.0211 0.161 0.1882
Echinococcus granulosus contactin 0.0391 0.5476 0.5476
Onchocerca volvulus 0.0255 0.2557 0.639
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0255 0.2557 0.2557
Echinococcus granulosus EG95 0.0255 0.2557 0.2557
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0322 0.4001 0.565
Loa Loa (eye worm) myotactin form A 0.0255 0.2557 0.3611
Loa Loa (eye worm) lethal protein 805 0.0255 0.2557 0.3611
Brugia malayi Fibronectin type III domain containing protein 0.0255 0.2557 0.3611
Loa Loa (eye worm) hypothetical protein 0.0255 0.2557 0.3611
Schistosoma mansoni hypothetical protein 0.0255 0.2557 0.2988
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0255 0.2557 0.5
Schistosoma mansoni hemicentin 0.0322 0.4001 0.4676
Echinococcus multilocularis titin 0.0255 0.2557 0.2557
Echinococcus granulosus Netrin receptor DCC 0.0255 0.2557 0.2557
Onchocerca volvulus 0.0255 0.2557 0.639
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0255 0.2557 0.2988
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0322 0.4001 0.565
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0255 0.2557 0.2557
Echinococcus granulosus nephrin 0.0322 0.4001 0.4001
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0255 0.2557 0.2557
Brugia malayi myotactin form A 0.0255 0.2557 0.3611
Loa Loa (eye worm) hypothetical protein 0.0391 0.5476 0.7733
Echinococcus multilocularis roundabout 2 0.0391 0.5476 0.5476
Echinococcus granulosus caspase 0.0141 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0255 0.2557 0.3611
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0255 0.2557 0.2988
Onchocerca volvulus 0.0255 0.2557 0.639
Echinococcus granulosus Immunoglobulin 0.0211 0.1605 0.1605
Brugia malayi Fibronectin type III domain containing protein 0.0255 0.2557 0.3611
Schistosoma mansoni protein tyrosine phosphatase 0.0255 0.2557 0.2988
Loa Loa (eye worm) hypothetical protein 0.0466 0.7081 1
Loa Loa (eye worm) hypothetical protein 0.0255 0.2557 0.3611
Onchocerca volvulus 0.0322 0.4001 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0255 0.2557 0.3611
Loa Loa (eye worm) hypothetical protein 0.0255 0.2557 0.3611
Echinococcus granulosus G1Y162 protein 0.0255 0.2557 0.2557
Echinococcus granulosus fibronectin type III domain-containing protein 0.0255 0.2557 0.2557
Onchocerca volvulus 0.0255 0.2557 0.639
Onchocerca volvulus 0.0255 0.2557 0.639
Schistosoma mansoni cell adhesion molecule 0.0391 0.5476 0.64
Loa Loa (eye worm) hypothetical protein 0.0211 0.1605 0.2267
Loa Loa (eye worm) hypothetical protein 0.0211 0.1605 0.2267
Loa Loa (eye worm) hypothetical protein 0.0322 0.4001 0.565
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.4001 0.4676
Brugia malayi Fibronectin type III domain containing protein 0.0255 0.2557 0.3611
Schistosoma mansoni cell adhesion molecule 0.0322 0.4001 0.4676
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0211 0.1605 0.1876
Onchocerca volvulus 0.0255 0.2557 0.639
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0354 0.469 0.6623
Echinococcus multilocularis neuroglian 0.0391 0.5476 0.5476
Loa Loa (eye worm) hypothetical protein 0.0255 0.2557 0.3611
Brugia malayi Fibronectin type III domain containing protein 0.0466 0.7081 1
Echinococcus granulosus roundabout 2 0.0391 0.5476 0.5476
Onchocerca volvulus 0.0255 0.2557 0.639
Echinococcus granulosus anosmin 1 0.0255 0.2557 0.2557
Schistosoma mansoni cell adhesion molecule 0.0322 0.4001 0.4676
Loa Loa (eye worm) hypothetical protein 0.0255 0.2557 0.3611
Echinococcus multilocularis transfer RNA-Phe 0.0322 0.4001 0.4001
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0255 0.2557 0.3611
Echinococcus multilocularis Fibronectin, type III 0.0255 0.2557 0.2557
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0255 0.2557 0.5
Onchocerca volvulus 0.0255 0.2557 0.639
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0391 0.5476 0.5476
Loa Loa (eye worm) projectin 0.0322 0.4001 0.565
Echinococcus multilocularis neuroglian 0.0278 0.3049 0.3049
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.033 0.4167 0.4167
Loa Loa (eye worm) hypothetical protein 0.0346 0.4524 0.6389
Brugia malayi Immunoglobulin I-set domain containing protein 0.0322 0.4001 0.565
Brugia malayi Immunoglobulin I-set domain containing protein 0.0322 0.4001 0.565
Echinococcus multilocularis Immunoglobulin 0.0211 0.1605 0.1605
Brugia malayi Immunoglobulin I-set domain containing protein 0.0322 0.4001 0.565
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0391 0.5476 0.5476
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0255 0.2557 0.2557
Brugia malayi Immunoglobulin I-set domain containing protein 0.0322 0.4001 0.565
Echinococcus multilocularis Netrin receptor DCC 0.0255 0.2557 0.2557
Brugia malayi myotactin form B 0.0255 0.2557 0.3611
Loa Loa (eye worm) hypothetical protein 0.0466 0.7081 1
Onchocerca volvulus 0.0322 0.4001 1
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0211 0.1605 0.1876
Loa Loa (eye worm) CAMK protein kinase 0.0322 0.4001 0.565
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0255 0.2557 0.2988
Schistosoma mansoni caspase-3 (C14 family) 0.0141 0.0115 0.0134
Echinococcus granulosus defective proboscis extension response 0.0211 0.1605 0.1605
Loa Loa (eye worm) hypothetical protein 0.0322 0.4001 0.565
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0255 0.2557 0.2557
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0391 0.5476 0.5476
Brugia malayi Fibronectin type III domain containing protein 0.0255 0.2557 0.3611
Schistosoma mansoni titin 0.0322 0.4001 0.4676
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0391 0.5476 0.64
Echinococcus granulosus Netrin receptor DCC 0.0255 0.2557 0.2557
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0255 0.2557 0.3611
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0255 0.2557 0.3611
Loa Loa (eye worm) hypothetical protein 0.0279 0.308 0.435
Loa Loa (eye worm) UNCoordinated family member 0.0255 0.2557 0.3611
Echinococcus granulosus neuroglian 0.0391 0.5476 0.5476
Schistosoma mansoni factor for adipocyte differentiation 0.0255 0.2557 0.2988
Echinococcus multilocularis cell adhesion molecule 0.0255 0.2557 0.2557
Echinococcus granulosus anosmin 1 0.0255 0.2557 0.2557
Echinococcus granulosus usherin 0.0255 0.2557 0.2557
Echinococcus granulosus Fibronectin type III 0.0255 0.2557 0.2557
Brugia malayi Immunoglobulin I-set domain containing protein 0.0354 0.469 0.6623
Brugia malayi protein unc-22 0.0322 0.4001 0.565
Loa Loa (eye worm) hypothetical protein 0.0466 0.7081 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0322 0.4001 0.565
Loa Loa (eye worm) hypothetical protein 0.0255 0.2557 0.3611
Echinococcus multilocularis anosmin 1 0.0255 0.2557 0.2557
Echinococcus granulosus Fibronectin type III domain containing protein 0.0255 0.2557 0.2557
Brugia malayi Immunoglobulin I-set domain containing protein 0.0391 0.5476 0.7733
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0141 0.0115 0.0115
Echinococcus multilocularis titin 0.0322 0.4001 0.4001
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0324 0.4032 0.4032
Schistosoma mansoni factor for adipocyte differentiation 0.0255 0.2557 0.2988
Loa Loa (eye worm) TK protein kinase 0.0142 0.0135 0.0191
Echinococcus multilocularis anosmin 1 0.0255 0.2557 0.2557
Echinococcus multilocularis Immunoglobulin 0.0211 0.1605 0.1605
Brugia malayi Immunoglobulin I-set domain containing protein 0.0322 0.4001 0.565
Brugia malayi Immunoglobulin I-set domain containing protein 0.0142 0.0135 0.0191
Brugia malayi hypothetical protein 0.0255 0.2557 0.3611
Brugia malayi SPRY domain containing protein 0.0255 0.2557 0.3611
Brugia malayi Immunoglobulin I-set domain containing protein 0.0391 0.5476 0.7733
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0211 0.1605 0.1605
Loa Loa (eye worm) hypothetical protein 0.0255 0.2557 0.3611
Brugia malayi Immunoglobulin I-set domain containing protein 0.0322 0.4001 0.565
Echinococcus granulosus neuroglian 0.0278 0.3049 0.3049
Brugia malayi Immunoglobulin I-set domain containing protein 0.0322 0.4001 0.565
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0391 0.5476 0.7733
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0142 0.0135 0.0135
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0142 0.0135 0.0135
Schistosoma mansoni neuroglian 0.0391 0.5476 0.64
Schistosoma mansoni hypothetical protein 0.0255 0.2557 0.2988
Brugia malayi Lethal protein 805 0.0255 0.2557 0.3611
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0255 0.2557 0.2988
Onchocerca volvulus 0.0255 0.2557 0.639
Brugia malayi Immunoglobulin I-set domain containing protein 0.0324 0.4032 0.5694
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0255 0.2557 0.2557
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0255 0.2557 0.3611
Onchocerca volvulus Tyrosine kinase homolog 0.0142 0.0135 0.0338
Echinococcus granulosus cell adhesion molecule 0.0255 0.2557 0.2557
Echinococcus granulosus titin 0.0322 0.4001 0.4001
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0255 0.2557 0.2557
Loa Loa (eye worm) hypothetical protein 0.0255 0.2557 0.3611
Onchocerca volvulus 0.0255 0.2557 0.639
Schistosoma mansoni cell adhesion molecule 0.0391 0.5476 0.64
Schistosoma mansoni nephrin 0.0391 0.5476 0.64
Brugia malayi Fibronectin type III domain containing protein 0.0255 0.2557 0.3611
Schistosoma mansoni myosin-binding protein-related 0.0322 0.4001 0.4676
Schistosoma mansoni nephrin 0.0533 0.8525 0.9964
Loa Loa (eye worm) hypothetical protein 0.0255 0.2557 0.3611
Loa Loa (eye worm) hypothetical protein 0.0255 0.2557 0.3611
Brugia malayi Immunoglobulin I-set domain containing protein 0.0391 0.5476 0.7733
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0391 0.5476 0.7733
Loa Loa (eye worm) hypothetical protein 0.0255 0.2557 0.3611
Schistosoma mansoni titin 0.0255 0.2557 0.2988
Loa Loa (eye worm) hypothetical protein 0.0346 0.4524 0.6389
Echinococcus granulosus anosmin 1 0.0255 0.2557 0.2557
Schistosoma mansoni cell adhesion molecule 0.0534 0.8556 1
Brugia malayi Lethal protein 805 0.0255 0.2557 0.3611
Echinococcus granulosus insulin growth factor 1 receptor beta 0.033 0.4167 0.4167
Brugia malayi Protein-tyrosine phosphatase 0.0255 0.2557 0.3611
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0255 0.2557 0.2557
Leishmania major hypothetical protein, conserved 0.0255 0.2557 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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