Detailed information for compound 1394112

Basic information

Technical information
  • TDR Targets ID: 1394112
  • Name: ethyl 1-[(4-methoxycarbonylphenyl)methyl]-4-( 2-methoxyethyl)piperidine-4-carboxylate
  • MW: 363.448 | Formula: C20H29NO5
  • H donors: 0 H acceptors: 2 LogP: 2.36 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCC1(CCN(CC1)Cc1ccc(cc1)C(=O)OC)C(=O)OCC
  • InChi: 1S/C20H29NO5/c1-4-26-19(23)20(11-14-24-2)9-12-21(13-10-20)15-16-5-7-17(8-6-16)18(22)25-3/h5-8H,4,9-15H2,1-3H3
  • InChiKey: VFPYAZSRBROSLL-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[(4-methoxycarbonylphenyl)methyl]-4-(2-methoxyethyl)-4-piperidinecarboxylic acid ethyl ester
  • 1-(4-carbomethoxybenzyl)-4-(2-methoxyethyl)isonipecotic acid ethyl ester
  • ethyl 1-[4-(methoxycarbonyl)benzyl]-4-(2-methoxyethyl)piperidine-4-carboxylate
  • MLS000734824
  • SMR000317830

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0235 0.1934 0.5499
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0156 0.0707
Giardia lamblia Cathepsin B precursor 0.0071 0.0521 0.131
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1934 0.5567
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0066 0.0481 0.048
Entamoeba histolytica cysteine protease, putative 0.0071 0.0521 0.259
Brugia malayi Protein cec-1. 0.0014 0.0027 0.0027
Onchocerca volvulus 0.0235 0.1934 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0014 0.0013
Echinococcus multilocularis cathepsin L 0.0137 0.1094 0.1093
Plasmodium vivax vivapain-2 0.0235 0.1934 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0316 0.0315
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0544 0.0531
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0481 0.0405
Brugia malayi cathepsin L-like precursor 0.0168 0.1362 0.1362
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0235 0.1934 0.1934
Onchocerca volvulus 0.0014 0.0027 0.007
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0235 0.1934 0.1934
Entamoeba histolytica cysteine protease, putative 0.0137 0.1094 0.5594
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0072 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0071 0.0521 0.1442
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0072 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0072 0.0131
Echinococcus multilocularis cathepsin L cysteine protease 0.0235 0.1934 0.1934
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0072 0.0131
Loa Loa (eye worm) hypothetical protein 0.0029 0.0156 0.0155
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0014 0.0013
Loa Loa (eye worm) helicase 0.0014 0.0027 0.0026
Loa Loa (eye worm) glutathione reductase 0.0057 0.0402 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1934 0.5567
Onchocerca volvulus 0.0235 0.1934 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0071 0.0521 0.0508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.234 0.6701
Echinococcus multilocularis cathepsin L cysteine protease 0.0235 0.1934 0.1934
Onchocerca volvulus 0.0015 0.0034 0.0104
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0079 0.0152
Giardia lamblia Cysteine protease 0.0071 0.0521 0.131
Echinococcus multilocularis expressed protein 0.0369 0.3097 0.3096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1934 0.5567
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0236 0.0235
Plasmodium vivax unspecified product 0.0137 0.1094 0.5594
Schistosoma mansoni cathepsin F (C01 family) 0.0235 0.1934 0.1923
Onchocerca volvulus 0.0029 0.0156 0.0739
Onchocerca volvulus 0.0235 0.1934 1
Brugia malayi Papain family cysteine protease containing protein 0.0071 0.0521 0.0521
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0014 0.0013
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0079 0.0273
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0095 0.0198
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0481 0.0405
Onchocerca volvulus 0.0235 0.1934 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0071 0.0521 0.259
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0316 0.0842
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0427 0.0414
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0072 0.0058
Loa Loa (eye worm) hypothetical protein 0.0168 0.1362 0.1361
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0402 0.1963
Plasmodium falciparum serine repeat antigen 2 0.0071 0.0521 0.259
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0014 0.0013
Giardia lamblia Cysteine protease 0.0071 0.0521 0.131
Echinococcus multilocularis musashi 0.0027 0.0139 0.0138
Echinococcus multilocularis cathepsin b 0.1168 1 1
Brugia malayi intermediate filament protein 0.0027 0.0139 0.0139
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0236 0.0235
Echinococcus granulosus cathepsin L cysteine protease 0.0137 0.1094 0.1093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0083 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0156 0.0155
Giardia lamblia Cathepsin B precursor 0.0071 0.0521 0.131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1934 0.5567
Brugia malayi cathepsin L-like cysteine proteinase 0.0071 0.0521 0.0521
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0064 0.0106
Loa Loa (eye worm) ctsf protein 0.0235 0.1934 0.1934
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0072 0.0071
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0072 0.0071
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0037 0.0228 0.0227
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0156 0.0156
Leishmania major cathepsin L-like protease 0.0235 0.1934 0.5499
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.1094 0.3008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0521 0.1442
Trypanosoma cruzi cysteine proteinase, putative 0.0137 0.1094 0.1023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0014 0.0014
Echinococcus granulosus GPCR family 2 0.0031 0.0178 0.0177
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0093 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0014 0.0013
Entamoeba histolytica cysteine protease, putative 0.0071 0.0521 0.259
Entamoeba histolytica cysteine proteinase 1, putative 0.0137 0.1094 0.5594
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.041 0.3453 1
Echinococcus granulosus dnaJ subfamily B 0.0494 0.4175 0.4174
Brugia malayi Cathepsin L-like precursor 0.0168 0.1362 0.1362
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0092
Schistosoma mansoni cathepsin F (C01 family) 0.0235 0.1934 0.1923
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.1034 0.8749
Echinococcus granulosus chromobox protein 2 0.0014 0.0027 0.0026
Plasmodium falciparum glutathione reductase 0.0057 0.0402 0.1963
Plasmodium vivax glutathione reductase, putative 0.0057 0.0402 0.1963
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0072 0.0072
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0427 1
Entamoeba histolytica cysteine protease, putative 0.0137 0.1094 0.5594
Brugia malayi ecdysteroid receptor 0.0012 0.0014 0.0014
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0071 0.0521 0.259
Brugia malayi Cathepsin L-like precursor 0.0235 0.1934 0.1934
Giardia lamblia Encystation-specific protease 0.0071 0.0521 0.131
Entamoeba histolytica cysteine protease, putative 0.0137 0.1094 0.5594
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1159 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0092
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0427 0.3221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1934 0.5567
Onchocerca volvulus 0.0014 0.0027 0.007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0095 0.0198
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0156 0.2196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1934 0.5567
Entamoeba histolytica cysteine proteinase, putative 0.0137 0.1094 0.5594
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0071 0.0521 0.259
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0521 0.1442
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0072 0.0071
Loa Loa (eye worm) hypothetical protein 0.0071 0.0521 0.052
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0236 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0521 0.1442
Echinococcus multilocularis cathepsin L 0.0071 0.0521 0.052
Leishmania major cathepsin L-like protease 0.0235 0.1934 0.5499
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.234 0.6701
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.234 0.6701
Echinococcus granulosus cathepsin l1 0.0168 0.1362 0.1361
Echinococcus multilocularis high affinity choline transporter 1 0.0344 0.2878 0.2877
Echinococcus multilocularis solute carrier family 5 0.0038 0.0236 0.0235
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0079 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0521 0.1442
Trypanosoma cruzi cysteine peptidase, putative 0.0137 0.1094 0.1023
Brugia malayi fibroinase precursor 0.0071 0.0521 0.0521
Giardia lamblia Cathepsin B precursor 0.041 0.3453 1
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0072 0.0058
Brugia malayi nuclear receptor NHR-88 0.0012 0.0014 0.0014
Plasmodium falciparum serine repeat antigen 6 0.0071 0.0521 0.259
Schistosoma mansoni lamin 0.0027 0.0139 0.0125
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0072 0.0071
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0079 0.0152
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0095 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1934 0.5567
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0079 0.0152
Trypanosoma cruzi cysteine proteinase, putative 0.0137 0.1094 0.1023
Trypanosoma cruzi cysteine peptidase, putative 0.0281 0.234 0.2279
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0045 0.0031
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.7107 0.7106
Echinococcus granulosus solute carrier family 5 0.0038 0.0236 0.0235
Onchocerca volvulus Cathepsin L homolog 0.0235 0.1934 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0095 0.0198
Brugia malayi Cathepsin L-like precursor 0.0235 0.1934 0.1934
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.076 0.076
Echinococcus multilocularis lamin 0.0027 0.0139 0.0138
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0347 0.0932
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1034 0.8837
Entamoeba histolytica cysteine protease, putative 0.0137 0.1094 0.5594
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0236 0.0235
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0072 0.0071
Schistosoma mansoni hypothetical protein 0.0031 0.0178 0.0164
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0156 0.0673
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1934 0.5567
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0316 0.0842
Loa Loa (eye worm) hypothetical protein 0.0149 0.1199 0.1198
Entamoeba histolytica cysteine proteinase, putative 0.0137 0.1094 0.5594
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0236 0.0235
Toxoplasma gondii cathepsin CPC1 0.0071 0.0521 0.1442
Onchocerca volvulus 0.0071 0.0521 0.2642
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0156 0.0226
Onchocerca volvulus 0.0235 0.1934 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1934 0.5567
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0093 0.0399
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0071 0.0521 0.259
Brugia malayi Cathepsin L-like precursor 0.0235 0.1934 0.1934
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0072 0.0071
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.002 0.0018
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0071 0.0521 0.0508
Schistosoma mansoni hypothetical protein 0.0031 0.0178 0.0164
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0072 0.0071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1934 0.5567
Onchocerca volvulus 0.0027 0.0139 0.0651
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0083 0.0035
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0476 0.131
Leishmania major cathepsin L-like protease 0.0281 0.234 0.6701
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0072 0.0071
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0347 0.0932
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1168 1 1
Brugia malayi Cathepsin L-like precursor 0.0235 0.1934 0.1934
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0072 0.0131
Schistosoma mansoni chromobox protein 0.0084 0.0635 0.0622
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0079 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0137 0.1094 0.1082
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0045 0.0043
Echinococcus granulosus expressed protein 0.0369 0.3097 0.3096
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0235 0.1934 0.1934
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0079 0.0273
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0095 0.0198
Loa Loa (eye worm) hypothetical protein 0.0029 0.0156 0.0155
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0635 0.1774
Entamoeba histolytica cysteine proteinase, putative 0.0168 0.1362 0.6996
Echinococcus multilocularis cathepsin b 0.1168 1 1
Schistosoma mansoni chromobox protein 0.0014 0.0027 0.0014
Echinococcus granulosus cathepsin L cysteine proteinase 0.0235 0.1934 0.1934
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0071 0.0521 0.1442
Plasmodium falciparum serine repeat antigen 8 0.0071 0.0521 0.259
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1034 0.8837
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0071
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0027 0.0014
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0071 0.0521 0.131
Giardia lamblia Cathepsin B precursor 0.0071 0.0521 0.131
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0178 0.0177
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0013
Onchocerca volvulus 0.0149 0.1199 0.6172
Echinococcus granulosus high affinity choline transporter 1 0.0344 0.2878 0.2877
Giardia lamblia Cathepsin L precursor 0.0071 0.0521 0.131
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0045 0.0043
Plasmodium falciparum cysteine proteinase falcipain 1 0.0137 0.1094 0.5594
Entamoeba histolytica cysteine proteinase, putative 0.0235 0.1934 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0197 0.0495
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0027 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0014 0.0013
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0168 0.1362 0.1361
Loa Loa (eye worm) cysteine protease 0.0235 0.1934 0.1934
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0137 0.1094 0.1023
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0236 0.0235
Brugia malayi GH02984p 0.0344 0.2878 0.2878
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0014 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0014 0.0013
Echinococcus granulosus microtubule associated protein 2 0.0833 0.7107 0.7106
Echinococcus granulosus chromobox protein 1 0.0084 0.0635 0.0634
Brugia malayi Cathepsin L-like precursor 0.0235 0.1934 0.1934
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0079 0.0078
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0156 0.0673
Brugia malayi steroid hormone receptor 0.0012 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0072 0.0058
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0139 0.0139
Onchocerca volvulus Cathepsin L homolog 0.0071 0.0521 0.2642
Giardia lamblia Cathepsin B precursor 0.041 0.3453 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0013
Brugia malayi glutathione reductase 0.0057 0.0402 0.0402
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0079 0.5
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0156 0.0673
Brugia malayi Valyl-tRNA synthetase 0.0014 0.0027 0.0027
Plasmodium vivax vivapain-2 0.0235 0.1934 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0139 0.0125
Entamoeba histolytica hypothetical protein 0.0019 0.0072 0.0235
Loa Loa (eye worm) hypothetical protein 0.0066 0.0481 0.048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.234 0.6701
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.234 0.6701
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0427 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.7107 0.7103
Treponema pallidum NADH oxidase 0.002 0.0079 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.1094 0.3114
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0072 0.0058
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0071 0.0521 0.259
Onchocerca volvulus 0.0037 0.0228 0.1114
Echinococcus multilocularis cpg binding protein 0.0037 0.0225 0.0224
Plasmodium vivax unspecified product 0.0066 0.0481 0.238
Schistosoma mansoni high-affinity choline transporter 0.0344 0.2878 0.2868
Giardia lamblia Cathepsin L-like protease 0.0071 0.0521 0.131
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0427 0.1031
Loa Loa (eye worm) hypothetical protein 0.1168 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0133
Schistosoma mansoni chromobox protein 0.0084 0.0635 0.0622
Schistosoma mansoni cpg binding protein 0.0037 0.0225 0.0212
Mycobacterium tuberculosis Probable reductase 0.013 0.1034 0.8837
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0427 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0072 0.0131
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1168 1 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0072 0.0071
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0071 0.0521 0.259
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0079 0.0079
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0014 0.0013
Entamoeba histolytica cysteine protease, putative 0.0137 0.1094 0.5594
Giardia lamblia Cathepsin L precursor 0.0071 0.0521 0.131
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0215 0.1767 0.1701
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0316 0.1572
Plasmodium falciparum serine repeat antigen 4 0.0071 0.0521 0.259
Entamoeba histolytica hypothetical protein 0.0019 0.0072 0.0235
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0071 0.0521 0.259
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0026
Brugia malayi Heterochromatin protein 1 0.0084 0.0635 0.0635
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0156 0.0226
Giardia lamblia Cysteine protease 0.0071 0.0521 0.131
Plasmodium falciparum serine repeat antigen 9 0.0071 0.0521 0.259
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0014
Echinococcus granulosus cathepsin b 0.1168 1 1
Entamoeba histolytica cysteine protease, putative 0.0235 0.1934 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0072 0.0071
Schistosoma mansoni chromobox protein 0.0014 0.0027 0.0014
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0071 0.0521 0.259
Schistosoma mansoni hypothetical protein 0.0067 0.0491 0.0477
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0208 0.0207
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0072 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0014 0.0014
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0014 0.0013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0139 0.0138
Entamoeba histolytica hypothetical protein 0.0071 0.0521 0.259
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0635 0.1774
Entamoeba histolytica cysteine protease, putative 0.0137 0.1094 0.5594
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0072 0.0131
Entamoeba histolytica cysteine protease, putative 0.0137 0.1094 0.5594
Loa Loa (eye worm) fibroinase 0.0235 0.1934 0.1934
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0072 0.0071
Brugia malayi Cathepsin L-like precursor 0.0168 0.1362 0.1362
Entamoeba histolytica cysteine proteinase, putative 0.0137 0.1094 0.5594
Loa Loa (eye worm) hypothetical protein 0.0071 0.0521 0.052
Echinococcus granulosus Chromo domain 0.0014 0.0027 0.0026
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0071 0.0521 0.259
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.076 0.0759
Mycobacterium ulcerans hypothetical protein 0.0029 0.0156 0.2196
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0427 0.0426
Brugia malayi SET domain containing protein 0.0015 0.0034 0.0034
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0402 0.0401
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0402 0.0401
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.002 0.0018
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0034 0.0034
Brugia malayi hypothetical protein 0.0019 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0013
Toxoplasma gondii cathepsin CPC2 0.0071 0.0521 0.1442
Echinococcus multilocularis Chromo domain 0.0014 0.0027 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0072 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.234 0.6701
Trypanosoma brucei cysteine peptidase C (CPC) 0.041 0.3453 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1034 0.8837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.1362 0.3895
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0083 0.0035
Plasmodium vivax vivapain-1 0.0137 0.1094 0.5594
Echinococcus granulosus cathepsin l1 0.0235 0.1934 0.1934
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0156 0.2196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0521 0.1442
Giardia lamblia Hypothetical protein 0.0071 0.0521 0.131
Onchocerca volvulus 0.0235 0.1934 1
Entamoeba histolytica cysteine protease, putative 0.0137 0.1094 0.5594
Echinococcus multilocularis cysteine protease 0.0235 0.1934 0.1934
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0156 0.0707
Echinococcus granulosus intermediate filament protein 0.0027 0.0139 0.0138
Toxoplasma gondii cathepsin CPL 0.0235 0.1934 0.5567
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0026
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0071 0.0521 0.052
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1159 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0236 0.0235
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0034 0.0034
Echinococcus granulosus cathepsin L 0.0137 0.1094 0.1093
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0015 0.0034 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1934 0.5567
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0071
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0178 0.0177
Plasmodium vivax serine-repeat antigen (SERA) 0.0071 0.0521 0.259
Plasmodium falciparum serine repeat antigen 1 0.0071 0.0521 0.259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0521 0.1442
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0071 0.0521 0.1442
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0093 0.0128
Giardia lamblia Cathepsin B precursor 0.0071 0.0521 0.131
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0402 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0014 0.0014
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0427 0.0414
Loa Loa (eye worm) hypothetical protein 0.0066 0.0481 0.048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.1094 0.3114
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0014 0.0014
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0072 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1934 0.5567
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0071 0.0521 0.259
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0071 0.0521 0.259
Plasmodium vivax serine-repeat antigen (SERA) 0.0071 0.0521 0.259
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0071 0.0521 0.0521
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0014 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.041 0.3453 1
Entamoeba histolytica cysteine protease, putative 0.0137 0.1094 0.5594
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0156 0.2196
Brugia malayi M-phase phosphoprotein, mpp8 0.0014 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0018
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0066 0.0481 0.0481
Leishmania major cathepsin L-like protease 0.0281 0.234 0.6701
Toxoplasma gondii cathepsin B 0.041 0.3453 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0521 0.1442
Entamoeba histolytica cysteine protease, putative 0.0071 0.0521 0.259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.234 0.6701
Brugia malayi Cathepsin L-like precursor 0.0235 0.1934 0.1934
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1168 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0178 0.0177
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0071 0.0521 0.131
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0071 0.0521 0.1442
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0014 0.0013
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0071 0.0521 0.0508
Giardia lamblia Cathepsin B precursor 0.0071 0.0521 0.131
Loa Loa (eye worm) hypothetical protein 0.0071 0.0521 0.052
Entamoeba histolytica cysteine protease, putative 0.0137 0.1094 0.5594
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0178 0.0178
Onchocerca volvulus 0.0038 0.0236 0.1156
Brugia malayi chromobox protein homolog 3 0.0047 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0071
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0156 0.2196
Schistosoma mansoni inositol transporter 0.0038 0.0236 0.0222
Trypanosoma cruzi cysteine peptidase, putative 0.0281 0.234 0.2279
Brugia malayi Cathepsin L-like cysteine proteinase 0.0168 0.1362 0.1362
Echinococcus multilocularis chromobox protein 2 0.0014 0.0027 0.0026
Trypanosoma cruzi cruzipain precursor, putative 0.0281 0.234 0.2279
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0013
Echinococcus multilocularis chromobox protein 1 0.0084 0.0635 0.0634
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0235 0.1934 0.5567
Onchocerca volvulus 0.0235 0.1934 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0071 0.0521 0.1442
Trypanosoma cruzi cysteine protease, putative 0.0137 0.1094 0.1023
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1034 0.8837
Onchocerca volvulus 0.0168 0.1362 0.7017
Brugia malayi CXXC zinc finger family protein 0.0035 0.0208 0.0208
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0095 0.0198
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0072 0.0072
Schistosoma mansoni cathepsin F (C01 family) 0.0168 0.1362 0.135
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0178 0.0178
Echinococcus granulosus cysteine protease 0.0137 0.1094 0.1093
Brugia malayi Papain family cysteine protease containing protein 0.0071 0.0521 0.0521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1934 0.5567
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0072 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.1094 0.3008
Loa Loa (eye worm) hypothetical protein 0.0027 0.0139 0.0138
Schistosoma mansoni cathepsin S (C01 family) 0.0071 0.0521 0.0508
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0079 0.0152
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0156 0.2196
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0071 0.0521 0.1442
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0014 0.0013
Entamoeba histolytica cysteine protease, putative 0.0071 0.0521 0.259
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0079 0.0078
Echinococcus granulosus cpg binding protein 0.0037 0.0225 0.0224
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1934 0.5567
Schistosoma mansoni hypothetical protein 0.0031 0.0178 0.0164
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0491 0.0491
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0026
Plasmodium falciparum thioredoxin reductase 0.0057 0.0402 0.1963
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0071 0.0521 0.0508
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0521 0.1442
Leishmania major cathepsin L-like protease 0.0235 0.1934 0.5499
Onchocerca volvulus 0.0035 0.0208 0.1011
Leishmania major cathepsin L-like protease 0.0281 0.234 0.6701
Entamoeba histolytica cysteine proteinase, putative 0.0235 0.1934 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0079 0.0273
Entamoeba histolytica hypothetical protein 0.0019 0.0072 0.0235
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1168 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0014 0.0014
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0402 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0014 0.0014
Brugia malayi cathepsin F-like cysteine proteinase 0.0066 0.0481 0.0481
Plasmodium vivax vivapain-3 0.0137 0.1094 0.5594
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0083 0.0035
Onchocerca volvulus 0.0027 0.0139 0.0651
Entamoeba histolytica cysteine proteinase, putative 0.0137 0.1094 0.5594
Brugia malayi Cathepsin L-like precursor 0.0066 0.0481 0.0481
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1934 0.5567
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.076 0.076
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0014 0.0014
Giardia lamblia Cathepsin B precursor 0.041 0.3453 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0521 0.1442
Loa Loa (eye worm) hypothetical protein 0.0099 0.076 0.0759
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0236 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1934 0.5567
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0072 0.0071
Entamoeba histolytica cysteine protease, putative 0.0137 0.1094 0.5594
Trypanosoma cruzi major cysteine proteinase, putative 0.0118 0.0927 0.0854
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.1362 0.3895
Schistosoma mansoni hypothetical protein 0.0494 0.4175 0.4167
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0635 0.0634
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0014 0.0013
Trypanosoma cruzi major cysteine proteinase, putative 0.0071 0.0521 0.0446
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0013
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0235 0.1934 1
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0236 0.0235
Loa Loa (eye worm) hypothetical protein 0.0071 0.0521 0.052
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0072 0.0058
Leishmania major cathepsin L-like protease 0.0235 0.1934 0.5499
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0071 0.0521 0.131
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0014 0.0013
Entamoeba histolytica cysteine protease, putative 0.0137 0.1094 0.5594
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0092
Schistosoma mansoni inositol transporter 0.0038 0.0236 0.0222
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0045 0.0043
Echinococcus multilocularis cysteine protease 0.0235 0.1934 0.1934
Brugia malayi hypothetical protein 0.0019 0.0072 0.0072
Schistosoma mansoni cathepsin C 0.0071 0.0521 0.0508
Schistosoma mansoni cpg binding protein 0.0037 0.0225 0.0212
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0178 0.0177
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0168 0.1362 0.1361
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0072 0.0071
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0137 0.1094 0.1082
Echinococcus granulosus Chromobox protein 3 0.0014 0.0027 0.0026
Echinococcus granulosus lamin dm0 0.0027 0.0139 0.0138
Plasmodium falciparum serine repeat antigen 5 0.0071 0.0521 0.259
Entamoeba histolytica cysteine protease, putative 0.0071 0.0521 0.259
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0072 0.0058
Echinococcus granulosus cathepsin l cysteine peptidase 0.0235 0.1934 0.1934
Giardia lamblia Cathepsin L precursor 0.0071 0.0521 0.131
Echinococcus granulosus lamin 0.0027 0.0139 0.0138
Giardia lamblia Cathepsin L precursor 0.0071 0.0521 0.131
Brugia malayi Papain family cysteine protease containing protein 0.0137 0.1094 0.1094
Schistosoma mansoni sodium/solute symporter 0.0038 0.0236 0.0222
Brugia malayi nuclear hormone receptor 0.0012 0.0014 0.0014
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0072 0.0058
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0521 0.1442
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1154 0.1153
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0236 0.0609
Schistosoma mansoni hypothetical protein 0.0031 0.0178 0.0164
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0178 0.0177
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0347 0.1733
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0059 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0071 0.0521 0.1442
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0427 0.0426
Loa Loa (eye worm) hypothetical protein 0.0067 0.0491 0.049
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0071 0.0521 0.0508
Trypanosoma brucei trypanothione reductase 0.0057 0.0402 0.0955
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1034 0.8837
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0027 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.234 0.6701
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1154 0.1153
Plasmodium falciparum serine repeat antigen 3 0.0071 0.0521 0.259
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0802 0.6836 0.6835
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0014 0.0013
Echinococcus granulosus chromobox protein 1 0.0084 0.0635 0.0634
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0014 0.0013
Brugia malayi MH2 domain containing protein 0.0144 0.1154 0.1154
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0072 0.0071
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1159 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0235 0.1934 0.5567
Entamoeba histolytica cysteine protease, putative 0.0137 0.1094 0.5594
Loa Loa (eye worm) hypothetical protein 0.0235 0.1934 0.1934
Plasmodium falciparum glutathione reductase 0.002 0.0079 0.0273
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0072 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1934 0.5567
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.041 0.3453 0.3444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1934 0.5567
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0137 0.1094 0.1082
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0093 0.0345
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0072 0.0071
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0095 0.0198
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0402 0.2985
Leishmania major trypanothione reductase 0.0057 0.0402 0.0955
Schistosoma mansoni hypothetical protein 0.0014 0.0027 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0071
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0079 0.0066
Leishmania major cysteine peptidase A (CPA) 0.0235 0.1934 0.5499
Plasmodium falciparum cysteine proteinase falcipain 3 0.0235 0.1934 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0071 0.0521 0.0508
Loa Loa (eye worm) hypothetical protein 0.0031 0.0178 0.0177
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0014 0.0013
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0071 0.0521 0.259
Toxoplasma gondii preprocathepsin c precursor, putative 0.0071 0.0521 0.1442
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.234 0.6701
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0156 0.2196
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0072 0.0058
Onchocerca volvulus Cathepsin L homolog 0.0235 0.1934 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0071
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0071 0.0521 0.259
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0064 0.0106
Schistosoma mansoni lamin 0.0027 0.0139 0.0125
Brugia malayi cathepsin Z-like cysteine proteinase 0.0071 0.0521 0.0521
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0072 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.234 0.6701
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1934 0.5567
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0071 0.0521 0.0508
Echinococcus granulosus cathepsin b 0.1168 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0156 0.2196
Brugia malayi hypothetical protein 0.0014 0.0027 0.0027
Giardia lamblia Cathepsin L precursor 0.0071 0.0521 0.131
Loa Loa (eye worm) cathepsin B 0.041 0.3453 0.3452
Brugia malayi Papain family cysteine protease containing protein 0.0235 0.1934 0.1934
Loa Loa (eye worm) hypothetical protein 0.0071 0.0521 0.052
Brugia malayi hypothetical protein 0.0149 0.1199 0.1199
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.041 0.3453 0.3401
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0026
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0071 0.0521 0.052
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0072 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0071 0.0521 0.1442
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0072 0.0072
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0093 0.0345
Toxoplasma gondii thioredoxin reductase 0.0057 0.0402 0.1093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0235 0.1934 0.5567
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0071 0.0521 0.131
Trypanosoma cruzi cysteine peptidase, putative 0.0281 0.234 0.2279
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0072 0.0071
Brugia malayi Papain family cysteine protease containing protein 0.0071 0.0521 0.0521
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0197 0.0495
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0027 0.0026
Brugia malayi cathepsin Z-like cysteine proteinase 0.0071 0.0521 0.0521
Schistosoma mansoni cathepsin s 0.0066 0.0481 0.0468
Brugia malayi CHD4 protein 0.0016 0.0045 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.234 0.6701
Plasmodium falciparum thioredoxin reductase 0.002 0.0079 0.0273
Schistosoma mansoni cathepsin B (C01 family) 0.0071 0.0521 0.0508
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0235 0.1934 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0095 0.0198
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1168 1 1
Brugia malayi cathepsin L precursor 0.0071 0.0521 0.0521
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0014 0.0013
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0235 0.1934 0.1934
Giardia lamblia Cathepsin L precursor 0.0071 0.0521 0.131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0071 0.0521 0.052
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0071 0.0521 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1934 0.5567
Brugia malayi cathepsin F-like cysteine proteinase 0.0071 0.0521 0.0521
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0014 0.0013
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0027 0.0026
Giardia lamblia Hypothetical protein 0.0071 0.0521 0.131
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0071 0.0521 0.259
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0072 0.0071
Giardia lamblia Cathepsin L-like protease 0.0071 0.0521 0.131
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0014 0.0014
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0014 0.0013
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0072 0.0072
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0072 0.0072
Plasmodium falciparum serine repeat antigen 7 0.0071 0.0521 0.259
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0014 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0014 0.0013
Brugia malayi Thioredoxin reductase 0.0057 0.0402 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0072 0.0131
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0014 0.0014
Echinococcus multilocularis lamin dm0 0.0027 0.0139 0.0138
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0156 0.0226
Entamoeba histolytica cysteine proteinase 2 0.0137 0.1094 0.5594
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0014 0.0013
Schistosoma mansoni cpg binding protein 0.0035 0.0208 0.0194
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0026
Echinococcus granulosus cathepsin L 0.0071 0.0521 0.052
Entamoeba histolytica cysteine protease, putative 0.0071 0.0521 0.259
Brugia malayi Papain family cysteine protease containing protein 0.0137 0.1094 0.1094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1934 0.5567
Trypanosoma cruzi cysteine peptidase, putative 0.0235 0.1934 0.187
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0072 0.0071
Echinococcus multilocularis chromobox protein 1 0.0084 0.0635 0.0634
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0072 0.0058
Echinococcus multilocularis GPCR, family 2 0.0031 0.0178 0.0177
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0066 0.0481 0.048
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0071 0.0521 0.0508
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.1934 0.5567
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0521 0.1442
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1159 1
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0072 0.0058
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0072 0.0058
Onchocerca volvulus Cathepsin F homolog 0.0235 0.1934 1
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0427 0.1167
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0156 0.0156
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.4175 0.4174
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0027 0.0014
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0071 0.0521 0.0508
Loa Loa (eye worm) hypothetical protein 0.0344 0.2878 0.2877
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0072 0.0071
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0013
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0139 0.0138
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0071 0.0521 0.259
Giardia lamblia Cysteine protease 0.0071 0.0521 0.131
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0032 0.0031
Brugia malayi PXA domain containing protein 0.0019 0.0072 0.0072
Plasmodium vivax unspecified product 0.0071 0.0521 0.259
Brugia malayi PXA domain containing protein 0.0019 0.0072 0.0072

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (binding) = 2.2387 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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