Detailed information for compound 1404193

Basic information

Technical information
  • TDR Targets ID: 1404193
  • Name: 2-[(3-methyl-6-oxo-7,8,9,10-tetrahydrobenzo[c ]chromen-1-yl)oxy]-N-(pyridin-3-ylmethyl)acet amide
  • MW: 378.421 | Formula: C22H22N2O4
  • H donors: 1 H acceptors: 3 LogP: 2.95 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1cccnc1)COc1cc(C)cc2c1c1CCCCc1c(=O)o2
  • InChi: 1S/C22H22N2O4/c1-14-9-18(27-13-20(25)24-12-15-5-4-8-23-11-15)21-16-6-2-3-7-17(16)22(26)28-19(21)10-14/h4-5,8-11H,2-3,6-7,12-13H2,1H3,(H,24,25)
  • InChiKey: IVDHKFJKBKZWON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(3-methyl-6-oxo-7,8,9,10-tetrahydrobenzo[c]chromen-1-yl)oxy]-N-(3-pyridylmethyl)acetamide
  • 2-[(6-keto-3-methyl-7,8,9,10-tetrahydrobenzo[c]chromen-1-yl)oxy]-N-(3-pyridylmethyl)acetamide
  • 2-[(3-methyl-6-oxo-7,8,9,10-tetrahydrobenzo[c]chromen-1-yl)oxy]-N-(pyridin-3-ylmethyl)ethanamide
  • ZINC05205741

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0126 0.5582 0.7698
Loa Loa (eye worm) fibroinase 0.0126 0.5582 0.7698
Echinococcus granulosus GPCR family 2 0.0019 0.0409 0.0556
Onchocerca volvulus 0.0126 0.5582 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0069 0.2842 0.3935
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0126 0.5582 0.7698
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.0868 0.0695
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.148 0.2042
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0069 0.2842 0.4665
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0029 0.0868 0.0443
Plasmodium falciparum serine repeat antigen 5 0.0029 0.0868 0.0443
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.016 0.7249 1
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.5582 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.5582 0.8435
Schistosoma mansoni cpg binding protein 0.0035 0.1167 0.0789
Entamoeba histolytica cysteine protease, putative 0.0072 0.299 0.45
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0868 0.0695
Giardia lamblia Cathepsin L precursor 0.0029 0.0868 0.0443
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2402 0.3308
Trypanosoma cruzi cysteine proteinase, putative 0.0072 0.299 0.3739
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0868 0.0695
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.016 0.7249 0.7132
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0445 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0029 0.0868 0.0695
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0868 0.0695
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0029 0.0868 0.0695
Echinococcus multilocularis cathepsin L 0.0029 0.0868 0.119
Onchocerca volvulus 0.0082 0.3461 0.55
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0868 0.0695
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0191 0.0263
Loa Loa (eye worm) hypothetical protein 0.0041 0.148 0.2034
Entamoeba histolytica cysteine proteinase, putative 0.0082 0.3461 0.55
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.5582 1
Brugia malayi cathepsin L precursor 0.0029 0.0868 0.1198
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.5582 0.8435
Trypanosoma cruzi major cysteine proteinase, putative 0.0029 0.0868 0.0622
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0868 0.0695
Giardia lamblia Cathepsin L precursor 0.0029 0.0868 0.0443
Loa Loa (eye worm) hypothetical protein 0.0029 0.0868 0.119
Leishmania major cathepsin L-like protease 0.0126 0.5582 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0868 0.119
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.5582 0.755
Entamoeba histolytica cysteine proteinase, putative 0.0072 0.299 0.45
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0191 0.0263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0868 0.0695
Entamoeba histolytica cysteine proteinase 2 0.0072 0.299 0.45
Onchocerca volvulus 0.0126 0.5582 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0126 0.5582 0.7698
Giardia lamblia Cathepsin L-like protease 0.0029 0.0868 0.0443
Leishmania major cathepsin L-like protease 0.0126 0.5582 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0126 0.5582 0.5376
Giardia lamblia Cathepsin B precursor 0.0029 0.0868 0.0443
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.5582 0.8435
Trypanosoma cruzi cruzipain precursor, putative 0.0126 0.5582 0.755
Trypanosoma cruzi cysteine proteinase, putative 0.0072 0.299 0.3739
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.5582 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.299 0.4953
Brugia malayi cathepsin Z-like cysteine proteinase 0.0029 0.0868 0.1198
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0126 0.5582 0.5376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.5582 0.8435
Entamoeba histolytica cysteine protease, putative 0.0072 0.299 0.45
Leishmania major cathepsin L-like protease 0.0126 0.5582 1
Plasmodium vivax vivapain-2 0.0126 0.5582 0.5376
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0126 0.5582 0.8435
Leishmania major cathepsin L-like protease 0.0126 0.5582 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0069 0.2842 0.3522
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.01 0.4333 0.4069
Plasmodium falciparum serine repeat antigen 4 0.0029 0.0868 0.0443
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0409 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.0868 0.0695
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.5582 0.8435
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0029 0.0868 0.0443
Brugia malayi Cathepsin L-like precursor 0.0126 0.5582 0.77
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.0868 0.0695
Giardia lamblia Cysteine protease 0.0029 0.0868 0.0443
Leishmania major cathepsin L-like protease 0.0126 0.5582 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0072 0.299 0.269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.5582 0.8435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0082 0.3461 0.4952
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0868 0.0479
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.5582 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0072 0.299 0.269
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.2252 0.2985
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.5582 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.5795 0.8837
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.305 0.2753
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0044 0.1608 0.2211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0082 0.3461 0.4952
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0126 0.5582 0.7698
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.6499 1
Onchocerca volvulus Cathepsin L homolog 0.0126 0.5582 1
Plasmodium vivax vivapain-3 0.0072 0.299 0.2663
Plasmodium falciparum thioredoxin reductase 0.0057 0.2252 0.1891
Brugia malayi Cathepsin L-like precursor 0.0126 0.5582 0.77
Giardia lamblia Hypothetical protein 0.0029 0.0868 0.0443
Onchocerca volvulus 0.0126 0.5582 1
Toxoplasma gondii thioredoxin reductase 0.0057 0.2252 0.1891
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.5582 0.8435
Loa Loa (eye worm) hypothetical protein 0.0019 0.0409 0.0556
Echinococcus multilocularis cathepsin L 0.0072 0.299 0.4119
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0445 0.5
Leishmania major trypanothione reductase 0.0057 0.2252 0.3518
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0044 0.1608 0.2218
Loa Loa (eye worm) hypothetical protein 0.0082 0.3461 0.4769
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.6499 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.2252 0.3101
Loa Loa (eye worm) glutathione reductase 0.0057 0.2252 0.3101
Loa Loa (eye worm) hypothetical protein 0.006 0.2402 0.3308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.5582 0.8435
Entamoeba histolytica cysteine proteinase, putative 0.0072 0.299 0.45
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0868 0.0695
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0445 0.5
Entamoeba histolytica cysteine protease, putative 0.0126 0.5582 1
Toxoplasma gondii cathepsin CPL 0.0126 0.5582 0.5376
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0445 0.0614
Giardia lamblia Cathepsin L precursor 0.0029 0.0868 0.0443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.5582 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0409 0.0556
Leishmania major cysteine peptidase A (CPA) 0.0126 0.5582 1
Echinococcus multilocularis cysteine protease 0.0126 0.5582 0.7698
Brugia malayi Cathepsin L-like precursor 0.0082 0.3461 0.4774
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.5582 0.8435
Onchocerca volvulus 0.0035 0.1167 0.0633
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2402 0.3314
Plasmodium falciparum serine repeat antigen 6 0.0029 0.0868 0.0443
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0409 0.0556
Trypanosoma cruzi cysteine protease, putative 0.0072 0.299 0.3739
Echinococcus multilocularis cathepsin L cysteine protease 0.0126 0.5582 0.7698
Echinococcus granulosus cathepsin b 0.016 0.7249 1
Entamoeba histolytica cysteine protease, putative 0.0072 0.299 0.45
Loa Loa (eye worm) cathepsin B 0.0069 0.2842 0.3915
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.5582 0.8435
Brugia malayi Cathepsin L-like cysteine proteinase 0.0082 0.3461 0.4774
Brugia malayi cathepsin L-like precursor 0.0082 0.3461 0.4774
Plasmodium falciparum glutathione reductase 0.0057 0.2252 0.1891
Entamoeba histolytica cysteine protease, putative 0.0072 0.299 0.45
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0445 0.0606
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.2252 0.3101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.5582 0.8435
Brugia malayi Cathepsin L-like precursor 0.0082 0.3461 0.4774
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.5582 0.755
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0445 0.0606
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.5582 0.8435
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0868 0.0479
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.5582 0.755
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0445 0.5
Plasmodium vivax unspecified product 0.0029 0.0868 0.0443
Giardia lamblia Cysteine protease 0.0029 0.0868 0.0443
Entamoeba histolytica cysteine proteinase, putative 0.0072 0.299 0.45
Treponema pallidum NADH oxidase 0.002 0.0445 0.5
Brugia malayi fibroinase precursor 0.0029 0.0868 0.1198
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0029 0.0868 0.1198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.5582 1
Trypanosoma brucei trypanothione reductase 0.0057 0.2252 0.3518
Leishmania major cathepsin L-like protease 0.0126 0.5582 1
Toxoplasma gondii cathepsin B 0.0069 0.2842 0.2508
Giardia lamblia Cathepsin L precursor 0.0029 0.0868 0.0443
Plasmodium falciparum cysteine proteinase falcipain 1 0.0072 0.299 0.2663
Echinococcus multilocularis cpg binding protein 0.0037 0.1262 0.1734
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.5795 0.8837
Mycobacterium tuberculosis Probable reductase 0.013 0.5795 0.8837
Echinococcus granulosus cathepsin L 0.0072 0.299 0.4119
Echinococcus multilocularis cysteine protease 0.0126 0.5582 0.7698
Trypanosoma brucei cysteine peptidase C (CPC) 0.0069 0.2842 0.4665
Plasmodium vivax serine-repeat antigen (SERA) 0.0029 0.0868 0.0443
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0868 0.1198
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0126 0.5582 0.8435
Entamoeba histolytica cysteine protease, putative 0.0072 0.299 0.45
Loa Loa (eye worm) ctsf protein 0.0126 0.5582 0.7698
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0072 0.299 0.3739
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.5582 0.8435
Loa Loa (eye worm) hypothetical protein 0.0029 0.0868 0.119
Brugia malayi Papain family cysteine protease containing protein 0.0126 0.5582 0.77
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.5582 0.8435
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0868 0.1198
Plasmodium vivax unspecified product 0.0072 0.299 0.2663
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0082 0.3461 0.4432
Echinococcus granulosus cathepsin l cysteine peptidase 0.0126 0.5582 0.7698
Plasmodium vivax vivapain-1 0.0072 0.299 0.2663
Schistosoma mansoni hypothetical protein 0.0041 0.148 0.1116
Echinococcus multilocularis cathepsin b 0.016 0.7249 1
Plasmodium falciparum serine repeat antigen 8 0.0029 0.0868 0.0443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.5582 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.5582 0.8435
Brugia malayi Cathepsin L-like precursor 0.0126 0.5582 0.77
Schistosoma mansoni cathepsin S (C01 family) 0.0029 0.0868 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0146 0.6535 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.1608 0.2211
Plasmodium falciparum serine repeat antigen 1 0.0029 0.0868 0.0443
Echinococcus granulosus cathepsin l1 0.0082 0.3461 0.4769
Echinococcus granulosus cathepsin L cysteine proteinase 0.0126 0.5582 0.7698
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.2669 0.2327
Brugia malayi Thioredoxin reductase 0.0057 0.2252 0.3107
Brugia malayi Cathepsin L-like precursor 0.0126 0.5582 0.77
Entamoeba histolytica cysteine protease, putative 0.0072 0.299 0.45
Echinococcus granulosus cpg binding protein 0.0037 0.1262 0.1734
Brugia malayi cathepsin Z-like cysteine proteinase 0.0029 0.0868 0.1198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.5582 0.8435
Entamoeba histolytica cysteine protease, putative 0.0072 0.299 0.45
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.016 0.7249 0.7132
Entamoeba histolytica cysteine protease, putative 0.0072 0.299 0.45
Brugia malayi cathepsin F-like cysteine proteinase 0.0044 0.1608 0.2218
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.6499 1
Giardia lamblia Encystation-specific protease 0.01 0.4333 0.4069
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0445 0.5
Schistosoma mansoni cpg binding protein 0.0037 0.1262 0.0889
Plasmodium vivax vivapain-2 0.0126 0.5582 0.5376
Onchocerca volvulus Cathepsin F homolog 0.0126 0.5582 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0072 0.299 0.269
Loa Loa (eye worm) hypothetical protein 0.0029 0.0868 0.119
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0029 0.0868 0.0443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.299 0.4953
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.5582 0.755
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.5582 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.5795 0.8837
Entamoeba histolytica cysteine proteinase 1, putative 0.0072 0.299 0.45
Echinococcus multilocularis cathepsin L cysteine protease 0.0126 0.5582 0.7698
Giardia lamblia Cathepsin B precursor 0.0029 0.0868 0.0443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.5582 1
Brugia malayi Papain family cysteine protease containing protein 0.0072 0.299 0.4124
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0868 0.119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.5582 0.8435
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0029 0.0868 0.0695
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0029 0.0868 0.0443
Plasmodium vivax unspecified product 0.0044 0.1608 0.1217
Entamoeba histolytica cysteine protease, putative 0.0072 0.299 0.45
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.5582 0.8435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.5582 0.8435
Schistosoma mansoni cathepsin F (C01 family) 0.0126 0.5582 0.5394
Plasmodium vivax glutathione reductase, putative 0.0057 0.2252 0.1891
Giardia lamblia Cathepsin B precursor 0.0029 0.0868 0.0443
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0409 0.0556
Entamoeba histolytica cysteine protease, putative 0.0072 0.299 0.45
Brugia malayi Cathepsin L-like precursor 0.0044 0.1608 0.2218
Loa Loa (eye worm) hypothetical protein 0.0082 0.3461 0.4769
Trypanosoma cruzi major cysteine proteinase, putative 0.0029 0.0868 0.0622
Echinococcus granulosus cathepsin b 0.016 0.7249 1
Giardia lamblia Cathepsin B precursor 0.0069 0.2842 0.2508
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0126 0.5582 0.5376
Brugia malayi CXXC zinc finger family protein 0.0035 0.1167 0.1609
Brugia malayi Papain family cysteine protease containing protein 0.0072 0.299 0.4124
Entamoeba histolytica cysteine protease, putative 0.0072 0.299 0.45
Onchocerca volvulus 0.0126 0.5582 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0029 0.0868 0.0443
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.01 0.4333 0.4069
Giardia lamblia Cysteine protease 0.0029 0.0868 0.0443
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0029 0.0868 0.0443
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0868 0.0695
Entamoeba histolytica cysteine protease, putative 0.0072 0.299 0.45
Onchocerca volvulus 0.0126 0.5582 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0029 0.0868 0.1198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.299 0.4178
Leishmania major cathepsin L-like protease 0.0126 0.5582 1
Schistosoma mansoni cathepsin F (C01 family) 0.0082 0.3461 0.3182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0868 0.0695
Giardia lamblia Hypothetical protein 0.0029 0.0868 0.0443
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0868 0.1198
Giardia lamblia Dipeptidyl-peptidase I precursor 0.01 0.4333 0.4069
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.6499 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.01 0.4333 0.4069
Plasmodium falciparum serine repeat antigen 7 0.0029 0.0868 0.0443
Entamoeba histolytica cysteine protease, putative 0.0072 0.299 0.45
Giardia lamblia Cathepsin B precursor 0.0069 0.2842 0.2508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.299 0.4178
Giardia lamblia Cathepsin L precursor 0.0029 0.0868 0.0443
Onchocerca volvulus 0.0126 0.5582 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.5582 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2402 0.3314
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0445 0.0037
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.2252 0.3101
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0029 0.0868 0.0479
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0069 0.2842 0.2536
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.1167 0.1602
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.2252 0.1891
Loa Loa (eye worm) hypothetical protein 0.0044 0.1608 0.2211
Schistosoma mansoni cathepsin s 0.0044 0.1608 0.125
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0029 0.0868 0.0695
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0445 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.5582 0.8435
Loa Loa (eye worm) hypothetical protein 0.0044 0.1608 0.2211
Giardia lamblia Cathepsin B precursor 0.0069 0.2842 0.2508
Plasmodium falciparum serine repeat antigen 9 0.0029 0.0868 0.0443
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0868 0.0479
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0029 0.0868 0.0443
Loa Loa (eye worm) hypothetical protein 0.0082 0.3461 0.4769
Schistosoma mansoni cpg binding protein 0.0037 0.1262 0.0889
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.299 0.3739
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0409 0.0556
Giardia lamblia Cathepsin L-like protease 0.0029 0.0868 0.0443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.5582 1
Brugia malayi cathepsin B-like cysteine proteinase 0.016 0.7249 1
Trypanosoma cruzi cruzipain precursor, putative 0.0044 0.1608 0.1709
Toxoplasma gondii cathepsin CPC2 0.01 0.4333 0.4069
Echinococcus granulosus cysteine protease 0.0072 0.299 0.4119
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0029 0.0868 0.0443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.5582 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0868 0.119
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0029 0.0868 0.0479
Schistosoma mansoni cathepsin C 0.0029 0.0868 0.0479
Plasmodium falciparum serine repeat antigen 2 0.0029 0.0868 0.0443
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0029 0.0868 0.0479
Entamoeba histolytica cysteine proteinase, putative 0.0072 0.299 0.45
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.5582 0.8435
Schistosoma mansoni cathepsin B (C01 family) 0.0029 0.0868 0.0479
Giardia lamblia Cathepsin B precursor 0.0029 0.0868 0.0443
Loa Loa (eye worm) hypothetical protein 0.0029 0.0868 0.119
Loa Loa (eye worm) hypothetical protein 0.016 0.7249 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.5582 0.8435
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.5582 0.8435
Brugia malayi Cathepsin L-like precursor 0.0126 0.5582 0.77
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0409 0.0565
Brugia malayi cathepsin L-like cysteine proteinase 0.0029 0.0868 0.1198
Plasmodium falciparum serine repeat antigen 3 0.0029 0.0868 0.0443
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.016 0.7249 0.7132
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.2252 0.2656
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.1608 0.1709
Brugia malayi glutathione reductase 0.0057 0.2252 0.3107
Echinococcus multilocularis cathepsin b 0.016 0.7249 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0868 0.0695
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0868 0.0479
Plasmodium vivax serine-repeat antigen (SERA) 0.0029 0.0868 0.0443
Loa Loa (eye worm) cysteine protease 0.0126 0.5582 0.7698
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0409 0.0565
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0029 0.0868 0.119
Giardia lamblia Cathepsin L precursor 0.0029 0.0868 0.0443
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.5795 0.8837
Giardia lamblia Cathepsin B precursor 0.0029 0.0868 0.0443
Echinococcus granulosus cathepsin L cysteine protease 0.0072 0.299 0.4119
Echinococcus granulosus cathepsin l1 0.0126 0.5582 0.7698
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0126 0.5582 0.7698
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.016 0.7249 0.7132
Onchocerca volvulus Cathepsin L homolog 0.0126 0.5582 1
Echinococcus granulosus cathepsin L 0.0029 0.0868 0.119
Onchocerca volvulus 0.0126 0.5582 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0409 0.0556
Schistosoma mansoni cathepsin F (C01 family) 0.0126 0.5582 0.5394
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0868 0.0695
Giardia lamblia Cysteine protease 0.0029 0.0868 0.0443
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.5795 0.8837
Brugia malayi Cathepsin L-like precursor 0.0126 0.5582 0.77
Loa Loa (eye worm) hypothetical protein 0.0029 0.0868 0.119
Leishmania major cathepsin L-like protease 0.0126 0.5582 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0868 0.0479

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.