Detailed information for compound 1406600

Basic information

Technical information
  • TDR Targets ID: 1406600
  • Name: 2-amino-4-(1,3-benzodioxol-5-yl)-5,6-dihydrob enzo[h]quinoline-3-carbonitrile
  • MW: 341.363 | Formula: C21H15N3O2
  • H donors: 1 H acceptors: 2 LogP: 4.17 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(N)nc2c(c1c1ccc3c(c1)OCO3)CCc1c2cccc1
  • InChi: 1S/C21H15N3O2/c22-10-16-19(13-6-8-17-18(9-13)26-11-25-17)15-7-5-12-3-1-2-4-14(12)20(15)24-21(16)23/h1-4,6,8-9H,5,7,11H2,(H2,23,24)
  • InChiKey: WQMGKVCBGMZBHL-UHFFFAOYSA-N  


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Synonyms

  • MLS000551907
  • SMR000172400
  • 2-Amino-4-benzo[1,3]dioxol-5-yl-5,6-dihydro-benzo[h]quinoline-3-carbonitrile
  • ASN 00758986
  • Oprea1_093938
  • Oprea1_422524

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens galactosidase, alpha Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii melibiase subfamily protein Get druggable targets OG5_127620 All targets in OG5_127620
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Neospora caninum hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Alpha-N-acetylgalactosaminidase precursor, putative Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum expressed protein Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis Glycoside hydrolase, family 27 Get druggable targets OG5_127620 All targets in OG5_127620
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative Get druggable targets OG5_127620 All targets in OG5_127620
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Melibiase family protein Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.4195 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0038 0.0325 0.0325
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0038 0.0325 0.0398
Plasmodium falciparum serine repeat antigen 9 0.0038 0.0325 0.0398
Leishmania major cysteine peptidase A (CPA) 0.0163 0.4195 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0509 0.0476
Brugia malayi Papain family cysteine protease containing protein 0.0088 0.1894 0.1866
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1428 0.185
Loa Loa (eye worm) cathepsin B 0.0132 0.3244 0.322
Leishmania major trypanothione reductase 0.0057 0.0925 0.1129
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0925 0.0948
Plasmodium falciparum serine repeat antigen 1 0.0038 0.0325 0.0398
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1428 0.1462
Brugia malayi Bromodomain containing protein 0.0046 0.0589 0.0517
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.1188 0.1216
Plasmodium vivax serine-repeat antigen (SERA) 0.0038 0.0325 0.0398
Loa Loa (eye worm) hypothetical protein 0.0343 0.9764 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1428 0.1428
Brugia malayi fibroinase precursor 0.0038 0.0325 0.0244
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.2081 0.5
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.2987 0.2987
Brugia malayi cathepsin L precursor 0.0038 0.0325 0.0244
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0509 0.0476
Echinococcus multilocularis lamin 0.0033 0.0165 0.0169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.4195 1
Trypanosoma cruzi cysteine peptidase, putative 0.0163 0.4195 0.41
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.1711 0.1711
Loa Loa (eye worm) hypothetical protein 0.0066 0.1188 0.1082
Brugia malayi Thioredoxin reductase 0.0057 0.0925 0.0865
Brugia malayi mbt repeat family protein 0.0058 0.0941 0.0881
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.4195 1
Onchocerca volvulus 0.0058 0.0941 0.167
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1021 0.0909
Loa Loa (eye worm) hypothetical protein 0.0038 0.0325 0.0185
Echinococcus multilocularis lamin dm0 0.0033 0.0165 0.0169
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.2081 0.4756
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.5249 0.5376
Onchocerca volvulus 0.0163 0.4195 0.868
Brugia malayi intermediate filament protein 0.0033 0.0165 0.0079
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0509 0.0476
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.5249 0.5376
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0163 0.4195 0.4296
Entamoeba histolytica cysteine protease, putative 0.0088 0.1894 0.4054
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0925 0.0948
Loa Loa (eye worm) glutathione reductase 0.0057 0.0925 0.0809
Loa Loa (eye worm) hypothetical protein 0.0085 0.1802 0.172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.2626 0.5946
Loa Loa (eye worm) fibroinase 0.0163 0.4195 0.4209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.4195 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0038 0.0325 0.0398
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.1062 0.1088
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.1062 0.1502
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0343 0.9764 0.9764
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0019
Loa Loa (eye worm) hypothetical protein 0.0082 0.1711 0.1626
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0088 0.1894 0.1894
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.2081 0.2132
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0163 0.4195 1
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.1062 0.1088
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1389 0.1423
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0509 0.0855
Entamoeba histolytica cysteine protease, putative 0.0163 0.4195 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.1062 0.0781
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.2081 0.2081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.4195 1
Brugia malayi Cathepsin L-like precursor 0.0163 0.4195 0.4244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.4195 1
Plasmodium vivax vivapain-3 0.0088 0.1894 0.429
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0038 0.0325 0.0185
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0509 0.0521
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0132 0.3244 0.7421
Schistosoma mansoni hypothetical protein 0.0205 0.5493 0.5493
Entamoeba histolytica cysteine protease, putative 0.0088 0.1894 0.4054
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.2081 0.2132
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0163 0.4195 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.4195 1
Trypanosoma cruzi cruzipain precursor, putative 0.0051 0.0726 0.0425
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.3244 0.3244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.4195 1
Schistosoma mansoni cathepsin F (C01 family) 0.0163 0.4195 0.4195
Loa Loa (eye worm) hypothetical protein 0.0112 0.2626 0.2578
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.1711 0.1711
Schistosoma mansoni lamin 0.0033 0.0165 0.0165
Plasmodium falciparum glutathione reductase 0.0057 0.0925 0.1887
Brugia malayi cathepsin L-like cysteine proteinase 0.0038 0.0325 0.0244
Leishmania major cathepsin L-like protease 0.0163 0.4195 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.4195 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.2081 0.4756
Brugia malayi glutathione reductase 0.0057 0.0925 0.0865
Onchocerca volvulus 0.0163 0.4195 0.868
Echinococcus granulosus cathepsin l1 0.0163 0.4195 0.4296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.4195 1
Brugia malayi Papain family cysteine protease containing protein 0.0163 0.4195 0.4244
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0925 0.1887
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0124 0.2987 0.3059
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.1188 0.1216
Brugia malayi Cathepsin L-like precursor 0.0163 0.4195 0.4244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.4195 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.4807 0.4846
Toxoplasma gondii melibiase subfamily protein 0.0124 0.2987 0.7004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0038 0.0325 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.4195 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0325 0.0185
Onchocerca volvulus Cathepsin L homolog 0.0163 0.4195 0.868
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0961 0.0901
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.2626 0.5946
Toxoplasma gondii cathepsin CPL 0.0163 0.4195 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0088 0.1894 0.1662
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0132 0.3244 0.7543
Loa Loa (eye worm) hypothetical protein 0.0038 0.0325 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.4195 1
Schistosoma mansoni alpha-glucosidase 0.0169 0.4401 0.4401
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0509 0.0476
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0038 0.0325 0.0398
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0038 0.0325 0.0398
Loa Loa (eye worm) hypothetical protein 0.0051 0.0726 0.0602
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0509 0.0476
Plasmodium falciparum serine repeat antigen 3 0.0038 0.0325 0.0398
Plasmodium falciparum cysteine proteinase falcipain 3 0.0163 0.4195 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0038 0.0325 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0163 0.4195 1
Echinococcus multilocularis cysteine protease 0.0163 0.4195 0.4296
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0509 0.0195
Onchocerca volvulus 0.0114 0.2681 0.5418
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0941 0.0941
Brugia malayi hypothetical protein 0.0182 0.4807 0.4877
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0343 0.9764 0.9764
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0325 0.0244
Brugia malayi Cathepsin L-like cysteine proteinase 0.0112 0.2626 0.2622
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0509 0.0195
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.1188 0.1216
Entamoeba histolytica cysteine proteinase, putative 0.0088 0.1894 0.4054
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0509 0.0476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.4195 1
Entamoeba histolytica cysteine protease, putative 0.0088 0.1894 0.4054
Onchocerca volvulus 0.0163 0.4195 0.868
Plasmodium vivax unspecified product 0.0051 0.0726 0.1393
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.5249 0.5334
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0038 0.0325 0.0398
Entamoeba histolytica cysteine protease, putative 0.0088 0.1894 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.2626 0.5946
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.364 1
Onchocerca volvulus 0.0163 0.4195 0.868
Loa Loa (eye worm) hypothetical protein 0.0286 0.7999 0.8165
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0038 0.0325 0.0325
Echinococcus multilocularis cathepsin L cysteine protease 0.0163 0.4195 0.4296
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.4195 1
Plasmodium vivax unspecified product 0.0088 0.1894 0.429
Entamoeba histolytica cysteine proteinase, putative 0.0088 0.1894 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0088 0.1894 0.4054
Entamoeba histolytica cysteine protease, putative 0.0088 0.1894 0.4054
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.6186 0.6335
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0132 0.3244 0.3093
Schistosoma mansoni cathepsin C 0.0038 0.0325 0.0325
Brugia malayi cathepsin F-like cysteine proteinase 0.0051 0.0726 0.0659
Echinococcus granulosus cathepsin L cysteine protease 0.0088 0.1894 0.1939
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.2081 1
Plasmodium vivax unspecified product 0.0038 0.0325 0.0398
Giardia lamblia Cathepsin B precursor 0.0132 0.3244 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0941 0.0963
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.6186 0.6335
Echinococcus multilocularis cathepsin L 0.0088 0.1894 0.1939
Schistosoma mansoni hypothetical protein 0.0205 0.5493 0.5493
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.2081 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0088 0.1894 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.4195 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0038 0.0325 0.0325
Echinococcus granulosus lamin dm0 0.0033 0.0165 0.0169
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0038 0.0325 0.0325
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0325 0.0244
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0038 0.0325 0.0244
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0501 0.0513
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.319 0.8342
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0163 0.4195 0.4209
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0038 0.0325 0.0325
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.2081 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.4195 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1021 0.0909
Loa Loa (eye worm) hypothetical protein 0.0163 0.4195 0.4209
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1062 0.1906
Entamoeba histolytica cysteine protease, putative 0.0088 0.1894 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0325 0.0244
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.319 0.8342
Leishmania major cathepsin L-like protease 0.0163 0.4195 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.364 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.4195 1
Entamoeba histolytica cysteine protease, putative 0.0088 0.1894 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0112 0.2626 0.2626
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0509 0.0476
Entamoeba histolytica cysteine proteinase 2 0.0088 0.1894 0.4054
Toxoplasma gondii cathepsin B 0.0132 0.3244 0.7641
Toxoplasma gondii cathepsin CPC2 0.0038 0.0325 0.0398
Giardia lamblia Cathepsin B precursor 0.0132 0.3244 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0088 0.1894 0.429
Echinococcus granulosus lamin 0.0033 0.0165 0.0169
Echinococcus granulosus cathepsin l1 0.0112 0.2626 0.2689
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.4195 1
Schistosoma mansoni hypothetical protein 0.0058 0.0961 0.0961
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.4195 1
Schistosoma mansoni cathepsin s 0.0051 0.0726 0.0726
Brugia malayi cathepsin L-like precursor 0.0112 0.2626 0.2622
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1021 0.0964
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0038 0.0325 0.0398
Brugia malayi mbt repeat family protein 0.0058 0.0941 0.0881
Brugia malayi Cathepsin L-like precursor 0.0051 0.0726 0.0659
Leishmania major cathepsin L-like protease 0.0163 0.4195 1
Loa Loa (eye worm) cysteine protease 0.0163 0.4195 0.4209
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.1062 0.1502
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0509 0.0376
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0509 0.0476
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.7999 0.8193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0088 0.1894 0.3757
Echinococcus granulosus cathepsin b 0.0343 0.9764 1
Mycobacterium tuberculosis Probable reductase 0.013 0.319 0.8342
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0124 0.2987 0.3059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.4195 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1062 0.0781
Trypanosoma cruzi cysteine peptidase, putative 0.0088 0.1894 0.1662
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.2987 0.2987
Leishmania major cathepsin L-like protease 0.0163 0.4195 1
Entamoeba histolytica cysteine protease, putative 0.0088 0.1894 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.4195 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0088 0.1894 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.4195 1
Echinococcus multilocularis geminin 0.0205 0.5493 0.5626
Onchocerca volvulus 0.0163 0.4195 0.868
Brugia malayi Cathepsin L-like precursor 0.0112 0.2626 0.2622
Loa Loa (eye worm) MBCTL1 0.0066 0.1188 0.1082
Brugia malayi MAP kinase sur-1 0.0062 0.1062 0.1007
Plasmodium falciparum serine repeat antigen 7 0.0038 0.0325 0.0398
Schistosoma mansoni intermediate filament proteins 0.0033 0.0165 0.0165
Plasmodium falciparum serine repeat antigen 5 0.0038 0.0325 0.0398
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.319 0.8342
Loa Loa (eye worm) hypothetical protein 0.0046 0.0592 0.0463
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.4195 1
Trypanosoma cruzi cysteine protease, putative 0.0088 0.1894 0.1662
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.4195 1
Echinococcus multilocularis cysteine protease 0.0163 0.4195 0.4296
Onchocerca volvulus 0.0112 0.2626 0.53
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0165 0.0019
Plasmodium vivax serine-repeat antigen (SERA) 0.0038 0.0325 0.0398
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.4195 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0132 0.3244 0.7421
Brugia malayi Cathepsin L-like precursor 0.0163 0.4195 0.4244
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0038 0.0325 0.0325
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0112 0.2626 0.2438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.4195 1
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0941 0.0963
Schistosoma mansoni bromodomain containing protein 0.0076 0.1523 0.1523
Plasmodium vivax vivapain-2 0.0163 0.4195 1
Trypanosoma cruzi cysteine peptidase, putative 0.0163 0.4195 0.41
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.1074 0.2616
Trypanosoma brucei protein kinase, putative 0.0062 0.1062 0.1502
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.7999 0.8193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.1894 0.4054
Brugia malayi Cathepsin L-like precursor 0.0163 0.4195 0.4244
Onchocerca volvulus Cathepsin L homolog 0.0163 0.4195 0.868
Plasmodium vivax glutathione reductase, putative 0.0057 0.0925 0.1887
Leishmania major cathepsin L-like protease 0.0163 0.4195 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0343 0.9764 0.9764
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0088 0.1894 0.4054
Brugia malayi cathepsin Z-like cysteine proteinase 0.0038 0.0325 0.0244
Trypanosoma cruzi cruzipain precursor, putative 0.0163 0.4195 0.41
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.0325 0.0185
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0941 0.0825
Loa Loa (eye worm) hypothetical protein 0.0038 0.0325 0.0185
Leishmania major cathepsin L-like protease 0.0163 0.4195 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.319 0.8342
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.4195 1
Brugia malayi Melibiase family protein 0.0082 0.1711 0.1677
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.2081 0.4756
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.2081 1
Schistosoma mansoni cathepsin S (C01 family) 0.0038 0.0325 0.0325
Echinococcus granulosus cathepsin L 0.0038 0.0325 0.0333
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.1062 0.1088
Brugia malayi Cathepsin L-like precursor 0.0163 0.4195 0.4244
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.364 1
Schistosoma mansoni lamin 0.0033 0.0165 0.0165
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0726 0.0602
Trypanosoma brucei trypanothione reductase 0.0057 0.0925 0.1129
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0038 0.0325 0.0398
Echinococcus granulosus intermediate filament protein 0.0033 0.0165 0.0169
Trypanosoma cruzi cysteine peptidase, putative 0.0163 0.4195 0.41
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1021 0.0964
Giardia lamblia Cathepsin B precursor 0.0132 0.3244 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.2626 0.2578
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.4195 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1389 0.1423
Plasmodium falciparum thioredoxin reductase 0.0057 0.0925 0.1887
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1062 0.1906
Loa Loa (eye worm) hypothetical protein 0.0038 0.0325 0.0185
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.1188 0.1136
Schistosoma mansoni cathepsin F (C01 family) 0.0163 0.4195 0.4195
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.1188 0.1216
Brugia malayi Cathepsin L-like precursor 0.0163 0.4195 0.4244
Schistosoma mansoni cathepsin B (C01 family) 0.0038 0.0325 0.0325
Brugia malayi Probable ClpP-like protease 0.0094 0.2081 0.206
Toxoplasma gondii preprocathepsin c precursor, putative 0.0038 0.0325 0.0398
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0163 0.4195 0.4209
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.2987 0.2987
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0509 0.0476
Loa Loa (eye worm) hypothetical protein 0.0052 0.0752 0.0629
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0038 0.0325 0.0398
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0165 0.0079
Plasmodium falciparum serine repeat antigen 8 0.0038 0.0325 0.0398
Echinococcus multilocularis cathepsin L 0.0038 0.0325 0.0333
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1062 0.1906
Echinococcus multilocularis cathepsin b 0.0343 0.9764 1
Trypanosoma cruzi cysteine peptidase, putative 0.0163 0.4195 0.41
Loa Loa (eye worm) hypothetical protein 0.0112 0.2626 0.2578
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0325 0.0343
Trypanosoma cruzi cysteine proteinase, putative 0.0088 0.1894 0.1662
Onchocerca volvulus 0.0182 0.4807 1
Entamoeba histolytica cysteine protease, putative 0.0088 0.1894 0.4054
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0509 0.0521
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0051 0.0726 0.0659
Brugia malayi cathepsin F-like cysteine proteinase 0.0038 0.0325 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.4195 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0124 0.2987 0.3059
Plasmodium vivax vivapain-2 0.0163 0.4195 1
Plasmodium vivax vivapain-1 0.0088 0.1894 0.429
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1062 0.0781
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.2081 0.4756
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.364 1
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.1062 0.2527
Plasmodium falciparum serine repeat antigen 6 0.0038 0.0325 0.0398
Brugia malayi Papain family cysteine protease containing protein 0.0088 0.1894 0.1866
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0038 0.0325 0.0325
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.1062 0.1062
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.1074 0.0547
Toxoplasma gondii cathepsin CPC1 0.0038 0.0325 0.0398
Loa Loa (eye worm) hypothetical protein 0.0094 0.2081 0.2011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0088 0.1894 0.3757
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.1062 0.0952
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1428 0.1462
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1062 0.1906
Leishmania major cathepsin L-like protease 0.0163 0.4195 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.2081 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.1074 0.0547
Onchocerca volvulus 0.0163 0.4195 0.868
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0163 0.4195 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0343 0.9764 0.9764
Echinococcus granulosus cysteine protease 0.0088 0.1894 0.1939
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0038 0.0325 0.0398
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0509 0.0476
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0925 0.0809
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0501 0.0513
Echinococcus multilocularis musashi 0.0033 0.0165 0.0169
Loa Loa (eye worm) hypothetical protein 0.0049 0.068 0.0555
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.1074 0.11
Brugia malayi Bromodomain containing protein 0.0091 0.1961 0.1936
Entamoeba histolytica cysteine protease, putative 0.0088 0.1894 0.4054
Entamoeba histolytica cysteine protease, putative 0.0088 0.1894 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.4195 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.4195 1
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0941 0.0963
Loa Loa (eye worm) hypothetical protein 0.0051 0.0726 0.0602
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.2987 0.2987
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.2081 0.5514
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.319 0.8705
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0038 0.0325 0.0398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.4195 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0165 0.0019
Brugia malayi hypothetical protein 0.0286 0.7999 0.8176
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0726 0.0425
Loa Loa (eye worm) ctsf protein 0.0163 0.4195 0.4209
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.1188 0.1188
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0088 0.1894 0.1894
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0088 0.1894 0.1894
Entamoeba histolytica cysteine protease, putative 0.0088 0.1894 0.4054
Schistosoma mansoni hypothetical protein 0.0041 0.0431 0.0431
Plasmodium falciparum serine repeat antigen 2 0.0038 0.0325 0.0398
Plasmodium falciparum serine repeat antigen 4 0.0038 0.0325 0.0398
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0082 0.1711 0.3582
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.5249 0.5306
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.4195 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.319 0.8342
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0941 0.167
Toxoplasma gondii thioredoxin reductase 0.0057 0.0925 0.1887
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.5249 0.5376
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1428 0.3134
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0163 0.4195 0.4296
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1428 0.2492
Onchocerca volvulus Cathepsin F homolog 0.0163 0.4195 0.868
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.1062 0.1502
Onchocerca volvulus 0.0038 0.0325 0.0343
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0038 0.0325 0.0398
Echinococcus granulosus geminin 0.0205 0.5493 0.5626
Loa Loa (eye worm) hypothetical protein 0.0058 0.0941 0.0825
Loa Loa (eye worm) hypothetical protein 0.0038 0.0325 0.0185
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0941 0.0963
Schistosoma mansoni alpha glucosidase 0.0044 0.0509 0.0509
Echinococcus multilocularis cathepsin L cysteine protease 0.0163 0.4195 0.4296
Onchocerca volvulus 0.0163 0.4195 0.868
Loa Loa (eye worm) hypothetical protein 0.0051 0.0726 0.0602
Brugia malayi cathepsin B-like cysteine proteinase 0.0343 0.9764 1
Leishmania major cathepsin L-like protease 0.0163 0.4195 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0163 0.4195 0.4296
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0941 0.0941
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0509 0.0434
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.4195 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0163 0.4195 0.4296
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0343 0.9764 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0296
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1428 0.1428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.4195 1
Brugia malayi Cathepsin L-like precursor 0.0112 0.2626 0.2622
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0941 0.0941
Schistosoma mansoni survival motor neuron protein 0.0058 0.0961 0.0961
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.1062 0.0781
Onchocerca volvulus 0.0058 0.0961 0.1713
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0038 0.0325 0.0398
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0038 0.0325 0.0398
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.1074 0.11
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0509 0.0476
Schistosoma mansoni alpha-glucosidase 0.0169 0.4401 0.4401
Brugia malayi cathepsin Z-like cysteine proteinase 0.0038 0.0325 0.0244
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0925 0.0636
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.1062 0.1088
Echinococcus multilocularis cathepsin b 0.0343 0.9764 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.0325 0.0185
Echinococcus granulosus cathepsin L 0.0088 0.1894 0.1939
Trypanosoma cruzi cysteine proteinase, putative 0.0088 0.1894 0.1662
Echinococcus granulosus cathepsin b 0.0343 0.9764 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0431 0.0354
Entamoeba histolytica cysteine protease, putative 0.0088 0.1894 0.4054
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.1062 0.2228

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6626 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Saccharomyces cerevisiae ChEMBL23
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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