Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | casein kinase I gamma | 0.0286 | 0.6977 | 0.6977 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0286 | 0.6977 | 0.6977 |
Loa Loa (eye worm) | protein kinase domain-containing protein | 0.0286 | 0.6977 | 0.6977 |
Brugia malayi | Protein kinase domain containing protein | 0.0286 | 0.6977 | 0.6977 |
Onchocerca volvulus | 0.0352 | 0.9715 | 0.9715 | |
Echinococcus multilocularis | casein kinase I gamma | 0.0286 | 0.6977 | 0.6977 |
Trypanosoma cruzi | casein kinase, delta isoform, putative | 0.0352 | 0.9715 | 0.9715 |
Loa Loa (eye worm) | casein kinase | 0.028 | 0.6692 | 0.6692 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.