Detailed view for Bm1_35945

Basic information

TDR Targets ID: 243846
Brugia malayi, Protein kinase domain containing protein
Source Database / ID:  GenBank

pI: 9.2448 | Length (AA): 481 | MW (Da): 54221 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

Hedgehog signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
38 428 2rsv (A) 0 386 23.00 0 1 0.83149 1.07
70 390 2izr (A) 36 333 81.00 0 1 1.52306 -0.57
70 383 4nt4 (A) 36 335 73.00 0 1 1.34641 -0.14
72 465 5dvr (A) 46 484 22.00 0.000000000012 0.98 0.866027 0.71
373 455 4huq (B) 12 90 37.00 0.93 0.12 0.308257 0.35

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128520)

Species Accession Gene Product
Brugia malayi Bm1_35945   Protein kinase domain containing protein
Candida albicans CaO19.9766   similar to headcase protein
Candida albicans CaO19.2221   similar to headcase protein
Candida albicans CaO19.9767   second casein kinase I-like orf
Candida albicans CaO19.2222   second casein kinase I-like orf
Candida albicans CaO19.7001   casein kinase I-like orf
Candida albicans CaO19.1127   hypothetical protein
Caenorhabditis elegans CELE_Y106G6E.6   Protein CSNK-1
Drosophila melanogaster Dmel_CG6963   gilgamesh
Echinococcus granulosus EgrG_000345900   casein kinase I gamma
Echinococcus multilocularis EmuJ_000345900   casein kinase I gamma
Homo sapiens ENSG00000169118   casein kinase 1, gamma 1
Homo sapiens ENSG00000151292   casein kinase 1, gamma 3
Homo sapiens ENSG00000133275   casein kinase 1, gamma 2
Loa Loa (eye worm) LOAG_08358   protein kinase domain-containing protein
Loa Loa (eye worm) LOAG_04154   casein kinase
Mus musculus ENSMUSG00000032384   casein kinase 1, gamma 1
Mus musculus ENSMUSG00000003345   casein kinase 1, gamma 2
Mus musculus ENSMUSG00000073563   casein kinase 1, gamma 3
Saccharomyces cerevisiae YHR135C   Yck1p
Saccharomyces cerevisiae YNL154C   Yck2p
Schistosoma japonicum Sjp_0057830   ko:K08958 casein kinase 1, gamma, putative
Schistosoma japonicum Sjp_0102580   IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing
Schistosoma mansoni Smp_180400   serine/threonine protein kinase
Schmidtea mediterranea mk4.002034.02   Serine/threonine kinase
Schmidtea mediterranea mk4.007311.00  
Schmidtea mediterranea mk4.017055.00   Serine/threonine kinase
Schmidtea mediterranea mk4.001439.02   Serine/threonine kinase
Schmidtea mediterranea mk4.010891.00   Serine/threonine kinase
Schmidtea mediterranea mk4.002034.03   Serine/threonine kinase
Schmidtea mediterranea mk4.001887.00   Serine/threonine kinase
Schmidtea mediterranea mk4.014185.00  
Schmidtea mediterranea mk4.002334.00  
Schmidtea mediterranea mk4.024307.00   Serine/threonine kinase

Essentiality

Bm1_35945 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y106G6E.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y106G6E.6 Caenorhabditis elegans larval lethal wormbase
CELE_Y106G6E.6 Caenorhabditis elegans slow growth wormbase
CELE_Y106G6E.6 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens casein kinase 1, gamma 1 Compounds References
Homo sapiens casein kinase 1, gamma 3 Compounds References
Homo sapiens casein kinase 1, gamma 2 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Sus scrofa Casein kinase I isoform alpha 125 aa 53.1% 128 aa Compounds References
Bos taurus Glycogen synthase kinase-3 beta splice variant X1 419 aa 21.7% 336 aa Compounds References
Bos taurus Casein kinase I isoform alpha 325 aa 49.3% 343 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 25.9% 243 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0003 0.5 0.5
0.0042 0.5 0.5
0.0039 0.5 0.5
0.0011 1 1
0.0098 0.3242 0.2614
0.0081 1 1
0.0064 0.3377 0.3377
0.0191 0.4061 0.5898
0.028 0.307 0.7752
0.0004 0.5 0.5
0.0012 0.5 0.5
0.0033 0.5 0.5
0.0093 0.8828 0
0.0023 0.5 0.5
0.0074 0.4395 0.4395
0.0417 0.8526 0.8526
0.0066 0.3101 0
0.0029 0.5 0.5
0.0061 0.6883 0.6808
0.007 0.787 0.783
0.0152 0.4474 0.4902
0.0074 0.4395 0.4395
0.0267 0.7932 0.7932
0.0283 0.7752 0.7752
0.0335 0.3961 0.6206
0.0074 0.4395 0.4395
0.0007 0.5 0.5
0.0286 0.6977 0.6977
0.0074 0.4395 0.4395
0.0018 0.5 0.5
0.0032 0.5 0.5
0.0063 0.7244 0
0.0074 0.4395 0.4395
0.025 0.898 0.898
0.0059 1 1
0.0012 0.5 0.5
0.0074 0.3736 0.3736
0.0285 0.286 0.7938
0.0199506 0.301421 0.341332
0.0329 0.8519 0.8519
0.0062 0.6935 0.7231
0.0056 1 1
0.0069 0.3067 0.9179
0.0285 0.7608 0.7608
0.0036 0.5 0.5
0.0184 0.3668 0.7916
0.0016 0.5 0.5
0.0007 0.5 0.5
0.0026 0.5 0.5
0.0016 0.5 0.5
0.0074 0.4395 0.4395
0.0067 0.5 0.5
0.0007 0.5 0.5
0.0088 0.4477 0.4477
0.0131 0.3144 0.3144
0.0122 0.3185 0.7018
0.0064 0.2852 0.3098
0.0032 0.5 0.5
0.0037 1 0.5
0.0092 1 1
0.0027 1 1
0.0063 1 1
0.0081 0.5 0.5
0.0039 0.5 0.5
0.0008 0.5 0.5
0.0091 1 1
0.0039 0.9485 1
0.0306 0.5801 0.5801
0.0122 0.7235 0.7235
0.028 0.7545 0.7481
0.0074 0.3188 0.3088
0.0012 0.5 0.5
0.0033 1 1
0.0124 0.6066 0.6066
0.0022 0.5 0.5
0.0059 1 1
0.0325115 0.254266 0.259577
0.0059 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Bm1_35945 (Brugia malayi), Protein kinase domain containing protein
Title for this comment
Comment