Detailed information for compound 1407633

Basic information

Technical information
  • TDR Targets ID: 1407633
  • Name: [2-(1,3-dihydroxypropan-2-yl)-3-[(E)-3-methox yprop-1-enyl]-7-methyl-6,8-dioxoisoquinolin-7 -yl] quinoxaline-2-carboxylate
  • MW: 491.493 | Formula: C26H25N3O7
  • H donors: 2 H acceptors: 7 LogP: 0.77 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC/C=C/c1cc2=CC(=O)C(C(=O)c2cn1C(CO)CO)(C)OC(=O)c1cnc2c(n1)cccc2
  • InChi: 1S/C26H25N3O7/c1-26(36-25(34)22-12-27-20-7-3-4-8-21(20)28-22)23(32)11-16-10-17(6-5-9-35-2)29(18(14-30)15-31)13-19(16)24(26)33/h3-8,10-13,18,30-31H,9,14-15H2,1-2H3/b6-5+
  • InChiKey: KIHNLFWKLXZYFP-AATRIKPKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[2-hydroxy-1-(hydroxymethyl)ethyl]-3-[(E)-3-methoxyprop-1-enyl]-7-methyl-6,8-dioxo-7-isoquinolyl] quinoxaline-2-carboxylate
  • 2-quinoxalinecarboxylic acid [2-[2-hydroxy-1-(hydroxymethyl)ethyl]-3-[(E)-3-methoxyprop-1-enyl]-7-methyl-6,8-dioxo-7-isoquinolyl] ester
  • quinoxaline-2-carboxylic acid [2-(2-hydroxy-1-methylol-ethyl)-6,8-diketo-3-[(E)-3-methoxyprop-1-enyl]-7-methyl-7-isoquinolyl] ester
  • [2-(1,3-dihydroxypropan-2-yl)-3-[(E)-3-methoxyprop-1-enyl]-7-methyl-6,8-dioxo-isoquinolin-7-yl] quinoxaline-2-carboxylate
  • NCGC00162577-01
  • CMLD004285
  • MLS000438663
  • SMR000452712

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0199 0.3456 0.3427
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0045 0.5
Echinococcus multilocularis cathepsin b 0.0403 0.7341 0.7329
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0108 0.1717 0.1623
Loa Loa (eye worm) hypothetical protein 0.0108 0.1717 0.1717
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0111 0.0067
Giardia lamblia Cathepsin B precursor 0.0108 0.1717 0.2637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0366 0.6642 0.6627
Loa Loa (eye worm) hypothetical protein 0.0023 0.0111 0.0111
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.2423 0.819
Entamoeba histolytica cysteine protease, putative 0.0284 0.5075 0.5019
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0108 0.1717 0.1679
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0067
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0284 0.5075 0.5053
Giardia lamblia Cysteine protease 0.0108 0.1717 0.2637
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6384 0.6368
Trypanosoma brucei trypanothione reductase 0.0057 0.0755 0.0713
Entamoeba histolytica cysteine protease, putative 0.0284 0.5075 0.5019
Giardia lamblia Cysteine protease 0.0108 0.1717 0.2637
Entamoeba histolytica cysteine proteinase 1, putative 0.0284 0.5075 0.5019
Echinococcus multilocularis lamin 0.0033 0.0288 0.0244
Schistosoma mansoni lamin 0.0033 0.0288 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0108 0.1717 0.1679
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.2423 0.3447
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6384 0.6368
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0108 0.1717 0.1679
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0108 0.1717 0.2637
Brugia malayi Cathepsin L-like precursor 0.0366 0.6642 0.6642
Brugia malayi Cathepsin L-like precursor 0.0176 0.3026 0.3026
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0199 0.3456 0.3427
Giardia lamblia Cathepsin L precursor 0.0108 0.1717 0.2637
Brugia malayi Papain family cysteine protease containing protein 0.0284 0.5075 0.5075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.1717 0.1679
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0111 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0108 0.1717 0.1679
Schistosoma mansoni cathepsin C 0.0108 0.1717 0.1679
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.2949 1
Entamoeba histolytica cysteine proteinase, putative 0.0284 0.5075 0.5019
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0108 0.1717 0.1679
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0108 0.1717 0.1679
Loa Loa (eye worm) hypothetical protein 0.0366 0.6642 0.6642
Echinococcus granulosus cathepsin L 0.0108 0.1717 0.1679
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0108 0.1717 0.1679
Brugia malayi cathepsin B-like cysteine proteinase 0.0403 0.7341 0.7341
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0108 0.1717 0.1679
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6384 0.6368
Entamoeba histolytica cysteine protease, putative 0.0284 0.5075 0.5019
Entamoeba histolytica cysteine protease, putative 0.0284 0.5075 0.5019
Giardia lamblia Cathepsin L-like protease 0.0108 0.1717 0.2637
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0288 0.0288
Schistosoma mansoni cathepsin S (C01 family) 0.0108 0.1717 0.1679
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0403 0.7341 0.7329
Trypanosoma brucei unspecified product 0.0023 0.0111 0.0067
Entamoeba histolytica cysteine protease, putative 0.0108 0.1717 0.1623
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0108 0.1717 0.1679
Giardia lamblia Cathepsin B precursor 0.0108 0.1717 0.2637
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.6384 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.1717 0.1679
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.5075 0.5053
Echinococcus multilocularis musashi 0.0033 0.0288 0.0244
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0755 0.0713
Toxoplasma gondii cathepsin CPC1 0.0108 0.1717 0.1679
Giardia lamblia Cathepsin B precursor 0.0199 0.3456 0.5381
Giardia lamblia Cathepsin L-like protease 0.0108 0.1717 0.2637
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0111 0.0111
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.2147 0.7238
Giardia lamblia Cathepsin L precursor 0.0108 0.1717 0.2637
Plasmodium vivax glutathione reductase, putative 0.0057 0.0755 0.0713
Schistosoma mansoni lamin 0.0033 0.0288 0.0244
Echinococcus multilocularis dna polymerase eta 0.0023 0.0111 0.0067
Giardia lamblia Cathepsin L precursor 0.0108 0.1717 0.2637
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0108 0.1717 0.1717
Loa Loa (eye worm) hypothetical protein 0.0176 0.3026 0.3026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.1717 0.1679
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.2147 0.7238
Entamoeba histolytica hypothetical protein 0.0108 0.1717 0.1623
Brugia malayi cathepsin F-like cysteine proteinase 0.0108 0.1717 0.1717
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0108 0.1717 0.1679
Entamoeba histolytica cysteine protease, putative 0.0108 0.1717 0.1623
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0067
Trypanosoma cruzi cruzipain precursor, putative 0.0176 0.3026 0.2995
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0108 0.1717 0.1679
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6384 0.6368
Brugia malayi Thioredoxin reductase 0.0057 0.0755 0.0755
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0108 0.1717 0.1679
Plasmodium vivax unspecified product 0.0108 0.1717 0.1679
Plasmodium falciparum serine repeat antigen 9 0.0108 0.1717 0.1679
Giardia lamblia Cathepsin L precursor 0.0108 0.1717 0.2637
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0108 0.1717 0.1679
Toxoplasma gondii cathepsin CPC2 0.0108 0.1717 0.1679
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0067
Giardia lamblia Hypothetical protein 0.0108 0.1717 0.2637
Brugia malayi Cathepsin L-like precursor 0.0366 0.6642 0.6642
Plasmodium vivax serine-repeat antigen (SERA) 0.0108 0.1717 0.1679
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0108 0.1717 0.1679
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0111 0.023
Brugia malayi cathepsin Z-like cysteine proteinase 0.0108 0.1717 0.1717
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0199 0.3456 0.3427
Entamoeba histolytica cysteine proteinase, putative 0.0284 0.5075 0.5019
Echinococcus granulosus dna polymerase kappa 0.0023 0.0111 0.0067
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0111 0.023
Brugia malayi Papain family cysteine protease containing protein 0.0108 0.1717 0.1717
Loa Loa (eye worm) hypothetical protein 0.0032 0.0276 0.0276
Loa Loa (eye worm) cathepsin B 0.0199 0.3456 0.3456
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0755 0.0713
Giardia lamblia Cysteine protease 0.0108 0.1717 0.2637
Echinococcus multilocularis cathepsin b 0.0403 0.7341 0.7329
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0108 0.1717 0.1679
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0284 0.5075 0.5053
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0111 0.0111
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0111 0.0111
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0108 0.1717 0.1679
Schistosoma mansoni cathepsin B (C01 family) 0.0108 0.1717 0.1679
Plasmodium falciparum serine repeat antigen 7 0.0108 0.1717 0.1679
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0108 0.1717 0.1679
Entamoeba histolytica cysteine protease, putative 0.0108 0.1717 0.1623
Echinococcus multilocularis lamin dm0 0.0033 0.0288 0.0244
Toxoplasma gondii preprocathepsin c precursor, putative 0.0108 0.1717 0.1679
Plasmodium falciparum serine repeat antigen 2 0.0108 0.1717 0.1679
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0403 0.7341 0.7329
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0111 0.0067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6384 0.6368
Schistosoma mansoni intermediate filament proteins 0.0033 0.0288 0.0244
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0111 0.0067
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0045 0.5
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0403 0.7341 0.7329
Brugia malayi Papain family cysteine protease containing protein 0.0108 0.1717 0.1717
Leishmania major DNA polymerase kappa, putative 0.0023 0.0111 0.0067
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0111 0.0067
Loa Loa (eye worm) hypothetical protein 0.0108 0.1717 0.1717
Echinococcus granulosus cathepsin L 0.0284 0.5075 0.5053
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0111 0.0067
Schistosoma mansoni DNA polymerase eta 0.0023 0.0111 0.0067
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0111 0.0067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6384 0.6368
Entamoeba histolytica cysteine protease, putative 0.0284 0.5075 0.5019
Echinococcus granulosus cathepsin b 0.0403 0.7341 0.7329
Entamoeba histolytica cysteine protease, putative 0.0284 0.5075 0.5019
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0755 0.0713
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0111 0.0067
Entamoeba histolytica cysteine protease, putative 0.0284 0.5075 0.5019
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.2949 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.2423 0.819
Loa Loa (eye worm) hypothetical protein 0.0403 0.7341 0.7341
Loa Loa (eye worm) hypothetical protein 0.0176 0.3026 0.3026
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0755 0.0713
Echinococcus granulosus dna polymerase eta 0.0023 0.0111 0.0067
Entamoeba histolytica cysteine protease, putative 0.0284 0.5075 0.5019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0366 0.6642 0.6627
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0111 0.0067
Brugia malayi Cathepsin L-like cysteine proteinase 0.0366 0.6642 0.6642
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0067
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0755 0.0755
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.6384 1
Echinococcus granulosus cysteine protease 0.0284 0.5075 0.5053
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.1717 0.1679
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0067
Trypanosoma cruzi cysteine protease, putative 0.0284 0.5075 0.5053
Echinococcus granulosus cathepsin b 0.0403 0.7341 0.7329
Echinococcus granulosus intermediate filament protein 0.0033 0.0288 0.0244
Giardia lamblia DINP protein human, muc B family 0.0023 0.0111 0.0106
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0108 0.1717 0.1679
Loa Loa (eye worm) glutathione reductase 0.0057 0.0755 0.0755
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0108 0.1717 0.1623
Brugia malayi cathepsin L-like cysteine proteinase 0.0108 0.1717 0.1717
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0111 0.0067
Giardia lamblia Cathepsin B precursor 0.0108 0.1717 0.2637
Entamoeba histolytica cysteine protease, putative 0.0108 0.1717 0.1623
Entamoeba histolytica cysteine proteinase 2 0.0284 0.5075 0.5019
Plasmodium vivax vivapain-3 0.0284 0.5075 0.5053
Brugia malayi cathepsin L-like precursor 0.0366 0.6642 0.6642
Loa Loa (eye worm) hypothetical protein 0.0366 0.6642 0.6642
Plasmodium vivax serine-repeat antigen (SERA) 0.0108 0.1717 0.1679
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.2147 0.7238
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0288 0.0288
Plasmodium falciparum glutathione reductase 0.0057 0.0755 0.0713
Plasmodium vivax unspecified product 0.0176 0.3026 0.2995
Leishmania major DNA polymerase eta, putative 0.0023 0.0111 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0067
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0111 0.0067
Trypanosoma cruzi cysteine proteinase, putative 0.0284 0.5075 0.5053
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0067
Giardia lamblia Cysteine protease 0.0108 0.1717 0.2637
Toxoplasma gondii cathepsin B 0.0199 0.3456 0.3427
Plasmodium falciparum thioredoxin reductase 0.0057 0.0755 0.0713
Loa Loa (eye worm) hypothetical protein 0.0033 0.0288 0.0288
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0403 0.7341 0.7329
Brugia malayi glutathione reductase 0.0057 0.0755 0.0755
Giardia lamblia Cathepsin L precursor 0.0108 0.1717 0.2637
Giardia lamblia Cathepsin B precursor 0.0199 0.3456 0.5381
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0108 0.1717 0.1679
Loa Loa (eye worm) hypothetical protein 0.0108 0.1717 0.1717
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0111 0.0067
Leishmania major trypanothione reductase 0.0057 0.0755 0.0713
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0108 0.1717 0.1679
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0045 0.5
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.2147 0.7238
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0111 0.0067
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0108 0.1717 0.2637
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6384 0.6368
Brugia malayi cathepsin F-like cysteine proteinase 0.0176 0.3026 0.3026
Giardia lamblia Cathepsin B precursor 0.0108 0.1717 0.2637
Entamoeba histolytica cysteine protease, putative 0.0284 0.5075 0.5019
Echinococcus multilocularis cathepsin L 0.0284 0.5075 0.5053
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.2423 0.819
Schistosoma mansoni cathepsin s 0.0176 0.3026 0.2995
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0111 0.0067
Entamoeba histolytica cysteine protease, putative 0.0284 0.5075 0.5019
Echinococcus multilocularis cathepsin L 0.0108 0.1717 0.1679
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.1717 0.1679
Echinococcus granulosus lamin dm0 0.0033 0.0288 0.0244
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.2147 0.7238
Brugia malayi cathepsin Z-like cysteine proteinase 0.0108 0.1717 0.1717
Giardia lamblia Cathepsin B precursor 0.0199 0.3456 0.5381
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0108 0.1717 0.1679
Trypanosoma cruzi cysteine peptidase, putative 0.0284 0.5075 0.5053
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0108 0.1717 0.2637
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0284 0.5075 0.5053
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0755 0.2445
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0108 0.1717 0.1679
Plasmodium falciparum serine repeat antigen 8 0.0108 0.1717 0.1679
Onchocerca volvulus 0.0366 0.6642 0.6542
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0284 0.5075 0.5053
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0108 0.1717 0.1679
Mycobacterium tuberculosis Probable reductase 0.013 0.2147 0.7238
Plasmodium falciparum serine repeat antigen 5 0.0108 0.1717 0.1679
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0111 0.023
Giardia lamblia Hypothetical protein 0.0108 0.1717 0.2637
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0108 0.1717 0.1679
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0176 0.3026 0.3026
Entamoeba histolytica cysteine proteinase, putative 0.0284 0.5075 0.5019
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0108 0.1717 0.1717
Echinococcus granulosus lamin 0.0033 0.0288 0.0244
Entamoeba histolytica cysteine protease, putative 0.0284 0.5075 0.5019
Toxoplasma gondii thioredoxin reductase 0.0057 0.0755 0.0713
Plasmodium falciparum serine repeat antigen 1 0.0108 0.1717 0.1679
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0108 0.1717 0.1717
Brugia malayi cathepsin L precursor 0.0108 0.1717 0.1717
Trypanosoma cruzi cysteine proteinase, putative 0.0284 0.5075 0.5053
Brugia malayi Papain family cysteine protease containing protein 0.0108 0.1717 0.1717
Trypanosoma cruzi major cysteine proteinase, putative 0.0108 0.1717 0.1679
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0108 0.1717 0.1679
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.1717 0.1679
Schistosoma mansoni cathepsin F (C01 family) 0.0366 0.6642 0.6627
Entamoeba histolytica cysteine proteinase, putative 0.0366 0.6642 0.6604
Brugia malayi fibroinase precursor 0.0108 0.1717 0.1717
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.1717 0.1679
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.2949 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0284 0.5075 0.5053
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0366 0.6642 0.6627
Loa Loa (eye worm) hypothetical protein 0.0108 0.1717 0.1717
Plasmodium vivax unspecified product 0.0284 0.5075 0.5053
Trypanosoma cruzi major cysteine proteinase, putative 0.0108 0.1717 0.1679
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0199 0.3456 0.3427
Plasmodium falciparum serine repeat antigen 6 0.0108 0.1717 0.1679
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0403 0.7341 0.7329
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.6384 0.6344
Giardia lamblia Encystation-specific protease 0.0108 0.1717 0.2637
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0288 0.0288
Onchocerca volvulus 0.0108 0.1717 0.1471
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6384 0.6368
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0284 0.5075 0.5053
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0111 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0108 0.1717 0.1679
Entamoeba histolytica cysteine protease, putative 0.0108 0.1717 0.1623
Entamoeba histolytica cysteine protease, putative 0.0284 0.5075 0.5019
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0108 0.1717 0.1717
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.6384 0.6344
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0176 0.3026 0.3026
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0111 0.023
Entamoeba histolytica cysteine protease, putative 0.0284 0.5075 0.5019
Trypanosoma cruzi cysteine peptidase, putative 0.0176 0.3026 0.2995
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0067
Plasmodium falciparum cysteine proteinase falcipain 1 0.0284 0.5075 0.5053
Giardia lamblia Cathepsin B precursor 0.0108 0.1717 0.2637
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0067
Onchocerca volvulus Cathepsin L homolog 0.0108 0.1717 0.1471
Plasmodium falciparum serine repeat antigen 3 0.0108 0.1717 0.1679
Entamoeba histolytica cysteine protease, putative 0.0108 0.1717 0.1623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0108 0.1717 0.1679
Entamoeba histolytica cysteine proteinase, putative 0.0284 0.5075 0.5019
Giardia lamblia Cathepsin L precursor 0.0108 0.1717 0.2637
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0108 0.1717 0.1679
Trypanosoma brucei cysteine peptidase C (CPC) 0.0199 0.3456 0.3427
Loa Loa (eye worm) hypothetical protein 0.0108 0.1717 0.1717
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0108 0.1717 0.1717
Echinococcus granulosus cathepsin L cysteine protease 0.0284 0.5075 0.5053
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0108 0.1717 0.1679
Brugia malayi intermediate filament protein 0.0033 0.0288 0.0288
Brugia malayi Papain family cysteine protease containing protein 0.0284 0.5075 0.5075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0108 0.1717 0.1679
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0108 0.1717 0.2637
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0108 0.1717 0.1679
Plasmodium vivax vivapain-1 0.0284 0.5075 0.5053
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0284 0.5075 0.5053
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0111 0.0067
Echinococcus granulosus cathepsin l1 0.0366 0.6642 0.6627
Loa Loa (eye worm) hypothetical protein 0.0366 0.6642 0.6642
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0108 0.1717 0.1679
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0108 0.1717 0.1679
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0111 0.0067
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0108 0.1717 0.1679
Loa Loa (eye worm) hypothetical protein 0.0176 0.3026 0.3026
Plasmodium falciparum serine repeat antigen 4 0.0108 0.1717 0.1679

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0071 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.561 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 7.0627 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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