Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), beta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | polymerase (DNA directed), beta | 335 aa | 303 aa | 32.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0097 | 0.1241 | 0.1135 |
Loa Loa (eye worm) | haspin protein kinase | 0.027 | 0.6895 | 0.989 |
Plasmodium vivax | hypothetical protein, conserved | 0.0117 | 0.189 | 0.5 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0211 | 0.4959 | 0.4708 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0117 | 0.189 | 0.2205 |
Brugia malayi | GSG2 | 0.027 | 0.6895 | 1 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0211 | 0.4959 | 0.4245 |
Echinococcus multilocularis | dual specificity | 0.0211 | 0.4959 | 0.6985 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.0474 | 0.0956 |
Loa Loa (eye worm) | haspin protein kinase | 0.027 | 0.6895 | 0.989 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0097 | 0.1241 | 0.1195 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0211 | 0.4959 | 0.7062 |
Brugia malayi | Endochitinase | 0.0082 | 0.0768 | 0.0451 |
Brugia malayi | Protein kinase domain containing protein | 0.0097 | 0.1241 | 0.1189 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0097 | 0.1241 | 0.1135 |
Onchocerca volvulus | 0.0117 | 0.189 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.189 | 0.2205 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.0474 | 0.0825 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0211 | 0.4959 | 1 |
Echinococcus granulosus | dual specificity | 0.0097 | 0.1241 | 0.1195 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.027 | 0.6895 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0097 | 0.1241 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.189 | 0.2578 |
Onchocerca volvulus | Putative endochitinase | 0.0082 | 0.0768 | 0.2052 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.372 | 0.3407 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.027 | 0.6895 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0474 | 0.0825 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0211 | 0.4959 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.4357 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0082 | 0.0768 | 0.2052 |
Entamoeba histolytica | hypothetical protein | 0.0097 | 0.1241 | 0.1702 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0211 | 0.4959 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0173 | 0.372 | 0.283 |
Echinococcus granulosus | dual specificity | 0.0211 | 0.4959 | 0.6985 |
Toxoplasma gondii | hypothetical protein | 0.0117 | 0.189 | 0.3811 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0097 | 0.1241 | 0.1702 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0211 | 0.4959 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0211 | 0.4959 | 0.6985 |
Echinococcus granulosus | dual specificity | 0.0211 | 0.4959 | 0.6985 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0097 | 0.1241 | 0.1631 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1166 | 0.152 |
Echinococcus multilocularis | dual specificity | 0.0211 | 0.4959 | 0.6985 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0474 | 0.0825 |
Plasmodium falciparum | conserved protein, unknown function | 0.0117 | 0.189 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0211 | 0.4959 | 0.6985 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.189 | 0.2578 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.027 | 0.6895 | 1 |
Echinococcus multilocularis | dual specificity | 0.0097 | 0.1241 | 0.1195 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0117 | 0.189 | 0.2205 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0211 | 0.4959 | 0.6983 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0211 | 0.4959 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0211 | 0.4959 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.372 | 0.3643 |
Brugia malayi | hypothetical protein | 0.027 | 0.6895 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0211 | 0.4959 | 0.5 |
Onchocerca volvulus | 0.0117 | 0.189 | 1 | |
Giardia lamblia | Kinase, CMGC DYRK | 0.0211 | 0.4959 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0097 | 0.1241 | 0.1702 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0474 | 0.0825 |
Entamoeba histolytica | protein kinase, putative | 0.0097 | 0.1241 | 0.1702 |
Loa Loa (eye worm) | chitinase I | 0.0073 | 0.0479 | 0.0517 |
Echinococcus multilocularis | dual specificity | 0.0211 | 0.4959 | 0.6985 |
Leishmania major | chitinase | 0.0073 | 0.0479 | 0.0005 |
Schistosoma mansoni | hypothetical protein | 0.027 | 0.6895 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0211 | 0.4959 | 1 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0072 | 0.0414 | 0.0423 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0211 | 0.4959 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0073 | 0.0479 | 0.0517 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.4357 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0082 | 0.0768 | 0.2052 |
Brugia malayi | endochitinase | 0.0082 | 0.0768 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1166 | 0.152 |
Loa Loa (eye worm) | haspin protein kinase | 0.0272 | 0.697 | 1 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0117 | 0.189 | 0.2199 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.027 | 0.6895 | 1 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0211 | 0.4959 | 0.4898 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.027 | 0.6895 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.2818 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.