Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Squalene synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0046 | 0.011 | 0.011 |
Trypanosoma brucei | protein farnesyltransferase alpha subunit, putative | 0.0568 | 0.1967 | 0.5902 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0046 | 0.011 | 0.0142 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0053 | 0.0132 | 0.0479 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0018 | 0.001 | 0.0027 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0079 | 0.0226 | 0.0307 |
Mycobacterium tuberculosis | Probable peptidase | 0.0224 | 0.0742 | 0.273 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.004 | 0.0088 | 0.0117 |
Chlamydia trachomatis | dehyroquinate synthase | 0.0777 | 0.2711 | 0.384 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0006 | 0.0012 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0079 | 0.0226 | 0.0825 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.2192 | 0.7744 | 0.7744 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0224 | 0.0742 | 0.2208 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.0654 | 0.0654 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.095 | 0.3326 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0133 | 0.042 | 0.154 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.012 | 0.0372 | 0.0492 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0568 | 0.1967 | 0.5902 |
Brugia malayi | hypothetical protein | 0.0075 | 0.0213 | 0.0213 |
Trypanosoma cruzi | squalene synthase, putative | 0.0419 | 0.1435 | 0.4298 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0224 | 0.0742 | 0.0927 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0026 | 0.0029 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0026 | 0.0026 |
Onchocerca volvulus | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog | 0.0131 | 0.0409 | 0.0384 |
Plasmodium falciparum | plasmepsin II | 0.0046 | 0.011 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0006 | 0.0006 |
Echinococcus granulosus | protein farnesyltransferase subunit beta | 0.0195 | 0.0637 | 0.0637 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0224 | 0.0742 | 0.0927 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.004 | 0.0088 | 0.0316 |
Echinococcus granulosus | Squalene phytoene synthase | 0.0131 | 0.0409 | 0.0409 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.028 | 0.0941 | 0.0941 |
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.0131 | 0.0409 | 0.0573 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0195 | 0.0637 | 0.0637 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.2529 | 0.2529 |
Trypanosoma brucei | lanosterol synthase | 0.0079 | 0.0226 | 0.0652 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0103 | 0.0313 | 0.0313 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.004 | 0.0088 | 0.0117 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0409 | 0.0409 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.0195 | 0.0637 | 0.1893 |
Plasmodium vivax | geranylgeranyltransferase, putative | 0.0079 | 0.0226 | 0.0285 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.004 | 0.0088 | 0.0117 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.004 | 0.0088 | 0.0117 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.004 | 0.0088 | 0.0316 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.2826 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0026 | 0.005 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0568 | 0.1967 | 0.253 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0195 | 0.0637 | 0.0811 |
Brugia malayi | Probable protein farnesyltransferase beta subunit, putative | 0.0079 | 0.0226 | 0.0226 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0568 | 0.1967 | 0.1967 |
Plasmodium vivax | plasmepsin IV, putative | 0.0046 | 0.011 | 0.0134 |
Echinococcus multilocularis | geranylgeranyl transferase type 2 subunit alpha | 0.0568 | 0.1967 | 0.1967 |
Leishmania major | cytochrome p450-like protein | 0.0103 | 0.0313 | 0.0913 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.028 | 0.0941 | 0.0941 |
Trypanosoma cruzi | squalene synthase, putative | 0.0419 | 0.1435 | 0.4298 |
Brugia malayi | glutathione reductase | 0.0053 | 0.0132 | 0.0132 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0224 | 0.0742 | 0.0947 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0006 | 0.0006 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.2192 | 0.7744 | 0.7744 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0026 | 0.005 |
Plasmodium vivax | geranylgeranyl transferase type2 beta subunit, putative | 0.0079 | 0.0226 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.011 | 0.011 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.004 | 0.0088 | 0.0117 |
Echinococcus granulosus | prolyl endopeptidase | 0.0224 | 0.0742 | 0.0742 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0064 | 0.0064 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.004 | 0.0088 | 0.0117 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.001 | 0.001 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.028 | 0.0941 | 0.0941 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.095 | 0.3326 | 0.3326 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.004 | 0.0088 | 0.0316 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.095 | 0.3326 | 1 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0777 | 0.2711 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0079 | 0.0226 | 0.0652 |
Plasmodium falciparum | thioredoxin reductase | 0.0018 | 0.001 | 0.0005 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.0195 | 0.0637 | 0.1893 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.095 | 0.3326 | 0.3326 |
Entamoeba histolytica | protein farnesyltransferase beta subunit, putative | 0.0195 | 0.0637 | 0.0792 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.2826 | 1 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.012 | 0.0372 | 0.1364 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0026 | 0.0029 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.004 | 0.0088 | 0.0236 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0213 | 0.0242 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.0195 | 0.0637 | 0.0816 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.004 | 0.0088 | 0.0316 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.2192 | 0.7744 | 1 |
Echinococcus granulosus | protein prenyltransferase alpha subunit | 0.0568 | 0.1967 | 0.1967 |
Trypanosoma brucei | protein farnesyltransferase beta subunit | 0.0195 | 0.0637 | 0.1893 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.2826 | 1 | 1 |
Trypanosoma cruzi | phytoene synthase, putative | 0.0131 | 0.0409 | 0.1205 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0026 | 0.0029 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053 | 0.0132 | 0.0132 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0568 | 0.1967 | 0.1967 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0133 | 0.042 | 0.056 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0224 | 0.0742 | 0.0947 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0026 | 0.0029 |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.028 | 0.0941 | 0.0941 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0568 | 0.1967 | 0.5902 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0224 | 0.0742 | 0.273 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.122 | 0.4285 | 0.6074 |
Chlamydia trachomatis | phosphoshikimate 1-carboxyl vinyltransferase | 0.1997 | 0.705 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.008 | 0.0229 | 0.0229 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0018 | 0.001 | 0.0006 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0568 | 0.1967 | 0.253 |
Plasmodium vivax | hypothetical protein, conserved | 0.0224 | 0.0742 | 0.0951 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0224 | 0.0742 | 0.0742 |
Leishmania major | farnesyltransferase beta subunit | 0.0195 | 0.0637 | 0.1893 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.0195 | 0.0637 | 0.0816 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0103 | 0.0313 | 0.0913 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0053 | 0.0132 | 0.0132 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0018 | 0.001 | 0.0006 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0079 | 0.0226 | 0.0652 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.095 | 0.3326 | 0.3326 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0568 | 0.1967 | 0.5902 |
Plasmodium falciparum | plasmepsin I | 0.0046 | 0.011 | 0.0134 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0075 | 0.0213 | 0.0213 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0026 | 0.0029 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0224 | 0.0742 | 0.2208 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0166 | 0.0535 | 0.0535 |
Schistosoma mansoni | cytochrome P450 | 0.004 | 0.0088 | 0.0088 |
Plasmodium falciparum | peptidase, putative | 0.0224 | 0.0742 | 0.0951 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.004 | 0.0088 | 0.0236 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0137 | 0.0431 | 0.0431 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0195 | 0.0637 | 0.0811 |
Giardia lamblia | Prenyltransferase | 0.0195 | 0.0637 | 0.0811 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.2826 | 1 | 1 |
Plasmodium vivax | protein prenyltransferase alpha subunit, putative | 0.0568 | 0.1967 | 0.2534 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.004 | 0.0088 | 0.0117 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0195 | 0.0637 | 0.0811 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.0224 | 0.0742 | 0.104 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0166 | 0.0535 | 0.0535 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.1624 | 0.5722 | 0.7386 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.004 | 0.0088 | 0.0316 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0075 | 0.0213 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0226 | 0.0226 |
Echinococcus granulosus | geranylgeranyl transferase type 2 subunit alpha | 0.0568 | 0.1967 | 0.1967 |
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.0777 | 0.2711 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.2826 | 1 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0224 | 0.0742 | 0.0927 |
Brugia malayi | cytochrome P450 | 0.004 | 0.0088 | 0.0088 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0103 | 0.0313 | 0.0913 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0026 | 0.0029 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.004 | 0.0088 | 0.0117 |
Trypanosoma brucei | cytochrome P450, putative | 0.0103 | 0.0313 | 0.0913 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.095 | 0.3326 | 0.4709 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0226 | 0.0226 |
Trypanosoma cruzi | geranylgeranyl transferase type II beta subunit, putative | 0.0079 | 0.0226 | 0.0652 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0213 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0006 | 0.0006 |
Leishmania major | protein farnesyltransferase alpha subunit, putative | 0.0568 | 0.1967 | 0.5902 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0046 | 0.011 | 0.0129 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.028 | 0.0941 | 0.1204 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0213 | 0.0213 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.004 | 0.0088 | 0.0236 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0777 | 0.2711 | 0.2711 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0224 | 0.0742 | 0.0927 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0026 | 0.0088 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0224 | 0.0742 | 0.2208 |
Leishmania major | oligopeptidase b | 0.0224 | 0.0742 | 0.2208 |
Toxoplasma gondii | hypothetical protein | 0.0568 | 0.1967 | 0.278 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0224 | 0.0742 | 0.0947 |
Plasmodium falciparum | plasmepsin VI | 0.0046 | 0.011 | 0.0134 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.004 | 0.0088 | 0.0117 |
Echinococcus multilocularis | Rab geranylgeranyltransferase, beta subunit | 0.0079 | 0.0226 | 0.0226 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0213 | 0.0242 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0568 | 0.1967 | 0.5902 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.1997 | 0.705 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053 | 0.0132 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.0742 | 0.0742 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.004 | 0.0088 | 0.0117 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0103 | 0.0313 | 0.0313 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.004 | 0.0088 | 0.0117 |
Plasmodium falciparum | geranylgeranyl transferase type2 beta subunit, putative | 0.0079 | 0.0226 | 0.0285 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0046 | 0.011 | 0.011 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.095 | 0.3326 | 1 |
Leishmania major | cytochrome p450-like protein | 0.004 | 0.0088 | 0.0236 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.2192 | 0.7744 | 0.7744 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0195 | 0.0637 | 0.0637 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.004 | 0.0088 | 0.0316 |
Mycobacterium leprae | 3-dehydroquinate synthase AroB | 0.0777 | 0.2711 | 0.3822 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0018 | 0.001 | 0.0005 |
Leishmania major | geranylgeranyltransferase, putative | 0.0079 | 0.0226 | 0.0652 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.0116 | 0.0356 | 0.0453 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.012 | 0.0372 | 0.1364 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.004 | 0.0088 | 0.0236 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0224 | 0.0742 | 0.0742 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0046 | 0.011 | 0.011 |
Toxoplasma gondii | hypothetical protein | 0.0224 | 0.0742 | 0.104 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0006 | 0.0006 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0026 | 0.005 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0224 | 0.0742 | 0.1045 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0133 | 0.042 | 0.154 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.012 | 0.0372 | 0.1364 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0026 | 0.0029 |
Plasmodium falciparum | glutathione reductase | 0.0053 | 0.0132 | 0.0163 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.004 | 0.0088 | 0.0316 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.004 | 0.0088 | 0.0117 |
Mycobacterium leprae | Conserved hypothetical protein | 0.004 | 0.0088 | 0.0088 |
Mycobacterium tuberculosis | Probable reductase | 0.012 | 0.0372 | 0.1364 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0133 | 0.042 | 0.154 |
Plasmodium falciparum | glutathione reductase | 0.0018 | 0.001 | 0.0005 |
Brugia malayi | Thioredoxin reductase | 0.0053 | 0.0132 | 0.0132 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0119 | 0.0119 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.2192 | 0.7744 | 1 |
Trichomonas vaginalis | protein farnesyltransferase beta subunit, putative | 0.0079 | 0.0226 | 0.028 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0018 | 0.001 | 0.0005 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0064 | 0.0064 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0224 | 0.0742 | 0.2208 |
Brugia malayi | Cytochrome P450 family protein | 0.004 | 0.0088 | 0.0088 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.004 | 0.0088 | 0.0117 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.004 | 0.0088 | 0.0316 |
Brugia malayi | Cytochrome P450 family protein | 0.0103 | 0.0313 | 0.0313 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0224 | 0.0742 | 0.1019 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0.001 | 0.0006 |
Entamoeba histolytica | Rab geranylgeranyltransferase beta subunit, putative | 0.0079 | 0.0226 | 0.0259 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.004 | 0.0088 | 0.0316 |
Echinococcus multilocularis | 0.004 | 0.0088 | 0.0088 | |
Trypanosoma cruzi | Protein prenyltransferase alpha subunit repeat, putative | 0.0568 | 0.1967 | 0.5902 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0018 | 0.001 | 0.0005 |
Trypanosoma brucei | geranylgeranyl transferase type II beta subunit, putative | 0.0079 | 0.0226 | 0.0652 |
Leishmania major | cytochrome p450-like protein | 0.004 | 0.0088 | 0.0236 |
Leishmania major | hypothetical protein, conserved | 0.0131 | 0.0409 | 0.1205 |
Loa Loa (eye worm) | hypothetical protein | 0.2192 | 0.7744 | 0.7744 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.004 | 0.0088 | 0.0316 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0224 | 0.0742 | 0.0742 |
Brugia malayi | prolyl oligopeptidase family protein | 0.095 | 0.3326 | 0.3326 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0053 | 0.0132 | 0.0163 |
Leishmania major | squalene synthase, putative | 0.0419 | 0.1435 | 0.4298 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.1997 | 0.705 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.004 | 0.0088 | 0.0316 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.004 | 0.0088 | 0.0117 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.004 | 0.0088 | 0.0088 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0018 | 0.001 | 0.001 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.2192 | 0.7744 | 1 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0224 | 0.0742 | 0.2208 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0018 | 0.001 | 0.001 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.004 | 0.0088 | 0.0316 |
Brugia malayi | Cytochrome P450 family protein | 0.0103 | 0.0313 | 0.0313 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0026 | 0.0026 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0568 | 0.1967 | 0.5902 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.004 | 0.0088 | 0.0117 |
Loa Loa (eye worm) | cytochrome P450 | 0.004 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.0742 | 0.0742 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0568 | 0.1967 | 0.5902 |
Toxoplasma gondii | prolyl endopeptidase | 0.0224 | 0.0742 | 0.104 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0224 | 0.0742 | 0.2208 |
Trichomonas vaginalis | protein farnesyltransferase beta subunit, putative | 0.0079 | 0.0226 | 0.028 |
Entamoeba histolytica | geranylgeranyl transferase beta subunit | 0.028 | 0.0941 | 0.1185 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.095 | 0.3326 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0079 | 0.0226 | 0.0652 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0053 | 0.0132 | 0.0369 |
Trichomonas vaginalis | geranylgeranyl transferase type beta subunit, putative | 0.0195 | 0.0637 | 0.0811 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.004 | 0.0088 | 0.0111 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0224 | 0.0742 | 0.0742 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0026 | 0.0026 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0079 | 0.0226 | 0.0652 |
Leishmania major | trypanothione reductase | 0.0053 | 0.0132 | 0.0369 |
Plasmodium vivax | glutathione reductase, putative | 0.0053 | 0.0132 | 0.0163 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0018 | 0.001 | 0.001 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.095 | 0.3326 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0026 | 0.0029 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0224 | 0.0742 | 0.0742 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.004 | 0.0088 | 0.0117 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.122 | 0.4285 | 1 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0224 | 0.0742 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0026 | 0.0026 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.2192 | 0.7744 | 0.7744 |
Mycobacterium ulcerans | 3-dehydroquinate synthase | 0.0777 | 0.2711 | 0.384 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0224 | 0.0742 | 0.2208 |
Echinococcus multilocularis | protein farnesyltransferase subunit beta | 0.0195 | 0.0637 | 0.0637 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0224 | 0.0742 | 0.0947 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.008 | 0.0229 | 0.0229 |
Echinococcus multilocularis | Squalene phytoene synthase | 0.0131 | 0.0409 | 0.0409 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0103 | 0.0313 | 0.0436 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.004 | 0.0088 | 0.0236 |
Plasmodium falciparum | geranylgeranyltransferase, putative | 0.0079 | 0.0226 | 0.0285 |
Schistosoma mansoni | geranylgeranyl transferase type II beta subunit | 0.0079 | 0.0226 | 0.0226 |
Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.0195 | 0.0637 | 0.0637 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0006 | 0.0006 |
Toxoplasma gondii | Rab geranylgeranyl transferase type II beta subunit, putative | 0.0079 | 0.0226 | 0.0307 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.004 | 0.0088 | 0.0316 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.004 | 0.0088 | 0.0316 |
Mycobacterium leprae | putative cytochrome p450 | 0.004 | 0.0088 | 0.0088 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0195 | 0.0637 | 0.0891 |
Trypanosoma cruzi | oligopeptidase b | 0.0224 | 0.0742 | 0.2208 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0224 | 0.0742 | 0.0947 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.017 | 0.017 |
Trypanosoma brucei | trypanothione reductase | 0.0053 | 0.0132 | 0.0369 |
Echinococcus multilocularis | protein prenyltransferase alpha subunit | 0.0568 | 0.1967 | 0.1967 |
Trypanosoma cruzi | oligopeptidase b | 0.0224 | 0.0742 | 0.2208 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0103 | 0.0313 | 0.0313 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0046 | 0.011 | 0.011 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0409 | 0.0409 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.004 | 0.0088 | 0.0117 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0046 | 0.011 | 0.0134 |
Trypanosoma brucei | Alpha/beta hydrolase domain-containing protein | 0.0224 | 0.0742 | 0.2208 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.2192 | 0.7744 | 0.7744 |
Plasmodium falciparum | plasmepsin IV | 0.0046 | 0.011 | 0.0134 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0224 | 0.0742 | 0.0742 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.004 | 0.0088 | 0.0117 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0224 | 0.0742 | 0.0927 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.004 | 0.0088 | 0.0117 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0026 | 0.0026 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0224 | 0.0742 | 0.0742 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0046 | 0.011 | 0.0142 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.1997 | 0.705 | 1 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.028 | 0.0941 | 0.0941 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0079 | 0.0226 | 0.028 |
Brugia malayi | hypothetical protein | 0.0726 | 0.2529 | 0.2529 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.028 | 0.0941 | 0.0941 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.2192 | 0.7744 | 1 |
Trichomonas vaginalis | type I geranylgeranyltransferase beta subunit, putative | 0.0195 | 0.0637 | 0.0811 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.004 | 0.0088 | 0.0117 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.122 | 0.4285 | 0.6074 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.122 | 0.4285 | 1 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0224 | 0.0742 | 0.0742 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0213 | 0.0242 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0224 | 0.0742 | 0.2208 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0026 | 0.0088 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0195 | 0.0637 | 0.0811 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.004 | 0.0088 | 0.0316 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.004 | 0.0088 | 0.0316 |
Toxoplasma gondii | thioredoxin reductase | 0.0053 | 0.0132 | 0.0174 |
Plasmodium falciparum | thioredoxin reductase | 0.0053 | 0.0132 | 0.0163 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.004 | 0.0088 | 0.0316 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.2192 | 0.7744 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0137 | 0.0431 | 0.0431 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0018 | 0.001 | 0.0005 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0224 | 0.0742 | 0.2208 |
Loa Loa (eye worm) | glutathione reductase | 0.0053 | 0.0132 | 0.0132 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.012 | 0.0372 | 0.1364 |
Plasmodium falciparum | geranylgeranyl transferase type-2 subunit alpha, putative | 0.0568 | 0.1967 | 0.2534 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0018 | 0.001 | 0.0006 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0224 | 0.0742 | 0.0742 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0568 | 0.1967 | 0.1967 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0568 | 0.1967 | 0.5902 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.0742 | 0.0742 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.2192 | 0.7744 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.012 | 0.0372 | 0.1364 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.2192 | 0.7744 | 1 |
Trypanosoma brucei | oligopeptidase b | 0.0224 | 0.0742 | 0.2208 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0064 | 0.0064 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0224 | 0.0742 | 0.0742 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0224 | 0.0742 | 0.0742 |
Trypanosoma brucei | squalene synthase, putative | 0.0419 | 0.1435 | 0.4298 |
Mycobacterium tuberculosis | Probable phytoene synthase PhyA | 0.0131 | 0.0409 | 0.1502 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0199 | 0.0654 | 0.0654 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0224 | 0.0742 | 0.0927 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0119 | 0.0119 |
Trypanosoma brucei | prolyl endopeptidase | 0.0224 | 0.0742 | 0.2208 |
Onchocerca volvulus | 0.0568 | 0.1967 | 0.1946 | |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0088 | 0.0088 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0075 | 0.0213 | 0.0213 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.004 | 0.0088 | 0.0316 |
Toxoplasma gondii | hypothetical protein | 0.1624 | 0.5722 | 0.8113 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.004 | 0.0088 | 0.0316 |
Entamoeba histolytica | Rab geranylgeranyltransferase alpha subunit, putative | 0.0568 | 0.1967 | 0.2514 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.004 | 0.0088 | 0.0316 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.