TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 410.936 | Formula: C24H27ClN2O2
H donors: 1 H acceptors: 2 LogP: 5.91 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCCC(C1)COc1c(c2cc(C)cc(c2)C)c(O)nc2c1ccc(c2)Cl
InChi: 1S/C24H27ClN2O2/c1-15-9-16(2)11-18(10-15)22-23(29-14-17-5-4-8-27(3)13-17)20-7-6-19(25)12-21(20)26-24(22)28/h6-7,9-12,17H,4-5,8,13-14H2,1-3H3,(H,26,28)
InChiKey: NBJRZSKBRVEFLB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Gonadotropin-releasing hormone receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	GnHR receptor homolog	Get druggable targets OG5_131719	All targets in OG5_131719

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	tachykinin peptides receptor 99D	Gonadotropin-releasing hormone receptor	327 aa	283 aa	19.1 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Gonadotropin-releasing hormone receptor	327 aa	343 aa	21.6 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Gonadotropin-releasing hormone receptor	327 aa	263 aa	23.2 %
Onchocerca volvulus	Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog	Gonadotropin-releasing hormone receptor	327 aa	273 aa	19.8 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Gonadotropin-releasing hormone receptor	327 aa	272 aa	23.2 %
Onchocerca volvulus		Gonadotropin-releasing hormone receptor	327 aa	336 aa	19.0 %
Onchocerca volvulus		Gonadotropin-releasing hormone receptor	327 aa	271 aa	20.7 %
Onchocerca volvulus		Gonadotropin-releasing hormone receptor	327 aa	336 aa	20.8 %
Onchocerca volvulus		Gonadotropin-releasing hormone receptor	327 aa	292 aa	19.5 %
Echinococcus multilocularis	allatostatin A receptor	Gonadotropin-releasing hormone receptor	327 aa	279 aa	23.7 %
Echinococcus granulosus	allatostatin A receptor	Gonadotropin-releasing hormone receptor	327 aa	284 aa	22.9 %
Loa Loa (eye worm)	hypothetical protein	Gonadotropin-releasing hormone receptor	327 aa	334 aa	21.6 %
Schistosoma mansoni	neuropeptide receptor	Gonadotropin-releasing hormone receptor	327 aa	263 aa	24.0 %
Onchocerca volvulus		Gonadotropin-releasing hormone receptor	327 aa	284 aa	19.4 %
Onchocerca volvulus	E3 ubiquitin-protein ligase rpm-1 homolog	Gonadotropin-releasing hormone receptor	327 aa	288 aa	27.8 %
Schistosoma japonicum	5-hydroxytryptamine receptor 4, putative	Gonadotropin-releasing hormone receptor	327 aa	305 aa	24.9 %
Echinococcus multilocularis	tachykinin peptides receptor 99D	Gonadotropin-releasing hormone receptor	327 aa	283 aa	20.1 %
Schistosoma japonicum	Alpha-1A adrenergic receptor, putative	Gonadotropin-releasing hormone receptor	327 aa	290 aa	19.7 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Gonadotropin-releasing hormone receptor	327 aa	288 aa	24.3 %
Echinococcus granulosus	tm gpcr rhodopsin	Gonadotropin-releasing hormone receptor	327 aa	299 aa	23.1 %
Echinococcus multilocularis	neuropeptide receptor	Gonadotropin-releasing hormone receptor	327 aa	263 aa	20.9 %
Brugia malayi	ORL1-like opioid receptor	Gonadotropin-releasing hormone receptor	327 aa	293 aa	20.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0876	0.4632	0.4632
Echinococcus granulosus	cathepsin L cysteine protease	0.0474	0.2465	0.2465
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0199	0.0987	0.0987
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0876	0.4632	0.4632
Schistosoma mansoni	cathepsin B (C01 family)	0.0199	0.0987	0.0987
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.0546	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0987	0.0987
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0876	0.4632	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0275	0.1394	0.1394
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0199	0.0987	0.2131
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0158	0.0158
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0199	0.0987	0.0987
Onchocerca volvulus		0.0602	0.3154	0.5946
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0158	0.0158
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0655	0.3443	0.3443
Brugia malayi	hypothetical protein	0.0317	0.1621	0.1621
Loa Loa (eye worm)	cysteine protease	0.0876	0.4632	0.4632
Entamoeba histolytica	cysteine protease, putative	0.0474	0.2465	0.4054
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0199	0.0987	0.2131
Loa Loa (eye worm)	hypothetical protein	0.1874	1	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0199	0.0987	0.2131
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0987	0.0987
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0876	0.4632	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0275	0.1394	0.1394
Brugia malayi	Papain family cysteine protease containing protein	0.0474	0.2465	0.2465
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0158	0.0158
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0158	0.0158
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0317	0.1621	0.1621
Echinococcus granulosus	cathepsin L	0.0474	0.2465	0.2465
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0275	0.1394	0.1394
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0317	0.1621	1
Plasmodium vivax	unspecified product	0.0199	0.0987	0.2131
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0199	0.0987	0.2131
Echinococcus multilocularis	acetylcholinesterase	0.1874	1	1
Loa Loa (eye worm)	ctsf protein	0.0876	0.4632	0.4632
Brugia malayi	Cathepsin L-like precursor	0.0876	0.4632	0.4632
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0474	0.2465	0.2465
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0924	0.4886	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1675	0.8928	0.8928
Entamoeba histolytica	cysteine protease, putative	0.0876	0.4632	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0474	0.2465	0.2761
Leishmania major	cathepsin L-like protease	0.0876	0.4632	0.948
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0317	0.1621	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0876	0.4632	0.4632
Brugia malayi	cathepsin B-like cysteine proteinase	0.1675	0.8928	0.8928
Loa Loa (eye worm)	hypothetical protein	0.0602	0.3154	0.3154
Loa Loa (eye worm)	hypothetical protein	0.0317	0.1621	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1394	0.1394
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.005	0.0107
Onchocerca volvulus		0.0876	0.4632	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0474	0.2465	0.4054
Echinococcus multilocularis	cysteine protease	0.0876	0.4632	0.4632
Leishmania major	hypothetical protein, conserved	0.0025	0.005	0.0101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.3154	0.5946
Entamoeba histolytica	cysteine proteinase, putative	0.0876	0.4632	1
Plasmodium falciparum	serine repeat antigen 9	0.0199	0.0987	0.2131
Plasmodium falciparum	serine repeat antigen 1	0.0199	0.0987	0.2131
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0876	0.4632	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0876	0.4632	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0876	0.4632	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0317	0.1621	0.1621
Giardia lamblia	Cathepsin B precursor	0.0655	0.3443	1
Schistosoma mansoni	cathepsin C	0.0199	0.0987	0.0987
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0876	0.4632	1
Entamoeba histolytica	cysteine protease, putative	0.0474	0.2465	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0876	0.4632	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0924	0.4886	0.5473
Trypanosoma cruzi	cysteine proteinase, putative	0.0474	0.2465	0.2761
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0199	0.0987	0.2131
Brugia malayi	Papain family cysteine protease containing protein	0.0876	0.4632	0.4632
Plasmodium vivax	vivapain-3	0.0474	0.2465	0.5321
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0876	0.4632	0.4632
Leishmania major	cathepsin L-like protease	0.0876	0.4632	0.948
Entamoeba histolytica	cysteine protease, putative	0.0474	0.2465	0.4054
Plasmodium falciparum	serine repeat antigen 5	0.0199	0.0987	0.2131
Brugia malayi	Cathepsin L-like precursor	0.0876	0.4632	0.4632
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.0546	0.0546
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0876	0.4632	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0876	0.4632	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0158	0.0158
Leishmania major	cathepsin L-like protease	0.0876	0.4632	0.948
Onchocerca volvulus	Cathepsin F homolog	0.0876	0.4632	1
Plasmodium falciparum	serine repeat antigen 2	0.0199	0.0987	0.2131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0474	0.2465	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0924	0.4886	1
Echinococcus multilocularis	carboxylesterase 5A	0.1874	1	1
Echinococcus multilocularis	neuroligin	0.0317	0.1621	0.1621
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0876	0.4632	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0924	0.4886	0.5473
Brugia malayi	cathepsin L-like precursor	0.0602	0.3154	0.3154
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1394	0.1394
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0876	0.4632	1
Entamoeba histolytica	cysteine protease, putative	0.0474	0.2465	0.4054
Trypanosoma cruzi	major cysteine proteinase, putative	0.0199	0.0987	0.1106
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0924	0.4886	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0876	0.4632	0.4632
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.005	0.0055
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0876	0.4632	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1675	0.8928	1
Brugia malayi	Carboxylesterase family protein	0.0317	0.1621	0.1621
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0602	0.3154	0.5946
Loa Loa (eye worm)	hypothetical protein	0.0317	0.1621	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0317	0.1621	0.1621
Onchocerca volvulus		0.0876	0.4632	1
Schistosoma mansoni	acetylcholinesterase	0.0317	0.1621	0.1621
Entamoeba histolytica	cysteine protease, putative	0.0474	0.2465	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0317	0.1621	0.1621
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0876	0.4632	1
Loa Loa (eye worm)	hypothetical protein	0.0317	0.1621	0.1621
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0876	0.4632	0.4632
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0655	0.3443	0.7046
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0924	0.4886	1
Leishmania major	cathepsin L-like protease	0.0876	0.4632	0.948
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1675	0.8928	0.8928
Trypanosoma cruzi	cysteine peptidase, putative	0.0474	0.2465	0.2761
Loa Loa (eye worm)	carboxylesterase	0.0317	0.1621	0.1621
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.005	0.0055
Leishmania major	cathepsin L-like protease	0.0924	0.4886	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0199	0.0987	0.0987
Echinococcus granulosus	cathepsin l1	0.0876	0.4632	0.4632
Echinococcus granulosus	cathepsin l1	0.0602	0.3154	0.3154
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0924	0.4886	1
Entamoeba histolytica	cysteine proteinase, putative	0.0474	0.2465	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0474	0.2465	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0924	0.4886	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0199	0.0987	0.2131
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0317	0.1621	0.1738
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0317	0.1621	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0876	0.4632	1
Plasmodium vivax	vivapain-1	0.0474	0.2465	0.5321
Loa Loa (eye worm)	hypothetical protein	0.0602	0.3154	0.3154
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0199	0.0987	0.2131
Echinococcus granulosus	neuroligin	0.0317	0.1621	0.1621
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1675	0.8928	0.8928
Loa Loa (eye worm)	hypothetical protein	0.1675	0.8928	0.8928
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.005	0.0101
Echinococcus granulosus	cathepsin L	0.0199	0.0987	0.0987
Entamoeba histolytica	cysteine protease, putative	0.0474	0.2465	0.4054
Brugia malayi	fibroinase precursor	0.0199	0.0987	0.0987
Brugia malayi	cathepsin L-like cysteine proteinase	0.0199	0.0987	0.0987
Onchocerca volvulus	Cathepsin L homolog	0.0876	0.4632	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0199	0.0987	0.0987
Onchocerca volvulus		0.0876	0.4632	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0876	0.4632	1
Schistosoma mansoni	gliotactin	0.0317	0.1621	0.1621
Plasmodium vivax	vivapain-2	0.0876	0.4632	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0655	0.3443	0.7046
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0876	0.4632	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0474	0.2465	0.4054
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0317	0.1621	0.1621
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0876	0.4632	0.4632
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0602	0.3154	0.3154
Brugia malayi	Cathepsin L-like precursor	0.0602	0.3154	0.3154
Loa Loa (eye worm)	carboxylesterase	0.0317	0.1621	0.1621
Entamoeba histolytica	cysteine proteinase, putative	0.0474	0.2465	0.4054
Echinococcus multilocularis	cathepsin L	0.0474	0.2465	0.2465
Onchocerca volvulus	Cathepsin L homolog	0.0876	0.4632	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0876	0.4632	0.4632
Echinococcus multilocularis	cathepsin b	0.1675	0.8928	0.8928
Schistosoma mansoni	cathepsin s	0.0275	0.1394	0.1394
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0655	0.3443	0.3857
Trypanosoma cruzi	cysteine peptidase, putative	0.0876	0.4632	0.5188
Leishmania major	cathepsin L-like protease	0.0924	0.4886	1
Entamoeba histolytica	cysteine protease, putative	0.0474	0.2465	0.4054
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0199	0.0987	0.2131
Plasmodium falciparum	serine repeat antigen 4	0.0199	0.0987	0.2131
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1874	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0602	0.3154	0.5946
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0317	0.1621	0.1621
Echinococcus multilocularis	cathepsin b	0.1675	0.8928	0.8928
Loa Loa (eye worm)	hypothetical protein	0.0317	0.1621	0.1621
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0876	0.4632	1
Schistosoma mansoni	BC026374 protein (S09 family)	0.0317	0.1621	0.1621
Leishmania major	cathepsin L-like protease	0.0876	0.4632	0.948
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1394	0.1394
Entamoeba histolytica	cysteine protease, putative	0.0474	0.2465	0.4054
Echinococcus multilocularis	cysteine protease	0.0876	0.4632	0.4632
Entamoeba histolytica	cysteine proteinase 2	0.0474	0.2465	0.4054
Brugia malayi	cathepsin L precursor	0.0199	0.0987	0.0987
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0876	0.4632	1
Brugia malayi	Cathepsin L-like precursor	0.0876	0.4632	0.4632
Brugia malayi	Papain family cysteine protease containing protein	0.0199	0.0987	0.0987
Onchocerca volvulus		0.0317	0.1621	0.1738
Echinococcus multilocularis	acetylcholinesterase	0.1874	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0199	0.0987	0.0987
Giardia lamblia	Cathepsin B precursor	0.0655	0.3443	1
Onchocerca volvulus		0.0317	0.1621	0.1738
Brugia malayi	Carboxylesterase family protein	0.1874	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0158	0.0158
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0876	0.4632	1
Toxoplasma gondii	cathepsin CPL	0.0876	0.4632	1
Trypanosoma cruzi	cysteine protease, putative	0.0474	0.2465	0.2761
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0876	0.4632	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0275	0.1394	0.1562
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0924	0.4886	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0876	0.4632	0.4632
Trypanosoma cruzi	cysteine proteinase, putative	0.0474	0.2465	0.2761
Brugia malayi	cathepsin F-like cysteine proteinase	0.0199	0.0987	0.0987
Brugia malayi	Cathepsin L-like precursor	0.0602	0.3154	0.3154
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0876	0.4632	1
Giardia lamblia	Cathepsin B precursor	0.0655	0.3443	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0158	0.0158
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.005	0.0107
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0199	0.0987	0.0987
Leishmania major	cysteine peptidase A (CPA)	0.0876	0.4632	0.948
Loa Loa (eye worm)	hypothetical protein	0.0025	0.005	0.005
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0199	0.0987	0.0987
Plasmodium falciparum	serine repeat antigen 6	0.0199	0.0987	0.2131
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0474	0.2465	0.5044
Brugia malayi	Cathepsin L-like precursor	0.0876	0.4632	0.4632
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0199	0.0987	0.2131
Loa Loa (eye worm)	hypothetical protein	0.0602	0.3154	0.3154
Onchocerca volvulus		0.0876	0.4632	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0199	0.0987	0.0987
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0794	0.4188	0.4188
Brugia malayi	Papain family cysteine protease containing protein	0.0474	0.2465	0.2465
Plasmodium vivax	unspecified product	0.0275	0.1394	0.301
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0876	0.4632	1
Plasmodium vivax	unspecified product	0.0474	0.2465	0.5321
Brugia malayi	GnHR receptor homolog	0.0558	0.2921	0.2921
Entamoeba histolytica	cysteine proteinase, putative	0.0474	0.2465	0.4054
Brugia malayi	Carboxylesterase family protein	0.0317	0.1621	0.1621
Loa Loa (eye worm)	cathepsin B	0.0655	0.3443	0.3443
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0199	0.0987	0.0987
Loa Loa (eye worm)	acetylcholinesterase 1	0.1874	1	1
Onchocerca volvulus		0.0317	0.1621	0.1738
Toxoplasma gondii	cathepsin CPC1	0.0199	0.0987	0.2131
Entamoeba histolytica	cysteine protease, putative	0.0474	0.2465	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0876	0.4632	1
Plasmodium vivax	vivapain-2	0.0876	0.4632	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0924	0.4886	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0317	0.1621	0.1621
Brugia malayi	hypothetical protein	0.0016	0.0002	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0876	0.4632	1
Echinococcus granulosus	cysteine protease	0.0474	0.2465	0.2465
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0987	0.0987
Echinococcus multilocularis	cathepsin L cysteine protease	0.0876	0.4632	0.4632
Toxoplasma gondii	cathepsin CPC2	0.0199	0.0987	0.2131
Entamoeba histolytica	cysteine protease, putative	0.0474	0.2465	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0924	0.4886	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.005	0.0107
Onchocerca volvulus		0.0876	0.4632	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0317	0.1621	0.1621
Echinococcus granulosus	acetylcholinesterase	0.1874	1	1
Toxoplasma gondii	cathepsin B	0.0655	0.3443	0.7433
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0474	0.2465	0.5321
Echinococcus multilocularis	cathepsin L	0.0199	0.0987	0.0987
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0876	0.4632	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0246	0.1242	0.1391
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0199	0.0987	0.2131
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0199	0.0987	0.2131
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0158	0.0158
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0649	0.3409	0.3818
Plasmodium falciparum	serine repeat antigen 7	0.0199	0.0987	0.2131
Onchocerca volvulus		0.0317	0.1621	0.1738
Entamoeba histolytica	cysteine protease, putative	0.0474	0.2465	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0474	0.2465	0.2465
Brugia malayi	Carboxylesterase family protein	0.0317	0.1621	0.1621
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0199	0.0987	0.0987
Plasmodium falciparum	serine repeat antigen 3	0.0199	0.0987	0.2131
Mycobacterium ulcerans	carboxylesterase, LipT	0.0317	0.1621	0.5
Onchocerca volvulus		0.0317	0.1621	0.1738
Echinococcus granulosus	BC026374 protein S09 family	0.0317	0.1621	0.1621
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0199	0.0987	0.2131
Trypanosoma cruzi	cysteine peptidase, putative	0.0924	0.4886	0.5473
Trypanosoma cruzi	cysteine peptidase, putative	0.0275	0.1394	0.1562
Onchocerca volvulus		0.0876	0.4632	1
Onchocerca volvulus		0.0876	0.4632	1
Brugia malayi	Carboxylesterase family protein	0.0317	0.1621	0.1621
Echinococcus multilocularis	para nitrobenzyl esterase	0.0317	0.1621	0.1621
Trichomonas vaginalis	spcc417.12 protein, putative	0.0317	0.1621	0.1738
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0199	0.0987	0.2131
Echinococcus granulosus	cathepsin b	0.1675	0.8928	0.8928
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0655	0.3443	0.6738
Brugia malayi	Papain family cysteine protease containing protein	0.0199	0.0987	0.0987
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0474	0.2465	0.5044
Schistosoma mansoni	cathepsin F (C01 family)	0.0602	0.3154	0.3154
Brugia malayi	hypothetical protein	0.0025	0.005	0.005
Entamoeba histolytica	cysteine proteinase, putative	0.0474	0.2465	0.4054
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0199	0.0987	0.0987
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1675	0.8928	0.8928
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0924	0.4886	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0876	0.4632	1
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0987	0.0987
Plasmodium vivax	serine-repeat antigen (SERA)	0.0199	0.0987	0.2131
Loa Loa (eye worm)	hypothetical protein	0.1874	1	1
Brugia malayi	Cathepsin L-like precursor	0.0876	0.4632	0.4632
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.005	0.0107
Brugia malayi	Cathepsin L-like precursor	0.0876	0.4632	0.4632
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0876	0.4632	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0199	0.0987	0.0987
Entamoeba histolytica	cysteine protease, putative	0.0474	0.2465	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0987	0.0987
Entamoeba histolytica	cysteine proteinase, putative	0.0876	0.4632	1
Leishmania major	cathepsin L-like protease	0.0924	0.4886	1
Brugia malayi	Cathepsin L-like precursor	0.0275	0.1394	0.1394
Brugia malayi	MH2 domain containing protein	0.0117	0.0546	0.0546
Echinococcus granulosus	cathepsin b	0.1675	0.8928	0.8928
Echinococcus granulosus	acetylcholinesterase	0.1874	1	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0317	0.1621	0.1621
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0158	0.0158
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0199	0.0987	0.2131
Plasmodium vivax	serine-repeat antigen (SERA)	0.0199	0.0987	0.2131
Trypanosoma cruzi	cruzipain precursor, putative	0.0924	0.4886	0.5473
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0199	0.0987	0.0987
Echinococcus granulosus	carboxylesterase 5A	0.1874	1	1
Loa Loa (eye worm)	hypothetical protein	0.0317	0.1621	0.1621
Echinococcus granulosus	para nitrobenzyl esterase	0.0317	0.1621	0.1621
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0199	0.0987	0.0987
Loa Loa (eye worm)	carboxylesterase	0.1874	1	1
Loa Loa (eye worm)	fibroinase	0.0876	0.4632	0.4632
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0876	0.4632	1
Plasmodium falciparum	serine repeat antigen 8	0.0199	0.0987	0.2131
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0924	0.4886	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0199	0.0987	0.0987
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0199	0.0987	0.0987
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0474	0.2465	0.2465
Schistosoma mansoni	cathepsin F (C01 family)	0.0876	0.4632	0.4632
Brugia malayi	Papain family cysteine protease containing protein	0.0199	0.0987	0.0987
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0987	0.0987

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.3 uM	Inhibition of [125I]-Buserelin to GnRH receptor in rat pituitary membranes.	ChEMBL.	10498220
IC50 (binding)	= 0.3 uM	Inhibition of [125I]-Buserelin to GnRH receptor in rat pituitary membranes.	ChEMBL.	10498220

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 143534