Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | xaa Pro dipeptidase | 0.0051 | 0.0909 | 0.083 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.0411 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0051 | 0.0909 | 0.0639 |
Schistosoma mansoni | aminopeptidase P1 (M24 family) | 0.0051 | 0.0909 | 0.0909 |
Mycobacterium tuberculosis | Dipeptidase PepE | 0.0051 | 0.0909 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.003 | 0.0374 | 0.0088 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0051 | 0.0909 | 0.0555 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.0051 | 0.0909 | 0.083 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.0051 | 0.0909 | 0.0555 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0051 | 0.0909 | 0.0639 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0411 | 1 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0051 | 0.0909 | 0.083 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0909 | 0.083 |
Plasmodium falciparum | methionine aminopeptidase 1c, putative | 0.0051 | 0.0909 | 0.0555 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24, putative | 0.0051 | 0.0909 | 0.0555 |
Leishmania major | transcription factor-like protein | 0.0051 | 0.0909 | 0.0639 |
Schistosoma mansoni | cytochrome P450 reductase | 0.003 | 0.0374 | 0.0374 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0374 | 0.0291 |
Schistosoma mansoni | chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) | 0.0051 | 0.0909 | 0.0909 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0411 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0411 | 1 | 1 |
Echinococcus multilocularis | Xaa Pro aminopeptidase 3 | 0.0051 | 0.0909 | 0.083 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0051 | 0.0909 | 0.083 |
Treponema pallidum | methionine aminopeptidase (map) | 0.0051 | 0.0909 | 0.5 |
Trypanosoma brucei | Metallopeptidase family M24, putative | 0.0051 | 0.0909 | 0.0555 |
Echinococcus multilocularis | xaa Pro dipeptidase | 0.0051 | 0.0909 | 0.083 |
Leishmania major | aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 | 0.0051 | 0.0909 | 0.0639 |
Echinococcus multilocularis | methionine aminopeptidase, type I | 0.0051 | 0.0909 | 0.083 |
Leishmania major | methionine aminopeptidase 2, putative | 0.0411 | 1 | 1 |
Echinococcus granulosus | Proliferation associated protein 2G4 | 0.0051 | 0.0909 | 0.083 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0051 | 0.0909 | 0.0909 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.003 | 0.0374 | 0.0291 |
Leishmania major | aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 | 0.0051 | 0.0909 | 0.0639 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0051 | 0.0909 | 0.0555 |
Plasmodium vivax | peptidase, putative | 0.0051 | 0.0909 | 0.0639 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24, putative | 0.0051 | 0.0909 | 0.0555 |
Echinococcus granulosus | methionine aminopeptidase type I | 0.0051 | 0.0909 | 0.083 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.0051 | 0.0909 | 0.0555 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0051 | 0.0909 | 0.0639 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0051 | 0.0909 | 0.0555 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.0051 | 0.0909 | 0.0555 |
Mycobacterium ulcerans | aminopeptidase | 0.0051 | 0.0909 | 1 |
Echinococcus multilocularis | xaa Pro dipeptidase | 0.0051 | 0.0909 | 0.083 |
Treponema pallidum | aminopeptidase P | 0.0051 | 0.0909 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.003 | 0.0374 | 0.0291 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0909 | 0.083 |
Trypanosoma cruzi | aminopeptidase P, putative | 0.0051 | 0.0909 | 0.0555 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0051 | 0.0909 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0051 | 0.0909 | 0.0639 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0051 | 0.0909 | 0.0555 |
Plasmodium falciparum | methionine aminopeptidase 2 | 0.0411 | 1 | 1 |
Trypanosoma cruzi | Metallopeptidase family M24, putative | 0.0051 | 0.0909 | 0.0555 |
Plasmodium falciparum | FACT complex subunit SPT16, putative | 0.0051 | 0.0909 | 0.0555 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0051 | 0.0909 | 0.0639 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.0051 | 0.0909 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0051 | 0.0909 | 0.0639 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.0051 | 0.0909 | 0.0639 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0051 | 0.0909 | 0.083 |
Echinococcus granulosus | FACT complex subunit SPT16 | 0.0051 | 0.0909 | 0.083 |
Echinococcus granulosus | xaa Pro dipeptidase | 0.0051 | 0.0909 | 0.083 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0051 | 0.0909 | 0.0555 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.0051 | 0.0909 | 1 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0909 | 0.083 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0411 | 1 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.0051 | 0.0909 | 0.5 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.0051 | 0.0909 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0051 | 0.0909 | 0.0639 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.0051 | 0.0909 | 0.083 |
Mycobacterium ulcerans | dipeptidase PepE | 0.0051 | 0.0909 | 1 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0051 | 0.0909 | 0.0909 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0411 | 1 | 1 |
Brugia malayi | Methionine aminopeptidase protein type I | 0.0051 | 0.0909 | 0.083 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0411 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0051 | 0.0909 | 0.0639 |
Trypanosoma brucei | Facilitates chromatin transcription complex subunit spt16 | 0.0051 | 0.0909 | 0.0555 |
Chlamydia trachomatis | aminopeptidase P | 0.0051 | 0.0909 | 1 |
Echinococcus granulosus | xaa pro aminopeptidase | 0.0051 | 0.0909 | 0.083 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.0051 | 0.0909 | 0.0639 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0411 | 1 | 1 |
Brugia malayi | DNA-binding protein, 42 kDa containing protein | 0.0051 | 0.0909 | 0.083 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0051 | 0.0909 | 0.0639 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | metallopeptidase family M24 containing protein | 0.0051 | 0.0909 | 0.083 |
Leishmania major | p450 reductase, putative | 0.003 | 0.0374 | 0.0088 |
Echinococcus multilocularis | FACT complex subunit SPT16 | 0.0051 | 0.0909 | 0.083 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0411 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.003 | 0.0374 | 0.0291 |
Trichomonas vaginalis | sulfite reductase, putative | 0.003 | 0.0374 | 0.0088 |
Leishmania major | aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 | 0.0051 | 0.0909 | 0.0639 |
Schistosoma mansoni | peptidase | 0.0051 | 0.0909 | 0.0909 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.0051 | 0.0909 | 0.5 |
Plasmodium vivax | FACT complex subunit SPT16, putative | 0.0051 | 0.0909 | 0.0639 |
Leishmania major | aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 | 0.0051 | 0.0909 | 0.0639 |
Plasmodium vivax | proliferation-associated protein 2g4, putative | 0.0051 | 0.0909 | 0.0639 |
Brugia malayi | FAD binding domain containing protein | 0.003 | 0.0374 | 0.0291 |
Plasmodium falciparum | proliferation-associated protein 2g4, putative | 0.0051 | 0.0909 | 0.0555 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.0051 | 0.0909 | 0.0555 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0411 | 1 | 1 |
Mycobacterium ulcerans | dipeptidase | 0.0051 | 0.0909 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0051 | 0.0909 | 0.0639 |
Trypanosoma brucei | Xaa-Pro aminopeptidase, putative | 0.0051 | 0.0909 | 0.0555 |
Giardia lamblia | Methionine aminopeptidase | 0.0411 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0411 | 1 | 1 |
Echinococcus multilocularis | Proliferation associated protein 2G4 | 0.0051 | 0.0909 | 0.083 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0051 | 0.0909 | 0.083 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0051 | 0.0909 | 0.0639 |
Trypanosoma cruzi | aminopeptidase P1, putative | 0.0051 | 0.0909 | 0.0555 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0051 | 0.0909 | 0.0909 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0051 | 0.0909 | 0.0639 |
Brugia malayi | flavodoxin family protein | 0.003 | 0.0374 | 0.0291 |
Wolbachia endosymbiont of Brugia malayi | Xaa-Pro aminopeptidase | 0.0051 | 0.0909 | 0.5 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0051 | 0.0909 | 0.083 |
Mycobacterium leprae | Probable cytoplasmic peptidase PepQ | 0.0051 | 0.0909 | 0.5 |
Loa Loa (eye worm) | DNA-binding protein | 0.0051 | 0.0909 | 0.083 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.003 | 0.0374 | 0.0291 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0018 | 0.0086 | 0.0086 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0051 | 0.0909 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.003 | 0.0374 | 0.0088 |
Schistosoma mansoni | Xaa-Pro dipeptidase (M24 family) | 0.0051 | 0.0909 | 0.0909 |
Mycobacterium tuberculosis | Probable cytoplasmic peptidase PepQ | 0.0051 | 0.0909 | 0.5 |
Mycobacterium ulcerans | cytoplasmic peptidase PepQ | 0.0051 | 0.0909 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.003 | 0.0374 | 0.0291 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.0051 | 0.0909 | 0.0555 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.0051 | 0.0909 | 0.5 |
Echinococcus granulosus | Xaa Pro aminopeptidase 3 | 0.0051 | 0.0909 | 0.083 |
Plasmodium falciparum | aminopeptidase P | 0.0051 | 0.0909 | 0.0555 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0051 | 0.0909 | 0.0555 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0411 | 1 | 1 |
Echinococcus multilocularis | xaa pro aminopeptidase | 0.0051 | 0.0909 | 0.083 |
Trypanosoma cruzi | Metallopeptidase family M24, putative | 0.0051 | 0.0909 | 0.0555 |
Trypanosoma cruzi | Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative | 0.0051 | 0.0909 | 0.0555 |
Plasmodium vivax | methionine aminopeptidase 1c, putative | 0.0051 | 0.0909 | 0.0639 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0051 | 0.0909 | 0.0639 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0051 | 0.0909 | 0.0639 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0051 | 0.0909 | 0.0909 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0051 | 0.0909 | 0.0909 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 28 pmolequiv/mg | Oxidative metabolism in human hepatocytes assessed as protein covalent binding per mg of protein after 2 hrs | ChEMBL. | 21126875 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.