pI: 6.3831 |
Length (AA): 401 |
MW (Da): 44867 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 9 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 397 | 2bwv (A) | 52 | 440 | 16.00 | 0 | 1 | 1.01 | 0.2 |
66 | 382 | 2b3h (A) | 90 | 393 | 55.00 | 0 | 1 | 1.46 | -1.11 |
127 | 383 | 2gg2 (A) | 3 | 262 | 42.00 | 0 | 1 | 1.27 | -1.28 |
2 | 42 | 4a24 (A) | 503 | 537 | 37.00 | 0 | 0.91 | 0.426444 | -0.44 |
2 | 42 | 2d8q (A) | 17 | 51 | 31.00 | 0 | 0.97 | 0.362444 | -0.34 |
37 | 378 | 3s6b (A) | 23 | 355 | 50.00 | 0 | 1 | 1.40807 | -0.43 |
64 | 397 | 4fuk (A) | 62 | 391 | 72.00 | 0 | 1 | 1.73532 | -1.24 |
66 | 375 | 2b3h (A) | 90 | 385 | 58.00 | 0 | 1 | 1.51427 | -1.26 |
125 | 371 | 3pka (A) | 37 | 283 | 47.00 | 0 | 1 | 1.30246 | -1.42 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | metacyclic. | Fernandes MC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | amastigotes. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_126721)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G45240 | methionine aminopeptidase 1A |
Arabidopsis thaliana | AT1G13270 | methionine aminopeptidase 1B |
Arabidopsis thaliana | AT4G37040 | methionine aminopeptidase 1D |
Babesia bovis | BBOV_IV006760 | methionine aminopeptidase, putative |
Babesia bovis | BBOV_III008650 | methionine aminopeptidase, putative |
Brugia malayi | Bm1_31345 | Methionine aminopeptidase protein type I |
Candida albicans | CaO19.10636 | methionine aminopeptidase |
Candida albicans | CaO19.3124 | methionine aminopeptidase |
Caenorhabditis elegans | CELE_Y37E11AL.7 | Protein MAP-1 |
Cryptosporidium hominis | Chro.10305 | methionine aminopeptidase 1 (MetAP 1) (MAP 1) (Peptidase M 1) |
Cryptosporidium parvum | cgd1_2700 | methionine aminopeptidase with MYND finger at N-terminus |
Chlamydia trachomatis | CT_851 | methionine aminopeptidase |
Dictyostelium discoideum | DDB_G0279433 | methionine aminopeptidase 1 |
Dictyostelium discoideum | DDB_G0280127 | methionine aminopeptidase |
Drosophila melanogaster | Dmel_CG13630 | CG13630 gene product from transcript CG13630-RA |
Drosophila melanogaster | Dmel_CG5188 | CG5188 gene product from transcript CG5188-RA |
Escherichia coli | b0168 | methionine aminopeptidase |
Echinococcus granulosus | EgrG_000923200 | methionyl aminopeptidase 1 M24 family |
Echinococcus multilocularis | EmuJ_000923200 | methionyl aminopeptidase 1 (M24 family) |
Echinococcus multilocularis | EmuJ_000025800 | methionyl aminopeptidase 1 (M24 family) |
Homo sapiens | 254042 | methionyl aminopeptidase type 1D (mitochondrial) |
Homo sapiens | ENSG00000164024 | methionyl aminopeptidase 1 |
Leishmania braziliensis | LbrM.19.0860 | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 |
Leishmania donovani | LdBPK_190540.1 | metallo- peptidase, Clan MG, Family M24 |
Leishmania infantum | LinJ.19.0540 | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 |
Leishmania major | LmjF.19.0550 | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 |
Leishmania mexicana | LmxM.19.0550 | methionine aminopeptidase |
Loa Loa (eye worm) | LOAG_04834 | methionine aminopeptidase type I |
Mycobacterium leprae | ML1576c | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) |
Mycobacterium leprae | ML1831c | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) |
Mus musculus | ENSMUSG00000041921 | methionyl aminopeptidase type 1D (mitochondrial) |
Mus musculus | ENSMUSG00000005813 | methionyl aminopeptidase 1 |
Mycobacterium tuberculosis | Rv2861c | Methionine aminopeptidase MapB (map) (peptidase M) |
Mycobacterium tuberculosis | Rv0734 | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) |
Mycobacterium ulcerans | MUL_2091 | methionine aminopeptidase MapB |
Mycobacterium ulcerans | MUL_0830 | methionine aminopeptidase |
Neospora caninum | NCLIV_028520 | methionine aminopeptidase, putative |
Neospora caninum | NCLIV_064990 | methionine aminopeptidase, putative |
Neospora caninum | NCLIV_011650 | methionine aminopeptidase, putative |
Oryza sativa | 4330811 | Os02g0761700 |
Oryza sativa | 4336948 | Os04g0610500 |
Oryza sativa | 4349075 | Os10g0508400 |
Plasmodium berghei | PBANKA_1242100 | methionine aminopeptidase 1a, putative |
Plasmodium berghei | PBANKA_1213700 | methionine aminopeptidase 1b, putative |
Plasmodium falciparum | PF3D7_1015300 | methionine aminopeptidase 1b, putative |
Plasmodium falciparum | PF3D7_0527300 | methionine aminopeptidase 1a, putative |
Plasmodium knowlesi | PKNH_1005400 | methionine aminopeptidase 1a, putative |
Plasmodium knowlesi | PKNH_0815400 | methionine aminopeptidase 1b, putative |
Plasmodium vivax | PVX_079875 | methionine aminopeptidase 1a, putative |
Plasmodium vivax | PVX_094985 | methionine aminopeptidase 1b, putative |
Plasmodium yoelii | PY01653 | methionine aminopeptidase, type I |
Plasmodium yoelii | PY04617 | methionine aminopeptidase, type I, putative |
Saccharomyces cerevisiae | YLR244C | Map1p |
Schistosoma japonicum | Sjp_0097930 | ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative |
Schistosoma japonicum | Sjp_0305740 | ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative |
Schistosoma japonicum | Sjp_0108750 | Methionine aminopeptidase 1, putative |
Schistosoma mansoni | Smp_142010.1 | methionyl aminopeptidase 1 (M24 family) |
Schistosoma mansoni | Smp_142010.2 | methionyl aminopeptidase 1 (M24 family) |
Schmidtea mediterranea | mk4.044698.02 | |
Schmidtea mediterranea | mk4.034199.00 | |
Schmidtea mediterranea | mk4.003233.01 | Methionine aminopeptidase 1 |
Trypanosoma brucei gambiense | Tbg972.10.18570 | methionine aminopeptidase, putative,metallo- peptidase, Clan MG, Family M24 |
Trypanosoma brucei | Tb11.v5.0998 | methionine aminopeptidase, putative |
Trypanosoma brucei | Tb927.10.15270 | metallo- peptidase, Clan MG, Family M24 |
Trypanosoma brucei | Tb11.1240 | methionine aminopeptidase, type I, putative |
Trypanosoma congolense | TcIL3000_10_13060 | metallo- peptidase, Clan MG, Family M24 |
Trypanosoma cruzi | TcCLB.507031.120 | metallo- peptidase, Clan MG, Family M24 |
Trypanosoma cruzi | TcCLB.504111.20 | metallo- peptidase, Clan MG, Family M24 |
Toxoplasma gondii | TGME49_248850 | methionine aminopeptidase |
Toxoplasma gondii | TGME49_211330 | methionine aminopeptidase |
Toxoplasma gondii | TGME49_257730 | methionine aminopeptidase, type i, putative |
Treponema pallidum | TP0842 | methionine aminopeptidase (map) |
Theileria parva | TP04_0770 | methionine aminopeptidase, type I, putative |
Theileria parva | TP04_0063 | methionine aminopeptidase, type I, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0112 | methionine aminopeptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2908 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.10.15270 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.15270 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.15270 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.10.15270 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0168 | Escherichia coli | essential | goodall |
PBANKA_1213700 | Plasmodium berghei | Dispensable | plasmo |
PBANKA_1242100 | Plasmodium berghei | Essential | plasmo |
TGME49_211330 | Toxoplasma gondii | Probably essential | sidik |
TGME49_248850 | Toxoplasma gondii | Probably essential | sidik |
TGME49_257730 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.8
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | methionyl aminopeptidase 1 | Compounds | References |
Staphylococcus aureus (strain COL) | Methionine aminopeptidase | Compounds | References |
Escherichia coli | methionine aminopeptidase | Compounds | References |
Saccharomyces cerevisiae | Map1p | Compounds | References |
Target | Type | Source | Notes |
---|---|---|---|
LmjF.19.0550 | cloned gene | BRENDA | A gene with this EC number or name or sequence has been cloned from Leishmania amazonensis ( 1 ) |
1 literature reference was collected for this gene.