Detailed information for compound 146855

Basic information

Technical information
  • TDR Targets ID: 146855
  • Name: (3Z)-5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2 -ylmethylidene)-1H-indol-2-one
  • MW: 343.218 | Formula: C17H15BrN2O
  • H donors: 2 H acceptors: 1 LogP: 3.64 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCCC3)/C(=O)N2
  • InChi: 1S/C17H15BrN2O/c18-11-5-6-16-13(8-11)14(17(21)20-16)9-12-7-10-3-1-2-4-15(10)19-12/h5-9,19H,1-4H2,(H,20,21)/b14-9-
  • InChiKey: RFHPWPWVGFSLOP-ZROIWOOFSA-N  


Substructure search Similarity search

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Synonyms

  • (3Z)-5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)indolin-2-one
  • (3Z)-5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-2-indolinone
  • (3Z)-5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)oxindole
  • 5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indol-2-one
  • 5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)indolin-2-one
  • 5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-2-indolinone
  • 5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)oxindole
  • (Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one
  • Indolin-2-one deriv. 4b
  • VEGF Receptor 2 Kinase Inhibitor II
  • HSCI1_000066
  • K00006

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fibroblast growth factor receptor 1 Starlite/ChEMBL References
Homo sapiens platelet-derived growth factor receptor, beta polypeptide Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai Get druggable targets OG5_128769 All targets in OG5_128769
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Fibroblast growth factor receptor precursor, putative Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0032 0.0025 0.0025
Trypanosoma brucei cytochrome P450, putative 0.0136 0.0226 0.3109
Echinococcus multilocularis potassium large conductance calcium activated 0.0032 0.0025 0.0025
Mycobacterium leprae Conserved hypothetical protein 0.0052 0.0063 0.5
Loa Loa (eye worm) hypothetical protein 0.0062 0.0082 0.0082
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0032 0.0025 0.0025
Echinococcus granulosus transient receptor potential gamma protein 0.0032 0.0025 0.0025
Echinococcus multilocularis Immunoglobulin 0.0037 0.0033 0.0033
Trypanosoma brucei C-8 sterol isomerase, putative 0.0368 0.0671 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0057 0.0057
Schistosoma mansoni transient receptor potential channel 4 0.0032 0.0025 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0052 0.0063 0.5
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0025 0.0025
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0047 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0906 0.1705 0.1705
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0052 0.0063 0.5
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0032 0.0025 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0052 0.0063 0.5
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0052 0.0063 0.5
Plasmodium vivax SET domain protein, putative 0.0062 0.0082 0.5
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0047 0.0053 0.0053
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0052 0.0063 0.0595
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0861 0.162 0.162
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0124 0.0201 0.0201
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0082 0.0082
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0052 0.0063 0.5
Schistosoma mansoni voltage-dependent calcium channel 0.0032 0.0025 0.0025
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0906 0.1705 0.1705
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0047 0.0053 0.0053
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0025 0.0025
Onchocerca volvulus 0.0052 0.0063 0.0038
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0047 0.0053 0.0053
Echinococcus multilocularis short transient receptor potential channel 6 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0084 0.0126 0.0126
Echinococcus granulosus voltage dependent calcium channel 0.0032 0.0025 0.0025
Echinococcus multilocularis calcium activated potassium channel 0.0032 0.0025 0.0025
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.0025 0.0025
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0032 0.0025 0.0025
Schistosoma mansoni tyrosine kinase 0.0021 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0052 0.0063 0.0595
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0037 0.0033 0.0033
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0032 0.0025 0.0025
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0025 0.0025
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0049 0.0057 0.0057
Loa Loa (eye worm) CYP4Cod1 0.0136 0.0226 0.0226
Schistosoma mansoni cell adhesion molecule 0.0044 0.0047 0.0047
Brugia malayi Pre-SET motif family protein 0.0062 0.0082 0.0082
Brugia malayi Pre-SET motif family protein 0.0429 0.0789 0.0789
Echinococcus granulosus tyrosine protein kinase Lyn 0.0049 0.0057 0.0057
Echinococcus granulosus tumor protein p63 0.0353 0.0643 0.0643
Echinococcus multilocularis tumor protein p63 0.0353 0.0643 0.0643
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0032 0.0025 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0052 0.0063 0.5
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0032 0.0025 0.0025
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.0025 0.0025
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0063 0.0063
Schistosoma mansoni ryanodine receptor related 0.0032 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0057 0.0073 0.0073
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0368 0.0671 1
Schistosoma mansoni ceramide glucosyltransferase 0.5217 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0063 0.0063
Echinococcus multilocularis sodium channel protein 0.0032 0.0025 0.0025
Echinococcus multilocularis voltage gated potassium channel 0.0057 0.0073 0.0073
Brugia malayi cation channel family protein 0.0032 0.0025 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0052 0.0063 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.005 0.005
Brugia malayi cation channel family protein 0.0032 0.0025 0.0025
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.0025 0.0025
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0047 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0025
Brugia malayi Cytochrome P450 family protein 0.0071 0.01 0.01
Echinococcus multilocularis 0.0052 0.0063 0.0063
Brugia malayi cytochrome P450 0.0052 0.0063 0.0063
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0052 0.0063 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0033
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0025 0.0025
Echinococcus multilocularis tyrosine protein kinase HCK 0.004 0.004 0.004
Echinococcus multilocularis transfer RNA-Gly 0.0032 0.0025 0.0025
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.0025 0.0025
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0032 0.0025 0.0025
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0049 0.0057 0.0057
Echinococcus granulosus twitchin 0.0046 0.0051 0.0051
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0044 0.0047 0.0047
Echinococcus granulosus tyrosine protein kinase HCK 0.004 0.004 0.004
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0049 0.0057 0.0057
Schistosoma mansoni calcium-activated potassium channel 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0137 0.0226 0.0226
Toxoplasma gondii cytochrome p450 superfamily protein 0.0052 0.0063 0.6755
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0049 0.0057 0.0057
Schistosoma mansoni cytochrome P450 0.0052 0.0063 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.005 0.005
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0047 0.0053 0.0053
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.0025 0.0025
Echinococcus multilocularis expressed protein 0.0373 0.0681 0.0681
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.018 0.0309 0.0309
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0052 0.0063 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Echinococcus multilocularis short transient receptor potential channel 6 0.0032 0.0025 0.0025
Brugia malayi Immunoglobulin I-set domain containing protein 0.0215 0.0377 0.0377
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0057 0.0073 0.0073
Echinococcus granulosus two pore calcium channel protein 1 0.0032 0.0025 0.0025
Loa Loa (eye worm) TK protein kinase 0.004 0.004 0.004
Echinococcus multilocularis transient receptor potential gamma protein 0.0032 0.0025 0.0025
Echinococcus multilocularis ryanodine receptor 44f 0.0032 0.0025 0.0025
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0032 0.0025 0.0025
Echinococcus granulosus cytochrome P450 2K1 0.0052 0.0063 0.0063
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0044 0.0044
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0032 0.0025 0.0025
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0057 0.0057
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0032 0.0025 0.0025
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0052 0.0063 0.5
Leishmania major cytochrome p450-like protein 0.0136 0.0226 0.3109
Echinococcus multilocularis roundabout 2 0.0053 0.0065 0.0065
Mycobacterium leprae putative cytochrome p450 0.0052 0.0063 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.0048 0.0048
Schistosoma mansoni voltage-gated potassium channel 0.0057 0.0073 0.0073
Schistosoma mansoni voltage-gated potassium channel 0.0147 0.0246 0.0246
Loa Loa (eye worm) cytochrome P450 family protein 0.0071 0.01 0.01
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0032 0.0025 0.0025
Echinococcus granulosus sodium channel protein 0.0032 0.0025 0.0025
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0063 0.0063
Echinococcus granulosus voltage gated potassium channel 0.0032 0.0025 0.0025
Echinococcus granulosus TRP transient receptor potential channel 0.0032 0.0025 0.0025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.005 0.005
Echinococcus granulosus potassium large conductance calcium activated 0.0032 0.0025 0.0025
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0032 0.0025 0.0025
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0032 0.0025 0.0025
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Echinococcus granulosus tm gpcr rhodopsin 0.0522 0.0968 0.0968
Onchocerca volvulus Tyrosine kinase homolog 0.0181 0.0311 0.0287
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0036 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0368 0.0671 0.0671
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0032 0.0025 0.0025
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.0025 0.0025
Echinococcus granulosus hyperpolarization activated cyclic 0.0047 0.0053 0.0053
Giardia lamblia Ceramide glucosyltransferase 0.2365 0.4513 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0032 0.0025 0.0025
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0063 0.0063
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.0025 0.0025
Brugia malayi Cytochrome P450 family protein 0.0136 0.0226 0.0226
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0032 0.0025 0.0025
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0044 0.0048 0.0048
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0025 0.0025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.005 0.005
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0025 0.0025
Echinococcus granulosus roundabout 2 0.0053 0.0065 0.0065
Schistosoma mansoni transient receptor potential channel 0.0032 0.0025 0.0025
Schistosoma mansoni voltage-gated cation channel 0.0032 0.0025 0.0025
Schistosoma mansoni 60S ribosomal protein L21 0.0042 0.0044 0.0044
Echinococcus multilocularis conserved hypothetical protein 0.0032 0.0025 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0052 0.0063 0.5
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0032 0.0025 0.0025
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0025 0.0025
Echinococcus multilocularis hyperpolarization activated cyclic 0.0047 0.0053 0.0053
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0047 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0025 0.0025
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0032 0.0025 0.0025
Echinococcus multilocularis tyrosine protein kinase Srms 0.0044 0.0048 0.0048
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0429 0.0789 0.0789
Loa Loa (eye worm) ryanodine receptor 0.0032 0.0025 0.0025
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0047 0.0053 0.0053
Schistosoma mansoni transient receptor potential channel 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Brugia malayi voltage-dependent calcium channel 0.0032 0.0025 0.0025
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0032 0.0025 0.0025
Echinococcus multilocularis two pore calcium channel protein 1 0.0032 0.0025 0.0025
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.0025 0.0025
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0032 0.0025 0.0025
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0052 0.0063 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0052 0.0063 0.5
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0032 0.0025 0.0025
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0047 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0053 0.0065 0.0065
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0032 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0025 0.0025
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.004 0.004
Echinococcus granulosus neuroglian 0.0046 0.0051 0.0051
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.0025 0.0025
Schistosoma mansoni nephrin 0.0046 0.0051 0.0051
Brugia malayi SRC-1 0.0049 0.0057 0.0057
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0032 0.0025 0.0025
Trypanosoma cruzi cytochrome P450, putative 0.0136 0.0226 0.3109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.005 0.005
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.0025 0.0025
Entamoeba histolytica protein kinase, putative 0.004 0.004 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0032 0.0025 0.0025
Echinococcus multilocularis geminin 0.018 0.0309 0.0309
Echinococcus granulosus hypothetical protein 0.0032 0.0025 0.0025
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0522 0.0968 0.0968
Echinococcus granulosus voltage dependent calcium channel 0.0032 0.0025 0.0025
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0368 0.0671 0.0671
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0032 0.0032
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0052 0.0063 0.5
Echinococcus multilocularis potassium voltage gated channel protein 0.0032 0.0025 0.0025
Loa Loa (eye worm) voltage-gated potassium channel 0.0032 0.0025 0.0025
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0052 0.0063 0.5
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0052 0.0063 0.5
Schistosoma mansoni hypothetical protein 0.0052 0.0063 0.0063
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0124 0.0201 0.0201
Brugia malayi hypothetical protein 0.0032 0.0025 0.0025
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0032 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0025 0.0025
Echinococcus granulosus tyrosine protein kinase Blk 0.0044 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0033
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0124 0.0201 0.0201
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0057 0.0073 0.0073
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0032 0.0025 0.0025
Loa Loa (eye worm) voltage-gated potassium channel 0.0032 0.0025 0.0025
Echinococcus granulosus Immunoglobulin 0.0037 0.0033 0.0033
Echinococcus granulosus voltage gated hydrogen channel 1 0.0032 0.0025 0.0025
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0052 0.0063 0.0595
Echinococcus granulosus shaker cognate 0.0032 0.0025 0.0025
Trypanosoma cruzi cytochrome P450, putative 0.0136 0.0226 0.3109
Echinococcus multilocularis neuroglian 0.0046 0.0051 0.0051
Echinococcus multilocularis potassium voltage gated channel protein 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0137 0.0226 0.0226
Echinococcus granulosus short transient receptor potential channel 6 0.0032 0.0025 0.0025
Loa Loa (eye worm) TK protein kinase 0.0044 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0033
Brugia malayi Fibronectin type III domain containing protein 0.0037 0.0033 0.0033
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0032 0.0025 0.0025
Echinococcus granulosus fibroblast growth factor receptor 4 0.0124 0.0201 0.0201
Brugia malayi protein-tyrosine kinase 0.0044 0.0048 0.0048
Loa Loa (eye worm) cytochrome P450 family protein 0.0136 0.0226 0.0226
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0136 0.0226 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0052 0.0063 0.0595
Loa Loa (eye worm) ceramide glucosyltransferase 0.5217 1 1
Schistosoma mansoni two-pore calcium channel 0.0032 0.0025 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.005 0.005
Schistosoma mansoni ceramide glucosyltransferase 0.5217 1 1
Schistosoma mansoni tyrosine kinase 0.0124 0.0201 0.0201
Echinococcus multilocularis shaker cognate 0.0032 0.0025 0.0025
Loa Loa (eye worm) calcium channel 0.0032 0.0025 0.0025
Echinococcus granulosus tyrosine protein kinase Src42A 0.0049 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0053 0.0065 0.0065
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0047 0.0053 0.0053
Leishmania major C-8 sterol isomerase-like protein 0.0368 0.0671 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0025 0.0025
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0037 0.0033 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0052 0.0063 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0025 0.0025
Brugia malayi Cyclic-nucleotide gated cation channel 0.0047 0.0053 0.0053
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0049 0.0057 0.0057
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0122 0.0197 0.0197
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0032 0.0025 0.0025
Echinococcus granulosus ryanodine receptor 44f 0.0032 0.0025 0.0025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0063 0.0063
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0033 0.0033
Echinococcus multilocularis hyperpolarization activated cyclic 0.0047 0.0053 0.0053
Loa Loa (eye worm) ion channel NompC 0.0032 0.0025 0.0025
Loa Loa (eye worm) SRC-1 0.0049 0.0057 0.0057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.005 0.005
Echinococcus multilocularis two pore calcium channel protein 2 0.0032 0.0025 0.0025
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0032 0.0025 0.0025
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Echinococcus granulosus geminin 0.018 0.0309 0.0309
Schistosoma mansoni vesicular amine transporter 0.0068 0.0095 0.0095
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0057 0.0073 0.0073
Echinococcus granulosus voltage gated potassium channel 0.0057 0.0073 0.0073
Echinococcus granulosus tyrosine kinase 0.0044 0.0048 0.0048
Echinococcus granulosus expressed protein 0.0373 0.0681 0.0681
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0215 0.0377 0.0377
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0164 0.1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0032 0.0025 0.0025
Loa Loa (eye worm) cytochrome P450 0.0052 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0057 0.0073 0.0073
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0049 0.0057 0.0057
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0025 0.0025
Echinococcus multilocularis potassium voltage gated channel protein 0.0032 0.0025 0.0025
Loa Loa (eye worm) cytochrome P450 family protein 0.0136 0.0226 0.0226
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0053 0.0053
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0052 0.0063 0.0595
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0874 0.1644 1
Loa Loa (eye worm) TK protein kinase 0.0133 0.0219 0.0219
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0049 0.0057 0.0057
Echinococcus multilocularis ceramide glucosyltransferase 0.5217 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0047 0.0053 0.0053
Echinococcus granulosus sodium leak channel non selective protein 0.0032 0.0025 0.0025
Echinococcus multilocularis sodium leak channel non selective protein 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0033
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0057 0.0057
Echinococcus multilocularis potassium voltage gated channel protein 0.0032 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0147 0.0246 0.0246
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0057 0.0057
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0047 0.0053 0.0053
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.5217 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0137 0.0226 0.0226
Loa Loa (eye worm) voltage-gated calcium channel 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0033
Schistosoma mansoni tyrosine kinase 0.0049 0.0057 0.0057
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0025 0.0025
Schistosoma mansoni transient receptor potential channel 0.0032 0.0025 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0052 0.0063 0.5
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.0025 0.0025
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.0025 0.0025
Echinococcus granulosus calcium activated potassium channel 0.0032 0.0025 0.0025
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0188 0.0325 0.0325
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0025 0.0025
Onchocerca volvulus 0.0167 0.0284 0.026
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0164 0.1
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0082 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.005 0.005
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0082 1
Leishmania major cytochrome p450-like protein 0.0052 0.0063 0.0595
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0032 0.0025 0.0025
Trichomonas vaginalis set domain proteins, putative 0.0488 0.0903 0.5491
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0033
Schistosoma mansoni voltage-gated ion channel 0.0032 0.0025 0.0025
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0032 0.0025 0.0025
Echinococcus granulosus defective proboscis extension response 0.0037 0.0033 0.0033
Brugia malayi olfactory channel protein osm-9 0.0032 0.0025 0.0025
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0032 0.0025 0.0025
Echinococcus granulosus two pore calcium channel protein 2 0.0032 0.0025 0.0025
Echinococcus granulosus ceramide glucosyltransferase 0.5217 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0082 0.0082
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.0025 0.0025
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0049 0.0057 0.0057
Brugia malayi hypothetical protein 0.0037 0.0033 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0025 0.0025
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0082 0.0082
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Schistosoma mansoni tyrosine kinase 0.0049 0.0057 0.0057
Brugia malayi Cytochrome P450 family protein 0.0136 0.0226 0.0226
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0044 0.0047 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.005 0.005
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0032 0.0025 0.0025
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0047 0.0053 0.0053
Echinococcus granulosus tyrosine protein kinase Src64B 0.0049 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0025 0.0025
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.0025 0.0025
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0052 0.0063 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0057 0.0057
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0047 0.0053 0.0323
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0077 0.0077
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0047 0.0053 0.0323
Loa Loa (eye worm) hypothetical protein 0.0052 0.0063 0.0063
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0052 0.0063 0.5
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0047 0.0053 0.0053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0133 0.0219 0.0219
Schistosoma mansoni hypothetical protein 0.018 0.0309 0.0309
Echinococcus granulosus hyperpolarization activated cyclic 0.0047 0.0053 0.0053
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0037 0.0033 0.0033
Echinococcus granulosus short transient receptor potential channel 6 0.0032 0.0025 0.0025
Onchocerca volvulus 0.0062 0.0082 0.0057
Leishmania major cytochrome p450-like protein 0.0052 0.0063 0.0595
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.0025 0.0025
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.0025 0.0025
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0047 0.0053 0.0053
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0032 0.0025 0.0025
Echinococcus multilocularis Immunoglobulin 0.0037 0.0033 0.0033
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0137 0.0226 0.0226
Brugia malayi Transient-receptor-potential like protein 0.0032 0.0025 0.0025
Brugia malayi Cytochrome P450 family protein 0.0052 0.0063 0.0063
Onchocerca volvulus 0.0488 0.0903 0.088
Loa Loa (eye worm) voltage-dependent calcium channel 0.0032 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Echinococcus multilocularis tyrosine protein kinase Blk 0.0044 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0082 0.0082
Brugia malayi ion channel NompC 0.0032 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0036 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.07 uM Evaluated for inhibitory activity towards tyrosine kinase Vascular endothelial growth factor receptor 2 ChEMBL. 10893303
IC50 (binding) = 0.07 uM Evaluated for inhibitory activity towards tyrosine kinase Vascular endothelial growth factor receptor 2 ChEMBL. 10893303
IC50 (functional) = 0.11 uM Evaluated for the inhibition of cell proliferation induced by VEGF in HUVEC or NIH3T3 cells ChEMBL. 10893303
IC50 (functional) = 0.11 uM Evaluated for the inhibition of cell proliferation induced by VEGF in HUVEC or NIH3T3 cells ChEMBL. 10893303
IC50 (binding) = 0.92 uM Evaluated for inhibitory activity towards tyrosine kinase PDGF-Rbeta ChEMBL. 10893303
IC50 (binding) = 0.92 uM Evaluated for inhibitory activity towards tyrosine kinase PDGF-Rbeta ChEMBL. 10893303
IC50 (functional) = 2.01 uM Evaluated for the inhibition of cell proliferation induced by PDGF in HUVEC or NIH3T3 cells ChEMBL. 10893303
IC50 (functional) = 2.01 uM Evaluated for the inhibition of cell proliferation induced by PDGF in HUVEC or NIH3T3 cells ChEMBL. 10893303
IC50 (binding) = 4.92 uM Evaluated for inhibitory activity towards p60 c-Src tyrosine kinase ChEMBL. 10893303
IC50 (binding) = 4.92 uM Evaluated for inhibitory activity towards p60 c-Src tyrosine kinase ChEMBL. 10893303
IC50 (binding) = 13.3 uM Evaluated for inhibitory activity towards Fibroblast growth factor receptor 1 ChEMBL. 10893303
IC50 (binding) = 13.3 uM Evaluated for inhibitory activity towards Fibroblast growth factor receptor 1 ChEMBL. 10893303
IC50 (functional) = 24.6 uM Evaluated for the inhibition of cell proliferation induced by FGF in HUVEC or NIH3T3 cells ChEMBL. 10893303
IC50 (functional) = 24.6 uM Evaluated for the inhibition of cell proliferation induced by FGF in HUVEC or NIH3T3 cells ChEMBL. 10893303
IC50 (functional) > 50 uM Evaluated for the inhibition of cell proliferation induced by EGF in HUVEC or NIH3T3 cells ChEMBL. 10893303
IC50 (functional) > 50 uM Evaluated for the inhibition of cell proliferation induced by EGF in HUVEC or NIH3T3 cells ChEMBL. 10893303
IC50 (binding) > 100 uM Evaluated for inhibitory activity towards tyrosine kinase Epidermal growth factor receptor ChEMBL. 10893303
IC50 (binding) > 100 uM Evaluated for inhibitory activity towards tyrosine kinase Epidermal growth factor receptor ChEMBL. 10893303

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 10893303

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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