Detailed information for compound 1481181

Basic information

Technical information
  • TDR Targets ID: 1481181
  • Name: 2-(4-chlorophenyl)-N-[2-(pyrrolidine-1-carbon yl)phenyl]acetamide
  • MW: 342.819 | Formula: C19H19ClN2O2
  • H donors: 1 H acceptors: 2 LogP: 3.82 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1C(=O)N1CCCC1)Cc1ccc(cc1)Cl
  • InChi: 1S/C19H19ClN2O2/c20-15-9-7-14(8-10-15)13-18(23)21-17-6-2-1-5-16(17)19(24)22-11-3-4-12-22/h1-2,5-10H,3-4,11-13H2,(H,21,23)
  • InChiKey: RAXRCJFONWFJGE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-chlorophenyl)-N-[2-(oxo-1-pyrrolidinylmethyl)phenyl]acetamide
  • 2-(4-chlorophenyl)-N-(2-pyrrolidin-1-ylcarbonylphenyl)ethanamide
  • ARONIS010849
  • ZINC06701949
  • ALD-N011866
  • AN-329/43201693

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyrotropin-releasing hormone receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04282 thyrotropin-releasing hormone receptor, putative Get druggable targets OG5_133661 All targets in OG5_133661
Echinococcus multilocularis thyrotropin releasing hormone receptor Get druggable targets OG5_133661 All targets in OG5_133661
Schistosoma mansoni thyrotropin-releasing hormone receptor Get druggable targets OG5_133661 All targets in OG5_133661
Echinococcus granulosus thyrotropin releasing hormone receptor Get druggable targets OG5_133661 All targets in OG5_133661
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi larval opioid receptor thyrotropin-releasing hormone receptor 398 aa 324 aa 23.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuropeptide s receptor 0.0046 0.0435 0.0435
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.3128 1
Schistosoma mansoni steroid dehydrogenase 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0435 0.0435
Onchocerca volvulus 0.0046 0.0435 0.2166
Loa Loa (eye worm) hypothetical protein 0.0358 0.4258 0.7889
Schistosoma mansoni alpha-1 adrenergic receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0033 0.028 0.0518
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.0435 0.0435
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0046 0.0435 0.1022
Leishmania major C-8 sterol isomerase-like protein 0.0358 0.4258 1
Schistosoma mansoni nAChR subunit 0.0033 0.028 0.028
Brugia malayi hypothetical protein 0.0011 0.0014 0.0032
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0176 0.0381
Echinococcus multilocularis allatostatin A receptor 0.0046 0.0435 0.0435
Echinococcus granulosus glycine receptor subunit beta 0.0033 0.028 0.028
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0107 1
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0011 0.0014 0.0038
Schistosoma mansoni hypothetical protein 0.0046 0.0435 0.0435
Leishmania major quinonoid dihydropteridine reductase 0.0244 0.2867 0.6732
Echinococcus granulosus geminin 0.0182 0.2104 0.2104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0435 0.0435
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0334 0.3963 0.3963
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Onchocerca volvulus 0.0046 0.0435 0.2166
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.028 0.0656
Echinococcus multilocularis serotonin receptor 0.0046 0.0435 0.0435
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0011 0.0014 0.0061
Brugia malayi RE15519p 0.0046 0.0435 0.1022
Brugia malayi hypothetical protein 0.0046 0.0435 0.1022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0435 0.0435
Schistosoma mansoni short chain dehydrogenase 0.0011 0.0014 0.0014
Loa Loa (eye worm) carboxylesterase 0.028 0.3299 0.6113
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0115
Brugia malayi AKH receptor 0.0046 0.0435 0.1022
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0033 0.028 0.028
Echinococcus multilocularis glycine receptor subunit beta 0.0033 0.028 0.028
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0011 0.0014 0.0061
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0093 0.0093
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0663 0.1228
Brugia malayi excitatory GABA receptor EXP-1A 0.0033 0.028 0.0656
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.001 0.0002 0.5
Onchocerca volvulus 0.0011 0.0014 0.0069
Onchocerca volvulus 0.0011 0.0014 0.0069
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0002 0.0002
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0011 0.0014 0.0014
Entamoeba histolytica hypothetical protein 0.0018 0.0093 0.2846
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Leishmania major short chain dehydrogenase/reductase, putative 0.0011 0.0014 0.0028
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0435 0.0435
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0011 0.0014 0.0069
Onchocerca volvulus 0.0046 0.0435 0.2166
Brugia malayi hypothetical protein 0.0036 0.0322 0.0757
Schistosoma mansoni neuropeptide receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0173
Schistosoma mansoni amine GPCR 0.0046 0.0435 0.0435
Schistosoma mansoni myosin xvIII 0.0046 0.0435 0.0435
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Loa Loa (eye worm) dehydrogenase 0.0011 0.0014 0.0026
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0115
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0107 0.022
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Echinococcus multilocularis neuropeptide FF receptor 2 0.0046 0.0435 0.0435
Onchocerca volvulus 0.0046 0.0435 0.2166
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0435 0.0435
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.0014 0.0038
Onchocerca volvulus 0.0108 0.1197 0.5958
Schistosoma mansoni short chain dehydrogenase 0.0011 0.0014 0.0014
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0107 0.0107
Echinococcus granulosus hypothetical protein 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0047 0.0454 0.0841
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0036 0.0111
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0033 0.028 0.0656
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0435 0.0435
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0115
Echinococcus multilocularis dnaJ subfamily B 0.0827 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0011 0.0014 0.0014
Onchocerca volvulus 0.0108 0.1197 0.5958
Brugia malayi PHD-finger family protein 0.0028 0.0223 0.0524
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Echinococcus multilocularis sex peptide receptor 0.0046 0.0435 0.0435
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0435 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0111
Loa Loa (eye worm) hypothetical protein 0.0024 0.0176 0.0325
Trypanosoma cruzi ISWI complex protein 0.0015 0.0064 0.0118
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0115
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0036 0.0111
Echinococcus multilocularis glycine receptor subunit beta 0.0033 0.028 0.028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0036 0.0111
Echinococcus granulosus g protein coupled receptor 0.0046 0.0435 0.0435
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0011 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0435 0.0435
Schistosoma mansoni neuroligin 3 (S09 family) 0.0047 0.0454 0.0454
Brugia malayi Serotonin receptor 0.0046 0.0435 0.1022
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0435 0.0806
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0176 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0071
Mycobacterium tuberculosis Possible oxidoreductase 0.0011 0.0014 0.0061
Echinococcus granulosus g protein coupled receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0026
Brugia malayi Melatonin receptor type 1A 0.0046 0.0435 0.1022
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0107 0.6068
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0334 0.3963 0.3963
Loa Loa (eye worm) multidrug resistance protein 3 0.001 0.0002 0.0003
Onchocerca volvulus 0.0047 0.0454 0.2259
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0033 0.028 0.028
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0046 0.0435 0.0435
Onchocerca volvulus Sepiapterin reductase homolog 0.0011 0.0014 0.0069
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0033 0.028 0.028
Brugia malayi Carboxylesterase family protein 0.0047 0.0454 0.1066
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0093 0.0219
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.3128 1
Schistosoma mansoni hypothetical protein 0.0182 0.2104 0.2104
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0322 0.0322
Brugia malayi hypothetical protein 0.0011 0.0014 0.0032
Onchocerca volvulus 0.0046 0.0435 0.2166
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0107 0.0199
Brugia malayi neuropeptide F receptor 0.0046 0.0435 0.1022
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0026
Schistosoma mansoni steroid dehydrogenase 0.0011 0.0014 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0995 0.0995
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.028 0.0656
Echinococcus multilocularis carbonyl reductase 1 0.0011 0.0014 0.0014
Onchocerca volvulus 0.0033 0.028 0.1391
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0002 0.0002
Brugia malayi NADH dehydrogenase subunit 1, identical 0.0046 0.0435 0.1022
Leishmania major quinonoid dihydropteridine reductase 0.0244 0.2867 0.6732
Entamoeba histolytica short chain dehydrogenase family protein 0.0011 0.0014 0.0372
Echinococcus granulosus retinol dehydrogenase 11 0.0011 0.0014 0.0014
Schistosoma mansoni opsin-like receptor 0.0046 0.0435 0.0435
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0435 0.0435
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0036 0.0111
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0435 0.0435
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0318 0.0318
Loa Loa (eye worm) carboxylesterase 0.0047 0.0454 0.0841
Mycobacterium tuberculosis Probable dehydrogenase 0.0011 0.0014 0.0061
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0663 0.1228
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.028 0.0656
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0435 0.0806
Echinococcus granulosus cpg binding protein 0.0063 0.065 0.065
Leishmania major short chain dehydrogenase, putative 0.0011 0.0014 0.0028
Echinococcus multilocularis zinc finger protein 0.0023 0.0157 0.0157
Echinococcus granulosus WW domain containing oxidoreductase 0.0011 0.0014 0.0014
Echinococcus multilocularis steroid dehydrogenase 0.0011 0.0014 0.0014
Brugia malayi hypothetical protein 0.0016 0.0069 0.0162
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0046 0.0435 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0111
Schistosoma mansoni short chain dehydrogenase 0.0011 0.0014 0.0014
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0002 0.0002
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0111
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0663 0.0663
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0047 0.0454 0.0841
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0026
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0002 0.0002
Echinococcus granulosus neuropeptide receptor A26 0.0046 0.0435 0.0435
Brugia malayi hypothetical protein 0.0015 0.0062 0.0145
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0003
Trypanosoma brucei ISWI complex protein 0.0015 0.0064 0.0118
Onchocerca volvulus 0.0046 0.0435 0.2166
Brugia malayi Retinol dehydrogenase 12 0.0011 0.0014 0.0032
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0334 0.3963 0.3963
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0652 0.0652
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0033 0.028 0.0656
Leishmania major pteridine reductase 1 0.0011 0.0014 0.0028
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0322 0.0322
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0052 0.0052
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0015 0.0062 0.0062
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0176 0.0381
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.001 0.0002 0.0003
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0033 0.028 0.0518
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0002 0.0002
Schistosoma mansoni steroid dehydrogenase 0.0011 0.0014 0.0014
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0101 0.0101
Onchocerca volvulus 0.0046 0.0435 0.2166
Schistosoma mansoni hypothetical protein 0.017 0.1954 0.1954
Brugia malayi hypothetical protein 0.0046 0.0435 0.1022
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0015 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0071
Onchocerca volvulus 0.0018 0.0093 0.0463
Loa Loa (eye worm) hypothetical protein 0.0047 0.0454 0.0841
Echinococcus granulosus orexin receptor type 2 0.0046 0.0435 0.0435
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2009 0.6422
Brugia malayi Dopamine receptor protein 2 0.0046 0.0435 0.1022
Leishmania major quinonoid dihydropteridine reductase 0.0244 0.2867 0.6732
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0011 0.0014 0.0061
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0026
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0036 0.0111
Loa Loa (eye worm) oxidoreductase 0.0011 0.0014 0.0026
Schistosoma mansoni nAChR subunit 0.0033 0.028 0.028
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Entamoeba histolytica hypothetical protein 0.0036 0.0322 1
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0115
Onchocerca volvulus 0.0047 0.0454 0.2259
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.3128 1
Onchocerca volvulus 0.0011 0.0014 0.0069
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0435 0.0435
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.0014 0.0038
Loa Loa (eye worm) hypothetical protein 0.0047 0.0454 0.0841
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0358 0.4258 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Echinococcus granulosus GPCR family 2 0.0016 0.0071 0.0071
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0108 0.1197 0.1197
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0435 0.0435
Onchocerca volvulus 0.0046 0.0435 0.2165
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0176 0.0381
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0002 0.0002
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0435 0.0435
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Mycobacterium ulcerans formate hydrogenlyase HycD 0.0046 0.0435 0.2171
Loa Loa (eye worm) hypothetical protein 0.0183 0.2115 0.392
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0663 0.0663
Schistosoma mansoni multidrug resistance protein 0.001 0.0002 0.0002
Trichomonas vaginalis helicase, putative 0.0013 0.0036 0.0111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0995 0.0995
Echinococcus granulosus nAChR subunit 0.0018 0.0093 0.0093
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0033 0.028 0.028
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.2009 1
Echinococcus granulosus allatostatin A receptor 0.0046 0.0435 0.0435
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0033 0.028 0.028
Brugia malayi hypothetical protein 0.0046 0.0435 0.1022
Schistosoma mansoni NADH dehydrogenase subunit 1 0.0046 0.0435 0.0435
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0052 0.0052
Echinococcus granulosus carbonyl reductase 1 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2009 0.6422
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0435 0.0435
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0435 0.0435
Trichomonas vaginalis spcc417.12 protein, putative 0.0047 0.0454 0.1446
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0033 0.028 0.0518
Brugia malayi G-protein coupled receptor 0.0046 0.0435 0.1022
Loa Loa (eye worm) hypothetical protein 0.028 0.3299 0.6113
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.028 0.3299 0.3299
Echinococcus granulosus para nitrobenzyl esterase 0.0047 0.0454 0.0454
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0033 0.028 0.0518
Schistosoma mansoni short chain dehydrogenase 0.0011 0.0014 0.0014
Plasmodium falciparum steroid dehydrogenase, putative 0.0011 0.0014 0.0687
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0663 0.0663
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0435 0.0435
Onchocerca volvulus 0.0011 0.0014 0.0069
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0002 0.0002
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0086 0.0086
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0036 0.0111
Brugia malayi hypothetical protein 0.0046 0.0435 0.1022
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0046 0.0435 0.1022
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0033 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0108 0.1197 0.2218
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Schistosoma mansoni amine GPCR 0.0046 0.0435 0.0435
Brugia malayi putative neuropeptide receptor NPR1 0.0046 0.0435 0.1022
Echinococcus granulosus g-protein coupled receptor 0.0046 0.0435 0.0435
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.0014 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0435 0.0435
Brugia malayi Serotonin receptor 0.0046 0.0435 0.1022
Onchocerca volvulus 0.0011 0.0014 0.0069
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0176 1
Onchocerca volvulus 0.0033 0.028 0.1391
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0033 0.028 0.0656
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0015 0.0062 0.0115
Brugia malayi Bromodomain containing protein 0.0079 0.084 0.1974
Loa Loa (eye worm) oxidoreductase 0.0011 0.0014 0.0026
Entamoeba histolytica hypothetical protein, conserved 0.0011 0.0014 0.0372
Onchocerca volvulus 0.0046 0.0435 0.2166
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.028 0.0656
Leishmania major quinonoid dihydropteridine reductase 0.0244 0.2867 0.6732
Leishmania major short chain dehydrogenase/reductase, putative 0.0011 0.0014 0.0028
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0018 0.0093 0.0219
Schistosoma mansoni neuropeptide receptor 0.0046 0.0435 0.0435
Echinococcus multilocularis carboxylesterase 5A 0.028 0.3299 0.3299
Loa Loa (eye worm) hypothetical protein 0.0047 0.0454 0.0841
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0266 0.3128 0.5795
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0033 0.028 0.028
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.0014 0.0061
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.0014 0.0061
Brugia malayi oxidoreductase 0.0011 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Onchocerca volvulus 0.0011 0.0014 0.0069
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0015 0.0062 0.0115
Onchocerca volvulus 0.0011 0.0014 0.0069
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0033 0.028 0.0656
Leishmania major oxidoreductase-like protein 0.0011 0.0014 0.0028
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0107 0.0107
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.001 0.001
Brugia malayi multidrug resistance protein 3 0.001 0.0002 0.0004
Toxoplasma gondii carbonyl reductase 1, putative 0.0011 0.0014 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.2124 0.679
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0047 0.0454 0.0454
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.3128 1
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0011 0.0014 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0435 0.0435
Echinococcus granulosus oxidoreductase 0.0011 0.0014 0.0014
Schistosoma mansoni nAChR subunit 0.0033 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Schistosoma mansoni acetylcholinesterase 0.0047 0.0454 0.0454
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0435 0.0435
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.3128 1
Brugia malayi RNA binding protein 0.0064 0.0663 0.1556
Brugia malayi hypothetical protein 0.0046 0.0435 0.1022
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0047 0.0454 0.2316
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) 0.017 0.1954 1
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0011 0.0014 0.0061
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0652 0.0652
Echinococcus multilocularis somatostatin receptor 0.0046 0.0435 0.0435
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0015 0.0062 0.0062
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0011 0.0014 0.0061
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0011 0.0014 0.0069
Brugia malayi hypothetical protein 0.0015 0.0062 0.0145
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.001
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0086 0.0086
Brugia malayi sulfakinin receptor protein 0.0046 0.0435 0.1022
Leishmania major hypothetical protein, conserved 0.0011 0.0014 0.0028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0995 0.0995
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0011 0.0014 0.0028
Echinococcus granulosus retinol dehydrogenase 11 0.0011 0.0014 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0663 0.0663
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0435 0.0435
Schistosoma mansoni carbonyl reductase 0.0011 0.0014 0.0014
Echinococcus multilocularis NAD(P) binding domain 0.0233 0.2729 0.2729
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0495 0.0917
Trichomonas vaginalis steroid dehydrogenase, putative 0.0011 0.0014 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0173
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0046 0.0435 0.0435
Onchocerca volvulus 0.0046 0.0435 0.2166
Brugia malayi Dopamine receptor 0.0046 0.0435 0.1022
Mycobacterium tuberculosis Carboxylesterase LipT 0.0047 0.0454 0.2316
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0046 0.0435 0.0435
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0011 0.0014 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0026
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.1251 0.4582
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0086 0.0086
Schistosoma mansoni cpg binding protein 0.0058 0.0586 0.0586
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0002 0.0002
Echinococcus granulosus dro:myosuppressin receptor 0.0046 0.0435 0.0435
Echinococcus multilocularis G protein coupled receptor 139 0.0046 0.0435 0.0435
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0107 0.0337
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0011 0.0014 0.0044
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0116 0.0273
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0033 0.028 0.028
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Brugia malayi Cation transporter family protein 0.0108 0.1197 0.2812
Echinococcus granulosus glycine receptor subunit alpha 1 0.0033 0.028 0.028
Entamoeba histolytica hypothetical protein 0.0036 0.0322 1
Brugia malayi CXXC zinc finger family protein 0.0058 0.0586 0.1377
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0036 0.0111
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2009 0.6422
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0046 0.0435 0.0435
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0101 0.0101
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0047 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0115
Echinococcus granulosus neuropeptide FF receptor 2 0.0046 0.0435 0.0435
Schistosoma mansoni bromodomain containing protein 0.0067 0.0696 0.0696
Onchocerca volvulus 0.0046 0.0435 0.2166
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0435 0.0435
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.0435 0.0435
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Onchocerca volvulus 0.0015 0.0062 0.0308
Mycobacterium tuberculosis Possible formate hydrogenlyase HycD (FHL) 0.0046 0.0435 0.2218
Echinococcus granulosus glycine receptor subunit alpha 1 0.0033 0.028 0.028
Schistosoma mansoni neurotransmitter gated ion channel 0.0015 0.0062 0.0062
Onchocerca volvulus 0.0011 0.0014 0.0069
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0011 0.0014 0.0372
Echinococcus multilocularis retinol dehydrogenase 13 0.0011 0.0014 0.0014
Echinococcus multilocularis GPCR, family 2 0.0016 0.0071 0.0071
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.0014 0.0038
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0015 0.0062 0.0062
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.0435 0.0435
Echinococcus granulosus neuropeptide receptor 0.0046 0.0435 0.0435
Entamoeba histolytica hypothetical protein 0.0036 0.0322 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0107 0.3287
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0435 0.0435
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0014 0.0687
Schistosoma mansoni cpg binding protein 0.0063 0.065 0.065
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0322 0.0322
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0033 0.028 0.028
Leishmania major hypothetical protein, conserved 0.0015 0.0064 0.0146
Schistosoma mansoni hypothetical protein 0.0036 0.0322 0.0322
Loa Loa (eye worm) TYRA-2 protein 0.0046 0.0435 0.0806
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0663 0.0663
Loa Loa (eye worm) NADH dehydrogenase subunit 1 0.0046 0.0435 0.0806
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0011 0.0014 0.0372
Loa Loa (eye worm) hypothetical protein 0.0018 0.0101 0.0187
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0108 0.1197 0.1197
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.028 0.0656
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0033 0.028 0.028
Echinococcus multilocularis nAChR subunit 0.0033 0.028 0.028
Loa Loa (eye worm) oxidoreductase 0.0011 0.0014 0.0026
Loa Loa (eye worm) carboxylesterase 0.0047 0.0454 0.0841
Onchocerca volvulus 0.0046 0.0435 0.2166
Schistosoma mansoni amine GPCR 0.0046 0.0435 0.0435
Brugia malayi hypothetical protein 0.0046 0.0435 0.1022
Brugia malayi follicle stimulating hormone receptor 0.0046 0.0435 0.1022
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0011 0.0014 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0011 0.0014 0.0014
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.013 0.024
Echinococcus multilocularis BC026374 protein (S09 family) 0.0047 0.0454 0.0454
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0435 0.0435
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0002 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0115
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Onchocerca volvulus 0.0011 0.0014 0.0069
Loa Loa (eye worm) hypothetical protein 0.0451 0.5397 1
Schistosoma mansoni nAChR subunit 0.0033 0.028 0.028
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.028 0.0656
Brugia malayi hypothetical protein 0.0046 0.0435 0.1022
Echinococcus granulosus somatostatin receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0173
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0011 0.0014 0.0061
Echinococcus multilocularis orexin receptor type 2 0.0046 0.0435 0.0435
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0107 0.022
Toxoplasma gondii oxidoreductase, putative 0.0011 0.0014 0.0044
Echinococcus granulosus tachykinin peptides receptor 99D 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0115
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0062 0.0145
Schistosoma mansoni ap endonuclease 0.0019 0.0107 0.0107
Echinococcus multilocularis nAChR subunit 0.0018 0.0093 0.0093
Mycobacterium tuberculosis Possible oxidoreductase 0.0011 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0015 0.0062 0.0062
Entamoeba histolytica hypothetical protein, conserved 0.0011 0.0014 0.0372
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2009 0.6422
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0011 0.0014 0.0038
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0046 0.0435 0.2166
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0052 0.0052
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2009 0.6422
Onchocerca volvulus Neuropeptide F receptor homolog 0.0046 0.0435 0.2166
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Onchocerca volvulus 0.0015 0.0062 0.0308
Brugia malayi G protein-coupled receptor 0.0046 0.0435 0.1022
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0663 0.1556
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0435 0.0435
Echinococcus granulosus glycine receptor subunit alpha 1 0.0033 0.028 0.028
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0011 0.0014 0.0038
Leishmania major quinonoid dihydropteridine reductase 0.0244 0.2867 0.6732
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0107 0.0482
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Schistosoma mansoni short chain dehydrogenase 0.0011 0.0014 0.0014
Schistosoma mansoni neuropeptide receptor 0.0046 0.0435 0.0435
Echinococcus granulosus steroid dehydrogenase 0.0011 0.0014 0.0014
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0018 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Brugia malayi ORL1-like opioid receptor 0.0046 0.0435 0.1022
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0002 0.0002
Brugia malayi Cation transporter family protein 0.0033 0.028 0.0656
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0093 0.0219
Echinococcus granulosus NADP binding domain 0.0233 0.2729 0.2729
Schistosoma mansoni carbonyl reductase 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Schistosoma mansoni cpg binding protein 0.0063 0.065 0.065
Loa Loa (eye worm) ACC-1 protein 0.0033 0.028 0.0518
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Trypanosoma brucei C-8 sterol isomerase, putative 0.0358 0.4258 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0266 0.3128 0.7346
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2009 0.6422
Onchocerca volvulus 0.0011 0.0014 0.0069
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0011 0.0014 0.0032
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Echinococcus multilocularis acetylcholinesterase 0.028 0.3299 0.3299
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0071 0.0071
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0046 0.0435 0.0806
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0107 0.0248
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0033 0.028 0.028
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0071 0.0168
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.3128 1
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0011 0.0014 0.0014
Schistosoma mansoni zinc finger protein 0.0023 0.0157 0.0157
Trypanosoma cruzi ISWI complex protein 0.0015 0.0064 0.0118
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0026
Echinococcus granulosus fmrfamide receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0046 0.0435 0.0435
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.0014 0.0038
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0014 0.0687
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.0014 0.0061
Entamoeba histolytica hypothetical protein 0.0011 0.0014 0.0372
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0011 0.0014 0.0014
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0101 0.0101
Echinococcus granulosus neuropeptide s receptor 0.0046 0.0435 0.0435
Onchocerca volvulus Putative nachr subunit 0.0033 0.028 0.1391
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0095 0.0095
Brugia malayi hypothetical protein 0.0015 0.0062 0.0145
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0036 0.0111
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0995 0.1843
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.0014 0.0061
Echinococcus multilocularis para nitrobenzyl esterase 0.0047 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Echinococcus granulosus hypothetical protein 0.0011 0.0014 0.0014
Leishmania major hypothetical protein, conserved 0.0024 0.0176 0.0408
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0176 0.0637
Loa Loa (eye worm) hypothetical protein 0.0047 0.0454 0.0841
Brugia malayi hypothetical protein 0.0046 0.0435 0.1022
Schistosoma mansoni carbonyl reductase 0.0011 0.0014 0.0014
Entamoeba histolytica hypothetical protein 0.0036 0.0322 1
Brugia malayi Carboxylesterase family protein 0.028 0.3299 0.7749
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0086 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0101 0.0101
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0435 0.0806
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0111
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0435 0.0435
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Onchocerca volvulus 0.0047 0.0454 0.2259
Schistosoma mansoni hypothetical protein 0.0021 0.013 0.013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0435 0.0435
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0033 0.028 0.028
Echinococcus multilocularis oxidoreductase 0.0011 0.0014 0.0014
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0011 0.0014 0.0061
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0318 0.0318
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0173
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0046 0.0435 0.0435
Echinococcus granulosus hypothetical protein 0.0011 0.0014 0.0014
Schistosoma mansoni short chain dehydrogenase 0.0011 0.0014 0.0014
Leishmania major hypothetical protein, conserved 0.0011 0.0014 0.0028
Brugia malayi Dopamine receptor protein 1 0.0046 0.0435 0.1022
Schistosoma mansoni nAChR subunit 0.0015 0.0062 0.0062
Schistosoma mansoni neurotransmitter gated ion channel 0.0015 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Schistosoma mansoni short chain dehydrogenase 0.0011 0.0014 0.0014
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0033 0.028 0.0656
Schistosoma mansoni short chain dehydrogenase 0.0011 0.0014 0.0014
Loa Loa (eye worm) oxidoreductase 0.0011 0.0014 0.0026
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0062 0.0145
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0033 0.028 0.028
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0033 0.028 0.028
Echinococcus multilocularis neuropeptide receptor A26 0.0046 0.0435 0.0435
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0011 0.0014 0.0069
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0062 0.0145
Schistosoma mansoni biogenic amine receptor 0.0046 0.0435 0.0435
Brugia malayi hypothetical protein 0.0046 0.0435 0.1022
Echinococcus multilocularis retinol dehydrogenase 11 0.0011 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0173
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0046 0.0435 0.0806
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.0014 0.0061
Schistosoma mansoni short chain dehydrogenase 0.0011 0.0014 0.0014
Mycobacterium leprae Probable oxidoreductase 0.0011 0.0014 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0046 0.0435 0.0435
Schistosoma mansoni short chain dehydrogenase 0.0011 0.0014 0.0014
Schistosoma mansoni biogenic amine receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Echinococcus granulosus sex peptide receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0095 0.0177
Schistosoma mansoni short chain dehydrogenase 0.0011 0.0014 0.0014
Echinococcus multilocularis geminin 0.0182 0.2104 0.2104
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.0014 0.0061
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0011 0.0014 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.0014 0.0061
Onchocerca volvulus 0.0047 0.0454 0.2259
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0435 0.0806
Loa Loa (eye worm) hypothetical protein 0.0108 0.1197 0.2218
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0033 0.028 0.028
Echinococcus multilocularis dro:myosuppressin receptor 0.0046 0.0435 0.0435
Brugia malayi putative neuropeptide receptor 0.0046 0.0435 0.1022
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0435 0.0435
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0011 0.0014 0.0026
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0194 0.0194
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0033 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0115
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.0435 0.0435
Brugia malayi Tachykinin-like peptides receptor 99D 0.0046 0.0435 0.1022
Schistosoma mansoni BC026374 protein (S09 family) 0.0047 0.0454 0.0454
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.0014 0.0061
Schistosoma mansoni amine GPCR 0.0046 0.0435 0.0435
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0046 0.0435 0.1022
Schistosoma mansoni retinal dehydrogenase 0.0011 0.0014 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0173
Loa Loa (eye worm) hypothetical protein 0.0051 0.0495 0.0917
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0194 0.0194
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Schistosoma mansoni multidrug resistance protein 0.001 0.0002 0.0002
Brugia malayi Bromodomain containing protein 0.0039 0.0348 0.0816
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0046 0.0435 0.1022
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Brugia malayi Carboxylesterase family protein 0.0047 0.0454 0.1066
Echinococcus granulosus nAChR subunit 0.0033 0.028 0.028
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.0435 0.0435
Onchocerca volvulus 0.0018 0.0093 0.0463
Echinococcus granulosus carbonyl reductase 1 0.0011 0.0014 0.0014
Echinococcus granulosus carbonyl reductase 1 0.0011 0.0014 0.0014
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0435 0.0435
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0033 0.028 0.028
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Brugia malayi Cation transporter family protein 0.0033 0.028 0.0656
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0495 0.1162
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0046 0.0435 0.0806
Brugia malayi larval opioid receptor 0.0046 0.0435 0.1022
Schistosoma mansoni short chain dehydrogenase 0.0011 0.0014 0.0014
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0194 0.0194
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0011 0.0014 0.0061
Echinococcus granulosus 7TM GPCR rhodopsin 0.0046 0.0435 0.0435
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0586 0.1086
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) acetylcholine receptor protein 0.0015 0.0062 0.0115
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0033 0.028 0.028
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0033 0.028 0.0518
Echinococcus granulosus BC026374 protein S09 family 0.0047 0.0454 0.0454
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0046 0.0435 0.0435
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0107 0.054
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0173
Onchocerca volvulus 0.0011 0.0014 0.0069
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0435 0.0435
Loa Loa (eye worm) ACC-1 protein 0.0033 0.028 0.0518
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0011 0.0014 0.0032
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0033 0.028 0.028
Schistosoma mansoni dihydropteridine reductase 0.0233 0.2729 0.2729
Echinococcus multilocularis conserved hypothetical protein 0.0011 0.0014 0.0014
Loa Loa (eye worm) oxidoreductase 0.0011 0.0014 0.0026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0995 0.0995
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0111
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0046 0.0435 0.0435
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0011 0.0014 0.0061
Schistosoma mansoni hypothetical protein 0.0827 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0299 0.0702
Plasmodium vivax steroid dehydrogenase, putative 0.0011 0.0014 0.0687
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0071 0.0071
Onchocerca volvulus 0.0046 0.0435 0.2166
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0026
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.0435 0.0435
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0015 0.0062 0.0145
Brugia malayi hypothetical protein 0.0015 0.0062 0.0145
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Brugia malayi dihydropteridine reductase-like 0.0233 0.2729 0.6409
Onchocerca volvulus 0.0046 0.0435 0.2166
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Brugia malayi hypothetical protein 0.0024 0.0176 0.0412
Brugia malayi TAR-binding protein 0.0064 0.0663 0.1556
Echinococcus granulosus carboxylesterase 5A 0.028 0.3299 0.3299
Onchocerca volvulus 0.0011 0.0014 0.0069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0995 0.0995
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0011 0.0014 0.0372
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0435 0.0435
Echinococcus multilocularis carbonyl reductase 1 0.0011 0.0014 0.0014
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.028 0.0656
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0173
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0011 0.0014 0.0014
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.028 0.0656
Brugia malayi G-protein coupled receptor 0.0046 0.0435 0.1022
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0071
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0046 0.0435 0.1022
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0107 0.0482
Schistosoma mansoni nAChR subunit 0.0033 0.028 0.028
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0011 0.0014 0.0044
Echinococcus multilocularis cpg binding protein 0.0063 0.065 0.065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0435 0.0435
Brugia malayi hypothetical protein 0.0047 0.0454 0.1066
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0001
Loa Loa (eye worm) acetylcholinesterase 1 0.028 0.3299 0.6113
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0115
Leishmania major hypothetical protein, conserved 0.0011 0.0014 0.0028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0115
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.0014 0.0038
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0107 0.5
Brugia malayi Carboxylesterase family protein 0.0047 0.0454 0.1066
Echinococcus multilocularis neuroligin 0.0047 0.0454 0.0454
Loa Loa (eye worm) RNA binding protein 0.0064 0.0663 0.1228
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0435 0.0435
Echinococcus granulosus NADH dehydrogenase subunit 1 0.017 0.1954 0.1954
Schistosoma mansoni steroid dehydrogenase 0.0011 0.0014 0.0014
Schistosoma mansoni nAChR subunit 0.0033 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0093 0.1011 0.1873
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0107 0.0252
Leishmania major short chain dehydrogenase, putative 0.0011 0.0014 0.0028
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0046 0.0435 0.0806
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0107 0.022
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0047 0.0454 0.1446
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0011 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0003
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0033 0.028 0.0656
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Echinococcus multilocularis carbonyl reductase 1 0.0011 0.0014 0.0014
Brugia malayi dehydrogenases, short chain protein 9 0.0011 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0026
Toxoplasma gondii exonuclease III APE 0.0019 0.0107 0.0386
Loa Loa (eye worm) oxidoreductase 0.0011 0.0014 0.0026
Brugia malayi Dehydrogenases, short chain protein 30 0.0011 0.0014 0.0032
Schistosoma mansoni acetylcholine receptor subunit beta 0.0015 0.0062 0.0062
Brugia malayi ABC transporter family protein 0.001 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0182 0.2104 0.2104
Onchocerca volvulus 0.0047 0.0454 0.2259
Schistosoma mansoni amine GPCR 0.0046 0.0435 0.0435
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.0014 0.0061
Onchocerca volvulus 0.0046 0.0435 0.2166
Echinococcus granulosus neuroligin 0.0047 0.0454 0.0454
Schistosoma mansoni ap endonuclease 0.0019 0.0107 0.0107
Schistosoma mansoni hypothetical protein 0.0046 0.0435 0.0435
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0033 0.028 0.028
Brugia malayi Carboxylesterase family protein 0.0047 0.0454 0.1066
Brugia malayi Dehydrogenases, short chain protein 2 0.0011 0.0014 0.0032
Echinococcus granulosus alpha 1A adrenergic receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0041 0.0378 0.07
Echinococcus granulosus zinc finger protein 0.0023 0.0157 0.0157
Schistosoma mansoni hypothetical protein 0.0035 0.0299 0.0299
Leishmania major 3-keto-dihydrosphingosine reductase 0.0011 0.0014 0.0028
Schistosoma mansoni growth hormone secretagogue receptor 0.0046 0.0435 0.0435
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0011 0.0014 0.0014
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0244 0.2867 0.6723
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0047 0.0454 0.2316
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0071 0.0132
Leishmania major quinonoid dihydropteridine reductase 0.0244 0.2867 0.6732
Schistosoma mansoni short chain dehydrogenase 0.0011 0.0014 0.0014
Schistosoma mansoni short chain dehydrogenase 0.0011 0.0014 0.0014
Echinococcus granulosus serotonin receptor 0.0046 0.0435 0.0435
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0002 0.0002
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0046 0.0435 0.0435
Brugia malayi NADH dehydrogenase subunit 1 0.0046 0.0435 0.1022
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0002 0.0002
Brugia malayi hypothetical protein 0.0046 0.0435 0.1022
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0046 0.0435 0.0435
Leishmania major hypothetical protein, conserved 0.0011 0.0014 0.0028
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0011 0.0014 0.0014
Brugia malayi G protein-coupled receptor F59B2.13 0.0046 0.0435 0.1022
Schistosoma mansoni steroid dehydrogenase 0.0011 0.0014 0.0014
Schistosoma mansoni nAChR subunit 0.0033 0.028 0.028
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0046 0.0435 0.0435
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0011 0.0014 0.0014
Echinococcus granulosus 7tm_1 domain containing protein 0.0046 0.0435 0.0435
Schistosoma mansoni adenoreceptor 0.0046 0.0435 0.0435
Echinococcus granulosus acetylcholinesterase 0.028 0.3299 0.3299
Schistosoma mansoni gliotactin 0.0047 0.0454 0.0454
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0015 0.0062 0.0145
Toxoplasma gondii oxidoreductase, putative 0.0011 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0011 0.0014 0.0032
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0011 0.0014 0.5
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.001 0.001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0046 0.0442 0.0818
Leishmania major dehydrogenase-like protein 0.0011 0.0014 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2009 0.6422
Onchocerca volvulus 0.0046 0.0435 0.2165
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0111
Schistosoma mansoni steroid dehydrogenase 0.0011 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0111
Brugia malayi hypothetical protein 0.0015 0.0062 0.0145
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Loa Loa (eye worm) hypothetical protein 0.028 0.3299 0.6113
Schistosoma mansoni opsin-like receptor 0.0046 0.0435 0.0435
Brugia malayi neuropeptide F receptor 0.0046 0.0435 0.1022
Schistosoma mansoni steroid dehydrogenase 0.0011 0.0014 0.0014
Echinococcus granulosus tar DNA binding protein 0.0064 0.0663 0.0663
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0115
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0358 0.4258 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0435 0.0435
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0011 0.0014 0.5
Schistosoma mansoni hypothetical protein 0.0015 0.0064 0.0064
Onchocerca volvulus 0.0046 0.0435 0.2166
Schistosoma mansoni hypothetical protein 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Onchocerca volvulus 0.0033 0.028 0.1391
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0011 0.0014 0.0014
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0044
Schistosoma mansoni histamine h1 receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0115
Echinococcus granulosus g protein coupled receptor 0.0046 0.0435 0.0435
Leishmania major short chain dehydrogenase-like protein 0.0011 0.0014 0.0028
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Loa Loa (eye worm) hypothetical protein 0.0071 0.0747 0.1384
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0435 0.0435
Onchocerca volvulus 0.001 0.0002 0.0009
Echinococcus multilocularis G-protein coupled receptor, putative 0.0046 0.0435 0.0435
Schistosoma mansoni opsin-like receptor 0.0046 0.0435 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0111
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0071
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0495 0.1162
Brugia malayi GnHR receptor homolog 0.0046 0.0435 0.1022
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Loa Loa (eye worm) melatonin receptor type 1A 0.0046 0.0435 0.0806
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0046 0.0435 0.0435
Mycobacterium ulcerans NADH dehydrogenase subunit H 0.017 0.1954 1
Leishmania major quinonoid dihydropteridine reductase 0.0244 0.2867 0.6732
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0033 0.028 0.0656
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0107 0.6068
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0044
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.0014 0.0061
Entamoeba histolytica short chain dehydrogenase family protein 0.0011 0.0014 0.0372
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.0014 0.0038
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) GABA receptor subunit 0.0018 0.0093 0.0173
Echinococcus granulosus G protein coupled receptor 139 0.0046 0.0435 0.0435
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0093 0.0173
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0002 0.0002
Onchocerca volvulus 0.0058 0.0586 0.2918
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0435 0.0435
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.1383 0.1383
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0026
Echinococcus granulosus glycine receptor subunit beta 0.0033 0.028 0.028
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0663 0.0663
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0033 0.028 0.028
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0071 0.0168
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0435 0.0435
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.0454 0.0454
Echinococcus granulosus carbonyl reductase 1 0.0011 0.0014 0.0014
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0011 0.0014 0.0014
Leishmania major hypothetical protein, conserved 0.0011 0.0014 0.0028
Brugia malayi Carboxylesterase family protein 0.028 0.3299 0.7749
Schistosoma mansoni steroid dehydrogenase 0.0011 0.0014 0.0014
Echinococcus multilocularis steroid dehydrogenase 0.0011 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0047 0.0454 0.0841
Loa Loa (eye worm) LGC-31 protein 0.0033 0.028 0.0518
Onchocerca volvulus 0.0046 0.0435 0.2166
Onchocerca volvulus 0.0108 0.1197 0.5958
Echinococcus multilocularis g-protein coupled receptor 0.0046 0.0435 0.0435
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0033 0.028 0.0518
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0435 0.0435
Schistosoma mansoni steroid dehydrogenase 0.0011 0.0014 0.0014
Schistosoma mansoni multidrug resistance protein 0.001 0.0002 0.0002
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0093 0.0219
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0518
Loa Loa (eye worm) oxidoreductase 0.0011 0.0014 0.0026
Onchocerca volvulus 0.0015 0.0062 0.0308
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0435 0.0435
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0032
Echinococcus multilocularis retinol dehydrogenase 11 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0132
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0176 1
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.2124 0.679
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0435 0.0435
Onchocerca volvulus 0.0011 0.0014 0.0069
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0044
Onchocerca volvulus 0.0046 0.0435 0.2166
Loa Loa (eye worm) dihydropteridine reductase-PC 0.0233 0.2729 0.5056
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0011 0.0014 0.0372
Loa Loa (eye worm) oxidoreductase 0.0011 0.0014 0.0026
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit H 0.017 0.1954 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0348 0.0646
Loa Loa (eye worm) hypothetical protein 0.0451 0.5397 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0435 0.0435
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0435 0.0435
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0011 0.0014 0.0372
Schistosoma mansoni nAChR subunit 0.0015 0.0062 0.0062
Schistosoma mansoni steroid dehydrogenase 0.0011 0.0014 0.0014
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0115
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.0014 0.0038
Echinococcus multilocularis acetylcholinesterase 0.028 0.3299 0.3299
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.0554
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0435 0.0435
Schistosoma mansoni neurotransmitter gated ion channel 0.0018 0.0093 0.0093
Schistosoma mansoni acetylcholine receptor-related 0.0015 0.0062 0.0062
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.0014 0.0038
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0046 0.0435 0.0806
Toxoplasma gondii 6,7-dihydropteridine reductase 0.0233 0.2729 1
Echinococcus granulosus acetylcholinesterase 0.028 0.3299 0.3299
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.0014 0.0061
Schistosoma mansoni smdr2 0.001 0.0002 0.0002
Schistosoma mansoni zinc finger protein 0.0015 0.0064 0.0064
Loa Loa (eye worm) dehydrogenase 0.0011 0.0014 0.0026
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0046 0.0435 0.0435
Schistosoma mansoni biogenic amine receptor 0.0046 0.0435 0.0435
Mycobacterium ulcerans carboxylesterase, LipT 0.0047 0.0454 0.2268
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0015 0.0062 0.0145
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0033 0.028 0.028
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0995 0.2336
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.0014 0.0044
Echinococcus granulosus neuropeptide receptor 0.0046 0.0435 0.0435
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0435 0.0435
Brugia malayi dehydrogenases, short chain protein 2 0.0011 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0995 0.0995
Schistosoma mansoni neuropeptide receptor 0.0046 0.0435 0.0435
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0107 0.0337
Echinococcus multilocularis serotonin receptor 0.0046 0.0435 0.0435
Echinococcus granulosus peptide allatostatin:somatostatin 0.0046 0.0435 0.0435
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0435 0.0435
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0011 0.0014 0.0061
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0011 0.0014 0.0687
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.0806
Loa Loa (eye worm) oxidoreductase 0.0011 0.0014 0.0026
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.028 0.0656
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0435 0.0435
Schistosoma mansoni short chain dehydrogenase 0.0011 0.0014 0.0014
Brugia malayi hypothetical protein 0.0046 0.0435 0.1022

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0329 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.9093 uM PUBCHEM_BIOASSAY: qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor: Confirmation Screen for Enhancers. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485365] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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