Detailed information for compound 1491194

Basic information

Technical information
  • TDR Targets ID: 1491194
  • Name: 2-phenyl-N-(3-pyrrolidin-1-ylsulfonylphenyl)p entanamide
  • MW: 386.508 | Formula: C21H26N2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.8 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(c1ccccc1)C(=O)Nc1cccc(c1)S(=O)(=O)N1CCCC1
  • InChi: 1S/C21H26N2O3S/c1-2-9-20(17-10-4-3-5-11-17)21(24)22-18-12-8-13-19(16-18)27(25,26)23-14-6-7-15-23/h3-5,8,10-13,16,20H,2,6-7,9,14-15H2,1H3,(H,22,24)
  • InChiKey: KYYGDDQYPLMUNI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-phenyl-N-(3-1-pyrrolidinylsulfonylphenyl)pentanamide
  • 2-phenyl-N-(3-pyrrolidin-1-ylsulfonylphenyl)valeramide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0029 0.0066
Brugia malayi beta-lactamase 0.0072 0.0215 0.0489
Echinococcus multilocularis muscleblind protein 0.1089 0.4389 0.4389
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0085 0.0589
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0164 0.4105
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0032 0.0612
Loa Loa (eye worm) hypothetical protein 0.0201 0.0746 0.1701
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0272 0.1093
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0072 0.0263
Onchocerca volvulus 0.0041 0.0089 0.0806
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0073 0.2044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.1144 1
Brugia malayi Augmenter of liver regeneration 0.0035 0.0064 0.0147
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0089 0.0202
Brugia malayi Ets-domain containing protein 0.0074 0.0224 0.051
Loa Loa (eye worm) RNA binding protein 0.0064 0.0185 0.0421
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0093 0.0301 0.1212
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0085 0.0085
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0093 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.1089 0.4389 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0089 0.0202
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0185 0.0421
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0089 0.0546
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0167
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0213 0.1721
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0089 0.0546
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0215 0.0429
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0084 0.0767
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0215 0.0489
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0205 0.1653
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0023 0.0053
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0069 0.0205 0.0467
Loa Loa (eye worm) hypothetical protein 0.0055 0.0145 0.0331
Onchocerca volvulus 0.0049 0.0122 0.1107
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0072 0.0263
Mycobacterium ulcerans lipase LipD 0.0072 0.0215 0.0419
Echinococcus multilocularis GPCR, family 2 0.0064 0.0182 0.0182
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0069 0.0205 0.1274
Echinococcus multilocularis zinc finger protein 0.0027 0.0031 0.0031
Schistosoma mansoni cpg binding protein 0.0063 0.0179 0.1103
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0089 0.0202
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0089 0.0806
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0145 0.0895
Brugia malayi fructose-bisphosphate aldolase 2 0.0093 0.0301 0.0686
Loa Loa (eye worm) hypothetical protein 0.0027 0.0032 0.0074
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0069 0.0205 0.1274
Mycobacterium tuberculosis Urease alpha subunit UreC (urea amidohydrolase) 0.1137 0.4587 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0145 0.0895
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0069 0.0205 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0084 0.0582
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0288 0.1104 0.4507
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0089 0.0202
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0089 0.0089
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0032 0.0612
Mycobacterium tuberculosis Urease gamma subunit UreA (urea amidohydrolase) 0.0541 0.2141 0.4645
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0074 0.0074
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0069 0.0205 0.0757
Brugia malayi AMP-binding enzyme family protein 0.005 0.0125 0.0285
Schistosoma mansoni inositol monophosphatase 0.004 0.0085 0.0524
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0063 0.0144
Schistosoma mansoni hypothetical protein 0.0064 0.0182 0.1121
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0108 0.0795
Loa Loa (eye worm) hypothetical protein 0.0072 0.0215 0.0489
Mycobacterium tuberculosis Conserved hypothetical protein 0.0321 0.1238 0.2669
Leishmania major hypothetical protein, conserved 0.0072 0.0215 0.0798
Brugia malayi AF-10 protein 0.0019 0 0.0001
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0009 0.0022
Brugia malayi fructose-bisphosphate aldolase 1 0.0093 0.0301 0.0686
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0023 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0022 0.0031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0089 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0074 0.0456
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0064 0.0147
Schistosoma mansoni chromobox protein 0.0071 0.0213 0.1309
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0085 0.0194
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0089 0.0546
Loa Loa (eye worm) hypothetical protein 0.0138 0.0485 0.1105
Brugia malayi Bromodomain containing protein 0.0043 0.0096 0.0219
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0073 0.2044
Mycobacterium tuberculosis Conserved protein 0.0072 0.0215 0.0429
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0215 0.1741
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0205 0.0812
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0089 0.0806
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0045 0.0107 0.0244
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0032 0.0132
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0021 0.0048
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0089 0.0089
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0085 0.0135
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0093 0.0301 0.7534
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0069 0.0205 0.5121
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0093 0.0301 0.1242
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0609 0.2421 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0089 0.0202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.1144 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0112
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0072 0.0165
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0045 0.0107 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0037 0.0158
Brugia malayi CXXC zinc finger family protein 0.0058 0.0158 0.0359
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0215 0.0429
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0022 0.0031
Echinococcus granulosus tar DNA binding protein 0.0064 0.0185 0.0421
Plasmodium falciparum phd finger protein, putative 0.0059 0.0164 0.522
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0069 0.0205 0.0812
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0167
Schistosoma mansoni cpg binding protein 0.0063 0.0179 0.1103
Loa Loa (eye worm) hypothetical protein 0.0039 0.0082 0.0186
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0108 0.0247
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0089 0.0806
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0069 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.015 0.0537 0.1225
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0089 0.0202
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0072 0.0042
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0215 0.0429
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0022
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0125 0.0223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0507 0.3119
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.0746 0.1701
Schistosoma mansoni ets-related 0.0224 0.0841 0.518
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0069 0.0205 0.1143
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.0916 0.2087
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0125 0.0532
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0215 0.0489
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0089 0.0202
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0085 0.2121
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0089 0.0089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.1144 1
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0093 0.0301 0.1854
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.0534 0.329
Brugia malayi Pre-SET motif family protein 0.0253 0.0957 0.2181
Onchocerca volvulus 0.0096 0.0315 0.2867
Giardia lamblia Fructose-bisphosphate aldolase 0.0298 0.1144 1
Mycobacterium ulcerans hypothetical protein 0.0321 0.1238 0.2661
Loa Loa (eye worm) hypothetical protein 0.0072 0.0217 0.0494
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0202
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0213 0.1721
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0037 0.0158
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0072 0.0475
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.0237 0.054
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0089 0.0202
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0202
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0069 0.0205 0.0812
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0215 0.0419
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0064 0.0231
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0458 0.1798 0.3895
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0215 0.0853
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0065 0.0101
Onchocerca volvulus 0.0072 0.0215 0.1952
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0125 0.0223
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0093 0.0301 0.1854
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0089 0.0202
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0125 0.0223
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0164 0.4105
Brugia malayi PHD-finger family protein 0.0059 0.0164 0.0374
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.0534 0.1217
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0158 0.0359
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0089 0.0202
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0069 0.0205 1
Echinococcus granulosus cpg binding protein 0.0063 0.0179 0.0408
Brugia malayi Pre-SET motif family protein 0.0037 0.0074 0.0169
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0182 0.0415
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0065 0.0101
Brugia malayi hypothetical protein 0.015 0.0537 0.1225
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0093 0.0301 0.7534
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0093 0.0301 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.0519 0.1085
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0009 0.0009
Echinococcus granulosus muscleblind protein 0.1089 0.4389 1
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0089 0.0202
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0007 0.0017
Schistosoma mansoni alpha-glucosidase 0.0143 0.0508 0.3128
Echinococcus multilocularis geminin 0.0205 0.076 0.076
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0164 0.0164
Loa Loa (eye worm) beta-lactamase 0.0072 0.0215 0.0489
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0055 0.0145 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0089 0.0202
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0093 0.0301 0.1212
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0205 0.1653
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0215 0.0429
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0072 0.0072
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0182 0.0415
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0069 0.0205 0.0398
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0185 0.1137
Schistosoma mansoni jumonji domain containing protein 0.0154 0.0554 0.3413
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0475
Onchocerca volvulus 0.0031 0.0049 0.0446
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0089 0.0202
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0125 0.0223
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0029 0.0177
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0194 0.0718 0.1636
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0089 0.0202
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0069 0.0205 0.1261
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0022 0.0031
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0023 0.006
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0205 0.0812
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0215 0.0489
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0253 0.0957 0.2181
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.026 0.026
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0064 0.1604
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0093 0.0301 0.0686
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0069 0.0205 0.1261
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.0423 0.0965
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0202
Onchocerca volvulus 0.0287 0.11 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0202
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.0107 0.0244
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0475
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0216 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0089 0.0202
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0185 0.1137
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0093 0.0301 0.0686
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0507 0.1154
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0069 0.0205 0.0844
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0069 0.0205 0.1274
Brugia malayi AMP-binding enzyme family protein 0.005 0.0125 0.0285
Mycobacterium ulcerans urease subunit gamma 0.0541 0.2141 0.464
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0108 0.2701
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0064 0.0147
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0089 0.0202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.1144 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0215 0.0429
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0182 0.0415
Loa Loa (eye worm) hypothetical protein 0.0064 0.0182 0.0415
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0022
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0089 0.0089
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0205 0.1653
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0045 0.0107 0.0406
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0065 0.0101
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0085 0.0257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0089 0.0202
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0125 0.0424
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0085 0.0162
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0072 0.0165
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0182 0.0182
Leishmania major hypothetical protein, conserved 0.0035 0.0064 0.0171
Mycobacterium tuberculosis Urease beta subunit UreB (urea amidohydrolase) 0.0541 0.2141 0.4645
Schistosoma mansoni alpha glucosidase 0.0037 0.0072 0.0445
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0074 0.1842
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0104 0.0349 0.1412
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0045 0.0107 0.0783
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.0534 0.0534
Brugia malayi PHD-finger family protein 0.0032 0.0053 0.0122
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0285
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0199 0.0454
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0073 0.0119
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0089 0.0202
Loa Loa (eye worm) fli-1 protein 0.0224 0.0841 0.1917
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0288 0.1104 0.456
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0023 0.006
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0285
Echinococcus granulosus lysine specific demethylase 5A 0.0077 0.0237 0.054
Trypanosoma cruzi hypothetical protein, conserved 0.0217 0.0811 0.3327
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0072 0.0203
Loa Loa (eye worm) hypothetical protein 0.0102 0.0338 0.0771
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.0237 0.146
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0194 0.0718 0.0718
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0609 0.2421 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0108 0.0795
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0089 0.0089
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0072 0.0475
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0089 0.0202
Trypanosoma brucei hypothetical protein, conserved 0.0217 0.0811 0.335
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0185 0.1137
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0084 0.2399
Brugia malayi Bromodomain containing protein 0.0083 0.0263 0.06
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0475
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0125 0.0223
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0089 0.0202
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0064 0.1733
Loa Loa (eye worm) hypothetical protein 0.0059 0.0164 0.0374
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0215 0.1322
Loa Loa (eye worm) hypothetical protein 0.1089 0.4389 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0167
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0108 0.2701
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0202
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0089 0.0089
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0023 0.001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0089 0.0546
Schistosoma mansoni hypothetical protein 0.0059 0.0164 0.1012
Echinococcus granulosus chromobox protein 1 0.0071 0.0213 0.0484
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0097 0.0693
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0205 0.0812
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0167
Onchocerca volvulus 0.005 0.0125 0.1137
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0069 0.0205 0.6636
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0085 0.0589
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0022 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0022 0.0031
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0215 0.0215
Loa Loa (eye worm) acetyltransferase 0.0149 0.0534 0.1217
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0224 0.051
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0272 0.1093
Mycobacterium tuberculosis Conserved protein 0.0072 0.0215 0.0429
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0045 0.0107 0.0783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0507 0.3119
Mycobacterium leprae Probable lipase LipE 0.0072 0.0215 0.3918
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0182 0.0182
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.0916 0.2087
Schistosoma mansoni hypothetical protein 0.0064 0.0182 0.1121
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0085 0.0316
Brugia malayi Fli-1 protein 0.0224 0.0841 0.1917
Brugia malayi Bromodomain containing protein 0.0065 0.0189 0.0431
Echinococcus granulosus peregrin 0.0065 0.0189 0.0431
Schistosoma mansoni hypothetical protein 0.0205 0.076 0.4683
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0072 0.1798
Schistosoma mansoni hypothetical protein 0.0019 0 0.0003
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0185 0.0185
Brugia malayi Muscleblind-like protein 0.1089 0.4389 1
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.0107 0.0244
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0089 0.0089
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0089 0.0202
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0167
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0064 0.1604
Loa Loa (eye worm) hypothetical protein 0.0072 0.0215 0.0489
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0288 0.1104 0.4541
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0064 0.0265
Brugia malayi TAR-binding protein 0.0064 0.0185 0.0421
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.0746 0.1701
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0068 0.0417
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0009 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.1144 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0009 0.0058
Brugia malayi hypothetical protein 0.0036 0.0068 0.0154
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0603 0.0603
Schistosoma mansoni gabp alpha 0.0074 0.0224 0.138
Schistosoma mansoni hypothetical protein 0.0205 0.076 0.4683
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0093 0.0301 0.1212
Leishmania major hypothetical protein, conserved 0.0027 0.0032 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0217 0.0811 0.3327
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0185 0.0421
Brugia malayi ecdysteroid receptor 0.0041 0.0089 0.0202
Brugia malayi hypothetical protein 0.0027 0.0032 0.0074
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0045 0.0107 0.0107
Echinococcus granulosus geminin 0.0205 0.076 0.1733
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0205 0.1653
Loa Loa (eye worm) inositol-1 0.004 0.0085 0.0194
Schistosoma mansoni coup transcription factor 0.0041 0.0089 0.0546
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0086 0.0272 0.1093
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0086 0.0272 0.1124
Mycobacterium ulcerans hypothetical protein 0.0072 0.0215 0.0419
Echinococcus multilocularis cpg binding protein 0.0063 0.0179 0.0179
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0024 0.0019 0.0043
Loa Loa (eye worm) hypothetical protein 0.0072 0.0215 0.0489
Echinococcus multilocularis dnaJ subfamily B 0.0415 0.1624 0.1624
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0064 0.1733
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0097 0.088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.0507 0.1154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0507 0.3119
Brugia malayi PHD-finger family protein 0.0025 0.0022 0.005
Echinococcus multilocularis chromobox protein 1 0.0071 0.0213 0.0213
Schistosoma mansoni hypothetical protein 0.0064 0.0182 0.1121
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0069 0.0205 0.0812
Brugia malayi Ets-domain containing protein 0.0074 0.0224 0.051
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0085 0.0589
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0069 0.0205 0.0205
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0213 0.0484
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.1144 1
Treponema pallidum fructose-bisphosphate aldolase 0.0298 0.1144 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0032 0.0612
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.0507 0.1154
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0603 0.0603
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0164 0.1012
Loa Loa (eye worm) hypothetical protein 0.005 0.0128 0.0291
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.005
Onchocerca volvulus 0.015 0.0537 0.4887
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0093 0.0301 0.7534
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0064 0.0231
Onchocerca volvulus 0.0072 0.0215 0.1952
Brugia malayi F/Y-rich N-terminus family protein 0.004 0.0086 0.0196
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0021 0.0009 0.002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0609 0.2421 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0182 0.0415
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0125 0.2123
Brugia malayi Heterochromatin protein 1 0.0071 0.0213 0.0484
Brugia malayi RNA binding protein 0.0064 0.0185 0.0421
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0475
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0069 0.0205 0.1261
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0089 0.0202
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0069 0.0205 0.0467
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0089 0.0546
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0065 0.0101
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0603 0.1374
Schistosoma mansoni bromodomain containing protein 0.0071 0.0214 0.1318
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0185 0.1137
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.1144 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0032 0.0098
Loa Loa (eye worm) hypothetical protein 0.0072 0.0215 0.0489
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0089 0.0089
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0068 0.0107
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0215 0.0419
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0224 0.051
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0071 0.0162
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.1144 1
Toxoplasma gondii ABC1 family protein 0.0072 0.0215 0.5368
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0072 0.0475
Schistosoma mansoni zinc finger protein 0.0027 0.0031 0.0192
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0215 0.0429
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0072 0.0165
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0023 0.0023
Mycobacterium tuberculosis Conserved protein 0.0025 0.0023 0.001
Brugia malayi chromobox protein homolog 3 0.004 0.0084 0.0192
Plasmodium falciparum fructose-bisphosphate aldolase 0.0093 0.0301 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0085 0.0316
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0089 0.0546
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0048 0.0117 0.0266
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0089 0.0202
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0089 0.0202
Schistosoma mansoni hypothetical protein 0.0138 0.0485 0.2987
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0029 0.0029
Brugia malayi AMP-binding enzyme family protein 0.005 0.0125 0.0285
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0009 0.0058
Echinococcus granulosus GPCR family 2 0.0064 0.0182 0.0415
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0125 0.0232
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0072 0.0042
Trichomonas vaginalis esterase, putative 0.0072 0.0215 0.1741
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0084 0.0582
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0125 0.0532
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.1144 1
Brugia malayi beta-lactamase family protein 0.0072 0.0215 0.0489
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.0519 0.1094
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0093 0.0301 0.0301
Echinococcus multilocularis peregrin 0.0065 0.0189 0.0189
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0093 0.0301 0.1212
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0069 0.0205 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0507 0.0507
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0224 0.0224
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0045 0.0107 0.0348
Mycobacterium ulcerans hypothetical protein 0.005 0.0125 0.0223
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0125 0.0424
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0089 0.0546
Brugia malayi Inositol-1 0.004 0.0085 0.0194
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0032 0.0098
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0242
Schistosoma mansoni alpha-glucosidase 0.0143 0.0508 0.3128
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.0107 0.0219
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.0746 0.1701
Brugia malayi jmjC domain containing protein 0.0077 0.0237 0.054
Echinococcus multilocularis muscleblind protein 1 0.1089 0.4389 0.4389
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0215 0.3918
Mycobacterium tuberculosis Conserved protein 0.0072 0.0215 0.0429
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0089 0.0202
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0022 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0089 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0089 0.0202
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0068 0.0154
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0084 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0089 0.0202
Echinococcus granulosus jumonji domain containing protein 0.0083 0.026 0.0592
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0202
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0089 0.0546
Trichomonas vaginalis set domain proteins, putative 0.0287 0.11 0.9604
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0022
Brugia malayi nuclear hormone receptor 0.0041 0.0089 0.0202
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0603 0.1374
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0202
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0164 0.0374
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0032 0.08
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0049 0.0122 0.0749
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.04 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0069 0.0205 0.0757
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0164 0.0374
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0069 0.0205 0.0844
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0072 0.0475
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0125 0.0223
Schistosoma mansoni hypothetical protein 0.0021 0.0007 0.0045
Schistosoma mansoni hypothetical protein 0.0036 0.0068 0.0417
Loa Loa (eye worm) hypothetical protein 0.0072 0.0215 0.0489
Echinococcus granulosus zinc finger protein 0.0027 0.0031 0.0071
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0089 0.0546
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0429 0.2639
Brugia malayi hypothetical protein 0.0022 0.0009 0.0022
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0089 0.0202
Schistosoma mansoni hypothetical protein 0.0064 0.0182 0.1121
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0009 0.0022
Leishmania major hypothetical protein, conserved 0.0217 0.0811 0.3286
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0185 0.0421
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.0519 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0064 0.0231
Leishmania major fructose-1,6-bisphosphate aldolase 0.0093 0.0301 0.1158
Mycobacterium ulcerans hypothetical protein 0.0228 0.0855 0.1823
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0069 0.0205 0.1261
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0215 0.698
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0089 0.0546
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.0485 0.1105
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0093 0.0301 0.0686
Onchocerca volvulus 0.0058 0.0158 0.1434
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0475
Schistosoma mansoni inositol monophosphatase 0.004 0.0085 0.0524
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0182 0.0415
Echinococcus multilocularis chromobox protein 1 0.0071 0.0213 0.0213
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0069 0.0205 0.0844
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0093 0.0301 0.0301
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0093 0.0301 0.0686
Brugia malayi MH2 domain containing protein 0.0243 0.0916 0.2087
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.1144 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0089 0.0202
Echinococcus granulosus chromobox protein 1 0.0071 0.0213 0.0484
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0097 0.0693
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0069 0.0205 0.6636
Schistosoma mansoni hypothetical protein 0.0415 0.1624 1
Brugia malayi steroid hormone receptor 0.0041 0.0089 0.0202
Brugia malayi hypothetical protein 0.0022 0.0009 0.0022
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0108 0.3262
Loa Loa (eye worm) hypothetical protein 0.004 0.0084 0.0192
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0022
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0125 0.0223
Leishmania major mitochondrial DNA polymerase beta 0.0609 0.2421 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0068 0.0068
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0215 0.0885
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0093 0.0301 0.0686
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0093 0.0301 0.0301
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0045 0.0107 0.0406
Brugia malayi beta-lactamase family protein 0.0072 0.0215 0.0489
Giardia lamblia PHD finger protein 15 0.0059 0.0164 0.0761
Loa Loa (eye worm) hypothetical protein 0.0045 0.0107 0.0244
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0215 0.1741
Trypanosoma brucei glucosidase, putative 0.0037 0.0072 0.0296
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0089 0.0202
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0205 0.0812
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0022 0.0031
Echinococcus granulosus dnaJ subfamily B 0.0415 0.1624 0.37
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0202
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0068 0.098
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0215 0.0853
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0125 0.0232
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0507 0.1156
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.001 0.0022
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0215 0.0429
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.0237 0.146
Mycobacterium ulcerans urease subunit beta UreB 0.0541 0.2141 0.464
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0035 0.0065 0.0398
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0125 0.0424
Brugia malayi nuclear receptor NHR-88 0.0041 0.0089 0.0202
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0048 0.0117 0.0266
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0199 0.0199
Schistosoma mansoni cpg binding protein 0.0058 0.0158 0.0971
Echinococcus granulosus histone lysine methyltransferase setb 0.0055 0.0145 0.0331
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0071 0.0071
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0125 0.0532
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0285
Loa Loa (eye worm) hypothetical protein 0.0072 0.0215 0.0489
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0089 0.0202
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0069 0.0205 0.5121
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0215 0.1741
Brugia malayi jmjC domain containing protein 0.0194 0.0718 0.1636
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0064 0.0064
Mycobacterium ulcerans beta-lactamase 0.0072 0.0215 0.0419
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0009 0.0022
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0089 0.0546
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0215 0.1741
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0185 0.1137
Mycobacterium ulcerans urease subunit alpha 0.1137 0.4587 1
Onchocerca volvulus Alhambra homolog 0.0059 0.0164 0.1494
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0085 0.035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0215 0.1322
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0603 0.1374
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0507 0.1154
Schistosoma mansoni chromobox protein 0.0071 0.0213 0.1309
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0215 0.1741
Brugia malayi nuclear receptor RXR 0.0022 0.0009 0.0022
Toxoplasma gondii hypothetical protein 0.0098 0.0324 0.8111
Loa Loa (eye worm) hypothetical protein 0.0063 0.018 0.041
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0089 0.0546
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0205 0.1653
Plasmodium vivax SET domain protein, putative 0.0037 0.0074 0.2064
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0093 0.0301 0.0686
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0089 0.0202
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0073 0.011
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0164 0.522
Onchocerca volvulus 0.0072 0.0215 0.1952
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0022 0.0031
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0125 0.2123

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.206 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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