Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyl-diphosphate farnesyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.3453 | 0.985 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0428 | 0.0392 | 1 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.1564 | 0.3942 | 0.3809 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0401 | 0.0307 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0428 | 0.0392 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0428 | 0.0392 | 1 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.3453 | 0.985 | 1 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0428 | 0.0392 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0428 | 0.0392 | 1 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.2339 | 0.6365 | 0.6348 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0373 | 0.022 | 0.1438 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.2339 | 0.6365 | 0.6348 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0373 | 0.022 | 0.1438 |
Loa Loa (eye worm) | hypothetical protein | 0.0373 | 0.022 | 0.1438 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0428 | 0.0392 | 0.5 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0428 | 0.0392 | 1 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0428 | 0.0392 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.1564 | 0.3942 | 0.375 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0428 | 0.0392 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.0392 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0428 | 0.0392 | 0.5 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0428 | 0.0392 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0428 | 0.0392 | 1 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.3453 | 0.985 | 1 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0428 | 0.0392 | 1 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.2339 | 0.6365 | 0.6348 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0428 | 0.0392 | 1 |
Brugia malayi | Cation transporter family protein | 0.0428 | 0.0392 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0428 | 0.0392 | 0.5 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0428 | 0.0392 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.1 nM | Inhibition of squalene synthase | ChEMBL. | 21353782 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.