Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0147 | 0.1031 | 0.0692 |
Loa Loa (eye worm) | haspin protein kinase | 0.0817 | 0.9921 | 0.9921 |
Entamoeba histolytica | hypothetical protein | 0.0097 | 0.037 | 0.0286 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0637 | 0.7527 | 0.7527 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0129 | 0.0795 | 0.0444 |
Entamoeba histolytica | protein kinase, putative | 0.0637 | 0.7527 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0817 | 0.9921 | 0.9921 |
Trypanosoma cruzi | Mitogen-activated protein kinase 10, putative | 0.0147 | 0.1031 | 0.0923 |
Plasmodium falciparum | MO15-related protein kinase | 0.0147 | 0.1031 | 1 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0637 | 0.7527 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0091 | 0.029 | 0.2052 |
Mycobacterium ulcerans | chitinase/cellulase | 0.007 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0817 | 0.9921 | 1 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.0147 | 0.1031 | 0.1183 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0147 | 0.1031 | 0.0692 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0637 | 0.7527 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0111 | 0.0553 | 0.0191 |
Trypanosoma cruzi | serine/threonine protein kinase, putative | 0.0147 | 0.1031 | 0.0923 |
Onchocerca volvulus | 0.0129 | 0.0795 | 1 | |
Onchocerca volvulus | 0.0129 | 0.0795 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0404 | 0.4433 | 0.4433 |
Echinococcus multilocularis | hypothetical protein | 0.0141 | 0.0952 | 0.0609 |
Trypanosoma cruzi | Mitogen-activated protein kinase 10, putative | 0.0147 | 0.1031 | 0.0923 |
Mycobacterium ulcerans | chitinase/cellulase | 0.007 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0404 | 0.4433 | 0.4254 |
Loa Loa (eye worm) | CMGC/CDK/CRK7 protein kinase | 0.0147 | 0.1031 | 0.1031 |
Brugia malayi | Endochitinase | 0.0091 | 0.029 | 0.0134 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.0147 | 0.1031 | 0.1183 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0147 | 0.1031 | 0.0692 |
Brugia malayi | Protein kinase domain containing protein | 0.0097 | 0.037 | 0.0216 |
Echinococcus granulosus | carboxylesterase 5A | 0.0404 | 0.4433 | 0.4254 |
Loa Loa (eye worm) | carboxylesterase | 0.0404 | 0.4433 | 0.4433 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0637 | 0.7527 | 0.7494 |
Brugia malayi | Protein kinase domain containing protein | 0.0147 | 0.1031 | 0.0893 |
Entamoeba histolytica | protein kinase, putative | 0.0097 | 0.037 | 0.0286 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0147 | 0.1031 | 0.1183 |
Echinococcus granulosus | acetylcholinesterase | 0.0404 | 0.4433 | 0.4254 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0097 | 0.037 | 0.0286 |
Echinococcus granulosus | dual specificity | 0.0637 | 0.7527 | 0.7494 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.0952 | 0.0609 |
Onchocerca volvulus | Putative endochitinase | 0.0091 | 0.029 | 0.2052 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0817 | 0.9921 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0291 | 0.0291 |
Echinococcus multilocularis | acetylcholinesterase | 0.0404 | 0.4433 | 0.4254 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0147 | 0.1031 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0404 | 0.4433 | 0.4378 |
Mycobacterium tuberculosis | Possible chitinase | 0.007 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0147 | 0.1031 | 0.0692 |
Entamoeba histolytica | protein kinase, putative | 0.0097 | 0.037 | 0.0286 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0097 | 0.037 | 0.037 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0637 | 0.7527 | 1 |
Echinococcus multilocularis | dual specificity | 0.0637 | 0.7527 | 0.7494 |
Echinococcus multilocularis | dual specificity | 0.0637 | 0.7527 | 0.7494 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0147 | 0.1031 | 0.0692 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0147 | 0.1031 | 0.0692 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0553 | 0.0553 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0637 | 0.7527 | 0.7548 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0637 | 0.7527 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0404 | 0.4433 | 0.4254 |
Echinococcus granulosus | dual specificity | 0.0637 | 0.7527 | 0.7494 |
Loa Loa (eye worm) | chitinase I | 0.0082 | 0.0159 | 0.0159 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0147 | 0.1031 | 0.1183 |
Entamoeba histolytica | hypothetical protein | 0.0141 | 0.0952 | 0.1075 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0637 | 0.7527 | 1 |
Trypanosoma brucei | Mitogen-activated protein kinase 10, putative | 0.0147 | 0.1031 | 0.0923 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0111 | 0.0553 | 0.0191 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0817 | 0.9921 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0817 | 0.9921 | 1 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0129 | 0.0795 | 0.0444 |
Schistosoma mansoni | protein kinase | 0.0147 | 0.1031 | 0.0692 |
Echinococcus granulosus | Pfam-B_8186 domain containing protein | 0.0141 | 0.0952 | 0.0609 |
Echinococcus multilocularis | serotonin receptor | 0.0111 | 0.0553 | 0.0191 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0079 | 0.013 | 0.013 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0147 | 0.1031 | 0.1031 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0637 | 0.7527 | 1 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0147 | 0.1031 | 0.0692 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0637 | 0.7527 | 1 |
Echinococcus granulosus | dual specificity | 0.0637 | 0.7527 | 0.7494 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0404 | 0.4433 | 0.4254 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0291 | 0.0291 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0637 | 0.7527 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0637 | 0.7527 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.4433 | 0.4433 |
Trypanosoma brucei | protein kinase, putative | 0.0147 | 0.1031 | 0.0923 |
Brugia malayi | Carboxylesterase family protein | 0.0404 | 0.4433 | 0.4378 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0795 | 0.0795 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0795 | 0.0795 |
Brugia malayi | GSG2 | 0.0817 | 0.9921 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.0795 | 0.0444 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0637 | 0.7527 | 1 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0637 | 0.7527 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0817 | 0.9921 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0091 | 0.029 | 0.2052 |
Echinococcus multilocularis | serotonin receptor | 0.0111 | 0.0553 | 0.0191 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0147 | 0.1031 | 0.0893 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0404 | 0.4433 | 0.4254 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0082 | 0.0159 | 0.0159 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0097 | 0.037 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0553 | 0.0553 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0817 | 0.9921 | 1 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0637 | 0.7527 | 1 |
Brugia malayi | Cell division protein kinase 2 | 0.0147 | 0.1031 | 0.0893 |
Echinococcus multilocularis | dual specificity | 0.0637 | 0.7527 | 0.7494 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0129 | 0.0795 | 0.0651 |
Brugia malayi | endochitinase | 0.0091 | 0.029 | 0.0134 |
Schistosoma mansoni | hypothetical protein | 0.0817 | 0.9921 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.0147 | 0.1031 | 0.0692 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0147 | 0.1031 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0147 | 0.1031 | 0.0692 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.4433 | 0.4433 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Concentration | = 11 mg ml-1 | Solubility of 20 mg compound in aqueous buffer at pH 7.3 and 37 degree centigrade after 8.0 hr | ChEMBL. | 6321734 |
Concentration | = 11.1 mg ml-1 | Solubility of 20 mg compound in aqueous buffer at pH 7.3 and 37 degree centigrade after 4.0 hr | ChEMBL. | 6321734 |
Concentration | = 13 mg ml-1 | Solubility of 20 mg compound in aqueous buffer at pH 7.3 and 37 degree centigrade after 13.5 hr | ChEMBL. | 6321734 |
MIC50 (functional) | = 29.3 ug ml-1 | Compound was evaluated in vitro for its activity against herpes simplex virus type 1(strain 377) and the minimum inhibitory concentration was determined | ChEMBL. | 6321734 |
Partition coefficient | = 0.318 | Compound was evaluated for the ocatanol/water partition coefficient at 37 degree centigrade at 4.5 hour | ChEMBL. | 6321734 |
Partition coefficient | = 0.329 | Compound was evaluated for the ocatanol/water partition coefficient at 37 degree centigrade at 24.5 hour | ChEMBL. | 6321734 |
Partition coefficient | = 0.335 | Compound was evaluated for the ocatanol/water partition coefficient at 37 degree centigrade at 10.5 hour | ChEMBL. | 6321734 |
Partition coefficient | = 0.336 | Compound was evaluated for the ocatanol/water partition coefficient at 37 degree centigrade at 1.0hr | ChEMBL. | 6321734 |
Partition coefficient | = 0.359 | Compound was evaluated for the ocatanol/water partition coefficient at 37 degree centigrade at 3.0 hr | ChEMBL. | 6321734 |
VR (functional) | = 1.9 | virus rating as the measure of the activity of the compound against herpes simplex virus type 1(strain 377) | ChEMBL. | 6321734 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.