TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 444.408 | Formula: C21H18BrNOS2
H donors: 0 H acceptors: 1 LogP: 6.36 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(/C=C/c1ccc(cc1)N(C)C)/C=C/c1ccc(s1)c1ccc(s1)Br
InChi: 1S/C21H18BrNOS2/c1-23(2)16-6-3-15(4-7-16)5-8-17(24)9-10-18-11-12-19(25-18)20-13-14-21(22)26-20/h3-14H,1-2H3/b8-5+,10-9+
InChiKey: GOEOSXUHHFXTAK-CPSCNVPRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	ETS domain containing protein Elk 1	0.0009	0.0043	0.004
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0086	0.2182	0.218
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0609	0.1378
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0086	0.2182	0.218
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0026	0.0504	0.1041
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0073	0.1833	0.4169
Leishmania major	hypothetical protein, conserved	0.001	0.0052	0.0108
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0052	0.1241	0.282
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.1833	0.4169
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0097	0.2497	0.5683
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0515	0.1153
Schistosoma mansoni	6-phosphofructokinase	0.0097	0.2497	0.2494
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0005	0.0002
Giardia lamblia	DINP protein human, muc B family	0.0038	0.0834	0.3223
Echinococcus multilocularis	ETS transcription factor Elf 5	0.0009	0.0043	0.004
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1334	0.2526
Brugia malayi	MGC83647 protein	0.001	0.0052	0.01
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.001	0.0052	0.0108
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.238	0.5413
Echinococcus granulosus	6 phosphofructokinase	0.0097	0.2497	0.2494
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0026	0.0498	0.094
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0073	0.1833	0.4169
Brugia malayi	Protein C20orf22	0.001	0.0052	0.01
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0008	0.0005	0.001
Trichomonas vaginalis	phosphofructokinase, putative	0.0097	0.2497	0.5679
Loa Loa (eye worm)	Smad1	0.0008	0.0005	0.0004
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0018	0.0284	0.0533
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0164	0.4389	1
Mycobacterium ulcerans	DNA polymerase IV	0.0073	0.1833	0.4169
Echinococcus granulosus	dna polymerase eta	0.0026	0.0504	0.0501
Leishmania major	monoglyceride lipase, putative	0.0164	0.4389	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0026	0.0504	0.0501
Plasmodium vivax	PST-A protein	0.001	0.0052	0.0108
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0086	0.2182	0.218
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0515	0.1153
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0086	0.2182	0.218
Plasmodium falciparum	prodrug activation and resistance esterase	0.001	0.0052	0.0108
Schistosoma mansoni	serine/threonine protein kinase	0.0093	0.238	0.2378
Schistosoma mansoni	elf1	0.0009	0.0043	0.004
Trypanosoma brucei	monoglyceride lipase, putative	0.0164	0.4389	1
Echinococcus granulosus	ETS transcription factor Elf 5	0.0009	0.0043	0.004
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0164	0.4389	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0515	0.1153
Giardia lamblia	Glucose-6-phosphate 1-dehydrogenase	0.01	0.2575	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0164	0.4389	1
Giardia lamblia	Glucosamine-6-phosphate deaminase	0.0008	0.0009	0.0016
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0038	0.0834	0.1801
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0164	0.4389	1
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0052	0.0099
Mycobacterium ulcerans	6-phosphofructokinase	0.0097	0.2497	0.5683
Trypanosoma brucei	DNA polymerase kappa, putative	0.0055	0.1334	0.3031
Trypanosoma brucei	DNA polymerase eta, putative	0.0026	0.0504	0.1138
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0041	0.0925	0.2098
Loa Loa (eye worm)	hypothetical protein	0.001	0.0052	0.0094
Echinococcus multilocularis	voltage dependent calcium channel	0.0086	0.2182	0.218
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0041	0.0925	0.2091
Mycobacterium ulcerans	6-phosphogluconolactonase	0.0008	0.0009	0.0009
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.1524	0.2886
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0223	0.0418
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0005	0.0002
Schistosoma mansoni	cpg binding protein	0.0027	0.0539	0.0537
Toxoplasma gondii	phospholipase/carboxylesterase	0.001	0.0052	0.0193
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0161	0.4291	1
Leishmania major	ubiquitin-conjugating enzyme e2, putative	0.0041	0.0925	0.2098
Schistosoma mansoni	hypothetical protein	0.0009	0.0043	0.004
Echinococcus multilocularis	protein C ets 2	0.0009	0.0043	0.004
Loa Loa (eye worm)	6-phosphogluconolactonase	0.0008	0.0009	0.0012
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0041	0.0925	0.2091
Brugia malayi	CXXC zinc finger family protein	0.0026	0.0498	0.0945
Toxoplasma gondii	esterase/lipase/thioesterase domain-containing protein	0.001	0.0052	0.0193
Mycobacterium ulcerans	hydrolase	0.001	0.0052	0.0108
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0048	0.114	0.4421
Leishmania major	DNA polymerase eta, putative	0.0026	0.0504	0.1138
Plasmodium vivax	hypothetical protein, conserved	0.001	0.0052	0.0108
Brugia malayi	phosphofructokinase	0.0097	0.2497	0.4734
Plasmodium falciparum	lysophospholipase, putative	0.0164	0.4389	1
Brugia malayi	hypothetical protein	0.0008	0.0003	0.0005
Echinococcus granulosus	dna polymerase kappa	0.0073	0.1833	0.183
Chlamydia trachomatis	acyltransferase family protein	0.001	0.0052	0.0185
Echinococcus granulosus	tar DNA binding protein	0.0062	0.1524	0.1522
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0041	0.0925	0.175
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.1833	0.4169
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0008	0.0003	0.0005
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0026	0.0504	0.0951
Mycobacterium tuberculosis	Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD)	0.0032	0.0671	0.1426
Trypanosoma brucei	6-phosphogluconolactonase	0.0008	0.0009	0.0009
Echinococcus granulosus	ETS transcription factor Elf 2	0.0009	0.0043	0.004
Echinococcus multilocularis	sodium channel protein	0.0036	0.0799	0.0797
Toxoplasma gondii	glucose-6-phosphate 1-dehydrogenase	0.01	0.2575	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1524	0.1522
Toxoplasma gondii	transporter, cation channel family protein	0.0018	0.0284	0.1091
Plasmodium vivax	6-phosphofructokinase, putative	0.0026	0.0515	0.1162
Plasmodium falciparum	glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0.01	0.2575	0.5863
Echinococcus granulosus	ewsr:fli fusion protein type	0.0009	0.0043	0.004
Entamoeba histolytica	hypothetical protein	0.001	0.0052	0.0099
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.007	0.0067
Schistosoma mansoni	voltage-gated cation channel	0.0086	0.2182	0.218
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.238	0.5413
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.001	0.0052	0.005
Toxoplasma gondii	hypothetical protein	0.001	0.0052	0.0193
Leishmania major	hypothetical protein, conserved	0.001	0.0052	0.0108
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1524	0.1522
Loa Loa (eye worm)	hypothetical protein	0.001	0.0052	0.0094
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0515	0.1153
Brugia malayi	DIX domain containing protein	0.001	0.007	0.0133
Mycobacterium ulcerans	hypothetical protein	0.001	0.0052	0.0108
Brugia malayi	transcription factor E74 isoform	0.0009	0.0043	0.0082
Trypanosoma brucei	unspecified product	0.0061	0.1503	0.3417
Echinococcus granulosus	Smad4	0.0008	0.0005	0.0002
Plasmodium vivax	lysophospholipase, putative	0.001	0.0052	0.0108
Loa Loa (eye worm)	hypothetical protein	0.001	0.007	0.0127
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0609	0.1378
Plasmodium falciparum	lysophospholipase, putative	0.0164	0.4389	1
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0097	0.2497	1
Echinococcus multilocularis	ewsr:fli fusion protein type	0.0009	0.0043	0.004
Echinococcus granulosus	6 phosphogluconolactonase	0.0008	0.0009	0.0006
Plasmodium falciparum	esterase, putative	0.001	0.0052	0.0108
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0054	0.1303	0.13
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.007	0.0067
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0009	0.0043	0.004
Brugia malayi	Smad1	0.0008	0.0005	0.0009
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0073	0.1833	0.4163
Plasmodium falciparum	alpha/beta-hydrolase, putative	0.001	0.0052	0.0108
Trypanosoma cruzi	DNA polymerase eta, putative	0.0026	0.0504	0.1138
Chlamydia trachomatis	glucose-6-phosphate 1-dehydrogenase	0.0091	0.2347	1
Schistosoma mansoni	DNA polymerase eta	0.0026	0.0504	0.0501
Plasmodium vivax	PST-A protein	0.001	0.0052	0.0108
Trypanosoma brucei	glucose-6-phosphate 1-dehydrogenase	0.0091	0.2347	0.5341
Echinococcus multilocularis	smad	0.0008	0.0005	0.0002
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0038	0.0834	0.189
Echinococcus multilocularis	6 phosphofructokinase	0.0097	0.2497	0.2494
Brugia malayi	MGC79044 protein	0.001	0.0052	0.01
Schistosoma mansoni	glucosamine-6-phosphate isomerase	0.0008	0.0009	0.0006
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0093	0.238	0.5544
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0834	0.189
Echinococcus granulosus	smad	0.0008	0.0005	0.0002
Brugia malayi	MH2 domain containing protein	0.0008	0.0005	0.0009
Plasmodium falciparum	epoxide hydrolase 2	0.001	0.0052	0.0108
Toxoplasma gondii	protein c14orf29, putative	0.001	0.0052	0.0193
Brugia malayi	hypothetical protein	0.0148	0.3939	0.7469
Echinococcus multilocularis	ets variant gene 4	0.0009	0.0043	0.004
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0026	0.0515	0.1981
Echinococcus multilocularis	voltage dependent calcium channel	0.0086	0.2182	0.218
Schistosoma mansoni	ubiquitin conjugating enzyme 13	0.0041	0.0925	0.0923
Schistosoma mansoni	hypothetical protein	0.0364	1	1
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.001	0.0052	0.0193
Trichomonas vaginalis	DNA polymerase eta, putative	0.0073	0.1833	0.4163
Brugia malayi	abnormal cell lineage protein 10 (Protein lin-10), putative	0.0055	0.1316	0.2495
Brugia malayi	6-phosphogluconolactonase family protein	0.0008	0.0009	0.0018
Entamoeba histolytica	hypothetical protein	0.001	0.0052	0.0099
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.01	0.2575	0.5859
Schistosoma mansoni	dishevelled	0.001	0.007	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0148	0.3939	0.7468
Echinococcus multilocularis	GA binding protein alpha chain	0.0065	0.159	0.1588
Brugia malayi	Ets-domain containing protein	0.0065	0.159	0.3015
Echinococcus granulosus	Phospholipase carboxylesterase	0.001	0.0052	0.005
Onchocerca volvulus		0.0148	0.3939	0.9179
Echinococcus multilocularis	Phospholipase carboxylesterase	0.001	0.0052	0.005
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0052	0.0099
Brugia malayi	regulator of G-protein signaling egl-10	0.0008	0.0003	0.0005
Brugia malayi	RasGEF domain containing protein	0.0008	0.0006	0.0012
Schistosoma mansoni	smad	0.0008	0.0005	0.0002
Plasmodium falciparum	exported lipase 1	0.001	0.0052	0.0108
Trypanosoma cruzi	hydrolase, alpha/beta fold family, putative	0.001	0.0052	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0052	0.0099
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0086	0.2182	0.218
Trypanosoma brucei	glucosamine-6-phosphate isomerase, putative	0.0008	0.0009	0.0009
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0026	0.0515	0.2161
Brugia malayi	TAR-binding protein	0.0062	0.1524	0.289
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0515	0.1153
Giardia lamblia	Kinase, PLK	0.0093	0.238	0.9241
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.238	0.5413
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.007	0.0067
Brugia malayi	6-phosphofructokinase	0.0097	0.2497	0.4734
Toxoplasma gondii	hypothetical protein	0.0016	0.0223	0.0856
Plasmodium falciparum	alpha/beta hydrolase fold domain containing protein, putative	0.001	0.0052	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0052	0.0099
Trichomonas vaginalis	conserved hypothetical protein	0.0164	0.4389	1
Toxoplasma gondii	hypothetical protein	0.001	0.0052	0.0193
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.0041	0.0925	0.2091
Toxoplasma gondii	phospholipase	0.001	0.0052	0.0193
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.1833	0.4169
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.001	0.0052	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0161	0.4291	0.8136
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0097	0.2497	0.5679
Echinococcus multilocularis	glucose 6 phosphate 1 dehydrogenase	0.0091	0.2347	0.2345
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0073	0.1833	0.4169
Loa Loa (eye worm)	DNA-binding protein D-ETS-3	0.0009	0.0043	0.0077
Plasmodium vivax	hypothetical protein, conserved	0.001	0.0052	0.0108
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.001	0.0052	0.0099
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0097	0.2497	0.5683
Brugia malayi	Ets-domain containing protein	0.0065	0.159	0.3015
Trypanosoma cruzi	serine peptidase, putative	0.001	0.0052	0.0108
Plasmodium vivax	unspecified product	0.001	0.0052	0.0108
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.001	0.0052	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0043	0.0077
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.001	0.0052	0.005
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0005	0.0002
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0041	0.0925	0.175
Trypanosoma brucei	unspecified product	0.0018	0.028	0.0626
Plasmodium falciparum	esterase, putative	0.001	0.0052	0.0108
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.1833	0.4169
Brugia malayi	glucose-6-phosphate dehydrogenase	0.0091	0.2347	0.445
Treponema pallidum	glucose-6-phosphate 1-dehydrogenase	0.0091	0.2347	0.9399
Plasmodium vivax	glucose-6-phosphate 1-dehydrogenase, putative	0.01	0.2575	0.5863
Plasmodium falciparum	alpha/beta hydrolase, putative	0.001	0.0052	0.0108
Mycobacterium ulcerans	DNA polymerase IV	0.0073	0.1833	0.4169
Brugia malayi	hypothetical protein	0.0008	0.0003	0.0005
Loa Loa (eye worm)	hypothetical protein	0.001	0.0052	0.0094
Schistosoma mansoni	Smad4	0.0008	0.0005	0.0002
Mycobacterium ulcerans	glucose-6-phosphate 1-dehydrogenase	0.0091	0.2347	0.5341
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0026	0.0515	0.1989
Trypanosoma brucei	Serine peptidase, Clan SC, Family S09X	0.001	0.0052	0.0108
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.1068	0.2416
Trichomonas vaginalis	phosphofructokinase, putative	0.0097	0.2497	0.5679
Trypanosoma brucei	unspecified product	0.0018	0.028	0.0626
Echinococcus granulosus	glucose 6 phosphate 1 dehydrogenase	0.0091	0.2347	0.2345
Entamoeba histolytica	phosphofructokinase, putative	0.0097	0.2497	0.5679
Schistosoma mansoni	ets	0.0009	0.0043	0.004
Echinococcus multilocularis	cpg binding protein	0.0027	0.0539	0.0537
Leishmania major	ATP-dependent phosphofructokinase	0.0097	0.2497	0.5683
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0005	0.0002
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.001	0.0052	0.0099
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.002	0.0335	0.1291
Mycobacterium ulcerans	glucose-6-phosphate 1-dehydrogenase	0.006	0.1457	0.3311
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0093	0.238	0.2378
Leishmania major	Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X	0.001	0.0052	0.0108
Trypanosoma brucei	DNA polymerase IV, putative	0.0061	0.1503	0.3417
Echinococcus granulosus	ETS transcription factor Elf 1	0.0009	0.0043	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0052	0.0099
Plasmodium vivax	alpha/beta hydrolase, putative	0.001	0.0052	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0052	0.0099
Mycobacterium tuberculosis	Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed))	0.0012	0.0111	0.0134
Plasmodium falciparum	exported lipase 2	0.001	0.0052	0.0108
Echinococcus granulosus	voltage dependent calcium channel	0.0018	0.0284	0.0281
Trypanosoma cruzi	glucose-6-phosphate 1-dehydrogenase, putative	0.003	0.0631	0.1428
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.001	0.0052	0.0099
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.1833	0.4169
Echinococcus granulosus	cpg binding protein	0.0027	0.0539	0.0537
Brugia malayi	polk-prov protein	0.0055	0.1334	0.253
Entamoeba histolytica	phosphofructokinase, putative	0.0097	0.2497	0.5679
Loa Loa (eye worm)	6-phosphofructokinase	0.0097	0.2497	0.4731
Echinococcus granulosus	voltage dependent calcium channel	0.0086	0.2182	0.218
Echinococcus granulosus	abhydrolase domain containing 3	0.001	0.0052	0.005
Schistosoma mansoni	6-phosphofructokinase	0.0097	0.2497	0.2494
Trypanosoma cruzi	Glucose-6-phosphate dehydrogenase, putative	0.0029	0.0606	0.1371
Trichomonas vaginalis	phosphofructokinase, putative	0.0097	0.2497	0.5679
Echinococcus multilocularis	ubiquitin conjugating enzyme E2 N	0.0041	0.0925	0.0923
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0003	0.00000095306
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0008	0.0005	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0052	0.0099
Trypanosoma cruzi	glucose-6-phosphate 1-dehydrogenase, putative	0.0091	0.2347	0.5341
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0041	0.0925	0.2098
Loa Loa (eye worm)	hypothetical protein	0.001	0.0052	0.0094
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.01	0.2575	0.5859
Leishmania major	6-phosphogluconolactonase	0.0008	0.0009	0.0009
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0065	0.159	0.3011
Brugia malayi	Ets-domain containing protein	0.0009	0.0043	0.0082
Loa Loa (eye worm)	phosphofructokinase	0.0097	0.2497	0.4731
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0052	0.0099
Brugia malayi	ubiquitin conjugating enzyme protein 13	0.0041	0.0925	0.1754
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.1068	0.2416
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0026	0.0504	0.0501
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.001	0.0052	0.0099
Schistosoma mansoni	cpg binding protein	0.0027	0.0539	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2182	0.4134
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1524	0.1522
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0093	0.238	0.5417
Trichomonas vaginalis	phosphofructokinase, putative	0.0097	0.2497	0.5679
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.1524	0.1522
Plasmodium falciparum	alpha/beta hydrolase, putative	0.001	0.0052	0.0108
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.238	0.5413
Trypanosoma brucei	DNA polymerase IV, putative	0.0073	0.1833	0.4169
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0026	0.0504	0.0501
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.238	0.5417
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0093	0.238	0.451
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.3066	0.5812
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1328	0.2514
Brugia malayi	MH2 domain containing protein	0.0117	0.3066	0.5814
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0005	0.0002
Trypanosoma cruzi	6-phosphogluconolactonase, putative	0.0008	0.0009	0.0009
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.001	0.0052	0.0099
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.007	0.0067
Plasmodium falciparum	ubiquitin-conjugating enzyme E2 N, putative	0.0041	0.0925	0.2098
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.238	0.5413
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0026	0.0515	0.2161
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0026	0.0504	0.113
Mycobacterium tuberculosis	Possible lysophospholipase	0.0164	0.4389	1
Brugia malayi	DNA-binding protein D-ETS-3	0.0009	0.0043	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0043	0.0077
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	0.0041	0.0925	0.3586
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0504	0.0951
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0005	0.0002
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.1833	0.4169
Echinococcus multilocularis	dna polymerase eta	0.0026	0.0504	0.0501
Plasmodium falciparum	lysophospholipase, putative	0.0164	0.4389	1
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.001	0.0052	0.0099
Loa Loa (eye worm)	calcium channel	0.0086	0.2182	0.4134
Schistosoma mansoni	polyomavirus enhancer activator 3 pea3	0.0009	0.0043	0.004
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0097	0.2497	0.5636
Toxoplasma gondii	phosphofructokinase PFKII	0.0026	0.0515	0.1989
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0284	0.0533
Trypanosoma brucei	DNA polymerase IV, putative	0.0073	0.1833	0.4169
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0093	0.238	0.5413
Brugia malayi	Fli-1 protein	0.0196	0.5274	1
Plasmodium vivax	ubiquitin-conjugating enzyme E2 N, putative	0.0041	0.0925	0.2098
Echinococcus granulosus	ubiquitin conjugating enzyme E2 N	0.0041	0.0925	0.0923
Plasmodium vivax	alpha/beta hydrolase, putative	0.001	0.0052	0.0108
Brugia malayi	MH2 domain containing protein	0.0008	0.0005	0.0009
Plasmodium falciparum	alpha/beta hydrolase, putative	0.001	0.0052	0.0108
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0093	0.238	0.2378
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.001	0.0052	0.0099
Schistosoma mansoni	ets-related	0.0009	0.0043	0.004
Plasmodium vivax	PST-A protein	0.001	0.0052	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0164	0.4389	1
Echinococcus multilocularis	dnaJ subfamily B	0.0364	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.238	0.5413
Brugia malayi	serine/threonine-protein kinase plk-2	0.0093	0.238	0.4513
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0086	0.2182	0.218
Brugia malayi	N-terminal motif family protein	0.0161	0.4291	0.8137
Trypanosoma brucei	monoglyceride lipase, putative	0.0164	0.4389	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0026	0.0515	0.1162
Giardia lamblia	Cgi67 serine protease precursor-like protein	0.001	0.0052	0.0184
Toxoplasma gondii	hypothetical protein	0.001	0.0052	0.0193
Schistosoma mansoni	hypothetical protein	0.0009	0.0043	0.004
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.001	0.0052	0.0099
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.007	0.0133
Schistosoma mansoni	dishevelled	0.001	0.007	0.0067
Echinococcus granulosus	amyloid beta A4 protein	0.0061	0.1497	0.1494
Echinococcus multilocularis	monoacylglycerol lipase abhd12	0.001	0.0052	0.005
Brugia malayi	MH1 domain containing protein	0.0008	0.0005	0.0009
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0086	0.2182	0.4137
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0009	0.0043	0.004
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0223	0.0418
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.001	0.007	0.0157
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0005	0.0004
Loa Loa (eye worm)	DIX domain-containing protein	0.001	0.007	0.0127
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.1524	0.289
Loa Loa (eye worm)	ets-domain-containing protein	0.0009	0.0043	0.0077
Schistosoma mansoni	kinase	0.0047	0.1102	0.1099
Echinococcus granulosus	ETS transcription factor Elf 2	0.0009	0.0043	0.004
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.1833	0.4169
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0005	0.0004
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.238	0.5413
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0164	0.4389	1
Schistosoma mansoni	6-phosphogluconolactonase	0.0008	0.0009	0.0006
Trypanosoma cruzi	glucosamine-6-phosphate isomerase, putative	0.0008	0.0009	0.0009
Loa Loa (eye worm)	6-phosphofructokinase	0.0097	0.2497	0.4731
Plasmodium vivax	lysophospholipase, putative	0.001	0.0052	0.0108
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1524	0.1522
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1524	0.1522
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0003	0.00000095306
Loa Loa (eye worm)	histone methyltransferase	0.0008	0.0003	0.0000018076
Trypanosoma cruzi	glucosamine-6-phosphate isomerase, putative	0.0008	0.0009	0.0009
Schistosoma mansoni	ets-related	0.0196	0.5274	0.5272
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.001	0.0052	0.0108
Mycobacterium ulcerans	lysophospholipase	0.0164	0.4389	1
Toxoplasma gondii	6-phosphofructokinase	0.0026	0.0515	0.1989
Plasmodium vivax	unspecified product	0.001	0.0052	0.0108
Brugia malayi	ImpB/MucB/SamB family protein	0.0026	0.0504	0.0956
Echinococcus granulosus	abhydrolase domain containing protein 13	0.001	0.0052	0.005
Plasmodium falciparum	BEM46-like protein, putative	0.001	0.0052	0.0108
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0052	0.1241	0.282
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0026	0.0515	0.1162
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.001	0.0052	0.0193
Brugia malayi	6-phosphofructokinase	0.0097	0.2497	0.4734
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0052	0.0099
Echinococcus multilocularis	Smad4	0.0008	0.0005	0.0002
Plasmodium falciparum	esterase, putative	0.0164	0.4389	1
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0005	0.0002
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0086	0.2182	0.218
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0008	0.0006	0.0006
Trypanosoma cruzi	Serine peptidase, Clan SC, Family S09X, putative	0.001	0.0052	0.0108
Brugia malayi	MH1 domain containing protein	0.0008	0.0005	0.0009
Plasmodium vivax	PST-A protein	0.001	0.0052	0.0108
Loa Loa (eye worm)	D-ets-2 protein	0.0009	0.0043	0.0077
Loa Loa (eye worm)	X11 protein	0.0061	0.1497	0.2835
Toxoplasma gondii	glucose-6-phosphate 1-dehydrogenase	0.006	0.1457	0.5652
Brugia malayi	RNA binding protein	0.0062	0.1524	0.289
Trypanosoma cruzi	serine peptidase, putative	0.001	0.0052	0.0108
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0164	0.4389	1
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0164	0.4389	1
Echinococcus granulosus	ETS domain containing protein Elk 1	0.0009	0.0043	0.004
Brugia malayi	Ubiquitin conjugating enzyme protein 13	0.0041	0.0925	0.1754
Echinococcus granulosus	GA binding protein alpha chain	0.0065	0.159	0.1588
Entamoeba histolytica	;Alias	0.001	0.0052	0.0099
Onchocerca volvulus		0.0026	0.0498	0.1156
Plasmodium vivax	PST-A protein	0.001	0.0052	0.0108
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.1524	0.2886
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0086	0.2182	0.218
Plasmodium vivax	PST-A protein	0.0164	0.4389	1
Echinococcus multilocularis	abhydrolase domain containing 3	0.001	0.0052	0.005
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0073	0.1833	0.4169
Loa Loa (eye worm)	glucose-6-phosphate dehydrogenase	0.0091	0.2347	0.4447
Plasmodium falciparum	alpha/beta hydrolase, putative	0.001	0.0052	0.0108
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0515	0.1153
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.001	0.0052	0.0099
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0026	0.0515	0.1153
Mycobacterium ulcerans	hypothetical protein	0.0164	0.4389	1
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0086	0.2182	0.218
Leishmania major	DNA polymerase kappa, putative	0.0038	0.0834	0.189
Chlamydia trachomatis	hydrolase	0.001	0.0052	0.0185
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0164	0.4389	1
Mycobacterium ulcerans	hypothetical protein	0.001	0.0052	0.0108
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0164	0.4389	1
Plasmodium falciparum	lysophospholipase, putative	0.001	0.0052	0.0108
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0026	0.0504	0.0501
Trypanosoma cruzi	monoglyceride lipase, putative	0.0164	0.4389	1
Plasmodium vivax	lysophospholipase, putative	0.001	0.0052	0.0108
Schistosoma mansoni	6-phosphogluconolactonase	0.0008	0.0009	0.0006
Trypanosoma brucei	polo-like protein kinase	0.0093	0.238	0.5417
Loa Loa (eye worm)	hypothetical protein	0.0059	0.143	0.2707
Schistosoma mansoni	peptidase	0.001	0.0052	0.005
Brugia malayi	ImpB/MucB/SamB family protein	0.0026	0.0504	0.0956
Echinococcus granulosus	monoacylglycerol lipase abhd12	0.001	0.0052	0.005
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.1833	0.4169
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.3066	0.5812
Entamoeba histolytica	phosphofructokinase, putative	0.0097	0.2497	0.5679
Schistosoma mansoni	amyloid beta A4 protein related	0.0061	0.1497	0.1494
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0036	0.0799	0.0797
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.001	0.0052	0.0108
Brugia malayi	hypothetical protein	0.0059	0.143	0.2711
Trichomonas vaginalis	6-phosphogluconolactonase, putative	0.01	0.2575	0.5859
Schistosoma mansoni	DNA polymerase IV / kappa	0.0008	0.0005	0.0002
Trypanosoma brucei	ubiquitin-protein ligase, putative	0.0041	0.0925	0.2098
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.1833	0.4169
Trypanosoma brucei	DNA polymerase kappa, putative	0.0055	0.1334	0.3031
Leishmania major	glucose-6-phosphate 1-dehydrogenase, putative	0.0091	0.2347	0.5341
Echinococcus multilocularis	ETS transcription factor Elf 1	0.0009	0.0043	0.004
Echinococcus multilocularis	dna polymerase kappa	0.0073	0.1833	0.183
Echinococcus multilocularis	6 phosphogluconolactonase	0.0008	0.0009	0.0006
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.001	0.0052	0.0099
Plasmodium falciparum	alpha/beta hydrolase, putative	0.001	0.0052	0.0108
Trypanosoma cruzi	6-phosphogluconolactonase, putative	0.0008	0.0009	0.0009
Toxoplasma gondii	peptidase S15, putative	0.001	0.0052	0.0193
Loa Loa (eye worm)	hypothetical protein	0.001	0.0052	0.0094
Schistosoma mansoni	cpg binding protein	0.0026	0.0498	0.0496
Toxoplasma gondii	hypothetical protein	0.001	0.0052	0.0193
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0005	0.0002
Leishmania major	glucosamine-6-phosphate isomerase, putative	0.0008	0.0009	0.0009
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.238	0.5417
Echinococcus granulosus	protein C ets 2	0.0009	0.0043	0.004
Loa Loa (eye worm)	fli-1 protein	0.0196	0.5274	1
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0026	0.0515	0.2031
Giardia lamblia	Glucosamine-6-phosphate deaminase	0.0008	0.0009	0.0016
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0609	0.1378
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0026	0.0515	0.1153
Loa Loa (eye worm)	RNA binding protein	0.0062	0.1524	0.2886
Plasmodium vivax	hypothetical protein, conserved	0.001	0.0052	0.0108
Plasmodium falciparum	lysophospholipase, putative	0.001	0.0052	0.0108
Schistosoma mansoni	glucose-6-phosphate 1-dehydrogenase	0.0091	0.2347	0.2345
Schistosoma mansoni	gabp alpha	0.0065	0.159	0.1588
Plasmodium vivax	6-phosphofructokinase, putative	0.0026	0.0515	0.1162
Echinococcus multilocularis	amyloid beta A4 protein	0.0061	0.1497	0.1494
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0009	0.0043	0.0077

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1767196

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1528229