Detailed information for compound 1585012

Basic information

Technical information
  • TDR Targets ID: 1585012
  • Name: 3-[7-methoxy-2-oxo-5-(phenylmethoxy)chromen-4 -yl]propanoic acid
  • MW: 354.353 | Formula: C20H18O6
  • H donors: 1 H acceptors: 3 LogP: 2.65 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OCc2ccccc2)c2c(c1)oc(=O)cc2CCC(=O)O
  • InChi: 1S/C20H18O6/c1-24-15-10-16(25-12-13-5-3-2-4-6-13)20-14(7-8-18(21)22)9-19(23)26-17(20)11-15/h2-6,9-11H,7-8,12H2,1H3,(H,21,22)
  • InChiKey: NXJIKRBFQOSGGP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[7-methoxy-2-oxo-5-(phenylmethoxy)-4-chromenyl]propanoic acid
  • 3-[5-(benzyloxy)-2-keto-7-methoxy-chromen-4-yl]propionic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.022 0.017
Entamoeba histolytica hypothetical protein 0.0043 0.0116 0.0116
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.016 0.1003 0.1003
Schistosoma mansoni hypothetical protein 0.0043 0.0116 0.0066
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.016 0.1003 0.1003
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0776 0.8342
Leishmania major eukaryotic translation initiation factor-like protein 0.1343 1 1
Brugia malayi eukaryotic translation initiation factor 4E-1 0.016 0.1003 0.0958
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0116 0.0066
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.016 0.1003 0.0958
Plasmodium falciparum thioredoxin reductase 0.0057 0.022 0.1779
Schistosoma mansoni hypothetical protein 0.0372 0.2613 0.2576
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.1343 1 1
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.1343 1 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.016 0.1003 0.1003
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.016 0.1003 0.0958
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0776 0.8342
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.1343 1 1
Entamoeba histolytica hypothetical protein 0.016 0.1003 0.1003
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.016 0.1003 0.1003
Entamoeba histolytica translation initiation factor 4e, putative 0.016 0.1003 0.1003
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2613 0.2576
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.016 0.1003 0.0958
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0776 0.8342
Leishmania major hypothetical protein, conserved 0.016 0.1003 0.1003
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0887 1
Plasmodium falciparum glutathione reductase 0.0057 0.022 0.1779
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.1343 1 1
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.016 0.1003 0.1003
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.016 0.1003 0.1003
Entamoeba histolytica hypothetical protein 0.0043 0.0116 0.0116
Plasmodium falciparum eukaryotic translation initiation factor 4E 0.016 0.1003 1
Toxoplasma gondii thioredoxin reductase 0.0057 0.022 0.017
Giardia lamblia hypothetical protein 0.016 0.1003 0.5
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.1343 1 1
Mycobacterium tuberculosis Probable reductase 0.013 0.0776 0.8342
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.1343 1 1
Entamoeba histolytica hypothetical protein 0.016 0.1003 0.1003
Plasmodium vivax glutathione reductase, putative 0.0057 0.022 0.1779
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.016 0.1003 0.1003
Leishmania major eukaryotic translation initiation factor-like 0.1343 1 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.016 0.1003 0.1003
Leishmania major hypothetical protein, conserved 0.016 0.1003 0.1003
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.016 0.1003 0.1003
Plasmodium falciparum eukaryotic translation initiation factor 4E, putative 0.016 0.1003 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0116 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.016 0.1003 0.1003
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.016 0.1003 0.0958
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.016 0.1003 0.1003
Giardia lamblia Translation elongation factor 0.016 0.1003 0.5
Leishmania major eukaryotic translation initiation factor, putative 0.016 0.1003 0.1003
Loa Loa (eye worm) translation initiation factor 4E 0.1343 1 1
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.1343 1 1
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.016 0.1003 0.0958
Trichomonas vaginalis hypothetical protein 0.016 0.1003 0.1003
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0887 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.1343 1 1
Echinococcus granulosus snurportin 1 0.0372 0.2613 0.2576
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0776 0.8342
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.016 0.1003 0.0958
Loa Loa (eye worm) glutathione reductase 0.0057 0.022 0.017
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.016 0.1003 0.1003
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.016 0.1003 0.1003
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.016 0.1003 0.1003
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0887 1
Giardia lamblia Hypothetical protein 0.016 0.1003 0.5
Plasmodium vivax hypothetical protein, conserved 0.016 0.1003 1
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.022 0.017
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.016 0.1003 0.1003
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.016 0.1003 0.1003
Entamoeba histolytica hypothetical protein 0.0043 0.0116 0.0116
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.022 0.022
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.016 0.1003 0.0958
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.1343 1 1
Brugia malayi glutathione reductase 0.0057 0.022 0.017
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.016 0.1003 0.0958
Toxoplasma gondii hypothetical protein 0.016 0.1003 0.0958
Leishmania major eukaryotic translation initiation factor 4e, putative 0.016 0.1003 0.1003
Entamoeba histolytica hypothetical protein 0.0043 0.0116 0.0116
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.016 0.1003 0.1003
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.016 0.1003 0.1003
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.1343 1 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.016 0.1003 0.1003
Trichomonas vaginalis conserved hypothetical protein 0.016 0.1003 0.1003
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.016 0.1003 0.1003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0116 0.0066
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.016 0.1003 0.1003
Trypanosoma brucei trypanothione reductase 0.0057 0.022 0.017
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-3 0.016 0.1003 0.1003
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.022 0.1779
Echinococcus multilocularis snurportin 1 0.0372 0.2613 0.2576
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0776 0.8342
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0887 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.1343 1 1
Brugia malayi Thioredoxin reductase 0.0057 0.022 0.017
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.016 0.1003 0.1003
Leishmania major trypanothione reductase 0.0057 0.022 0.022
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.016 0.1003 0.1003
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.016 0.1003 0.0958
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.1343 1 1
Onchocerca volvulus Putative eukaryotic translation initiation factor 4e 0.016 0.1003 0.5
Brugia malayi hypothetical protein 0.0043 0.0116 0.0066
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.022 0.017
Plasmodium vivax translation initiation factor 4E, putative 0.016 0.1003 1
Giardia lamblia Hypothetical protein 0.016 0.1003 0.5
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.016 0.1003 0.1003
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.1343 1 1
Brugia malayi RNA, U transporter 1 0.0099 0.0538 0.0491
Trichomonas vaginalis conserved hypothetical protein 0.016 0.1003 0.1003
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.1343 1 1
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.016 0.1003 0.1003

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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