TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 317.426 | Formula: C18H27N3O2
H donors: 0 H acceptors: 0 LogP: 1.85 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CN1C[C@H]2CON([C@H]2C[C@H]1c1cccc(c1)N1CCOCC1)C
InChi: 1S/C18H27N3O2/c1-19-12-15-13-23-20(2)18(15)11-17(19)14-4-3-5-16(10-14)21-6-8-22-9-7-21/h3-5,10,15,17-18H,6-9,11-13H2,1-2H3/t15-,17-,18-/m0/s1
InChiKey: FFSLRBJOMGZACC-SZMVWBNQSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	GDP L fucose synthase	0.0012	0.0101	0.0106
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0285	0.0297
Trypanosoma brucei	GDP-L-fucose synthetase	0.0012	0.0101	0.0101
Loa Loa (eye worm)	RNA binding protein	0.0076	0.2309	0.2333
Trichomonas vaginalis	dihydroflavonal-4-reductase, putative	0.0012	0.0101	0.0106
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0285	0.0297
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0285	0.0297
Entamoeba histolytica	hypothetical protein	0.0037	0.0959	0.0999
Entamoeba histolytica	hypothetical protein	0.0037	0.0959	0.0999
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.1059	0.0967
Trypanosoma cruzi	major cysteine proteinase, putative	0.0051	0.1455	0.1517
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.006	0.174	0.1813
Mycobacterium ulcerans	UDP-glucose 4-epimerase GalE2	0.0012	0.0101	0.5
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0148	0.4748	0.4948
Schistosoma mansoni	CREB-binding protein 2	0.0092	0.2849	0.2969
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.0285	0.2687
Plasmodium falciparum	GDP-L-fucose synthase	0.0012	0.0101	0.0958
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1934	0.1934
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.0445	0.0373
Leishmania major	cathepsin L-like protease	0.0017	0.0285	0.0185
Leishmania major	cathepsin L-like protease	0.0066	0.1934	0.1851
Trichomonas vaginalis	UDP-glucose 4-epimerase, putative	0.029	0.9596	1
Leishmania major	cathepsin L-like protease	0.0017	0.0285	0.0185
Trypanosoma cruzi	UDP-galactose 4-epimerase, putative	0.029	0.9596	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0285	0.0297
Mycobacterium ulcerans	UDP-glucose 4-epimerase	0.0012	0.0101	0.5
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0251	0.0261
Leishmania major	udp-glc 4-epimerase, putative	0.0302	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0285	0.0297
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2309	0.2406
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0285	0.0297
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.2309	0.2406
Echinococcus multilocularis	epimerase family protein sdr39u1	0.0012	0.0101	0.0106
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.2309	0.2333
Brugia malayi	cathepsin L-like precursor	0.0012	0.0091	0.0094
Onchocerca volvulus		0.0017	0.0285	1
Brugia malayi	NAD dependent epimerase/dehydratase family protein	0.0012	0.0101	0.0106
Echinococcus granulosus	tar DNA binding protein	0.0076	0.2309	0.2406
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.1212	0.1263
Brugia malayi	follicle stimulating hormone receptor	0.0224	0.735	0.766
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0012	0.0091	0.0094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0285	0.0297
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.1212	0.1263
Trypanosoma brucei	L-threonine 3-dehydrogenase	0.0012	0.0101	0.0101
Loa Loa (eye worm)	oxidoreductase	0.0012	0.0101	0.0011
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.1445	0.1506
Echinococcus granulosus	GPCR family 2	0.0016	0.0251	0.0261
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.1212	0.1263
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0044	0.1183	0.1233
Echinococcus multilocularis	NAD(P) binding domain	0.0012	0.0101	0.0106
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0101	0.0106
Onchocerca volvulus		0.0012	0.0101	0.056
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0285	0.0297
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.1212	0.1263
Echinococcus multilocularis	UDP glucose 4 epimerase	0.029	0.9596	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0285	0.0297
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0285	0.0297
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0285	0.0297
Schistosoma mansoni	hypothetical protein	0.0016	0.0251	0.0261
Mycobacterium ulcerans	oxidoreductase	0.0012	0.0101	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1934	0.1934
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0044	0.1183	0.1139
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0285	0.0297
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0101	0.0106
Leishmania major	cathepsin L-like protease	0.0017	0.0285	0.0185
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0285	1
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0285	0.0185
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.1212	0.1263
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0285	0.0297
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0285	0.0297
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0285	1
Echinococcus multilocularis	cysteine protease	0.0017	0.0285	0.0297
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0091	0.0094
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0251	0.0261
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.0285	0.2687
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2309	0.2406
Leishmania major	cathepsin L-like protease	0.0066	0.1934	0.1851
Trypanosoma brucei	NAD dependent epimerase/dehydratase family, putative	0.0012	0.0101	0.0101
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.029	0.9596	1
Trypanosoma cruzi	NAD dependent epimerase/dehydratase family, putative	0.0012	0.0101	0.0106
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0285	0.0297
Brugia malayi	TAR-binding protein	0.0076	0.2309	0.2406
Mycobacterium leprae	POSSIBLE UDP-GLUCOSE 4-EPIMERASE GALE2 (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE 4-EPIMERASE	0.0012	0.0101	0.5
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 27	0.0012	0.0101	0.0106
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.1212	0.1263
Trypanosoma cruzi	GDP-L-fucose synthetase, putative	0.0012	0.0101	0.0106
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0285	0.0297
Trypanosoma cruzi	L-threonine 3-dehydrogenase, putative	0.0012	0.0101	0.0106
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0148	0.4748	0.4948
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0101	0.0011
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0285	0.0297
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0251	0.0168
Echinococcus granulosus	NADP binding domain	0.0012	0.0101	0.0106
Brugia malayi	epimerase/reductase	0.0012	0.0101	0.0106
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0251	0.0261
Entamoeba histolytica	hypothetical protein, conserved	0.0012	0.0101	0.0106
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0285	0.0297
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0959	0.0999
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0285	0.0297
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0285	0.0297
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.0012	0.0101	0.0106
Onchocerca volvulus		0.0012	0.0101	0.056
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0251	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0251	0.0168
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.1934	0.2015
Leishmania major	cathepsin L-like protease	0.0017	0.0285	0.0185
Brugia malayi	UDP galactose 4'-epimerase	0.029	0.9596	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0251	0.0261
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2309	0.2406
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.0012	0.0101	0.0106
Mycobacterium tuberculosis	Possible oxidoreductase	0.0012	0.0101	0.5
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.0012	0.0101	0.0106
Schistosoma mansoni	hypothetical protein	0.0035	0.0892	0.093
Loa Loa (eye worm)	CBP-B	0.0092	0.2849	0.2902
Mycobacterium ulcerans	hypothetical protein	0.0012	0.0101	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1934	0.1934
Plasmodium vivax	GDP-L-fucose synthase, putative	0.0012	0.0101	0.0857
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1934	0.1934
Trypanosoma cruzi	NAD dependent epimerase/dehydratase family, putative	0.0012	0.0101	0.0106
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0285	0.0297
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0285	0.0297
Onchocerca volvulus		0.0017	0.0285	1
Mycobacterium ulcerans	non-ribosomal peptide synthetase	0.0012	0.0101	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.1934	0.2015
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0285	0.0297
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.1212	0.118
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.0012	0.0101	0.0106
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.0012	0.0101	0.0106
Mycobacterium tuberculosis	Probable nucleotide-sugar epimerase EpiA	0.0012	0.0101	0.5
Schistosoma mansoni	hypothetical protein	0.0016	0.0251	0.0261
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.2309	0.2333
Leishmania major	cathepsin L-like protease	0.0066	0.1934	0.1851
Echinococcus multilocularis	NADH dehydrogenase (ubiquinone) 1 alpha	0.0012	0.0101	0.0106
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.0091	0.0094
Mycobacterium ulcerans	hypothetical protein	0.0012	0.0101	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1934	0.1934
Trypanosoma cruzi	L-threonine 3-dehydrogenase, putative	0.0012	0.0101	0.0106
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0445	0.0464
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.029	0.9596	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.1934	0.2015
Onchocerca volvulus		0.0012	0.0101	0.056
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0285	0.0297
Trypanosoma brucei	UDP-galactose 4-epimerase	0.0302	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1934	0.1934
Echinococcus multilocularis	CREB binding protein	0.0092	0.2849	0.2969
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0959	0.0999
Plasmodium vivax	vivapain-2	0.0017	0.0285	0.2406
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0285	0.0297
Leishmania major	cathepsin L-like protease	0.0017	0.0285	0.0185
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0285	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0285	0.0204
Toxoplasma gondii	cathepsin CPL	0.0017	0.0285	0.0193
Echinococcus multilocularis	cysteine protease	0.0017	0.0285	0.0297
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0091	0.0094
Brugia malayi	GDP-L-fucose synthetase	0.0012	0.0101	0.0106
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1934	0.1934
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0285	0.0297
Trypanosoma brucei	NAD dependent epimerase/dehydratase family, putative	0.0012	0.0101	0.0101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0285	0.0297
Schistosoma mansoni	hypothetical protein	0.0016	0.0251	0.0261
Mycobacterium tuberculosis	Conserved protein	0.0012	0.0101	0.5
Mycobacterium ulcerans	hypothetical protein	0.0012	0.0101	0.5
Mycobacterium ulcerans	hypothetical protein	0.0012	0.0101	0.5
Onchocerca volvulus		0.0017	0.0285	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0285	0.0297
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2309	0.2406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0285	0.0297
Echinococcus granulosus	cathepsin l1	0.0017	0.0285	0.0297
Brugia malayi	acetyltransferase, GNAT family protein	0.0148	0.4748	0.4948
Entamoeba histolytica	acetyltransferase, GNAT family	0.004	0.1059	0.1104
Entamoeba histolytica	hypothetical protein	0.0037	0.0959	0.0999
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2309	0.2406
Echinococcus granulosus	CREB binding protein	0.0092	0.2849	0.2969
Echinococcus granulosus	GDP L fucose synthase	0.0012	0.0101	0.0106
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.0012	0.0101	0.0106
Mycobacterium tuberculosis	Possible dTDP-glucose 4,6-dehydratase	0.0012	0.0101	0.5
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.0285	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0285	0.0297
Mycobacterium tuberculosis	Possible oxidoreductase	0.0012	0.0101	0.5
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0091	0.0094
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0044	0.1183	0.1233
Brugia malayi	RNA binding protein	0.0076	0.2309	0.2406
Onchocerca volvulus		0.0012	0.0101	0.056
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1934	0.1934
Onchocerca volvulus		0.0017	0.0285	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0285	0.0297
Brugia malayi	hypothetical protein	0.0037	0.0959	0.0999
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.1445	0.1425
Mycobacterium ulcerans	UDP-glucose 4-epimerase	0.0012	0.0101	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0285	0.0297
Trypanosoma cruzi	UDP-galactose 4-epimerase	0.029	0.9596	1
Loa Loa (eye worm)	acetyltransferase	0.0148	0.4748	0.49
Mycobacterium leprae	conserved hypothetical protein	0.0012	0.0101	0.5
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0044	0.1183	1
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.2309	0.2406
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0892	0.093
Entamoeba histolytica	UDP-glucose 4-epimerase, putative	0.029	0.9596	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0285	0.0297
Mycobacterium ulcerans	oxidoreductase	0.0012	0.0101	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1934	0.1934
Mycobacterium tuberculosis	Probable UDP-glucose 4-epimerase GalE3 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase	0.0012	0.0101	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0959	0.0999
Mycobacterium ulcerans	nucleoside-diphosphate-sugar epimerase	0.0012	0.0101	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1934	0.1934
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0091	0.0094
Schistosoma mansoni	NAD dependent epimerase/dehydratase	0.0012	0.0101	0.0106
Brugia malayi	TAZ zinc finger family protein	0.0092	0.2849	0.2969
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0044	0.1183	0.1139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0285	0.0297
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.0012	0.0101	0.0106
Loa Loa (eye worm)	fibroinase	0.0017	0.0285	0.0204
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0285	0.0297
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.1212	0.1263
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0285	0.0297
Schistosoma mansoni	hypothetical protein	0.0037	0.0959	0.0999
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0285	0.0297
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0251	0.0261
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0285	0.0297
Loa Loa (eye worm)	UDP galactose 4'-epimerase	0.029	0.9596	1
Echinococcus granulosus	UDP glucose 4 epimerase	0.029	0.9596	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0285	0.0297
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.1212	0.1263
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1934	0.1934
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0285	0.0204
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.1445	0.1506
Echinococcus granulosus	cathepsin l1	0.0012	0.0091	0.0094
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0251	0.0261
Schistosoma mansoni	UDP-glucose 4-epimerase	0.029	0.9596	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0285	0.0297
Plasmodium vivax	vivapain-2	0.0017	0.0285	0.2406
Echinococcus granulosus	epimerase family protein sdr39u1	0.0012	0.0101	0.0106
Echinococcus granulosus	NADH dehydrogenase ubiquinone 1 alpha	0.0012	0.0101	0.0106
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0101	0.0106
Onchocerca volvulus		0.0017	0.0285	1
Onchocerca volvulus		0.0017	0.0285	1
Echinococcus granulosus	CREB binding protein	0.0092	0.2849	0.2969
Schistosoma mansoni	CREB-binding protein 1 (SmCBP1)	0.0092	0.2849	0.2969
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0285	0.0297
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0044	0.1183	0.1233
Trypanosoma cruzi	GDP-mannose 4,6 dehydratase, putative	0.0012	0.0101	0.0106
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.1934	0.2015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0285	0.0297
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0224	0.735	0.7637
Trypanosoma cruzi	hypothetical protein	0.0012	0.0101	0.0106
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.1059	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0144	0.4606	0.48
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0892	0.0843
Loa Loa (eye worm)	cysteine protease	0.0017	0.0285	0.0204
Entamoeba histolytica	hypothetical protein	0.0037	0.0959	0.0999
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0285	0.0204
Toxoplasma gondii	UDP-glucose 4-epimerase	0.029	0.9596	1
Wolbachia endosymbiont of Brugia malayi	nucleoside-diphosphate-sugar epimerase	0.0012	0.0101	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0101	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0101	0.0011
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.0285	0.2687
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0251	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1445	0.1425
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0285	0.0297
Entamoeba histolytica	hypothetical protein, conserved	0.0012	0.0101	0.0106
Onchocerca volvulus		0.0017	0.0285	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0091	0.0094
Loa Loa (eye worm)	ctsf protein	0.0017	0.0285	0.0204

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.3162 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1888141

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1587452