Detailed information for compound 1590296

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 367.4 | Formula: C16H25N5O5
  • H donors: 5 H acceptors: 7 LogP: -0.17 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H](Nc1ncnc2c1ncn2C1O[C@@H]([C@H]([C@H]1O)O)CO)CC(C)C
  • InChi: 1S/C16H25N5O5/c1-8(2)3-9(4-22)20-14-11-15(18-6-17-14)21(7-19-11)16-13(25)12(24)10(5-23)26-16/h6-10,12-13,16,22-25H,3-5H2,1-2H3,(H,17,18,20)/t9-,10+,12+,13+,16?/m0/s1
  • InChiKey: IFXXETIETNTLBL-NZSBSDKHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adenosine A1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 286 aa 26.9 %
Echinococcus granulosus allatostatin A receptor Adenosine A1 receptor   326 aa 303 aa 24.1 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 304 aa 21.1 %
Schistosoma mansoni dro/myosuppressin receptor Adenosine A1 receptor   326 aa 326 aa 22.1 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 306 aa 21.2 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Adenosine A1 receptor   326 aa 295 aa 28.1 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 300 aa 24.3 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 317 aa 24.6 %
Echinococcus multilocularis allatostatin A receptor Adenosine A1 receptor   326 aa 303 aa 24.1 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 323 aa 20.7 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.9 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 311 aa 21.2 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 305 aa 21.0 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A1 receptor   326 aa 315 aa 21.6 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Adenosine A1 receptor   326 aa 321 aa 22.7 %
Echinococcus multilocularis neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Echinococcus granulosus thyrotropin releasing hormone receptor Adenosine A1 receptor   326 aa 321 aa 23.1 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 274 aa 22.6 %
Echinococcus granulosus neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 327 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0396 0.3457 0.3438
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0166 0.1361 0.1338
Brugia malayi Cathepsin L-like precursor 0.0865 0.7732 0.7727
Giardia lamblia Pyruvate kinase 0.0033 0.0148 0.0578
Plasmodium falciparum serine repeat antigen 8 0.0166 0.1361 0.1338
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0166 0.1361 0.1731
Loa Loa (eye worm) hypothetical protein 0.0166 0.1361 0.1338
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.005 0.0022
Echinococcus multilocularis pyruvate kinase 0.0065 0.0438 0.0411
Onchocerca volvulus 0.0396 0.3457 0.3438
Plasmodium falciparum serine repeat antigen 7 0.0166 0.1361 0.1338
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0126 0.0099
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0036
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0396 0.3457 0.447
Brugia malayi Zinc finger, C2H2 type family protein 0.002 0.0027 0.0004
Schistosoma mansoni pyruvate kinase 0.0033 0.0148 0.0121
Echinococcus multilocularis cathepsin L cysteine protease 0.0865 0.7732 0.7726
Loa Loa (eye worm) hypothetical protein 0.0582 0.5149 0.5136
Entamoeba histolytica hypothetical protein 0.0042 0.0223 0.0254
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0166 0.1361 0.1338
Entamoeba histolytica hypothetical protein 0.0166 0.1361 0.1731
Leishmania major hypothetical protein, conserved 0.0396 0.3457 0.4451
Giardia lamblia Kinase, NEK 0.0022 0.0045 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Loa Loa (eye worm) sugar transporter 0.0101 0.0766 0.074
Brugia malayi RING zinc finger protein 0.002 0.0027 0.0004
Echinococcus multilocularis pyruvate kinase 0.0033 0.0148 0.0121
Giardia lamblia Cysteine protease 0.0166 0.1361 0.6372
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.013 0.0133
Onchocerca volvulus 0.0865 0.7732 0.7726
Schistosoma mansoni hypothetical protein 0.0396 0.3457 0.3438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0396 0.3457 0.4451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.045 0.3944 0.5083
Brugia malayi fibroinase precursor 0.0166 0.1361 0.1341
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0865 0.7732 0.7726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.1361 0.134
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.012 0.012
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0766 0.074
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.0766 0.074
Plasmodium falciparum serine repeat antigen 1 0.0166 0.1361 0.1338
Plasmodium vivax unspecified product 0.045 0.3944 0.3927
Brugia malayi B-box zinc finger family protein 0.002 0.0027 0.0004
Loa Loa (eye worm) hypothetical protein 0.0045 0.0258 0.0231
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.005 0.0022
Loa Loa (eye worm) ctsf protein 0.0865 0.7732 0.7726
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0166 0.1361 0.1338
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Schistosoma mansoni protein kinase 0.0031 0.0126 0.0099
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0865 0.7732 0.7727
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0396 0.3457 0.3438
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Loa Loa (eye worm) pyruvate kinase-PB 0.0045 0.0258 0.0231
Trypanosoma cruzi cysteine peptidase, putative 0.0865 0.7732 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0166 0.1361 0.1338
Brugia malayi Cam kinase protein 1 0.0031 0.0126 0.0103
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0396 0.3457 0.3441
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0223 0.0196
Entamoeba histolytica cysteine proteinase, putative 0.045 0.3944 0.5083
Entamoeba histolytica cysteine proteinase, putative 0.0582 0.5149 0.6648
Brugia malayi Papain family cysteine protease containing protein 0.0166 0.1361 0.1341
Trypanosoma cruzi cysteine peptidase, putative 0.045 0.3944 0.5101
Brugia malayi Papain family cysteine protease containing protein 0.0166 0.1361 0.1341
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0126 0.0099
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0036
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0438 0.0411
Entamoeba histolytica cysteine proteinase, putative 0.045 0.3944 0.5083
Schistosoma mansoni hypothetical protein 0.0042 0.0223 0.0196
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0166 0.1361 0.1731
Echinococcus granulosus cathepsin L 0.0166 0.1361 0.1338
Giardia lamblia Cathepsin B precursor 0.025 0.2121 1
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Plasmodium vivax pyruvate kinase, putative 0.0065 0.0438 0.0411
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0126 0.0099
Schistosoma mansoni hypothetical protein 0.0101 0.0766 0.074
Giardia lamblia Pyruvate kinase 0.0065 0.0438 0.1959
Schistosoma mansoni pyruvate kinase 0.0065 0.0438 0.0411
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0166 0.1361 0.134
Trypanosoma cruzi cysteine peptidase, putative 0.0865 0.7732 1
Schistosoma mansoni pyruvate kinase 0.0065 0.0438 0.0411
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0438 0.0411
Onchocerca volvulus Cathepsin L homolog 0.0865 0.7732 0.7726
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.045 0.3944 0.3927
Toxoplasma gondii ran binding protein 0.0396 0.3457 0.3438
Brugia malayi Cathepsin L-like precursor 0.0865 0.7732 0.7727
Giardia lamblia Hypothetical protein 0.0166 0.1361 0.6372
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Loa Loa (eye worm) hypothetical protein 0.003 0.012 0.0093
Echinococcus multilocularis General substrate transporter 0.0087 0.0636 0.061
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0126 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.005 0.0022
Schistosoma mansoni TRABID protein (C64 family) 0.0396 0.3457 0.3438
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0396 0.3457 0.447
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Giardia lamblia Cathepsin L precursor 0.0166 0.1361 0.6372
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0223 0.0196
Chlamydia trachomatis SWIB complex protein 0.1114 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.045 0.3944 0.5101
Plasmodium falciparum protein kinase 6 0.0429 0.3758 0.374
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0166 0.1361 0.1338
Plasmodium falciparum hexose transporter 0.0101 0.0766 0.074
Trichomonas vaginalis sugar transporter, putative 0.0031 0.013 0.0106
Trypanosoma cruzi cysteine peptidase, putative 0.0865 0.7732 1
Entamoeba histolytica hypothetical protein 0.0042 0.0223 0.0254
Toxoplasma gondii pyruvate kinase PyK1 0.0065 0.0438 0.0411
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0166 0.1361 0.134
Trichomonas vaginalis ion channel nompc, putative 0.002 0.0027 0.0003
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.002 0.0027 0.0003
Trypanosoma brucei pyruvate kinase 1, putative 0.0065 0.0438 0.0532
Echinococcus multilocularis cathepsin L 0.045 0.3944 0.3927
Echinococcus granulosus zinc finger protein Ran binding 0.0396 0.3457 0.3438
Brugia malayi cathepsin L-like precursor 0.0582 0.5149 0.5138
Plasmodium falciparum serine repeat antigen 9 0.0166 0.1361 0.1338
Brugia malayi brahma associated protein 60 kDa 0.1114 1 1
Echinococcus granulosus cathepsin b 0.0436 0.3817 0.38
Brugia malayi Cathepsin L-like cysteine proteinase 0.0582 0.5149 0.5138
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0396 0.3457 0.447
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Brugia malayi cathepsin F-like cysteine proteinase 0.0166 0.1361 0.1341
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0396 0.3457 0.3438
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0126 0.0099
Echinococcus granulosus cathepsin b 0.0436 0.3817 0.38
Trypanosoma brucei hypothetical protein, conserved 0.0396 0.3457 0.4451
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0126 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0031 0.013 0.0106
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0166 0.1361 0.1338
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trypanosoma cruzi major cysteine proteinase, putative 0.0166 0.1361 0.1761
Brugia malayi hypothetical protein 0.002 0.0027 0.0004
Brugia malayi Cathepsin L-like precursor 0.0283 0.2426 0.2409
Plasmodium vivax vivapain-1 0.045 0.3944 0.3927
Entamoeba histolytica cysteine proteinase, putative 0.0865 0.7732 1
Echinococcus granulosus pyruvate kinase 0.0033 0.0148 0.0121
Loa Loa (eye worm) fibroinase 0.0865 0.7732 0.7726
Giardia lamblia Cathepsin L-like protease 0.0166 0.1361 0.6372
Brugia malayi hypothetical protein 0.002 0.0027 0.0004
Echinococcus multilocularis pyruvate kinase 0.0051 0.0312 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Echinococcus granulosus General substrate transporter 0.0087 0.0636 0.061
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1114 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0166 0.1361 0.1761
Trichomonas vaginalis hypothetical protein 0.002 0.0027 0.0003
Brugia malayi Pyruvate kinase, M2 isozyme 0.0065 0.0438 0.0415
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.0766 0.074
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0166 0.1361 0.1338
Trypanosoma cruzi cruzipain precursor, putative 0.0865 0.7732 1
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0041
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0582 0.5149 0.666
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Giardia lamblia Cathepsin L precursor 0.0166 0.1361 0.6372
Leishmania major hypothetical protein, conserved 0.0396 0.3457 0.4451
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Echinococcus granulosus Zinc finger RanBP2 type 0.0396 0.3457 0.3438
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0126 0.0099
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Leishmania major cysteine peptidase A (CPA) 0.0865 0.7732 1
Giardia lamblia Cathepsin B precursor 0.0166 0.1361 0.6372
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0166 0.1361 0.1338
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0396 0.3457 0.3438
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0166 0.1361 0.6372
Loa Loa (eye worm) hypothetical protein 0.0283 0.2426 0.2406
Leishmania major pyruvate kinase 0.0065 0.0438 0.0532
Loa Loa (eye worm) hypothetical protein 0.0166 0.1361 0.1338
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Trypanosoma cruzi hexose transporter 0.0031 0.013 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0166 0.0215
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0036
Entamoeba histolytica hypothetical protein 0.0042 0.0223 0.0254
Toxoplasma gondii cathepsin CPC2 0.0166 0.1361 0.1338
Trypanosoma cruzi hypothetical protein 0.002 0.0027 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Brugia malayi Cathepsin L-like precursor 0.0865 0.7732 0.7727
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Echinococcus multilocularis cathepsin L 0.0166 0.1361 0.1338
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.045 0.3944 0.5101
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0166 0.1361 0.134
Onchocerca volvulus 0.0582 0.5149 0.5136
Giardia lamblia Cathepsin L precursor 0.0166 0.1361 0.6372
Echinococcus granulosus pyruvate kinase 0.0033 0.0148 0.0121
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0166 0.1361 0.1338
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0163 0.1334 0.131
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.0438 0.0414
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.012 0.0093
Brugia malayi Cathepsin L-like precursor 0.0865 0.7732 0.7727
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0126 0.0099
Onchocerca volvulus 0.0865 0.7732 0.7726
Leishmania major hypothetical protein, conserved 0.0396 0.3457 0.4451
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Giardia lamblia Cathepsin L precursor 0.0166 0.1361 0.6372
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0396 0.3457 0.447
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.002 0.0027 0.0003
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.002 0.0028 0.0036
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.002 0.0028 0.0036
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.005 0.0064
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0166 0.1361 0.1338
Loa Loa (eye worm) hypothetical protein 0.0396 0.3457 0.3438
Plasmodium falciparum serine repeat antigen 6 0.0166 0.1361 0.1338
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0126 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0436 0.3817 0.38
Mycobacterium ulcerans pyruvate kinase 0.0065 0.0438 1
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trichomonas vaginalis glucose transporter, putative 0.0031 0.013 0.0106
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.025 0.2121 0.2743
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0166 0.0139
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.012 0.0093
Schistosoma mansoni hypothetical protein 0.1114 1 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Onchocerca volvulus 0.0396 0.3457 0.3438
Loa Loa (eye worm) hypothetical protein 0.0166 0.1361 0.1338
Giardia lamblia Cathepsin L precursor 0.0166 0.1361 0.6372
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.002 0.0027 0.0003
Onchocerca volvulus Cathepsin F homolog 0.0865 0.7732 0.7726
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0166 0.1361 0.134
Plasmodium vivax vivapain-2 0.0865 0.7732 0.7726
Trypanosoma cruzi cysteine peptidase, putative 0.0283 0.2426 0.3138
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.1361 0.134
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.013 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.1361 0.134
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0166 0.1361 0.1338
Onchocerca volvulus 0.0396 0.3457 0.3438
Echinococcus granulosus cathepsin L cysteine proteinase 0.0865 0.7732 0.7726
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.002 0.0027 0.0003
Brugia malayi Cathepsin L-like precursor 0.0582 0.5149 0.5138
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0036
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.005 0.0022
Giardia lamblia Hypothetical protein 0.0166 0.1361 0.6372
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0438 0.0411
Brugia malayi hypothetical protein 0.0042 0.0223 0.02
Loa Loa (eye worm) hypothetical protein 0.0396 0.3457 0.3438
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0436 0.3817 0.38
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0438 0.0411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Schistosoma mansoni zinc finger protein 0.0396 0.3457 0.3438
Giardia lamblia Cysteine protease 0.0166 0.1361 0.6372
Brugia malayi hypothetical protein 0.002 0.0027 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.013 0.0106
Echinococcus multilocularis pyruvate kinase 0.0065 0.0438 0.0411
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.013 0.0133
Brugia malayi cathepsin F-like cysteine proteinase 0.0283 0.2426 0.2409
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0865 0.7732 0.7726
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.0438 0.0414
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0166 0.0139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Plasmodium vivax pyruvate kinase 2, putative 0.0033 0.0148 0.0121
Leishmania major pyruvate kinase 0.0065 0.0438 0.0532
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0166 0.1361 0.134
Onchocerca volvulus 0.0166 0.1361 0.1338
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Brugia malayi cathepsin Z-like cysteine proteinase 0.0166 0.1361 0.1341
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1114 1 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0166 0.1361 0.1338
Brugia malayi Papain family cysteine protease containing protein 0.045 0.3944 0.393
Giardia lamblia Cathepsin B precursor 0.0166 0.1361 0.6372
Loa Loa (eye worm) hypothetical protein 0.0065 0.0438 0.0411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Trypanosoma brucei pyruvate kinase 1 0.0065 0.0438 0.0532
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0766 0.0744
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0166 0.018
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0166 0.1361 0.6372
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0126 0.0099
Loa Loa (eye worm) hypothetical protein 0.0582 0.5149 0.5136
Entamoeba histolytica cysteine proteinase, putative 0.045 0.3944 0.5083
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0396 0.3457 0.447
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0126 0.0099
Loa Loa (eye worm) hypothetical protein 0.0283 0.2426 0.2406
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.005 0.0029
Echinococcus multilocularis cathepsin b 0.0436 0.3817 0.38
Loa Loa (eye worm) hypothetical protein 0.0023 0.005 0.0022
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0438 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Echinococcus multilocularis ring and YY1 binding protein 0.0396 0.3457 0.3438
Giardia lamblia Cathepsin B precursor 0.0166 0.1361 0.6372
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Trypanosoma cruzi hypothetical protein 0.002 0.0027 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0166 0.1361 0.134
Brugia malayi hypothetical protein 0.002 0.0027 0.0004
Giardia lamblia Cathepsin B precursor 0.0166 0.1361 0.6372
Brugia malayi Sugar transporter family protein 0.0101 0.0766 0.0744
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0396 0.3457 0.447
Loa Loa (eye worm) hypothetical protein 0.0865 0.7732 0.7726
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0166 0.1361 0.1338
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0166 0.1361 0.1338
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.012 0.0093
Loa Loa (eye worm) hypothetical protein 0.0166 0.1361 0.1338
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0166 0.1361 0.1338
Trypanosoma cruzi hypothetical protein, conserved 0.0396 0.3457 0.447
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0283 0.2426 0.2409
Plasmodium vivax serine-repeat antigen (SERA) 0.0166 0.1361 0.1338
Schistosoma mansoni cathepsin s 0.0283 0.2426 0.2406
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.0766 0.074
Brugia malayi lysyl-tRNA synthetase 0.0023 0.005 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Entamoeba histolytica cysteine protease, putative 0.0166 0.1361 0.1731
Onchocerca volvulus Cathepsin L homolog 0.0166 0.1361 0.1338
Giardia lamblia Cathepsin B precursor 0.0166 0.1361 0.6372
Trichomonas vaginalis conserved hypothetical protein 0.1114 1 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.1361 0.1338
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0109 0.0081
Schistosoma mansoni protein kinase 0.0031 0.0126 0.0099
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.012 0.0096
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Giardia lamblia Kinase 0.0022 0.0045 0.0084
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.0438 0.0566
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1114 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0436 0.3817 0.4937
Trypanosoma cruzi WLM domain containing protein, putative 0.0396 0.3457 0.447
Onchocerca volvulus 0.0865 0.7732 0.7726
Entamoeba histolytica hypothetical protein 0.0042 0.0223 0.0254
Plasmodium vivax unspecified product 0.0283 0.2426 0.2406
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0396 0.3457 0.3441
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Loa Loa (eye worm) brahma associated protein 0.1114 1 1
Echinococcus multilocularis pyruvate kinase 0.0033 0.0148 0.0121
Brugia malayi hypothetical protein 0.002 0.0027 0.0004
Echinococcus granulosus pyruvate kinase 0.0033 0.0148 0.0121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0126 0.0099
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0045 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Plasmodium vivax vivapain-3 0.045 0.3944 0.3927
Leishmania major glucose transporter, lmgt1 0.0031 0.013 0.0133
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0766 0.074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.005 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Plasmodium falciparum serine repeat antigen 4 0.0166 0.1361 0.1338
Loa Loa (eye worm) hypothetical protein 0.0283 0.2426 0.2406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.1361 0.134
Entamoeba histolytica pyruvate kinase, putative 0.0045 0.0258 0.0299
Trypanosoma brucei cysteine peptidase C (CPC) 0.025 0.2121 0.2717
Entamoeba histolytica cysteine protease, putative 0.0166 0.1361 0.1731
Onchocerca volvulus 0.0396 0.3457 0.3438
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trypanosoma cruzi cysteine protease, putative 0.045 0.3944 0.5101
Trypanosoma brucei glucose transporter 1E 0.0031 0.013 0.0133
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Echinococcus granulosus cathepsin L 0.045 0.3944 0.3927
Trypanosoma cruzi hexose transporter, putative 0.0031 0.013 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0582 0.5149 0.5138
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0865 0.7732 0.7726
Giardia lamblia Cysteine protease 0.0166 0.1361 0.6372
Entamoeba histolytica protein kinase, putative 0.0031 0.0126 0.0128
Giardia lamblia Cathepsin L-like protease 0.0166 0.1361 0.6372
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Onchocerca volvulus 0.0865 0.7732 0.7726
Echinococcus multilocularis SWI:SNF matrix associated 0.1114 1 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Loa Loa (eye worm) hypothetical protein 0.0396 0.3457 0.3438
Schistosoma mansoni RNA binding protein 0.0396 0.3457 0.3438
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.002 0.0027 0.0003
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0436 0.3817 0.3803
Schistosoma mansoni fusion 0.0396 0.3457 0.3438
Toxoplasma gondii cathepsin CPC1 0.0166 0.1361 0.1338
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0865 0.7732 0.7726
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Entamoeba histolytica cysteine protease, putative 0.0166 0.1361 0.1731
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.002 0.0027 0.0003
Trichomonas vaginalis ankyrin, putative 0.002 0.0027 0.0003
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1114 1 1
Echinococcus granulosus pyruvate kinase 0.0065 0.0438 0.0411
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0126 0.0099
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0126 0.0099
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Plasmodium falciparum pyruvate kinase 0.0065 0.0438 0.0411
Brugia malayi cathepsin Z-like cysteine proteinase 0.0166 0.1361 0.1341
Giardia lamblia Kinase, NEK 0.0022 0.0045 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0036
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.013 0.0133
Brugia malayi cathepsin L-like cysteine proteinase 0.0166 0.1361 0.1341
Plasmodium falciparum mitogen-activated protein kinase 2 0.0163 0.1334 0.131
Echinococcus multilocularis SWI:SNF matrix associated 0.1114 1 1
Brugia malayi hypothetical protein 0.002 0.0027 0.0004
Schistosoma mansoni brg-1 associated factor 0.1114 1 1
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.1361 0.134
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0865 0.7732 0.7726
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Trypanosoma cruzi hexose transporter, putative 0.0031 0.013 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Schistosoma mansoni glucose transport protein 0.0101 0.0766 0.074
Echinococcus granulosus cathepsin l cysteine peptidase 0.0865 0.7732 0.7726
Loa Loa (eye worm) cysteine protease 0.0865 0.7732 0.7726
Schistosoma mansoni glucose transport protein 0.0101 0.0766 0.074
Trichomonas vaginalis sugar transporter, putative 0.0031 0.013 0.0106
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0126 0.0099
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Plasmodium vivax hypothetical protein, conserved 0.1114 1 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0126 0.0103
Entamoeba histolytica cysteine proteinase, putative 0.0865 0.7732 1
Onchocerca volvulus 0.0865 0.7732 0.7726
Toxoplasma gondii cathepsin B 0.025 0.2121 0.2099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0166 0.0215
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0396 0.3457 0.3438
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0166 0.1361 0.1341
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.045 0.3944 0.3927
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0865 0.7732 0.7727
Trichomonas vaginalis ankyrin, putative 0.002 0.0027 0.0003
Brugia malayi cathepsin L precursor 0.0166 0.1361 0.1341
Giardia lamblia Cysteine protease 0.0166 0.1361 0.6372
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0166 0.1361 0.1338
Schistosoma mansoni cathepsin C 0.0166 0.1361 0.1338
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0166 0.1361 0.1338
Giardia lamblia Cathepsin B precursor 0.025 0.2121 1
Entamoeba histolytica cysteine proteinase 1, putative 0.045 0.3944 0.5083
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Brugia malayi Pyruvate kinase, muscle isozyme 0.0065 0.0438 0.0415
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.0766 0.074
Chlamydia trachomatis pyruvate kinase 0.0065 0.0438 0.039
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0396 0.3457 0.3438
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0126 0.0099
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trichomonas vaginalis glucose transporter, putative 0.0031 0.013 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.045 0.3944 0.393
Toxoplasma gondii protein kinase, putative 0.0286 0.2449 0.2428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0166 0.1361 0.1338
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0283 0.2426 0.2406
Chlamydia trachomatis DNA topoisomerase I 0.1114 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.1361 0.134
Echinococcus multilocularis cathepsin b 0.0436 0.3817 0.38
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0166 0.1361 0.6372
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Entamoeba histolytica cysteine protease, putative 0.0166 0.1361 0.1731
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.005 0.0022
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1114 1 1
Leishmania major hypothetical protein, conserved 0.0396 0.3457 0.4451
Onchocerca volvulus Cathepsin L homolog 0.0865 0.7732 0.7726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.045 0.3944 0.393
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.005 0.0029
Schistosoma mansoni hypothetical protein 0.1114 1 1
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.005 0.0105
Echinococcus multilocularis cysteine protease 0.0865 0.7732 0.7726
Plasmodium vivax hexose transporter 0.0101 0.0766 0.074
Brugia malayi YY1-associated factor 2 0.0396 0.3457 0.3441
Plasmodium falciparum serine repeat antigen 5 0.0166 0.1361 0.1338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.025 0.2121 0.2102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0166 0.1361 0.134
Echinococcus multilocularis cathepsin L cysteine protease 0.0865 0.7732 0.7726
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0166 0.1361 0.134
Brugia malayi Papain family cysteine protease containing protein 0.045 0.3944 0.393
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0109 0.0081
Echinococcus granulosus pyruvate kinase 0.0065 0.0438 0.0411
Echinococcus granulosus cathepsin l1 0.0865 0.7732 0.7726
Trichomonas vaginalis sex-determining protein fem-1, putative 0.002 0.0027 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0582 0.5149 0.5138
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.0438 0.0566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0166 0.1361 0.1338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.045 0.3944 0.5083
Trypanosoma cruzi hypothetical protein, conserved 0.0396 0.3457 0.447
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0223 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0166 0.1361 0.134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0436 0.3817 0.38
Plasmodium falciparum cysteine proteinase falcipain 1 0.045 0.3944 0.3927
Plasmodium falciparum cysteine proteinase falcipain 3 0.0865 0.7732 0.7726
Echinococcus granulosus cathepsin l1 0.0582 0.5149 0.5136
Plasmodium falciparum protein kinase 7 0.0286 0.2449 0.2428
Entamoeba histolytica cysteine protease, putative 0.0166 0.1361 0.1731
Schistosoma mansoni glucose transport protein 0.0101 0.0766 0.074
Brugia malayi Cathepsin L-like precursor 0.0582 0.5149 0.5138
Onchocerca volvulus 0.1114 1 1
Brugia malayi Zinc finger protein 183 homolog 0.002 0.0027 0.0004
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1114 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0166 0.1361 0.1338
Brugia malayi Neuralized family protein 0.002 0.0027 0.0004
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0396 0.3457 0.3441
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.012 0.0097
Brugia malayi RING finger protein 20 0.002 0.0027 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0396 0.3457 0.447
Toxoplasma gondii cathepsin CPL 0.0865 0.7732 0.7726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0126 0.0099
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.012 0.0097
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0126 0.0099
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0163 0.1334 0.131
Entamoeba histolytica cysteine proteinase, putative 0.045 0.3944 0.5083
Loa Loa (eye worm) hypothetical protein 0.0436 0.3817 0.38
Leishmania major glucose transporter, lmgt3 0.0031 0.013 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0126 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0036
Entamoeba histolytica cysteine proteinase 2 0.045 0.3944 0.5083
Trypanosoma cruzi cruzipain precursor, putative 0.0283 0.2426 0.3138
Onchocerca volvulus 0.0865 0.7732 0.7726
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.005 0.0022
Schistosoma mansoni cathepsin F (C01 family) 0.0865 0.7732 0.7726
Trypanosoma cruzi cysteine peptidase, putative 0.0865 0.7732 1
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.012 0.0443
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0166 0.018
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Giardia lamblia Cathepsin B precursor 0.025 0.2121 1
Entamoeba histolytica protein kinase, putative 0.0031 0.0126 0.0128
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0166 0.1361 0.1338
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0865 0.7732 0.7726
Loa Loa (eye worm) hypothetical protein 0.0582 0.5149 0.5136
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0166 0.1361 0.1338
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Echinococcus multilocularis cysteine protease 0.0865 0.7732 0.7726
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0166 0.1361 0.1338
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0065 0.0438 1
Brugia malayi Papain family cysteine protease containing protein 0.0166 0.1361 0.1341
Brugia malayi Cathepsin L-like precursor 0.0865 0.7732 0.7727
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0766 0.074
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.012 0.243
Leishmania major glucose transporter, lmgt2 0.0031 0.013 0.0133
Toxoplasma gondii pyruvate kinase PyKII 0.0033 0.0148 0.0121
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Schistosoma mansoni cathepsin B (C01 family) 0.0166 0.1361 0.1338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.1361 0.134
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Onchocerca volvulus 0.0865 0.7732 0.7726
Echinococcus multilocularis pyruvate kinase 0.0033 0.0148 0.0121
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0126 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0166 0.1361 0.134
Echinococcus multilocularis zinc finger protein Ran binding 0.0396 0.3457 0.3438
Schistosoma mansoni protein kinase 0.0031 0.0126 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0126 0.0099
Loa Loa (eye worm) cathepsin B 0.025 0.2121 0.2099
Brugia malayi Papain family cysteine protease containing protein 0.0865 0.7732 0.7727
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0166 0.1361 0.1338
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0396 0.3457 0.3441
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0099
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0126 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.013 0.0106
Plasmodium vivax serine-repeat antigen (SERA) 0.0166 0.1361 0.1338
Entamoeba histolytica hypothetical protein 0.0023 0.005 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.002 0.0027 0.0003
Trypanosoma cruzi hexose transporter, putative 0.0031 0.013 0.0168
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0126 0.0099
Leishmania major hypothetical protein, conserved 0.0396 0.3457 0.4451
Plasmodium vivax vivapain-2 0.0865 0.7732 0.7726
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.045 0.3944 0.3927
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0166 0.018
Loa Loa (eye worm) hypothetical protein 0.0396 0.3457 0.3438
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0166 0.1361 0.6372
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Echinococcus granulosus cysteine protease 0.045 0.3944 0.3927
Echinococcus granulosus SWI:SNF matrix associated 0.1114 1 1
Giardia lamblia Encystation-specific protease 0.0166 0.1361 0.6372
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0166 0.1361 0.134
Leishmania major protein kinase, putative 0.0031 0.0126 0.0128
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0166 0.1361 0.1338
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.002 0.0027 0.0003
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.012 0.0093
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.002 0.0027 0.0003
Trypanosoma cruzi cysteine proteinase, putative 0.045 0.3944 0.5101
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0436 0.3817 0.38
Brugia malayi Cathepsin L-like precursor 0.0865 0.7732 0.7727
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Loa Loa (eye worm) hypothetical protein 0.0166 0.1361 0.1338
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1114 1 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0166 0.1361 0.1338
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0126 0.0099
Brugia malayi SWIB/MDM2 domain containing protein 0.1114 1 1
Echinococcus multilocularis SWI:SNF matrix associated 0.1114 1 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1114 1 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0766 0.074
Plasmodium vivax unspecified product 0.0166 0.1361 0.1338
Schistosoma mansoni hypothetical protein 0.1114 1 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.025 0.2121 0.2717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0036
Echinococcus granulosus ring and YY1 binding protein 0.0396 0.3457 0.3438
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.025 0.2121 0.2099
Plasmodium falciparum serine repeat antigen 3 0.0166 0.1361 0.1338
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.1361 0.134
Mycobacterium leprae Probable pyruvate kinase PykA 0.0065 0.0438 1
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0438 0.0411
Plasmodium vivax CDK-related protein kinase 6, putative 0.0429 0.3758 0.374
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Schistosoma mansoni cathepsin S (C01 family) 0.0166 0.1361 0.1338
Giardia lamblia Cathepsin L precursor 0.0166 0.1361 0.6372
Plasmodium falciparum pyruvate kinase 2 0.0033 0.0148 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0166 0.0139
Schistosoma mansoni cathepsin F (C01 family) 0.0865 0.7732 0.7726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.005 0.0022
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0126 0.0099
Schistosoma mansoni cathepsin F (C01 family) 0.0582 0.5149 0.5136
Entamoeba histolytica cysteine protease, putative 0.0865 0.7732 1
Plasmodium falciparum serine repeat antigen 2 0.0166 0.1361 0.1338
Loa Loa (eye worm) hypothetical protein 0.003 0.012 0.0093
Entamoeba histolytica cysteine protease, putative 0.0166 0.1361 0.1731
Trichomonas vaginalis ankyrin, putative 0.002 0.0027 0.0003
Trypanosoma brucei glucose transporter 2A 0.0031 0.013 0.0133
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.0766 0.074
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.002 0.0027 0.0004
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.005 0.074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0396 0.3457 0.4451
Trypanosoma brucei hypothetical protein, conserved 0.0396 0.3457 0.4451
Echinococcus granulosus cathepsin L cysteine protease 0.045 0.3944 0.3927
Loa Loa (eye worm) hypothetical protein 0.0396 0.3457 0.3438
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036

Activities

Activity type Activity value Assay description Source Reference
Displacement (binding) < 10 % Displacement of [3H]-CGS- 21680 from Adenosine A2 receptor in rat striatal membranes at 10e-5 M ChEMBL. No reference
Ki (binding) = 139 nM Binding affinity at Adenosine A1 receptor in rat brain membranes by [3H]-(R)-PIA displacement. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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