TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 322.384 | Formula: C17H14N4OS
H donors: 1 H acceptors: 3 LogP: 3.72 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CNc1ncnc2c1c1ccn(c(=O)c1s2)c1ccc(cc1)C
InChi: 1S/C17H14N4OS/c1-10-3-5-11(6-4-10)21-8-7-12-13-15(18-2)19-9-20-16(13)23-14(12)17(21)22/h3-9H,1-2H3,(H,18,19,20)
InChiKey: ZUOKDHCWCLGJBQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutamate receptor, metabotropic 1	Starlite/ChEMBL	References
Rattus norvegicus	Metabotropic glutamate receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	ko:K04606 glutamate receptor, metabotropic 3, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	Metabotropic glutamate receptor precursor.	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	Metabotropic glutamate receptor precursor, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	Get druggable targets OG5_127095	All targets in OG5_127095

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.004	0.0185	0.0185
Brugia malayi	hypothetical protein	0.004	0.0185	0.0185
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.004	0.0185	0.0643
Echinococcus granulosus	hyperpolarization activated cyclic	0.004	0.0185	0.0185
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0185	0.0263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0066	0.3078
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0132	0.6145
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0185	0.0263
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.004	0.0185	0.0185
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.004	0.0185	0.0185
Schistosoma mansoni	mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3	0.0408	0.287	0.287
Schistosoma mansoni	vam6/vps39 related	0.0408	0.287	0.287
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0185	0.0263
Schistosoma mansoni	protein kinase	0.0413	0.2907	0.2907
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0044	0.0214	0.0305
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0111	0.0704	0.0704
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Brugia malayi	hypothetical protein	0.0408	0.287	0.287
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0214	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.004	0.0185	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.004	0.0185	0.0185
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0185	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0101	0.4722
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Giardia lamblia	GTOR	0.0044	0.0214	0.5
Schistosoma mansoni	transient receptor potential channel	0.004	0.0185	0.0185
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.004	0.0185	0.0185
Loa Loa (eye worm)	STE/STE20/MSN protein kinase	0.0976	0.7022	0.7047
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.004	0.0185	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Echinococcus granulosus	potassium voltage gated channel protein	0.004	0.0185	0.0185
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.004	0.0185	0.0185
Schistosoma mansoni	voltage-gated cation channel	0.004	0.0185	0.0185
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.0185	0.8612
Brugia malayi	TAR-binding protein	0.0062	0.0346	0.0346
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.004	0.0185	0.0643
Brugia malayi	voltage-dependent calcium channel	0.004	0.0185	0.0185
Echinococcus granulosus	voltage gated hydrogen channel 1	0.004	0.0185	0.0185
Echinococcus multilocularis	voltage dependent calcium channel	0.004	0.0185	0.0263
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0185	0.0185
Loa Loa (eye worm)	glutamate receptor	0.0098	0.0606	0.0608
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.004	0.0185	0.0185
Schistosoma mansoni	hypothetical protein	0.0408	0.287	0.287
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.004	0.0185	0.0185
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0035	0.0149	0.6934
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.004	0.0185	0.0185
Schistosoma mansoni	metabotropic glutamate receptor	0.0048	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Echinococcus multilocularis	sodium channel protein	0.004	0.0185	0.0263
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Echinococcus multilocularis	calcium activated potassium channel	0.0045	0.0221	0.0315
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Echinococcus granulosus	voltage gated potassium channel	0.004	0.0185	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0132	0.6145
Echinococcus multilocularis	short transient receptor potential channel 6	0.004	0.0185	0.0263
Echinococcus granulosus	microtubule associated protein 2	0.0678	0.4845	0.4862
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0413	0.2907	0.414
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.004	0.0185	0.0618
Onchocerca volvulus		0.0049	0.0247	0.0835
Brugia malayi	RNA binding protein	0.0062	0.0346	0.0346
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.004	0.0185	0.0185
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0346	0.0348
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0018	0.0026	0.009
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.004	0.0185	0.0185
Loa Loa (eye worm)	voltage-gated potassium channel	0.004	0.0185	0.0185
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.004	0.0185	0.0185
Echinococcus multilocularis	microtubule associated protein 2	0.0678	0.4845	0.69
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0044	0.0214	1
Loa Loa (eye worm)	hypothetical protein	0.0408	0.287	0.2881
Schistosoma mansoni	two-pore calcium channel	0.004	0.0185	0.0185
Onchocerca volvulus		0.004	0.0185	0.0618
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0214	1
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0089	0.0539	0.0539
Echinococcus granulosus	TRP transient receptor potential channel	0.004	0.0185	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0148	0.6922
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0346	0.0348
Echinococcus granulosus	potassium large conductance calcium activated	0.004	0.0185	0.0185
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0025	0.0075	0.0075
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0148	0.6922
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0016	0.0008	0.0008
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.0185	0.8612
Schistosoma mansoni	serine/threonine protein kinase	0.0413	0.2907	0.2907
Trypanosoma cruzi	target of rapamycin kinase 3	0.0035	0.0149	0.0518
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0148	0.6922
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Loa Loa (eye worm)	STE/STE20/KHS protein kinase	0.0413	0.2907	0.2917
Echinococcus granulosus	calcium activated potassium channel	0.0045	0.0221	0.0222
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.004	0.0185	0.0185
Echinococcus granulosus	GTPase activating Rap:RanGAP domain 3	0.0408	0.287	0.2881
Loa Loa (eye worm)	calcium channel	0.004	0.0185	0.0185
Echinococcus granulosus	potassium voltage gated channel protein	0.004	0.0185	0.0185
Schistosoma mansoni	microtubule-associated protein tau	0.0678	0.4845	0.4845
Echinococcus multilocularis	potassium voltage gated channel protein	0.004	0.0185	0.0263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0167	0.78
Schistosoma mansoni	calcium-activated potassium channel	0.004	0.0185	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0066	0.3078
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.004	0.0185	0.0185
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0082	0.049	0.0698
Echinococcus granulosus	shaker cognate	0.004	0.0185	0.0185
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Echinococcus multilocularis	GPCR, family 3, C terminal	0.0016	0.0008	0.0011
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Echinococcus granulosus	potassium voltage gated channel protein	0.004	0.0185	0.0185
Echinococcus multilocularis	ryanodine receptor 44f	0.004	0.0185	0.0263
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.004	0.0185	0.0263
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.004	0.0185	0.0185
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.004	0.0185	0.0185
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0185	0.0185
Schistosoma mansoni	transient receptor potential channel 4	0.004	0.0185	0.0185
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.004	0.0185	0.0263
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.004	0.0185	0.0185
Schistosoma mansoni	transient receptor potential channel	0.004	0.0185	0.0185
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.004	0.0185	0.0263
Toxoplasma gondii	transporter, cation channel family protein	0.004	0.0185	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Schistosoma mansoni	vesicular amine transporter	0.004	0.0185	0.0185
Echinococcus granulosus	voltage gated potassium channel	0.004	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Echinococcus multilocularis	sodium leak channel non selective protein	0.004	0.0185	0.0263
Echinococcus granulosus	metabotropic glutamate receptor 5	0.012	0.0771	0.0774
Brugia malayi	Protein kinase domain containing protein	0.0413	0.2907	0.2907
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0066	0.3066
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0044	0.0214	0.5
Trypanosoma cruzi	Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative	0.0408	0.287	1
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.004	0.0185	0.0185
Echinococcus multilocularis	voltage dependent calcium channel	0.004	0.0185	0.0263
Trypanosoma cruzi	Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative	0.0408	0.287	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0066	0.3078
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0066	0.3078
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.004	0.0185	0.0185
Leishmania major	hypothetical protein, unknown function	0.004	0.0185	0.8612
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.004	0.0185	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0132	0.6145
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Echinococcus granulosus	voltage dependent calcium channel	0.004	0.0185	0.0185
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0185	0.0263
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.004	0.0185	0.0185
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0346	0.0348
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.004	0.0185	0.0185
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.004	0.0185	0.0185
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.004	0.0185	0.0185
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.004	0.0185	0.0185
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0346	0.0346
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0185	0.0185
Echinococcus multilocularis	hyperpolarization activated cyclic	0.004	0.0185	0.0263
Echinococcus multilocularis	voltage gated potassium channel	0.004	0.0185	0.0263
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.012	0.0771	0.1098
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0083	0.3855
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.004	0.0185	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0148	0.6922
Brugia malayi	olfactory channel protein osm-9	0.004	0.0185	0.0185
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0044	0.0214	0.5
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.004	0.0185	0.0643
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0346	0.0346
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.004	0.0185	0.0185
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.004	0.0185	0.0185
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.004	0.0185	0.0185
Echinococcus multilocularis	tumor protein p63	0.0332	0.2317	0.33
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Echinococcus granulosus	two pore calcium channel protein 1	0.004	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0075	0.0075
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.004	0.0185	0.0185
Echinococcus granulosus	ryanodine receptor 44f	0.004	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Echinococcus granulosus	protein kinase	0.0976	0.7022	0.7047
Brugia malayi	MH2 domain containing protein	0.0117	0.0749	0.0749
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0082	0.049	0.0492
Schistosoma mansoni	voltage-gated ion channel	0.004	0.0185	0.0185
Schistosoma mansoni	transient receptor potential channel	0.004	0.0185	0.0185
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.004	0.0185	0.0185
Echinococcus multilocularis	GTPase activating Rap:RanGAP domain 3	0.0408	0.287	0.4088
Loa Loa (eye worm)	ryanodine receptor	0.004	0.0185	0.0185
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0044	0.0214	0.0747
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.004	0.0185	0.0263
Echinococcus granulosus	short transient receptor potential channel 6	0.004	0.0185	0.0185
Echinococcus granulosus	serine:threonine protein kinase mig 15	0.1379	0.9964	1
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0346	0.0348
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.004	0.0185	0.0263
Echinococcus multilocularis	voltage gated potassium channel	0.004	0.0185	0.0263
Echinococcus multilocularis	potassium voltage gated channel protein	0.004	0.0185	0.0263
Echinococcus granulosus	transient receptor potential gamma protein	0.004	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Echinococcus granulosus	sodium channel protein	0.004	0.0185	0.0185
Echinococcus multilocularis	two pore calcium channel protein 1	0.004	0.0185	0.0263
Brugia malayi	Transient-receptor-potential like protein	0.004	0.0185	0.0185
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.004	0.0185	0.0618
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0083	0.3855
Brugia malayi	Cyclic-nucleotide gated cation channel	0.004	0.0185	0.0185
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0346	0.0346
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.004	0.0185	0.0185
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.004	0.0185	0.0263
Echinococcus granulosus	GPCR family 3 C terminal	0.0016	0.0008	0.0008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0132	0.6145
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0413	0.2907	0.2917
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.004	0.0185	0.0185
Toxoplasma gondii	hypothetical protein	0.004	0.0185	1
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.004	0.0185	0.0185
Schistosoma mansoni	hypothetical protein	0.0016	0.0008	0.0008
Echinococcus multilocularis	conserved hypothetical protein	0.004	0.0185	0.0263
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.004	0.0185	0.0185
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0185	0.0185
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.004	0.0185	0.0185
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.004	0.0185	0.0185
Brugia malayi	ion channel NompC	0.004	0.0185	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0066	0.3066
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.004	0.0185	0.0263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0214	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0085	0.3945
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0185	0.0263
Echinococcus multilocularis	two pore calcium channel protein 2	0.004	0.0185	0.0263
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.004	0.0185	0.0185
Echinococcus multilocularis	transfer RNA-Gly	0.004	0.0185	0.0263
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0035	0.0149	0.0518
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.004	0.0185	0.0263
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Echinococcus granulosus	voltage dependent calcium channel	0.004	0.0185	0.0185
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.0749	0.0751
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.004	0.0185	0.0263
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0025	0.0075	0.0075
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0413	0.2907	0.414
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0148	0.6922
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.004	0.0185	0.0185
Trypanosoma brucei	Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative	0.0408	0.287	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.004	0.0185	0.0185
Echinococcus granulosus	two pore calcium channel protein 2	0.004	0.0185	0.0185
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.004	0.0185	0.0185
Echinococcus granulosus	sodium leak channel non selective protein	0.004	0.0185	0.0185
Brugia malayi	cation channel family protein	0.004	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Schistosoma mansoni	rap gtpase-activating protein	0.0408	0.287	0.287
Loa Loa (eye worm)	hypothetical protein	0.0408	0.287	0.2881
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.004	0.0185	0.0185
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0044	0.0214	0.0214
Onchocerca volvulus		0.0408	0.287	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0132	0.6145
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.004	0.0185	0.0185
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0021	0.0044	0.0155
Echinococcus multilocularis	transient receptor potential gamma protein	0.004	0.0185	0.0263
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.004	0.0185	0.0185
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.004	0.0185	0.0185
Toxoplasma gondii	transporter, cation channel family protein	0.004	0.0185	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0085	0.3945
Schistosoma mansoni	serine/threonine protein kinase	0.0413	0.2907	0.2907
Loa Loa (eye worm)	voltage-dependent calcium channel	0.004	0.0185	0.0185
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0044	0.0214	0.0747
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.004	0.0185	0.0185
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0214	0.0215
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0346	0.0346
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.004	0.0185	0.0185
Brugia malayi	metabotropic glutamate receptor type 2	0.0048	0.024	0.024
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.004	0.0185	0.0263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0108	0.5047
Schistosoma mansoni	protein kinase	0.0976	0.7022	0.7022
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0247	0.0248
Loa Loa (eye worm)	glutamate receptor	0.0038	0.0173	0.0173
Schistosoma mansoni	60S ribosomal protein L21	0.004	0.0185	0.0185
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.004	0.0185	0.0185
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0185	0.0185
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.004	0.0185	0.0263
Loa Loa (eye worm)	ion channel NompC	0.004	0.0185	0.0185
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.004	0.0185	0.0185
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.004	0.0185	0.0185
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.004	0.0185	0.0643
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.0749	0.0751
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0044	0.0214	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Echinococcus multilocularis	shaker cognate	0.004	0.0185	0.0263
Echinococcus granulosus	potassium voltage gated channel protein	0.004	0.0185	0.0185
Loa Loa (eye worm)	voltage-gated calcium channel	0.004	0.0185	0.0185
Brugia malayi	cation channel family protein	0.004	0.0185	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0132	0.6145
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0185	0.0263
Echinococcus granulosus	hypothetical protein	0.004	0.0185	0.0185
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0044	0.0214	0.0747
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0085	0.3945
Schistosoma mansoni	hypothetical protein	0.004	0.0185	0.0185
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0346	0.0346
Echinococcus multilocularis	potassium voltage gated channel protein	0.004	0.0185	0.0263
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Echinococcus granulosus	Vam6:Vps39 protein	0.0408	0.287	0.2881
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.004	0.0185	0.0263
Echinococcus granulosus	short transient receptor potential channel 6	0.004	0.0185	0.0185
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0413	0.2907	0.414
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Echinococcus multilocularis	potassium voltage gated channel protein	0.004	0.0185	0.0263
Loa Loa (eye worm)	hypothetical protein	0.012	0.0771	0.0774
Schistosoma mansoni	ryanodine receptor related	0.004	0.0185	0.0185
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.004	0.0185	0.0185
Toxoplasma gondii	transporter, cation channel family protein	0.004	0.0185	1
Toxoplasma gondii	hypothetical protein	0.004	0.0185	1
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0247	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0408	0.287	0.2881
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Leishmania major	hypothetical protein, conserved	0.004	0.0185	0.8612
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Echinococcus multilocularis	potassium large conductance calcium activated	0.004	0.0185	0.0263
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.004	0.0185	0.0263
Echinococcus multilocularis	short transient receptor potential channel 6	0.004	0.0185	0.0263
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0044	0.0214	0.0215
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0346	0.0346
Schistosoma mansoni	mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3	0.0408	0.287	0.287
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0413	0.2907	0.2917
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.004	0.0185	0.0185
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0214	0.0214
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0044	0.0214	0.0747
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0346	0.0493
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0066	0.3066
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0185
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.004	0.0185	0.8612
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0098	0.0606	0.0606
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0132	0.6145
Echinococcus multilocularis		0.0976	0.7022	1
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.004	0.0185	0.0263
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.004	0.0185	0.0263
Schistosoma mansoni	metabotropic glutamate receptor	0.0082	0.049	0.049
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0413	0.2907	0.2917
Echinococcus granulosus	potassium voltage gated channel protein	0.004	0.0185	0.0185
Echinococcus multilocularis	hyperpolarization activated cyclic	0.004	0.0185	0.0263
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0185	0.0185
Brugia malayi	Receptor family ligand binding region containing protein	0.0025	0.0075	0.0075
Echinococcus granulosus	hyperpolarization activated cyclic	0.004	0.0185	0.0185
Loa Loa (eye worm)	voltage-gated potassium channel	0.004	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.1379	0.9964	1
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.004	0.0185	0.0263
Brugia malayi	Temporarily assigned gene name protein 59	0.0408	0.287	0.287
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.004	0.0185	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0008	0.0008
Schistosoma mansoni	voltage-dependent calcium channel	0.004	0.0185	0.0185
Echinococcus granulosus	tumor protein p63	0.0332	0.2317	0.2325

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 31 nM	Antagonist activity at human metabotropic glutamate receptor 1	ChEMBL.	22266036
Ki (functional)	= 97 nM	Antagonist activity at rat metabotropic glutamate receptor 1	ChEMBL.	22266036

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1951888

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1614683