Detailed information for compound 1654455

Basic information

Technical information
  • TDR Targets ID: 1654455
  • Name: 1-(1-adamantyl)-3-[4-(2-morpholin-4-ylethoxy) phenyl]urea
  • MW: 399.526 | Formula: C23H33N3O3
  • H donors: 2 H acceptors: 1 LogP: 3.24 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC12CC3CC(C2)CC(C1)C3)Nc1ccc(cc1)OCCN1CCOCC1
  • InChi: 1S/C23H33N3O3/c27-22(25-23-14-17-11-18(15-23)13-19(12-17)16-23)24-20-1-3-21(4-2-20)29-10-7-26-5-8-28-9-6-26/h1-4,17-19H,5-16H2,(H2,24,25,27)
  • InChiKey: KBBPIMFKALETHC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(1-adamantyl)-3-[4-(2-morpholinoethoxy)phenyl]urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0318 0.3466 0.4322
Loa Loa (eye worm) hypothetical protein 0.0095 0.084 0.1067
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0177 0.1802 0.2218
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0177 0.1802 0.2218
Brugia malayi hypothetical protein 0.0082 0.0679 0.0739
Brugia malayi Protein kinase domain containing protein 0.0083 0.0692 0.0756
Echinococcus multilocularis expressed protein 0.0379 0.4186 0.5287
Loa Loa (eye worm) acetylcholine receptor protein 0.0082 0.0679 0.0858
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0067 0.0507 0.0507
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.027 0.0046
Schistosoma mansoni protein kinase 0.0053 0.0345 0.0345
Loa Loa (eye worm) GABA receptor subunit 0.0095 0.084 0.1067
Onchocerca volvulus 0.0082 0.0679 0.0739
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.0858
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.0858
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0095 0.084 0.0951
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0177 0.1802 0.2218
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.0858
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0078 0.0634 0.0533
Loa Loa (eye worm) hypothetical protein 0.0095 0.084 0.1067
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0263 0.0263
Onchocerca volvulus 0.032 0.349 0.4442
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0177 0.1802 0.2096
Entamoeba histolytica protein kinase, putative 0.0063 0.0458 0.0645
Loa Loa (eye worm) hypothetical protein 0.032 0.349 0.4513
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0177 0.1802 0.2096
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0118 0.0128
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0082 0.0679 0.0594
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0078 0.0634 0.0533
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0078 0.0634 0.0533
Schistosoma mansoni nAChR subunit 0.0177 0.1802 0.1802
Loa Loa (eye worm) hypothetical protein 0.0044 0.0236 0.0281
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.0858
Loa Loa (eye worm) hypothetical protein 0.0034 0.0118 0.0128
Loa Loa (eye worm) hypothetical protein 0.0044 0.0236 0.0281
Trichomonas vaginalis cyclins, putative 0.0044 0.0236 0.0543
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0603 0.6817 0.8841
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0177 0.1802 0.2318
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0286 0.3086 0.8327
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0177 0.1802 0.2096
Schistosoma mansoni nAChR subunit 0.0177 0.1802 0.1802
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.0858
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0318 0.3466 1
Echinococcus multilocularis glycine receptor subunit beta 0.0177 0.1802 0.2096
Loa Loa (eye worm) TK protein kinase 0.0063 0.0458 0.057
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0177 0.1802 0.1802
Echinococcus granulosus atrial natriuretic peptide receptor 0.0044 0.0238 0.0003
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0053 0.0345 0.0299
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0286 0.3086 0.5
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.0858
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0046 0.0263 0.0263
Echinococcus granulosus nAChR subunit 0.0177 0.1802 0.2096
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0082 0.0679 0.0858
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0082 0.0679 0.0594
Loa Loa (eye worm) hypothetical protein 0.0047 0.027 0.0326
Onchocerca volvulus 0.032 0.349 0.4442
Schistosoma mansoni nAChR subunit 0.0177 0.1802 0.1802
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0078 0.0634 0.0533
Mycobacterium ulcerans hypothetical protein 0.0337 0.3687 1
Echinococcus granulosus GPCR family 2 0.0047 0.027 0.0046
Schistosoma mansoni cyclin B 0.0044 0.0236 0.0236
Loa Loa (eye worm) TK/ROR protein kinase 0.0083 0.0692 0.0875
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0678 0.7708 1
Schistosoma mansoni hypothetical protein 0.0047 0.027 0.027
Loa Loa (eye worm) LGC-31 protein 0.0177 0.1802 0.2318
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0911 0.1044
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Schistosoma mansoni tyrosine kinase 0.0078 0.0634 0.0634
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.0858
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0678 0.7708 1
Trichomonas vaginalis cyclins, putative 0.0044 0.0236 0.0543
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0177 0.1802 0.1802
Echinococcus multilocularis glycine receptor subunit beta 0.0177 0.1802 0.2096
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Toxoplasma gondii peptidase family M13 protein 0.0092 0.0799 0.1975
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.0517 0.0647
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0286 0.3086 0.8327
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.027 0.02
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0177 0.1802 0.2218
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.0304
Leishmania major hypothetical protein, conserved 0.0079 0.0643 0.1261
Trichomonas vaginalis cyclins, putative 0.0044 0.0236 0.0543
Mycobacterium tuberculosis Conserved hypothetical protein 0.0337 0.3687 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Loa Loa (eye worm) hypothetical protein 0.0678 0.7708 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0799 0.1014
Schistosoma mansoni nAChR subunit 0.0177 0.1802 0.1802
Brugia malayi hypothetical protein 0.0082 0.0679 0.0739
Echinococcus granulosus tyrosine protein kinase Fyn 0.0078 0.0634 0.0533
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0177 0.1802 0.2218
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0678 0.7708 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0177 0.1802 0.2218
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0318 0.3466 1
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0082 0.0679 0.0858
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0177 0.1802 0.2096
Schistosoma mansoni memapsin-2 (A01 family) 0.0417 0.4626 0.4626
Entamoeba histolytica hypothetical protein 0.0095 0.084 0.1753
Toxoplasma gondii PAN domain-containing protein 0.0327 0.3565 1
Toxoplasma gondii PAN domain-containing protein 0.0327 0.3565 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.027 0.0046
Brugia malayi Cation transporter family protein 0.0177 0.1802 0.2218
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.027 0.0046
Loa Loa (eye worm) hypothetical protein 0.0034 0.0118 0.0128
Echinococcus granulosus glycine receptor subunit alpha 1 0.0177 0.1802 0.2096
Echinococcus granulosus tyrosine kinase 0.007 0.0547 0.0417
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Mycobacterium ulcerans hypothetical protein 0.0337 0.3687 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0078 0.0634 0.0533
Trichomonas vaginalis cyclin B, putative 0.0044 0.0236 0.0543
Echinococcus granulosus tyrosine protein kinase Fyn 0.0078 0.0634 0.0533
Onchocerca volvulus 0.0044 0.0236 0.0154
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0177 0.1802 0.2218
Echinococcus multilocularis tissue type plasminogen activator 0.0079 0.0643 0.0545
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0095 0.084 0.084
Trichomonas vaginalis cyclin A, putative 0.0044 0.0236 0.0543
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0177 0.1802 0.2218
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0177 0.1802 0.2218
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.1463 0.1772
Brugia malayi Cation transporter family protein 0.0177 0.1802 0.2218
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0078 0.0634 0.0533
Schistosoma mansoni tyrosine kinase 0.0078 0.0634 0.0634
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0678 0.7708 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0177 0.1802 0.2218
Echinococcus multilocularis tyrosine protein kinase Srms 0.007 0.0547 0.0417
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.027 0.0326
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.0858
Loa Loa (eye worm) hypothetical protein 0.0069 0.0536 0.0671
Echinococcus multilocularis receptor type guanylyl cyclase 0.0053 0.0345 0.0147
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0092 0.0799 0.0897
Echinococcus multilocularis tyrosine protein kinase Fyn 0.007 0.0547 0.0417
Giardia lamblia G2/mitotic-specific cyclin B 0.0044 0.0236 0.5
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0318 0.3466 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0078 0.0634 0.0533
Echinococcus granulosus endothelin converting enzyme 1 0.0092 0.0799 0.0754
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0177 0.1802 0.2218
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0678 0.7708 1
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0286 0.3086 0.8327
Loa Loa (eye worm) hypothetical protein 0.0095 0.084 0.1067
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0092 0.0799 0.1956
Onchocerca volvulus Putative nachr subunit 0.0678 0.7708 1
Onchocerca volvulus 0.0095 0.084 0.0951
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0082 0.0679 0.0739
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0078 0.0634 0.0533
Brugia malayi Cation transporter family protein 0.032 0.349 0.4442
Schistosoma mansoni acetylcholine receptor-related 0.0082 0.0679 0.0679
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0177 0.1802 0.2218
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0177 0.1802 0.2096
Echinococcus multilocularis nAChR subunit 0.0177 0.1802 0.2096
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.032 0.349 0.349
Entamoeba histolytica hypothetical protein, conserved 0.0337 0.3687 1
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0082 0.0679 0.0739
Echinococcus granulosus glycine receptor subunit alpha 1 0.0177 0.1802 0.2096
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0177 0.1802 0.2096
Onchocerca volvulus 0.0177 0.1802 0.2218
Loa Loa (eye worm) hypothetical protein 0.0095 0.084 0.1067
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0318 0.3466 0.4322
Echinococcus granulosus tissue type plasminogen activator 0.0079 0.0643 0.0545
Loa Loa (eye worm) hypothetical protein 0.0095 0.084 0.1067
Echinococcus granulosus tyrosine protein kinase Src42A 0.0066 0.0498 0.0351
Loa Loa (eye worm) hypothetical protein 0.0034 0.0118 0.0128
Schistosoma mansoni hypothetical protein 0.0079 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.0095 0.084 0.1067
Echinococcus granulosus receptor type guanylyl cyclase 0.0053 0.0345 0.0147
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0318 0.3466 0.9711
Loa Loa (eye worm) hypothetical protein 0.0095 0.084 0.1067
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0678 0.7708 1
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0082 0.0679 0.0739
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.0858
Schistosoma mansoni hypothetical protein 0.0047 0.027 0.027
Loa Loa (eye worm) RGC/RGC protein kinase 0.0053 0.0345 0.0423
Brugia malayi Cyclin, N-terminal domain containing protein 0.0044 0.0236 0.0154
Schistosoma mansoni nAChR subunit 0.0177 0.1802 0.1802
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0118 0.0128
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0678 0.7708 1
Echinococcus multilocularis nAChR subunit 0.0095 0.084 0.0809
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0082 0.0679 0.0594
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0177 0.1802 0.2318
Loa Loa (eye worm) TK protein kinase 0.007 0.0547 0.0686
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0095 0.084 0.0951
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0318 0.3466 0.4482
Brugia malayi hypothetical protein 0.0082 0.0679 0.0739
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.0858
Echinococcus multilocularis GPCR, family 2 0.0047 0.027 0.0046
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0088 0.0751 0.1596
Schistosoma mansoni neurotransmitter gated ion channel 0.0095 0.084 0.084
Onchocerca volvulus 0.0177 0.1802 0.2218
Loa Loa (eye worm) hypothetical protein 0.0068 0.0517 0.0647
Trichomonas vaginalis cyclin B, putative 0.0044 0.0236 0.0543
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0177 0.1802 0.2096
Onchocerca volvulus 0.032 0.349 0.4442
Loa Loa (eye worm) hypothetical protein 0.0069 0.0536 0.0671
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0318 0.3466 0.5
Echinococcus granulosus glycine receptor subunit alpha 1 0.0177 0.1802 0.2096
Echinococcus granulosus glycine receptor subunit beta 0.0177 0.1802 0.2096
Schistosoma mansoni nAChR subunit 0.0082 0.0679 0.0679
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0177 0.1802 0.2096
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0177 0.1802 0.1802
Echinococcus granulosus tyrosine protein kinase Fyn 0.0078 0.0634 0.0533
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0118 0.0128
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0512 0.5748 0.745
Schistosoma mansoni neurotransmitter gated ion channel 0.0082 0.0679 0.0679
Brugia malayi SRC-1 0.0078 0.0634 0.0679
Echinococcus multilocularis tyrosine protein kinase HCK 0.0063 0.0458 0.0298
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0082 0.0679 0.0594
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.027 0.0046
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0318 0.3466 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0512 0.5748 0.7417
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0082 0.0679 0.0739
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0078 0.0634 0.0533
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0177 0.1802 0.2318
Echinococcus multilocularis tyrosine protein kinase Blk 0.007 0.0547 0.0417
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0078 0.0634 0.0533
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.007 0.0547 0.0417
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.0517 0.0647
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0177 0.1802 0.1802
Onchocerca volvulus 0.0095 0.084 0.0951
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0092 0.0799 0.0799
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0177 0.1802 0.2096
Echinococcus multilocularis endothelin converting enzyme 1 0.0092 0.0799 0.0754
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0177 0.1802 0.2218
Schistosoma mansoni hypothetical protein 0.0101 0.0911 0.0911
Loa Loa (eye worm) hypothetical protein 0.0239 0.2528 0.3263
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0082 0.0679 0.0739
Loa Loa (eye worm) hypothetical protein 0.032 0.349 0.4513
Brugia malayi Peptidase family M13 containing protein 0.0092 0.0799 0.0897
Brugia malayi Kringle domain containing protein 0.0079 0.0643 0.0691
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0118 0.0128
Onchocerca volvulus 0.0177 0.1802 0.2218
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0177 0.1802 0.2318
Mycobacterium ulcerans adenylylate/guanylate cyclase 0.004 0.0185 0.0245
Mycobacterium leprae probable zinc metalloprotease 0.0092 0.0799 0.1956
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.0858
Loa Loa (eye worm) SRC-1 0.0078 0.0634 0.0799
Loa Loa (eye worm) hypothetical protein 0.0069 0.0536 0.0671
Brugia malayi Latrophilin receptor protein 2 0.0047 0.027 0.02
Brugia malayi Receptor family ligand binding region containing protein 0.0053 0.0345 0.0299
Echinococcus granulosus tyrosine protein kinase Blk 0.007 0.0547 0.0417
Loa Loa (eye worm) ACC-1 protein 0.0177 0.1802 0.2318
Schistosoma mansoni nAChR subunit 0.0177 0.1802 0.1802
Loa Loa (eye worm) ACC-1 protein 0.0177 0.1802 0.2318
Loa Loa (eye worm) hypothetical protein 0.0034 0.0118 0.0128
Loa Loa (eye worm) hypothetical protein 0.0092 0.0799 0.1014
Loa Loa (eye worm) hypothetical protein 0.0148 0.1463 0.1877
Schistosoma mansoni hypothetical protein 0.0047 0.027 0.027
Echinococcus granulosus tyrosine protein kinase HCK 0.0063 0.0458 0.0298
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.0858
Loa Loa (eye worm) hypothetical protein 0.0092 0.0799 0.1014
Echinococcus granulosus tyrosine protein kinase Src42A 0.0078 0.0634 0.0533
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0078 0.0634 0.0533
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.0858
Echinococcus granulosus expressed protein 0.0379 0.4186 0.5287
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0044 0.0238 0.0003
Brugia malayi hypothetical protein 0.0082 0.0679 0.0739
Loa Loa (eye worm) RGC/RGC protein kinase 0.0053 0.0345 0.0423
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.0858
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.032 0.349 0.349
Loa Loa (eye worm) hypothetical protein 0.0069 0.0536 0.0671
Trichomonas vaginalis cyclin B, putative 0.0044 0.0236 0.0543
Brugia malayi Angiotensin-converting enzyme family protein 0.0603 0.6817 0.8826
Loa Loa (eye worm) hypothetical protein 0.0034 0.0118 0.0128
Mycobacterium tuberculosis Conserved protein 0.0337 0.3687 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0177 0.1802 0.2096
Echinococcus granulosus tyrosine protein kinase Lyn 0.0078 0.0634 0.0533
Loa Loa (eye worm) hypothetical protein 0.0068 0.0517 0.0647
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0082 0.0679 0.0594
Onchocerca volvulus 0.0082 0.0679 0.0739
Schistosoma mansoni neurotransmitter gated ion channel 0.0082 0.0679 0.0679
Trichomonas vaginalis cyclin B, putative 0.0044 0.0236 0.0543
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0095 0.084 0.0951
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0318 0.3466 1
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0046 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0069 0.0536 0.0671
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0177 0.1802 0.2096
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0078 0.0634 0.0533
Trichomonas vaginalis cyclins, putative 0.0044 0.0236 0.0543
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0318 0.3466 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0118 0.0128
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Loa Loa (eye worm) hypothetical protein 0.0034 0.0118 0.0128
Schistosoma mansoni acetylcholine receptor subunit beta 0.0082 0.0679 0.0679
Loa Loa (eye worm) hypothetical protein 0.0068 0.0517 0.0647
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0318 0.3466 0.3466
Schistosoma mansoni nAChR subunit 0.0082 0.0679 0.0679
Toxoplasma gondii kringle domain-containing protein 0.0079 0.0643 0.1522
Loa Loa (eye worm) hypothetical protein 0.0082 0.0679 0.0858
Echinococcus granulosus glycine receptor subunit beta 0.0177 0.1802 0.2096
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0103 0.0929 0.2317
Brugia malayi protein-tyrosine kinase 0.007 0.0547 0.0565
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0177 0.1802 0.2218
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0177 0.1802 0.2218
Loa Loa (eye worm) hypothetical protein 0.0068 0.0517 0.0647
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0082 0.0679 0.0739
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0643 0.1261
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Schistosoma mansoni nAChR subunit 0.0177 0.1802 0.1802
Brugia malayi Cyclin, N-terminal domain containing protein 0.0044 0.0236 0.0154
Mycobacterium ulcerans zinc metalloprotease 0.0092 0.0799 0.1956
Loa Loa (eye worm) hypothetical protein 0.0095 0.084 0.1067
Loa Loa (eye worm) hypothetical protein 0.0101 0.0911 0.1159
Brugia malayi excitatory GABA receptor EXP-1A 0.0177 0.1802 0.2218
Loa Loa (eye worm) hypothetical protein 0.0069 0.0536 0.0671
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0118 0.0128
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0177 0.1802 0.2096
Loa Loa (eye worm) hypothetical protein 0.0079 0.0643 0.0811
Echinococcus granulosus nAChR subunit 0.0095 0.084 0.0809
Schistosoma mansoni neprilysin-2 (M13 family) 0.0046 0.0263 0.0263
Brugia malayi hypothetical protein 0.0082 0.0679 0.0739
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0286 0.3086 1
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0318 0.3466 0.441
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0678 0.7708 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Onchocerca volvulus 0.0082 0.0679 0.0739
Onchocerca volvulus 0.0045 0.0254 0.0178
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0177 0.1802 0.2318
Schistosoma mansoni serine-type protease inhibitor 0.0873 1 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0095 0.084 0.084
Schistosoma mansoni hypothetical protein 0.0047 0.027 0.027
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0095 0.084 0.0951
Loa Loa (eye worm) hypothetical protein 0.0177 0.1802 0.2318
Mycobacterium leprae conserved hypothetical protein 0.0337 0.3687 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0066 0.0498 0.0351
Onchocerca volvulus 0.0079 0.0643 0.0691

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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