Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0088 | 0.0473 | 0.0094 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0127 | 0.1385 | 0.115 |
Plasmodium falciparum | conserved protein, unknown function | 0.0127 | 0.1385 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0489 | 0.991 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.0088 | 0.0473 | 0.0094 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0381 | 0.7373 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1385 | 0.1385 |
Brugia malayi | Protein kinase domain containing protein | 0.0102 | 0.0797 | 0.0539 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.0088 | 0.0473 | 0.0275 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0127 | 0.1385 | 0.1052 |
Echinococcus granulosus | dual specificity | 0.0381 | 0.7373 | 0.7337 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0381 | 0.7373 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0102 | 0.0797 | 0.047 |
Onchocerca volvulus | Putative endochitinase | 0.009 | 0.0505 | 0.2052 |
Echinococcus multilocularis | dual specificity | 0.0381 | 0.7373 | 0.7337 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0381 | 0.7373 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0381 | 0.7373 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.009 | 0.0505 | 0.2052 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0489 | 0.991 | 1 |
Echinococcus granulosus | dual specificity | 0.0102 | 0.0797 | 0.0435 |
Entamoeba histolytica | protein kinase, putative | 0.0102 | 0.0797 | 0.0732 |
Echinococcus granulosus | dual specificity | 0.0381 | 0.7373 | 0.7337 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0102 | 0.0797 | 0.047 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0489 | 0.991 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0088 | 0.0473 | 0.0094 |
Echinococcus multilocularis | dual specificity | 0.0381 | 0.7373 | 0.7337 |
Echinococcus multilocularis | dual specificity | 0.0381 | 0.7373 | 0.7337 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0489 | 0.991 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.009 | 0.0505 | 0.2052 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0268 | 0.4706 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0102 | 0.0797 | 0.0732 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.0088 | 0.0473 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0707 | 0.0707 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0127 | 0.1385 | 0.1052 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0102 | 0.0797 | 0.0797 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1385 | 0.1385 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0088 | 0.0473 | 0.0094 |
Loa Loa (eye worm) | CMGC/CDK/CRK7 protein kinase | 0.0088 | 0.0473 | 0.0473 |
Schistosoma mansoni | protein kinase | 0.0088 | 0.0473 | 0.0094 |
Entamoeba histolytica | hypothetical protein | 0.0102 | 0.0797 | 0.0732 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0102 | 0.0797 | 0.047 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0381 | 0.7373 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0085 | 0.0383 | 0.0148 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0288 | 0.5184 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0088 | 0.0473 | 0.0275 |
Loa Loa (eye worm) | chitinase I | 0.008 | 0.0278 | 0.0278 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0088 | 0.0473 | 0.0202 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0381 | 0.7373 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0381 | 0.7373 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0489 | 0.991 | 1 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0088 | 0.0473 | 0.0094 |
Brugia malayi | Protein kinase domain containing protein | 0.0088 | 0.0473 | 0.0202 |
Brugia malayi | GSG2 | 0.0489 | 0.991 | 1 |
Onchocerca volvulus | 0.0127 | 0.1385 | 1 | |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0088 | 0.0473 | 0.0094 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0088 | 0.0473 | 0.0094 |
Brugia malayi | endochitinase | 0.009 | 0.0505 | 0.0236 |
Brugia malayi | hypothetical protein | 0.0489 | 0.991 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0102 | 0.0797 | 0.0435 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0381 | 0.7373 | 1 |
Brugia malayi | Cell division protein kinase 2 | 0.0088 | 0.0473 | 0.0202 |
Loa Loa (eye worm) | haspin protein kinase | 0.0489 | 0.991 | 0.991 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0381 | 0.7373 | 0.7373 |
Loa Loa (eye worm) | haspin protein kinase | 0.0489 | 0.991 | 0.991 |
Schistosoma mansoni | hypothetical protein | 0.0489 | 0.991 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0088 | 0.0473 | 0.0094 |
Loa Loa (eye worm) | cuticular endochitinase | 0.008 | 0.0278 | 0.0278 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0088 | 0.0473 | 0.0275 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0381 | 0.7373 | 0.7366 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0381 | 0.7373 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.1385 | 0.1052 |
Echinococcus multilocularis | dual specificity | 0.0102 | 0.0797 | 0.0435 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0381 | 0.7373 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0381 | 0.7373 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0288 | 0.5184 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0127 | 0.1385 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0102 | 0.0797 | 0.0732 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0381 | 0.7373 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0381 | 0.7373 | 0.7337 |
Echinococcus granulosus | dual specificity | 0.0381 | 0.7373 | 0.7337 |
Onchocerca volvulus | 0.0127 | 0.1385 | 1 | |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0102 | 0.0797 | 0.0732 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0381 | 0.7373 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0707 | 0.0707 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0088 | 0.0473 | 0.0094 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0078 | 0.0227 | 0.0227 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0088 | 0.0473 | 0.0473 |
Brugia malayi | Endochitinase | 0.009 | 0.0505 | 0.0236 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0.142 uM | Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) | ChEMBL. | 12086483 |
Activity (binding) | = 0.142 uM | Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) | ChEMBL. | 12086483 |
GI50 (functional) | -4.885 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.857 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.837 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.822 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.814 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.762 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.762 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.723 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.705 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.506 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.