Detailed information for compound 169511

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 372.458 | Formula: C21H28N2O4
  • H donors: 0 H acceptors: 2 LogP: 2.85 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H]1CCC2C34[C@H]1CCC(OO3)(OC4N(C(=O)[C@@H]2C)Cc1ccccn1)C
  • InChi: 1S/C21H28N2O4/c1-13-7-8-17-14(2)18(24)23(12-15-6-4-5-11-22-15)19-21(17)16(13)9-10-20(3,25-19)26-27-21/h4-6,11,13-14,16-17,19H,7-10,12H2,1-3H3/t13-,14-,16+,17?,19?,20?,21?/m1/s1
  • InChiKey: VUFWDQIDRMHCAU-IQVJKHCNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Onchocerca volvulus 0.0064 0.0101 0.043
Brugia malayi hypothetical protein 0.0064 0.0101 0.0095
Loa Loa (eye worm) RGC/RGC protein kinase 0.0076 0.0162 0.017
Loa Loa (eye worm) hypothetical protein 0.0428 0.1834 0.2217
Loa Loa (eye worm) hypothetical protein 0.02 0.0748 0.0888
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0053
Schistosoma mansoni nAChR subunit 0.0122 0.038 0.0596
Echinococcus multilocularis neuropeptide receptor A26 0.0064 0.0101 0.0078
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.042 0.1796 0.5518
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0193 0.0717 0.0696
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0056 0.0066 0.0066
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.038 0.0437
Echinococcus granulosus expressed protein 0.0362 0.1522 0.1522
Onchocerca volvulus 0.0122 0.038 0.197
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0066 0.0111 0.0108
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0064 0.0101 0.013
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0053
Schistosoma mansoni integrin alpha-ps 0.0155 0.0534 0.0854
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.0101 0.013
Brugia malayi neuropeptide F receptor 0.0064 0.0101 0.0095
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0064 0.0101 0.013
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.042 0.1796 0.5185
Brugia malayi putative neuropeptide receptor 0.0064 0.0101 0.0095
Schistosoma mansoni amine GPCR 0.0064 0.0101 0.013
Echinococcus multilocularis protein patched 0.0173 0.062 0.0599
Schistosoma mansoni biogenic amine receptor 0.0064 0.0101 0.013
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0722 0.3237 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0064 0.0101 0.0101
Echinococcus granulosus Protein patched homolog 1 0.0173 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0155 0.0534 0.0625
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0722 0.3237 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Brugia malayi larval opioid receptor 0.0064 0.0101 0.0095
Brugia malayi Cation transporter family protein 0.02 0.0748 0.0888
Loa Loa (eye worm) latrophilin receptor protein 2 0.0193 0.0717 0.085
Loa Loa (eye worm) hypothetical protein 0.0066 0.0111 0.0108
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Brugia malayi excitatory GABA receptor EXP-1A 0.0122 0.038 0.0437
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.0101 0.0101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0101 0.013
Echinococcus multilocularis nAChR subunit 0.0122 0.038 0.0358
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Schistosoma mansoni hypothetical protein 0.0064 0.0101 0.013
Loa Loa (eye worm) ACC-1 protein 0.0122 0.038 0.0437
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0147 0.0498 0.0582
Echinococcus granulosus integrin alpha 3 0.0086 0.0205 0.0205
Echinococcus multilocularis protein jagged 2 0.0066 0.0113 0.009
Echinococcus multilocularis sterol regulatory element binding protein 0.0173 0.062 0.0599
Schistosoma mansoni nAChR subunit 0.0122 0.038 0.0596
Echinococcus multilocularis GPCR, family 2 0.0193 0.0717 0.0696
Plasmodium vivax RNA helicase-1, putative 0.0101 0.0277 0.0856
Trichomonas vaginalis cyclin B, putative 0.0094 0.0245 0.0879
Loa Loa (eye worm) hypothetical protein 0.0055 0.0058 0.0044
Loa Loa (eye worm) hypothetical protein 0.0066 0.0111 0.0108
Onchocerca volvulus 0.0064 0.0101 0.043
Echinococcus multilocularis glycine receptor subunit beta 0.0122 0.038 0.0358
Brugia malayi EGF-like domain containing protein 0.0066 0.0113 0.011
Echinococcus granulosus fibrillin 2 0.0066 0.0113 0.0113
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0627 0.2781 1
Trichomonas vaginalis cyclins, putative 0.0094 0.0245 0.0879
Echinococcus granulosus neuropeptide receptor A26 0.0064 0.0101 0.0101
Echinococcus granulosus neuropeptide s receptor 0.0064 0.0101 0.0101
Echinococcus multilocularis kelch ECH associated protein 1 0.0762 0.3424 0.3409
Onchocerca volvulus Neuropeptide F receptor homolog 0.0064 0.0101 0.043
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0122 0.038 0.0437
Echinococcus multilocularis cyclin B 0.0094 0.0245 0.0222
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0041 0.0031
Plasmodium falciparum plasmepsin I 0.0051 0.0041 0.0058
Brugia malayi G-protein coupled receptor 0.0064 0.0101 0.0095
Brugia malayi hypothetical protein 0.0064 0.0101 0.0095
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0122 0.038 0.0596
Brugia malayi Dopamine receptor 0.0064 0.0101 0.0095
Brugia malayi hypothetical protein 0.0183 0.0669 0.079
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0064 0.0101 0.013
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0082 0.0188 0.0188
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0101 0.0277 0.0277
Schistosoma mansoni hypothetical protein 0.0193 0.0717 0.116
Brugia malayi G protein-coupled receptor 0.0064 0.0101 0.0095
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0064 0.0101 0.013
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0056 0.0066 0.0066
Loa Loa (eye worm) acetyltransferase 0.0145 0.0486 0.0567
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0053
Loa Loa (eye worm) integrin beta-2 0.1763 0.8195 1
Onchocerca volvulus 0.0064 0.0101 0.043
Schistosoma mansoni neuropeptide receptor 0.0064 0.0101 0.013
Echinococcus granulosus neuropeptide receptor 0.0064 0.0101 0.0101
Brugia malayi RE15519p 0.0064 0.0101 0.0095
Schistosoma mansoni nAChR subunit 0.0122 0.038 0.0596
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.042 0.1796 0.5518
Leishmania major cyclin 0.0094 0.0245 0.069
Echinococcus granulosus GPCR family 2 0.0193 0.0717 0.0717
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0722 0.3237 0.3933
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0053
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Plasmodium falciparum plasmepsin X 0.0051 0.0041 0.0058
Echinococcus multilocularis orexin receptor type 2 0.0064 0.0101 0.0078
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Mycobacterium leprae conserved hypothetical protein 0.056 0.2463 0.874
Echinococcus multilocularis fmrfamide receptor 0.0064 0.0101 0.0078
Echinococcus multilocularis allatostatin A receptor 0.0064 0.0101 0.0078
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.0101 0.013
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0122 0.038 0.0358
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0066 0.0113 0.011
Schistosoma mansoni amine GPCR 0.0064 0.0101 0.013
Echinococcus granulosus neuropeptide FF receptor 2 0.0064 0.0101 0.0101
Echinococcus granulosus somatostatin receptor 0.0064 0.0101 0.0101
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0225 0.087 0.2441
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Schistosoma mansoni nAChR subunit 0.0122 0.038 0.0596
Schistosoma mansoni neuropeptide f receptor 76f 0.0064 0.0101 0.013
Schistosoma mansoni protein kinase 0.0076 0.0162 0.0232
Schistosoma mansoni hypothetical protein 0.0086 0.0205 0.0305
Onchocerca volvulus 0.02 0.0748 0.4004
Mycobacterium ulcerans hypothetical protein 0.056 0.2463 0.8821
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0051 0.0041 0.0023
Brugia malayi Protein kinase domain containing protein 0.005 0.0037 0.0018
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0122 0.038 0.0437
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.02 0.0748 0.1212
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0122 0.038 0.0596
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Brugia malayi hypothetical protein 0.0064 0.0101 0.0095
Onchocerca volvulus 0.0051 0.0041 0.0103
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Onchocerca volvulus 0.0066 0.0111 0.0488
Brugia malayi hypothetical protein 0.0051 0.0041 0.0023
Schistosoma mansoni hypothetical protein 0.0193 0.0717 0.116
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0101 0.0277 0.0255
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.0101 0.0078
Loa Loa (eye worm) hypothetical protein 0.0066 0.0111 0.0108
Onchocerca volvulus 0.0094 0.0245 0.1225
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Brugia malayi hypothetical protein 0.0064 0.0101 0.0095
Onchocerca volvulus 0.0122 0.038 0.197
Brugia malayi Latrophilin receptor protein 2 0.0193 0.0717 0.085
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0082 0.0188 0.0276
Trichomonas vaginalis cyclin B, putative 0.0094 0.0245 0.0879
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0183 0.0669 0.0647
Brugia malayi Receptor family ligand binding region containing protein 0.0076 0.0162 0.017
Onchocerca volvulus 0.0064 0.0101 0.043
Loa Loa (eye worm) LGC-31 protein 0.0122 0.038 0.0437
Loa Loa (eye worm) hypothetical protein 0.0066 0.0111 0.0108
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0047 0.0023 0.007
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0064 0.0101 0.013
Schistosoma mansoni integrin beta subunit 0.1209 0.5556 0.9244
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0066 0.0111 0.0148
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0122 0.038 0.038
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0101 0.0277 0.0706
Toxoplasma gondii PAN domain-containing protein 0.0303 0.1243 0.3839
Brugia malayi Melatonin receptor type 1A 0.0064 0.0101 0.0095
Brugia malayi Calcitonin receptor-like protein seb-1 0.061 0.2704 0.3281
Loa Loa (eye worm) hypothetical protein 0.0066 0.0111 0.0108
Schistosoma mansoni neurotransmitter gated ion channel 0.0056 0.0066 0.0072
Schistosoma mansoni cathepsin D (A01 family) 0.0051 0.0041 0.0031
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.0101 0.013
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0082 0.0188 0.0188
Echinococcus granulosus kelch ECH associated protein 1 like 0.0762 0.3424 0.3424
Loa Loa (eye worm) TK/ROR protein kinase 0.005 0.0037 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0101 0.013
Echinococcus multilocularis neuropeptide s receptor 0.0064 0.0101 0.0078
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.0101 0.0078
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Mycobacterium ulcerans hypothetical protein 0.056 0.2463 0.8821
Brugia malayi Serotonin receptor 0.0064 0.0101 0.0095
Brugia malayi hypothetical protein 0.0051 0.0041 0.0023
Schistosoma mansoni cathepsin D (A01 family) 0.0051 0.0041 0.0031
Loa Loa (eye worm) hypothetical protein 0.0057 0.007 0.0057
Echinococcus granulosus glycine receptor subunit alpha 1 0.0122 0.038 0.038
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0064 0.0101 0.0078
Echinococcus granulosus g protein coupled receptor 0.0064 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0082 0.0188 0.0276
Echinococcus multilocularis G protein coupled receptor 139 0.0064 0.0101 0.0078
Trichomonas vaginalis cyclin B, putative 0.0094 0.0245 0.0879
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0627 0.2781 1
Entamoeba histolytica cyclin, putative 0.0094 0.0245 0.0568
Entamoeba histolytica hypothetical protein 0.0183 0.0669 0.2371
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0066 0.0111 0.0108
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.0101 0.0101
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0467 0.0467
Schistosoma mansoni nAChR subunit 0.0056 0.0066 0.0072
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0053
Echinococcus multilocularis G-protein coupled receptor, putative 0.0064 0.0101 0.0078
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0053
Echinococcus granulosus allatostatin A receptor 0.0064 0.0101 0.0101
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0722 0.3237 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0064 0.0101 0.0078
Loa Loa (eye worm) hypothetical protein 0.0066 0.0111 0.0108
Schistosoma mansoni hypothetical protein 0.0082 0.0188 0.0276
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0066 0.0113 0.0406
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0428 0.1834 0.2217
Onchocerca volvulus 0.0051 0.0041 0.0103
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0053
Loa Loa (eye worm) hypothetical protein 0.0051 0.0041 0.0023
Brugia malayi neuropeptide F receptor 0.0064 0.0101 0.0095
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0066 0.0111 0.0108
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0122 0.038 0.0358
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0428 0.1834 0.1834
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Schistosoma mansoni hypothetical protein 0.0064 0.0101 0.013
Mycobacterium tuberculosis Conserved hypothetical protein 0.056 0.2463 0.874
Loa Loa (eye worm) TYRA-2 protein 0.0064 0.0101 0.0095
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0053
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0428 0.1834 0.1816
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0122 0.038 0.0437
Plasmodium vivax aspartyl protease, putative 0.0051 0.0041 0.0128
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0101 0.0277 0.0997
Schistosoma mansoni hypothetical protein 0.0193 0.0717 0.116
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0122 0.038 0.0358
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0122 0.038 0.0437
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0101 0.013
Loa Loa (eye worm) hypothetical protein 0.0066 0.0113 0.011
Toxoplasma gondii PAN domain-containing protein 0.0303 0.1243 0.3839
Trypanosoma cruzi cyclin, putative 0.0094 0.0245 0.069
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0122 0.038 0.0437
Leishmania major eukaryotic initiation factor 4a, putative 0.0101 0.0277 0.0792
Echinococcus granulosus glycine receptor subunit beta 0.0122 0.038 0.038
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0101 0.013
Brugia malayi hypothetical protein 0.0064 0.0101 0.0095
Onchocerca volvulus 0.0064 0.0101 0.043
Brugia malayi Cyclin, N-terminal domain containing protein 0.0094 0.0245 0.0272
Schistosoma mansoni amine GPCR 0.0064 0.0101 0.013
Echinococcus granulosus nAChR subunit 0.0122 0.038 0.038
Loa Loa (eye worm) hypothetical protein 0.0147 0.0498 0.0582
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0041 0.0031
Brugia malayi G-protein coupled receptor 0.0064 0.0101 0.0095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0193 0.0717 0.0696
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0101 0.0078
Loa Loa (eye worm) hypothetical protein 0.0417 0.1784 0.2156
Trichomonas vaginalis cyclins, putative 0.0064 0.0103 0.0371
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0056 0.0066 0.0053
Echinococcus granulosus adam 0.0066 0.0113 0.0113
Echinococcus granulosus fibrillin 1 0.0066 0.0113 0.0113
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0094 0.0245 0.069
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0064 0.0101 0.0078
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0064 0.0101 0.0095
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0056 0.0066 0.0043
Onchocerca volvulus Cell death protein 3 homolog 0.0057 0.007 0.0259
Plasmodium falciparum plasmepsin IV 0.0051 0.0041 0.0058
Echinococcus granulosus 7tm_1 domain containing protein 0.0064 0.0101 0.0101
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0101 0.0101
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0101 0.0277 0.0997
Echinococcus multilocularis g protein coupled receptor 0.0064 0.0101 0.0078
Echinococcus multilocularis kelch ECH associated protein 1 0.0762 0.3424 0.3409
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0722 0.3237 0.3222
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0122 0.038 0.038
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0122 0.038 0.0437
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0064 0.0101 0.0095
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.0101 0.0101
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.0101 0.0078
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0722 0.3237 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0101 0.013
Echinococcus multilocularis nAChR subunit 0.0066 0.0111 0.0089
Echinococcus multilocularis dro:myosuppressin receptor 0.0064 0.0101 0.0078
Brugia malayi Cation transporter family protein 0.0122 0.038 0.0437
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.0101 0.0095
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Brugia malayi Serotonin receptor 0.0064 0.0101 0.0095
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0428 0.1834 0.1834
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Plasmodium vivax aspartyl protease, putative 0.0051 0.0041 0.0128
Onchocerca volvulus 0.0064 0.0101 0.043
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0056 0.0066 0.0043
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0064 0.0101 0.0095
Echinococcus multilocularis neuropeptide receptor 0.0064 0.0101 0.0078
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.0101 0.0078
Brugia malayi follicle stimulating hormone receptor 0.0064 0.0101 0.0095
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.0101 0.013
Echinococcus multilocularis integrin beta 2 0.1521 0.7042 0.7036
Toxoplasma gondii hypothetical protein 0.0066 0.0113 0.0348
Plasmodium falciparum plasmepsin VIII, putative 0.0051 0.0041 0.0058
Schistosoma mansoni nAChR subunit 0.0122 0.038 0.0596
Onchocerca volvulus 0.02 0.0748 0.4004
Echinococcus multilocularis fmrfamide receptor 0.0064 0.0101 0.0078
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0722 0.3237 1
Onchocerca volvulus 0.0066 0.0111 0.0488
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0122 0.038 0.0437
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Brugia malayi hypothetical protein 0.0312 0.1284 0.1543
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0056 0.0066 0.0053
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.0101 0.0101
Schistosoma mansoni growth hormone secretagogue receptor 0.0064 0.0101 0.013
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Echinococcus multilocularis caspase 2 0.0057 0.007 0.0047
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Echinococcus granulosus sex peptide receptor 0.0064 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Schistosoma mansoni nAChR subunit 0.0056 0.0066 0.0072
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0122 0.038 0.0437
Echinococcus granulosus alpha 1A adrenergic receptor 0.0064 0.0101 0.0101
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0197 0.0735 1
Echinococcus multilocularis sex peptide receptor 0.0064 0.0101 0.0078
Loa Loa (eye worm) hypothetical protein 0.0051 0.0041 0.0023
Schistosoma mansoni neuropeptide receptor 0.0064 0.0101 0.013
Leishmania major eukaryotic initiation factor 4a, putative 0.0101 0.0277 0.0792
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Plasmodium vivax aspartyl protease, putative 0.0051 0.0041 0.0128
Brugia malayi EGF-like domain containing protein 0.0066 0.0113 0.011
Onchocerca volvulus 0.0064 0.0101 0.043
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Brugia malayi Cation transporter family protein 0.0122 0.038 0.0437
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0053
Trichomonas vaginalis cyclins, putative 0.0094 0.0245 0.0879
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Loa Loa (eye worm) melatonin receptor type 1A 0.0064 0.0101 0.0095
Plasmodium falciparum plasmepsin II 0.0051 0.0041 0.0058
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0173 0.062 0.0731
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0041 0.0031
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0064 0.0101 0.0101
Schistosoma mansoni amine GPCR 0.0064 0.0101 0.013
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.042 0.1796 0.1778
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0122 0.038 0.0437
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0101 0.0078
Trypanosoma cruzi cyclin 6, putative 0.0094 0.0245 0.069
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Schistosoma mansoni integrin alpha 0.0179 0.0648 0.1045
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0122 0.038 0.038
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.0101 0.0078
Trypanosoma cruzi CYC2-like cyclin, putative 0.0094 0.0245 0.069
Echinococcus granulosus eukaryotic initiation factor 4A 0.0101 0.0277 0.0277
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.0101 0.0101
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0066 0.0111 0.0148
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0066 0.0053
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0051 0.0041 0.0148
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0053
Onchocerca volvulus 0.0064 0.0101 0.043
Echinococcus granulosus dro:myosuppressin receptor 0.0064 0.0101 0.0101
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0627 0.2781 0.5
Brugia malayi eukaryotic initiation factor 4A 0.0101 0.0277 0.0311
Toxoplasma gondii aspartyl protease 0.0051 0.0041 0.0128
Schistosoma mansoni acetylcholine receptor-related 0.0056 0.0066 0.0072
Schistosoma mansoni neurotransmitter gated ion channel 0.0066 0.0111 0.0148
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.042 0.1796 0.217
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Loa Loa (eye worm) hypothetical protein 0.0062 0.0091 0.0083
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.0101 0.0095
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0064 0.0101 0.013
Echinococcus granulosus G protein coupled receptor 139 0.0064 0.0101 0.0101
Schistosoma mansoni myosin xvIII 0.0064 0.0101 0.013
Schistosoma mansoni apoptosis regulator bax 0.0082 0.0188 0.0276
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.038 0.0437
Trichomonas vaginalis cyclin B, putative 0.0094 0.0245 0.0879
Schistosoma mansoni cyclin B 0.0094 0.0245 0.0371
Echinococcus multilocularis somatostatin receptor 0.0064 0.0101 0.0078
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0064 0.0101 0.0095
Plasmodium falciparum eukaryotic initiation factor 4A 0.0101 0.0277 0.0792
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0722 0.3237 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0111 0.0108
Echinococcus granulosus caspase 2 0.0057 0.007 0.007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.061 0.2704 0.3281
Schistosoma mansoni opsin-like receptor 0.0064 0.0101 0.013
Echinococcus granulosus integrin alpha ps 0.0086 0.0205 0.0205
Echinococcus multilocularis g protein coupled receptor 0.0064 0.0101 0.0078
Loa Loa (eye worm) hypothetical protein 0.0094 0.0245 0.0272
Brugia malayi Kelch motif family protein 0.0312 0.1284 0.1543
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0064 0.0101 0.0101
Brugia malayi Cell death protein 3 precursor 0.0057 0.007 0.0057
Plasmodium falciparum plasmepsin VI 0.0051 0.0041 0.0058
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0193 0.0717 0.0717
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0197 0.0735 0.2644
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0101 0.0101
Schistosoma mansoni nAChR subunit 0.0122 0.038 0.0596
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.0486 0.0774
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.042 0.1796 0.217
Loa Loa (eye worm) hypothetical protein 0.0143 0.048 0.0559
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0122 0.038 0.0437
Plasmodium falciparum plasmepsin V 0.0051 0.0041 0.0058
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0066 0.0053
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0173 0.062 0.0999
Plasmodium falciparum plasmepsin IX 0.0051 0.0041 0.0058
Schistosoma mansoni hypothetical protein 0.0064 0.0101 0.013
Schistosoma mansoni histamine h1 receptor 0.0064 0.0101 0.013
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0064 0.0101 0.0078
Schistosoma mansoni alpha-1 adrenergic receptor 0.0064 0.0101 0.013
Plasmodium vivax plasmepsin IV, putative 0.0051 0.0041 0.0128
Onchocerca volvulus 0.0064 0.0101 0.043
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0122 0.038 0.0358
Onchocerca volvulus 0.0064 0.0101 0.043
Echinococcus multilocularis serotonin receptor 0.0064 0.0101 0.0078
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0101 0.0277 0.0425
Schistosoma mansoni opsin-like receptor 0.0064 0.0101 0.013
Echinococcus granulosus g protein coupled receptor 0.0064 0.0101 0.0101
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0627 0.2781 1
Trichomonas vaginalis cyclins, putative 0.0094 0.0245 0.0879
Schistosoma mansoni neuropeptide receptor 0.0064 0.0101 0.013
Schistosoma mansoni biogenic amine receptor 0.0064 0.0101 0.013
Echinococcus granulosus integrin beta 2 0.1521 0.7042 0.7042
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0122 0.038 0.0358
Onchocerca volvulus 0.0066 0.0113 0.0497
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0064 0.0101 0.0078
Brugia malayi CHE-14 protein 0.0173 0.062 0.0731
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0101 0.0101
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0122 0.038 0.0596
Echinococcus multilocularis glycine receptor subunit beta 0.0122 0.038 0.0358
Brugia malayi GnHR receptor homolog 0.0064 0.0101 0.0095
Brugia malayi AKH receptor 0.0064 0.0101 0.0095
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.038 0.0437
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0122 0.038 0.0437
Trichomonas vaginalis cyclin A, putative 0.0094 0.0245 0.0879
Echinococcus granulosus g protein coupled receptor 0.0064 0.0101 0.0101
Brugia malayi Tachykinin-like peptides receptor 99D 0.0064 0.0101 0.0095
Brugia malayi G protein-coupled receptor F59B2.13 0.0064 0.0101 0.0095
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0428 0.1834 0.1834
Loa Loa (eye worm) acetylcholine receptor protein 0.0056 0.0066 0.0053
Loa Loa (eye worm) hypothetical protein 0.0101 0.0277 0.0311
Echinococcus granulosus neuropeptide receptor 0.0064 0.0101 0.0101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0101 0.013
Echinococcus multilocularis protein dispatched 1 0.0173 0.062 0.0599
Trypanosoma cruzi cyclin, putative 0.0094 0.0245 0.069
Giardia lamblia G2/mitotic-specific cyclin B 0.0094 0.0245 0.2117
Echinococcus granulosus nAChR subunit 0.0066 0.0111 0.0111
Brugia malayi hypothetical protein 0.0064 0.0101 0.0095
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0122 0.038 0.038
Echinococcus granulosus glycine receptor subunit alpha 1 0.0122 0.038 0.038
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.0101 0.013
Loa Loa (eye worm) ACC-1 protein 0.0122 0.038 0.0437
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0183 0.0669 0.0669
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.0101 0.013
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Loa Loa (eye worm) hypothetical protein 0.0147 0.0498 0.0582
Schistosoma mansoni neuropeptide receptor 0.0064 0.0101 0.013
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0101 0.0101
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0122 0.038 0.0358
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0122 0.038 0.0437
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0428 0.1834 0.1816
Schistosoma mansoni patched 1 0.0173 0.062 0.0999
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0082 0.0188 0.0166
Echinococcus granulosus atrial natriuretic peptide receptor 0.0066 0.0112 0.0112
Plasmodium vivax aspartyl proteinase, putative 0.0051 0.0041 0.0128
Schistosoma mansoni adenoreceptor 0.0064 0.0101 0.013
Onchocerca volvulus 0.0064 0.0101 0.043
Onchocerca volvulus 0.0056 0.0066 0.0239
Schistosoma mansoni amine GPCR 0.0064 0.0101 0.013
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.038 0.0437
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Schistosoma mansoni serine-type protease inhibitor 0.1304 0.6009 1
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0197 0.0735 0.2644
Plasmodium falciparum plasmepsin VII 0.0051 0.0041 0.0058
Schistosoma mansoni transcription factor LCR-F1 0.0183 0.0669 0.1079
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.0101 0.0078
Echinococcus multilocularis fibrillin 1 0.0066 0.0113 0.009
Echinococcus multilocularis integrin alpha 3 0.0086 0.0205 0.0183
Loa Loa (eye worm) apoptosis regulator protein 0.0082 0.0188 0.0203
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0722 0.3237 1
Mycobacterium ulcerans transcriptional regulator NrdR 0.0096 0.0253 0.0642
Brugia malayi aspartic protease BmAsp-2, identical 0.0051 0.0041 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0101 0.0101
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0051 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0183 0.0669 0.1079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0101 0.0078
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0082 0.0188 0.0203
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0064 0.0101 0.0095
Schistosoma mansoni acetylcholine receptor subunit beta 0.0056 0.0066 0.0072
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0051 0.0041 0.0128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0101 0.013
Loa Loa (eye worm) GABA receptor subunit 0.0066 0.0111 0.0108
Loa Loa (eye worm) hypothetical protein 0.0066 0.0113 0.011
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0101 0.013
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0122 0.038 0.0437
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0064 0.0101 0.0078
Schistosoma mansoni memapsin-2 (A01 family) 0.0864 0.3914 0.65
Brugia malayi Integrin alpha pat-2 precursor 0.0179 0.0648 0.0766
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.0101 0.0101
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0051 0.0041 0.0019
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.0101 0.013
Echinococcus granulosus hypothetical protein 0.0064 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0722 0.3237 0.3237
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0053
Onchocerca volvulus 0.0064 0.0101 0.043
Schistosoma mansoni opsin-like receptor 0.0064 0.0101 0.013
Loa Loa (eye worm) hypothetical protein 0.0193 0.0717 0.085
Echinococcus granulosus tissue type plasminogen activator 0.0047 0.0023 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0101 0.0078
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0064 0.0101 0.0095
Schistosoma mansoni caspase-7 (C14 family) 0.0057 0.007 0.0078
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0428 0.1834 0.1816
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0101 0.0078
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0101 0.0277 0.0792
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.0101 0.0101
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.0101 0.0095
Onchocerca volvulus Putative nachr subunit 0.0428 0.1834 1
Echinococcus granulosus sterol regulatory element binding protein 0.0173 0.062 0.062
Schistosoma mansoni hypothetical protein 0.0064 0.0101 0.013
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Echinococcus granulosus glycine receptor subunit beta 0.0122 0.038 0.038
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0122 0.038 0.0596
Echinococcus multilocularis tachykinin peptides receptor 99D 0.2142 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0064 0.0101 0.0095
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.038 0.0437
Brugia malayi putative neuropeptide receptor NPR1 0.0064 0.0101 0.0095
Echinococcus multilocularis g protein coupled receptor 0.0064 0.0101 0.0078
Schistosoma mansoni hypothetical protein 0.0764 0.3434 0.5699
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0064 0.0101 0.0095
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0101 0.0277 0.1405
Echinococcus multilocularis serotonin receptor 0.0064 0.0101 0.0078
Brugia malayi sulfakinin receptor protein 0.0064 0.0101 0.0095
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Loa Loa (eye worm) hypothetical protein 0.0312 0.1284 0.1543
Trichomonas vaginalis hypothetical protein 0.0066 0.0113 0.0406
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.0101 0.013
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.0101 0.0078
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0101 0.0277 0.0997
Echinococcus multilocularis expressed protein 0.0362 0.1522 0.1503
Loa Loa (eye worm) RGC/RGC protein kinase 0.0076 0.0162 0.017
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0122 0.038 0.038
Loa Loa (eye worm) integrin alpha pat-2 0.0179 0.0648 0.0766
Onchocerca volvulus 0.0056 0.0066 0.0239
Brugia malayi Dopamine receptor protein 2 0.0064 0.0101 0.0095
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0041 0.0031
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0722 0.3237 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0064 0.0101 0.013
Brugia malayi hypothetical protein 0.0056 0.0066 0.0053
Loa Loa (eye worm) hypothetical protein 0.061 0.2704 0.3281
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0122 0.038 0.0437
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.0101 0.0078
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0041 0.0031
Brugia malayi hypothetical protein 0.0064 0.0101 0.0095
Echinococcus granulosus glycine receptor subunit alpha 1 0.0122 0.038 0.038
Echinococcus multilocularis adam 0.0066 0.0113 0.009
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.0486 0.0567
Loa Loa (eye worm) hypothetical protein 0.0066 0.0111 0.0108
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.0101 0.0101
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0056 0.0066 0.0043
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0101 0.0101
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0053
Echinococcus multilocularis integrin alpha ps 0.0179 0.0648 0.0627
Echinococcus granulosus orexin receptor type 2 0.0064 0.0101 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.062 0.2231
Loa Loa (eye worm) aspartyl protease 6 0.0051 0.0041 0.0023
Echinococcus multilocularis integrin alpha ps 0.0086 0.0205 0.0183
Loa Loa (eye worm) hypothetical protein 0.0066 0.0113 0.011
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0041 0.0031
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Onchocerca volvulus 0.02 0.0748 0.4004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.061 0.2704 0.3281
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0193 0.0717 0.085
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0101 0.0277 0.0094
Toxoplasma gondii aspartyl protease ASP3 0.0051 0.0041 0.0128
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0064 0.0101 0.013
Schistosoma mansoni neurotransmitter gated ion channel 0.0056 0.0066 0.0072
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0064 0.0101 0.0095
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.0486 0.0464
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.042 0.1796 0.1796
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.02 0.0748 0.1212
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0193 0.0717 0.0717
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0101 0.0277 0.0856
Entamoeba histolytica hypothetical protein, conserved 0.056 0.2463 1
Brugia malayi Integrin beta pat-3 precursor 0.1763 0.8195 1
Loa Loa (eye worm) hypothetical protein 0.0173 0.062 0.0731
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0066 0.0112 0.0089
Brugia malayi EGF-like domain containing protein 0.0066 0.0113 0.011
Brugia malayi Dopamine receptor protein 1 0.0064 0.0101 0.0095
Schistosoma mansoni biogenic amine receptor 0.0064 0.0101 0.013
Loa Loa (eye worm) hypothetical protein 0.0082 0.0188 0.0203
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0041 0.0031
Onchocerca volvulus 0.0064 0.0101 0.043
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Brugia malayi ORL1-like opioid receptor 0.0064 0.0101 0.0095
Echinococcus multilocularis Kelch repeat type 1 0.0764 0.3434 0.3419
Schistosoma mansoni nAChR subunit 0.0122 0.038 0.0596
Echinococcus granulosus g-protein coupled receptor 0.0064 0.0101 0.0101
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0082 0.0188 0.0166
Brugia malayi hypothetical protein 0.0056 0.0066 0.0053
Brugia malayi Pepsin A precursor 0.0051 0.0041 0.0023
Onchocerca volvulus 0.0122 0.038 0.197
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.0101 0.0078
Plasmodium vivax plasmepsin V, putative 0.0051 0.0041 0.0128
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0064 0.0101 0.043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0101 0.0078
Echinococcus granulosus 7TM GPCR rhodopsin 0.0064 0.0101 0.0101
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0064 0.0101 0.0078
Echinococcus granulosus receptor type guanylyl cyclase 0.0076 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Echinococcus granulosus integrin alpha ps 0.024 0.0941 0.0941
Brugia malayi Eukaryotic aspartyl protease family protein 0.0051 0.0041 0.0023
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0064 0.0101 0.0078
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.0101 0.013
Echinococcus multilocularis neuropeptide receptor 0.0064 0.0101 0.0078
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.0101 0.0101
Toxoplasma gondii aspartyl protease ASP1 0.0051 0.0041 0.0128
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0066 0.0053
Schistosoma mansoni hypothetical protein 0.0417 0.1784 0.2943
Toxoplasma gondii kringle domain-containing protein 0.0047 0.0023 0.007
Entamoeba histolytica hypothetical protein 0.0183 0.0669 0.2371
Brugia malayi hypothetical protein 0.0064 0.0101 0.0095
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0056 0.0066 0.0053
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Schistosoma mansoni serine-type protease inhibitor 0.1304 0.6009 1
Echinococcus multilocularis g-protein coupled receptor 0.0064 0.0101 0.0078
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0051 0.0041 0.0023
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0122 0.038 0.0358
Schistosoma mansoni hypothetical protein 0.0082 0.0188 0.0276
Brugia malayi Cyclin, N-terminal domain containing protein 0.0094 0.0245 0.0272
Onchocerca volvulus 0.0064 0.0101 0.043
Echinococcus multilocularis neuropeptide FF receptor 2 0.0064 0.0101 0.0078
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0312 0.1284 0.1543
Schistosoma mansoni hypothetical protein 0.0193 0.0717 0.116
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0041 0.0031
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0064 0.0101 0.0095
Trichomonas vaginalis cyclins, putative 0.0094 0.0245 0.0879
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0101 0.0277 0.0255
Brugia malayi hypothetical protein 0.0056 0.0066 0.0053
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0053
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0627 0.2781 1
Brugia malayi EGF-like domain containing protein 0.0066 0.0113 0.011
Plasmodium vivax aspartyl proteinase, putative 0.0051 0.0041 0.0128
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0051 0.0041 0.0128
Entamoeba histolytica hypothetical protein 0.0183 0.0669 0.2371
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0101 0.0078
Loa Loa (eye worm) hypothetical protein 0.0094 0.0245 0.0272
Onchocerca volvulus 0.0064 0.0101 0.043
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0722 0.3237 0.3933
Echinococcus granulosus kelch ECH associated protein 1 0.0762 0.3424 0.3424
Loa Loa (eye worm) hypothetical protein 0.02 0.0748 0.0888
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Echinococcus multilocularis Niemann Pick C1 protein 0.0173 0.062 0.0599
Echinococcus granulosus kelch ECH associated protein 1 like 0.0762 0.3424 0.3424
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0056 0.0066 0.0053
Brugia malayi hypothetical protein 0.0056 0.0066 0.0053
Echinococcus granulosus fmrfamide receptor 0.0064 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Echinococcus granulosus peptide allatostatin:somatostatin 0.0064 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Echinococcus granulosus Niemann Pick C1 protein 0.0173 0.062 0.062
Mycobacterium tuberculosis Conserved protein 0.056 0.2463 0.874
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0076 0.0162 0.0767
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.042 0.1796 0.6353
Onchocerca volvulus 0.0064 0.0101 0.043
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0101 0.0277 0.0109
Brugia malayi hypothetical protein 0.0064 0.0101 0.0095
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0056 0.0066 0.0053
Schistosoma mansoni integrin alpha-ps 0.0179 0.0648 0.1045
Entamoeba histolytica hypothetical protein 0.0183 0.0669 0.2371
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Onchocerca volvulus 0.0064 0.0101 0.043
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.042 0.1796 0.2963
Loa Loa (eye worm) hypothetical protein 0.0051 0.0041 0.0023
Echinococcus multilocularis receptor type guanylyl cyclase 0.0076 0.0162 0.0139
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0722 0.3237 0.537
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0101 0.0078
Brugia malayi hypothetical protein 0.0064 0.0101 0.0095
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0197 0.0735 0.2644
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0066 0.0111 0.0108
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.038 0.0437
Loa Loa (eye worm) hypothetical protein 0.0064 0.0101 0.0095
Brugia malayi hypothetical protein 0.0056 0.0066 0.0053
Loa Loa (eye worm) hypothetical protein 0.0093 0.0241 0.0267
Schistosoma mansoni integrin alpha-4 0.0384 0.1628 0.2682
Echinococcus multilocularis integrin alpha ps 0.024 0.0941 0.0921
Brugia malayi latrophilin 2 splice variant baaae 0.0417 0.1784 0.2156
Echinococcus multilocularis fibrillin 2 0.0066 0.0113 0.009
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0101 0.0277 0.0792
Plasmodium falciparum plasmepsin III 0.0051 0.0041 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0101 0.013
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0192 0.0713 0.2147
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0428 0.1834 0.2217
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0064 0.0101 0.0101
Brugia malayi aspartic protease BmAsp-1, identical 0.0051 0.0041 0.0023
Onchocerca volvulus 0.0056 0.0066 0.0239
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0041 0.0031
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0101 0.0277 0.2641
Echinococcus granulosus cyclin B 0.0094 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0122 0.038 0.0437
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.0101 0.0095
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0101 0.0277 0.0425
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.042 0.1796 0.5518
Echinococcus granulosus serotonin receptor 0.0064 0.0101 0.0101

Activities

Activity type Activity value Assay description Source Reference
Log RA (functional) = 1.46 Antimalarial activity of the compound was determined against chloroquine-resistant, mefloquine-sensitive Plasmodium falciparum W-2 clone ChEMBL. 11784134

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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