TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 357.357 | Formula: C19H19NO6
H donors: 2 H acceptors: 2 LogP: 2.92 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(c[nH]c2c(c1OC)OC)C(=O)c1ccc(c(c1)O)OC
InChi: 1S/C19H19NO6/c1-23-14-6-5-10(7-13(14)21)17(22)12-9-20-16-11(12)8-15(24-2)18(25-3)19(16)26-4/h5-9,20-21H,1-4H3
InChiKey: UTLIIGYUJICKRH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cathepsin C	0.0011	0.0051	0.0051
Trichomonas vaginalis	calcium binding protein, putative	0.0011	0.0045	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3214	0.3214
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0011	0.0051	0.035
Onchocerca volvulus		0.0024	0.055	0.2954
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0036	0.0982	0.0949
Plasmodium falciparum	serine repeat antigen 8	0.0011	0.0051	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0051	0.0051
Brugia malayi	calpain family protein 1	0.0095	0.3214	0.3214
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.2269	0.722
Leishmania major	cathepsin L-like protease	0.0024	0.055	0.1712
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0014	0.0174	0.0503
Brugia malayi	PAN domain containing protein	0.0014	0.0174	0.0174
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0348	0.3432
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.055	0.0515
Loa Loa (eye worm)	hypothetical protein	0.007	0.2269	0.2269
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0036	0.0982	0.0949
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0051	0.0351
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0017	0.0254	0.07
Onchocerca volvulus		0.0014	0.0174	0.0935
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0275	1	1
Brugia malayi	ABC transporter family protein	0.001	0.0018	0.0018
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0011	0.0051	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0348	0.1062
Onchocerca volvulus	Cathepsin L homolog	0.0024	0.055	0.2954
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0254	0.2452
Onchocerca volvulus		0.001	0.0018	0.0095
Schistosoma mansoni	calpain-7 (C02 family)	0.0036	0.0982	0.0982
Schistosoma mansoni	multidrug resistance protein	0.001	0.0018	0.0018
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0051	0.0351
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0011	0.0051	0.0634
Onchocerca volvulus		0.0011	0.0051	0.0276
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0011	0.0051	0.0108
Leishmania major	kinesin, putative	0.0025	0.0576	0.1795
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0348	0.1062
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0254	0.2452
Toxoplasma gondii	cathepsin CPL	0.0024	0.055	0.1712
Brugia malayi	PAN domain containing protein	0.0014	0.0174	0.0174
Toxoplasma gondii	microneme protein, putative	0.0014	0.0174	0.0503
Plasmodium falciparum	serine repeat antigen 7	0.0011	0.0051	0.0634
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0254	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0051	0.0051
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0254	0.2452
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Schistosoma mansoni	hypothetical protein	0.0011	0.0037	0.0037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0051	0.0108
Schistosoma mansoni	multidrug resistance protein	0.001	0.0018	0.0018
Entamoeba histolytica	cysteine proteinase 2	0.0017	0.0254	0.2452
Echinococcus granulosus	cathepsin b	0.0275	1	1
Trypanosoma cruzi	centrin, putative	0.0011	0.0045	0.0007
Brugia malayi	Cathepsin L-like precursor	0.0024	0.055	0.055
Echinococcus granulosus	cathepsin l1	0.0024	0.055	0.055
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0011	0.0051	0.0634
Plasmodium falciparum	serine repeat antigen 2	0.0011	0.0051	0.0634
Schistosoma mansoni	calpain (C02 family)	0.0036	0.0982	0.0982
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0011	0.0051	0.0108
Echinococcus granulosus	calpain A	0.0036	0.0982	0.0982
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0254	0.2452
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0254	0.2452
Toxoplasma gondii	PAN domain-containing protein	0.0014	0.0174	0.0503
Toxoplasma gondii	hypothetical protein	0.0014	0.0174	0.0503
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.098	0.5
Onchocerca volvulus		0.0014	0.0174	0.0935
Loa Loa (eye worm)	PAN domain-containing protein	0.0014	0.0174	0.0174
Plasmodium falciparum	serine repeat antigen 5	0.0011	0.0051	0.0634
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.098	0.3094
Loa Loa (eye worm)	fibroinase	0.0024	0.055	0.055
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.098	0.098
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.098	0.305
Toxoplasma gondii	microneme protein MIC17B	0.0014	0.0174	0.0503
Schistosoma mansoni	inositol monophosphatase	0.0036	0.098	0.098
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0011	0.0051	0.0051
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.098	0.098
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0011	0.0051	0.0108
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.2269	0.722
Toxoplasma gondii	PAN domain-containing protein	0.0014	0.0174	0.0503
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0254	0.2452
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.055	0.1712
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0036	0.0982	0.0949
Echinococcus granulosus	calpain	0.0036	0.0982	0.0982
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0093	0.3128	0.3103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.055	0.1712
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0011	0.0051	0.0108
Trichomonas vaginalis	calpain, putative	0.0011	0.0037	0.0063
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.098	0.0946
Leishmania major	hypothetical protein, unknown function	0.0011	0.0037	0.0063
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0036	0.0982	0.0949
Onchocerca volvulus		0.0014	0.0174	0.0935
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.055	0.1712
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0036	0.0982	0.0949
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0011	0.0051	0.0108
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0254	0.0217
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0254	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0051	0.0051
Onchocerca volvulus		0.0059	0.1862	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0174	0.0174
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0024	0.055	1
Trypanosoma brucei	kinesin, putative	0.0025	0.0576	0.1744
Trypanosoma cruzi	cruzipain precursor, putative	0.007	0.2269	0.224
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.098	0.3094
Onchocerca volvulus		0.0019	0.0348	0.1868
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Trypanosoma brucei	centrin-3	0.0011	0.0045	0.0024
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.055	0.5533
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0103	0.3497	0.3497
Brugia malayi	Cathepsin L-like precursor	0.0024	0.055	0.055
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0036	0.0982	0.3102
Brugia malayi	Papain family cysteine protease containing protein	0.0024	0.055	0.055
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0036	0.0982	0.0949
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.055	0.5533
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Echinococcus multilocularis	multidrug resistance protein 1	0.001	0.0018	0.0018
Trypanosoma brucei	calpain-like protein, putative	0.0036	0.0982	0.3058
Brugia malayi	Inositol-1	0.0036	0.098	0.098
Leishmania major	cysteine peptidase A (CPA)	0.0024	0.055	0.1712
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0254	0.2452
Trichomonas vaginalis	calmodulin, putative	0.0011	0.0045	0.0087
Toxoplasma gondii	microneme protein MIC17A	0.0014	0.0174	0.0503
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0011	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0013
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1862	0.1862
Toxoplasma gondii	subtilisin SUB12	0.0023	0.0486	0.1506
Trypanosoma brucei	antigen, putative	0.0036	0.0982	0.3058
Brugia malayi	PAN domain containing protein	0.0014	0.0174	0.0174
Brugia malayi	calpain family protein 1	0.0095	0.3214	0.3214
Echinococcus multilocularis	programmed cell death protein	0.0011	0.0045	0.0045
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0471	0.0471
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0018	0.0018
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0024	0.055	0.055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.055	0.1712
Trypanosoma brucei	calpain-like protein, putative	0.0036	0.0982	0.3058
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0051	0.0108
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.2269	0.722
Brugia malayi	Subtilase family protein	0.0268	0.9733	0.9733
Leishmania major	cathepsin L-like protease	0.0024	0.055	0.1712
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0036	0.0982	0.0982
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0018	0.0018
Loa Loa (eye worm)	cysteine protease	0.0024	0.055	0.055
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0022	0.0471	0.47
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0051	0.0108
Echinococcus granulosus	calpain A	0.0103	0.3505	0.3505
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0024	0.055	0.1712
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0471	0.0436
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0024	0.055	0.055
Brugia malayi	Papain family cysteine protease containing protein	0.0011	0.0051	0.0051
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0024	0.055	0.055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0051	0.0108
Loa Loa (eye worm)	calpain family protein 1	0.007	0.2269	0.2269
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0348	0.0348
Plasmodium vivax	vivapain-2	0.0024	0.055	0.5519
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.098	0.0946
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0011	0.0051	0.0051
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0093	0.3128	1
Entamoeba histolytica	calpain family cysteine protease, putative	0.0011	0.0037	0.0203
Toxoplasma gondii	cathepsin CPC1	0.0011	0.0051	0.0108
Schistosoma mansoni	cathepsin B (C01 family)	0.0011	0.0051	0.0051
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Echinococcus multilocularis	calpain	0.0036	0.0982	0.0982
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0011	0.0051	0.0051
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0011	0.0051	0.0051
Toxoplasma gondii	PAN domain-containing protein	0.0014	0.0174	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0084	0.2808	0.2808
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0036	0.0982	0.0949
Plasmodium vivax	serine-repeat antigen (SERA)	0.0011	0.0051	0.035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.055	0.1712
Onchocerca volvulus		0.0014	0.0174	0.0935
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0093	0.3128	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0275	1	1
Plasmodium falciparum	serine repeat antigen 3	0.0011	0.0051	0.0634
Onchocerca volvulus		0.0024	0.055	0.2954
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0011	0.0051	0.0051
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0017	0.0254	0.0254
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0011	0.0037	0.0063
Plasmodium vivax	serine-repeat antigen (SERA)	0.0011	0.0051	0.035
Brugia malayi	Cathepsin L-like precursor	0.0024	0.055	0.055
Echinococcus multilocularis	hypothetical protein	0.0036	0.0982	0.0982
Schistosoma mansoni	multidrug resistance protein	0.001	0.0018	0.0018
Toxoplasma gondii	kringle domain-containing protein	0.0022	0.0471	0.1458
Entamoeba histolytica	protein kinase, putative	0.0025	0.0576	0.5803
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.2269	0.722
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0037	0.0037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.055	0.1712
Brugia malayi	Cathepsin L-like precursor	0.0024	0.055	0.055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.055	0.1712
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0051	0.0108
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0018	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.055	0.1712
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0011	0.0051	0.0108
Onchocerca volvulus		0.0024	0.055	0.2954
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.055	0.1712
Echinococcus granulosus	programmed cell death protein	0.0011	0.0045	0.0045
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0065	0.2067	0.2037
Schistosoma mansoni	calpain-7 (C02 family)	0.0036	0.0982	0.0982
Onchocerca volvulus		0.0014	0.0174	0.0935
Onchocerca volvulus		0.0014	0.0174	0.0935
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.055	0.1712
Brugia malayi	calpain 5	0.0011	0.0037	0.0037
Loa Loa (eye worm)	PAN domain-containing protein	0.0014	0.0174	0.0174
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0011	0.0037	0.0063
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0011	0.0051	0.0051
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0011	0.0051	0.0108
Echinococcus granulosus	calpain 5	0.0036	0.0982	0.0982
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0254	0.0254
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.2269	0.722
Toxoplasma gondii	hypothetical protein	0.0011	0.0037	0.0063
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0011	0.0051	0.035
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.001	0.0013	0.0013
Toxoplasma gondii	cathepsin CPC2	0.0011	0.0051	0.0108
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0014	0.0174	0.0503
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0018	0.0018
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0024	0.055	0.055
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0348	0.0348
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0103	0.3497	0.3497
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0103	0.3497	0.3497
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0024	0.055	1
Brugia malayi	Cathepsin L-like precursor	0.0024	0.055	0.055
Trypanosoma brucei	calpain-like protein, putative	0.0036	0.0982	0.3058
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0051	0.0108
Entamoeba histolytica	grainin 2	0.0011	0.0045	0.028
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Plasmodium falciparum	serine repeat antigen 6	0.0011	0.0051	0.0634
Echinococcus multilocularis	programmed cell death protein	0.0011	0.0045	0.0045
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0011	0.0051	0.035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.2269	0.722
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.055	0.1712
Brugia malayi	fibroinase precursor	0.0011	0.0051	0.0051
Echinococcus multilocularis	cysteine protease	0.0024	0.055	0.055
Leishmania major	cathepsin L-like protease	0.007	0.2269	0.7237
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0174	0.0174
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.2269	0.722
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0017	0.0254	0.07
Leishmania major	cathepsin L-like protease	0.0024	0.055	0.1712
Plasmodium falciparum	calpain	0.0011	0.0037	0.0367
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0018	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.055	0.1712
Echinococcus multilocularis	cysteine protease	0.0024	0.055	0.055
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0011	0.0051	0.0351
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0011	0.0051	0.0108
Schistosoma mansoni	inositol monophosphatase	0.0036	0.098	0.098
Entamoeba histolytica	cysteine protease, putative	0.0024	0.055	0.5533
Giardia lamblia	Cathepsin B precursor	0.0093	0.3128	1
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0011	0.0037	0.0063
Loa Loa (eye worm)	PAN domain-containing protein	0.0014	0.0174	0.0174
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.2269	0.722
Echinococcus multilocularis	cathepsin L cysteine protease	0.0024	0.055	0.055
Echinococcus multilocularis	calpain family protein 1, d	0.007	0.2269	0.2269
Echinococcus granulosus	cathepsin L	0.0017	0.0254	0.0254
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0011	0.0037	0.0063
Brugia malayi	calpain 5	0.0025	0.0576	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0174	0.0174
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0011	0.0051	0.0051
Echinococcus granulosus	cysteine protease	0.0017	0.0254	0.0254
Plasmodium falciparum	cysteine repeat modular protein 1	0.0022	0.0471	0.8516
Loa Loa (eye worm)	subtilase	0.0268	0.9733	0.9733
Leishmania major	cathepsin L-like protease	0.007	0.2269	0.7237
Echinococcus multilocularis	calpain 7 (C02 family)	0.0036	0.0982	0.0982
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.001	0.0018	0.0018
Toxoplasma gondii	PAN domain-containing protein	0.0014	0.0174	0.0503
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0011	0.0051	0.0108
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.098	0.5
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0011	0.0051	0.0051
Echinococcus multilocularis	cathepsin b	0.0275	1	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0011	0.0051	0.035
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0348	0.0348
Echinococcus multilocularis	calpain A	0.0103	0.3505	0.3505
Loa Loa (eye worm)	TK/ROR protein kinase	0.0022	0.0471	0.0471
Echinococcus multilocularis	cathepsin b	0.0275	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.055	0.1712
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0254	0.0759
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.098	0.3094
Schistosoma mansoni	cathepsin F (C01 family)	0.0024	0.055	0.055
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.055	0.1712
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0019	0.0348	0.0348
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0036	0.0982	0.3058
Onchocerca volvulus		0.0024	0.055	0.2954
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0036	0.0982	0.0949
Brugia malayi	Cathepsin L-like precursor	0.0024	0.055	0.055
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.098	0.3094
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0036	0.0982	0.3102
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.01	0.3413	0.3413
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.055	0.1712
Loa Loa (eye worm)	hypothetical protein	0.001	0.0018	0.0018
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0018	0.0018
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0017	0.0254	0.0217
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0254	0.2452
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Trichomonas vaginalis	calpain, putative	0.0011	0.0037	0.0063
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.055	0.1712
Loa Loa (eye worm)	calpain D	0.0011	0.0037	0.0037
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0025	0.0576	0.5803
Brugia malayi	cathepsin L-like precursor	0.0019	0.0348	0.0348
Toxoplasma gondii	cathepsin B	0.0093	0.3128	1
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.098	1
Entamoeba histolytica	hypothetical protein	0.0011	0.0051	0.0351
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0011	0.0051	0.0108
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0254	0.2452
Loa Loa (eye worm)	inositol-1	0.0036	0.098	0.098
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0017	0.0254	0.4431
Echinococcus multilocularis	calpain 5	0.0036	0.0982	0.0982
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0037	0.0063
Leishmania major	cathepsin L-like protease	0.0024	0.055	0.1712
Schistosoma mansoni	smdr2	0.001	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0051	0.0051
Trypanosoma brucei	caltractin, putative	0.0011	0.0045	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.055	0.1712
Trichomonas vaginalis	hypothetical protein	0.0011	0.0037	0.0063
Giardia lamblia	Cathepsin B precursor	0.0093	0.3128	1
Brugia malayi	multidrug resistance protein 3	0.001	0.0018	0.0018
Toxoplasma gondii	microneme protein MIC17C	0.0014	0.0174	0.0503
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0051	0.0351
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0051	0.0351
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Brugia malayi	calpain D	0.0011	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0174	0.0174
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0275	1	1
Loa Loa (eye worm)	calpain 5	0.0025	0.0576	0.0576
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.055	0.1712
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0471	0.0471
Loa Loa (eye worm)	hypothetical protein	0.001	0.0018	0.0018
Plasmodium falciparum	serine repeat antigen 9	0.0011	0.0051	0.0634
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0093	0.3128	0.3128
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0024	0.055	0.055
Plasmodium falciparum	serine repeat antigen 4	0.0011	0.0051	0.0634
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Brugia malayi	Papain family cysteine protease containing protein	0.0011	0.0051	0.0051
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.001	0.0018	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.2269	0.224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0024	0.055	0.1712
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0011	0.0051	0.035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.2269	0.722
Trypanosoma cruzi	cysteine proteinase, putative	0.0017	0.0254	0.0217
Brugia malayi	Kringle domain containing protein	0.0022	0.0471	0.0471
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0011	0.0051	0.0351
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0839	1
Brugia malayi	PAN domain containing protein	0.0014	0.0174	0.0174
Leishmania major	calpain family cysteine protease-like protein	0.0011	0.0037	0.0063
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0036	0.0982	0.3102
Trichomonas vaginalis	calpain, putative	0.0011	0.0037	0.0063
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.055	0.1712
Echinococcus multilocularis	ATP binding cassette sub family B	0.001	0.0013	0.0013
Leishmania major	cathepsin L-like protease	0.0024	0.055	0.1712
Echinococcus granulosus	cathepsin L cysteine protease	0.0017	0.0254	0.0254
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0036	0.0982	0.0949
Onchocerca volvulus		0.0024	0.055	0.2954
Plasmodium vivax	unspecified product	0.0011	0.0051	0.035
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0011	0.0037	0.0063
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0839	0.5
Onchocerca volvulus		0.0014	0.0174	0.0935
Schistosoma mansoni	cathepsin F (C01 family)	0.0024	0.055	0.055
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0051	0.0351
Brugia malayi	PAN domain containing protein	0.0014	0.0174	0.0174
Brugia malayi	PAN domain containing protein	0.0014	0.0174	0.0174
Echinococcus multilocularis	multidrug resistance protein 1	0.001	0.0018	0.0018
Entamoeba histolytica	cysteine protease, putative	0.0011	0.0051	0.0351
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0011	0.0051	0.0051
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0018	0.0018
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.098	0.3094
Onchocerca volvulus		0.0014	0.0174	0.0935
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0024	0.055	0.055
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0024	0.055	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0036	0.0982	0.0949
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0254	0.2452
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0011	0.0051	0.035
Brugia malayi	PAN domain containing protein	0.0014	0.0174	0.0174
Trypanosoma cruzi	cysteine proteinase, putative	0.0017	0.0254	0.0217
Brugia malayi	cathepsin F-like cysteine proteinase	0.0011	0.0051	0.0051
Plasmodium vivax	vivapain-3	0.0017	0.0254	0.2446
Schistosoma mansoni	hypothetical protein	0.0022	0.0471	0.0471
Onchocerca volvulus	Cathepsin L homolog	0.0024	0.055	0.2954
Onchocerca volvulus		0.0024	0.055	0.2954
Loa Loa (eye worm)	calpain	0.0036	0.0982	0.0982
Brugia malayi	calpain 7	0.0036	0.0982	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0174	0.0174
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.055	0.1712
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.055	0.1712
Brugia malayi	cathepsin L-like cysteine proteinase	0.0011	0.0051	0.0051
Onchocerca volvulus		0.0024	0.055	0.2954
Trypanosoma cruzi	kinesin, putative	0.0025	0.0576	0.0541
Onchocerca volvulus	Cathepsin L homolog	0.0011	0.0051	0.0276
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0051	0.0108
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0103	0.3497	0.3497
Loa Loa (eye worm)	cathepsin B	0.0093	0.3128	0.3128
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0011	0.0051	0.0051
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0254	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0348	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0348	0.0348
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0011	0.0051	0.0051
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0011	0.0051	0.035
Leishmania major	hypothetical protein, conserved	0.0022	0.0471	0.1458
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Trypanosoma cruzi	centrin-3	0.0011	0.0045	0.0007
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0254	0.2452
Echinococcus multilocularis	cathepsin L cysteine protease	0.0024	0.055	0.055
Trypanosoma cruzi	cysteine protease, putative	0.0017	0.0254	0.0217
Trypanosoma cruzi	major cysteine proteinase, putative	0.0011	0.0051	0.0014
Plasmodium vivax	vivapain-2	0.0024	0.055	0.5519
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0348	0.0348
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Plasmodium vivax	unspecified product	0.0017	0.0254	0.2446
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0174	0.0174
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0011	0.0051	0.035
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0011	0.0051	0.0108
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0011	0.0051	0.0108
Onchocerca volvulus		0.0022	0.0471	0.253
Onchocerca volvulus	Cathepsin F homolog	0.0024	0.055	0.2954
Plasmodium vivax	vivapain-1	0.0017	0.0254	0.2446
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0011	0.0051	0.035
Schistosoma mansoni	calpain C (C02 family)	0.0036	0.0982	0.0982
Echinococcus multilocularis	cathepsin L	0.0017	0.0254	0.0254
Loa Loa (eye worm)	ctsf protein	0.0024	0.055	0.055
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0254	0.2452
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0254	0.0254
Trypanosoma cruzi	kinesin, putative	0.0025	0.0576	0.0541
Plasmodium vivax	calpain, putative	0.0036	0.0982	1
Echinococcus granulosus	tissue type plasminogen activator	0.0022	0.0471	0.0471
Loa Loa (eye worm)	hypothetical protein	0.0275	1	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0011	0.0051	0.0051
Toxoplasma gondii	PAN domain-containing protein	0.0014	0.0174	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0051	0.0051
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0011	0.0037	0.0063
Echinococcus granulosus	cathepsin L	0.0011	0.0051	0.0051
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0011	0.0051	0.035
Giardia lamblia	Cathepsin B precursor	0.0093	0.3128	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0174	0.0174
Echinococcus multilocularis	cathepsin L	0.0011	0.0051	0.0051
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.2269	0.722
Leishmania major	hypothetical protein, conserved	0.0011	0.0037	0.0063
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.2269	0.722
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0268	0.9733	0.9733
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0254	0.2452
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.2269	0.224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.055	0.1712
Loa Loa (eye worm)	PAN domain-containing protein	0.0014	0.0174	0.0174
Toxoplasma gondii	hypothetical protein	0.0014	0.0174	0.0503
Onchocerca volvulus		0.0014	0.0174	0.0935
Onchocerca volvulus		0.0014	0.0174	0.0935
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0011	0.0051	0.0051
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0011	0.0051	0.0051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0254	0.0759
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0093	0.3128	1
Brugia malayi	cathepsin L precursor	0.0011	0.0051	0.0051
Plasmodium falciparum	serine repeat antigen 1	0.0011	0.0051	0.0634
Onchocerca volvulus		0.0014	0.0174	0.0935
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0017	0.0254	0.0254
Echinococcus multilocularis	tissue type plasminogen activator	0.0022	0.0471	0.0471
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0018	0.0018
Schistosoma mansoni	calpain-2 (C02 family)	0.0011	0.0037	0.0037
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0275	1	1
Echinococcus granulosus	cathepsin l1	0.0019	0.0348	0.0348
Echinococcus granulosus	cathepsin b	0.0275	1	1
Leishmania major	calpain protease-like protein	0.0011	0.0037	0.0063
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0024	0.055	0.055
Loa Loa (eye worm)	PAN domain-containing protein	0.0014	0.0174	0.0174
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0095	0.3214	0.3214
Trypanosoma cruzi	major cysteine proteinase, putative	0.0057	0.177	0.1739
Brugia malayi	PAN domain containing protein	0.0014	0.0174	0.0174
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.055	0.1712
Brugia malayi	PAN domain containing protein	0.0014	0.0174	0.0174
Loa Loa (eye worm)	calpain family protein 1	0.0095	0.3214	0.3214
Entamoeba histolytica	cysteine proteinase 1, putative	0.0017	0.0254	0.2452
Leishmania major	cathepsin L-like protease	0.007	0.2269	0.7237
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0018	0.0018
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0017	0.0254	0.0254
Echinococcus granulosus	calpain 7 C02 family	0.0036	0.0982	0.0982
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0254	0.2452
Trypanosoma cruzi	centrin, putative	0.0011	0.0045	0.0007
Loa Loa (eye worm)	multidrug resistance protein 3	0.001	0.0018	0.0018
Brugia malayi	Papain family cysteine protease containing protein	0.0011	0.0051	0.0051
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.01	0.3413	0.3413
Toxoplasma gondii	microneme protein MIC4	0.0014	0.0174	0.0503
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0011	0.0037	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0051	0.0108
Toxoplasma gondii	PAN domain-containing protein	0.0014	0.0174	0.0503
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0011	0.0051	0.0051
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.2269	0.224
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0018	0.0018
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0011	0.0037	0.0063
Brugia malayi	PAN domain containing protein	0.0014	0.0174	0.0174
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0036	0.0982	0.3058
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0275	1	1
Trypanosoma brucei	calpain-like protein, putative	0.0036	0.0982	0.3058
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0018	0.0018

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (ADMET)	= 2975 nM	Antiproliferative activity against quesicent HUVECs after 48 hrs by CCK-8 assay	ChEMBL.	23360369

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23360369

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2331921

Bibliographic References

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Detailed information for compound 1735279