Detailed information for compound 1752173

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 303.399 | Formula: C17H25N3O2
  • H donors: 1 H acceptors: 0 LogP: 1.39 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1OC[C@H]2[C@@H]1C[C@H](NC2)c1cccc(c1)N1CCOCC1
  • InChi: 1S/C17H25N3O2/c1-19-17-10-16(18-11-14(17)12-22-19)13-3-2-4-15(9-13)20-5-7-21-8-6-20/h2-4,9,14,16-18H,5-8,10-12H2,1H3/t14-,16-,17-/m0/s1
  • InChiKey: PRNPFCBBLIINPL-XIRDDKMYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0017 0.0285 1
Mycobacterium ulcerans hypothetical protein 0.0012 0.0101 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0285 0.0297
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2309 0.2406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0285 0.0297
Echinococcus granulosus cathepsin l1 0.0017 0.0285 0.0297
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.4748 0.4948
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0285 0.0297
Trypanosoma brucei NAD dependent epimerase/dehydratase family, putative 0.0012 0.0101 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0285 0.0297
Schistosoma mansoni hypothetical protein 0.0016 0.0251 0.0261
Mycobacterium ulcerans hypothetical protein 0.0012 0.0101 0.5
Mycobacterium tuberculosis Conserved protein 0.0012 0.0101 0.5
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0285 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0285 0.0297
Mycobacterium tuberculosis Possible oxidoreductase 0.0012 0.0101 0.5
Brugia malayi Cathepsin L-like precursor 0.0012 0.0091 0.0094
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.1059 0.1104
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2309 0.2406
Entamoeba histolytica hypothetical protein 0.0037 0.0959 0.0999
Echinococcus granulosus CREB binding protein 0.0092 0.2849 0.2969
Echinococcus granulosus GDP L fucose synthase 0.0012 0.0101 0.0106
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0012 0.0101 0.0106
Mycobacterium tuberculosis Possible dTDP-glucose 4,6-dehydratase 0.0012 0.0101 0.5
Mycobacterium ulcerans UDP-glucose 4-epimerase 0.0012 0.0101 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0285 0.0297
Trypanosoma cruzi UDP-galactose 4-epimerase 0.029 0.9596 1
Onchocerca volvulus 0.0012 0.0101 0.056
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.1183 0.1233
Brugia malayi RNA binding protein 0.0076 0.2309 0.2406
Onchocerca volvulus 0.0017 0.0285 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1934 0.1934
Brugia malayi hypothetical protein 0.0037 0.0959 0.0999
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0285 0.0297
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1445 0.1425
Mycobacterium ulcerans oxidoreductase 0.0012 0.0101 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1934 0.1934
Mycobacterium tuberculosis Probable UDP-glucose 4-epimerase GalE3 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase 0.0012 0.0101 0.5
Mycobacterium ulcerans nucleoside-diphosphate-sugar epimerase 0.0012 0.0101 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0959 0.0999
Loa Loa (eye worm) acetyltransferase 0.0148 0.4748 0.49
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.2309 0.2406
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.1183 1
Mycobacterium leprae conserved hypothetical protein 0.0012 0.0101 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0892 0.093
Entamoeba histolytica UDP-glucose 4-epimerase, putative 0.029 0.9596 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0285 0.0297
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0012 0.0101 0.0106
Loa Loa (eye worm) fibroinase 0.0017 0.0285 0.0204
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0285 0.0297
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0285 0.0297
Schistosoma mansoni hypothetical protein 0.0037 0.0959 0.0999
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1212 0.1263
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0285 0.0297
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0251 0.0261
Loa Loa (eye worm) UDP galactose 4'-epimerase 0.029 0.9596 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0285 0.0297
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1934 0.1934
Brugia malayi Cathepsin L-like precursor 0.0012 0.0091 0.0094
Schistosoma mansoni NAD dependent epimerase/dehydratase 0.0012 0.0101 0.0106
Brugia malayi TAZ zinc finger family protein 0.0092 0.2849 0.2969
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0285 0.0297
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.1183 0.1139
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0285 0.0204
Echinococcus multilocularis GPCR, family 2 0.0016 0.0251 0.0261
Echinococcus granulosus cathepsin l1 0.0012 0.0091 0.0094
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1445 0.1506
Schistosoma mansoni UDP-glucose 4-epimerase 0.029 0.9596 1
Plasmodium vivax vivapain-2 0.0017 0.0285 0.2406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0285 0.0297
Echinococcus granulosus UDP glucose 4 epimerase 0.029 0.9596 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0285 0.0297
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1934 0.1934
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.1212 0.1263
Echinococcus granulosus CREB binding protein 0.0092 0.2849 0.2969
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0092 0.2849 0.2969
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0285 0.0297
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1934 0.2015
Trypanosoma cruzi GDP-mannose 4,6 dehydratase, putative 0.0012 0.0101 0.0106
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.1183 0.1233
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.735 0.7637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0285 0.0297
Trypanosoma cruzi hypothetical protein 0.0012 0.0101 0.0106
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.4606 0.48
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.1059 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0892 0.0843
Echinococcus granulosus NADH dehydrogenase ubiquinone 1 alpha 0.0012 0.0101 0.0106
Echinococcus granulosus epimerase family protein sdr39u1 0.0012 0.0101 0.0106
Onchocerca volvulus 0.0017 0.0285 1
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0101 0.0106
Onchocerca volvulus 0.0017 0.0285 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.1445 0.1425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0285 0.0297
Entamoeba histolytica hypothetical protein, conserved 0.0012 0.0101 0.0106
Onchocerca volvulus 0.0017 0.0285 1
Loa Loa (eye worm) ctsf protein 0.0017 0.0285 0.0204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0091 0.0094
Entamoeba histolytica hypothetical protein 0.0037 0.0959 0.0999
Loa Loa (eye worm) cysteine protease 0.0017 0.0285 0.0204
Toxoplasma gondii UDP-glucose 4-epimerase 0.029 0.9596 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0285 0.0204
Wolbachia endosymbiont of Brugia malayi nucleoside-diphosphate-sugar epimerase 0.0012 0.0101 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0101 0.0106
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0285 0.2687
Loa Loa (eye worm) hypothetical protein 0.0012 0.0101 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0251 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1934 0.1934
Plasmodium falciparum GDP-L-fucose synthase 0.0012 0.0101 0.0958
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0285 0.2687
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0445 0.0373
Leishmania major cathepsin L-like protease 0.0066 0.1934 0.1851
Leishmania major cathepsin L-like protease 0.0017 0.0285 0.0185
Trichomonas vaginalis UDP-glucose 4-epimerase, putative 0.029 0.9596 1
Leishmania major cathepsin L-like protease 0.0017 0.0285 0.0185
Trypanosoma cruzi UDP-galactose 4-epimerase, putative 0.029 0.9596 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0285 0.0297
Echinococcus multilocularis GDP L fucose synthase 0.0012 0.0101 0.0106
Trichomonas vaginalis dihydroflavonal-4-reductase, putative 0.0012 0.0101 0.0106
Loa Loa (eye worm) RNA binding protein 0.0076 0.2309 0.2333
Trypanosoma brucei GDP-L-fucose synthetase 0.0012 0.0101 0.0101
Entamoeba histolytica hypothetical protein 0.0037 0.0959 0.0999
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0285 0.0297
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0285 0.0297
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.1059 0.0967
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.1455 0.1517
Entamoeba histolytica hypothetical protein 0.0037 0.0959 0.0999
Schistosoma mansoni CREB-binding protein 2 0.0092 0.2849 0.2969
Mycobacterium ulcerans UDP-glucose 4-epimerase GalE2 0.0012 0.0101 0.5
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.4748 0.4948
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.174 0.1813
Brugia malayi Cathepsin L-like precursor 0.0017 0.0285 0.0297
Echinococcus multilocularis tar DNA binding protein 0.0076 0.2309 0.2406
Echinococcus multilocularis epimerase family protein sdr39u1 0.0012 0.0101 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0285 0.0297
Mycobacterium ulcerans UDP-glucose 4-epimerase 0.0012 0.0101 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0285 0.0297
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0251 0.0261
Leishmania major udp-glc 4-epimerase, putative 0.0302 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2309 0.2406
Echinococcus multilocularis NAD(P) binding domain 0.0012 0.0101 0.0106
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.1183 0.1233
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0101 0.0106
Onchocerca volvulus 0.0012 0.0101 0.056
Echinococcus multilocularis UDP glucose 4 epimerase 0.029 0.9596 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1212 0.1263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0285 0.0297
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0285 0.0297
Brugia malayi Cathepsin L-like precursor 0.0017 0.0285 0.0297
Brugia malayi Cathepsin L-like precursor 0.0017 0.0285 0.0297
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1934 0.1934
Mycobacterium ulcerans oxidoreductase 0.0012 0.0101 0.5
Schistosoma mansoni hypothetical protein 0.0016 0.0251 0.0261
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.2309 0.2333
Onchocerca volvulus 0.0017 0.0285 1
Brugia malayi cathepsin L-like precursor 0.0012 0.0091 0.0094
Echinococcus granulosus tar DNA binding protein 0.0076 0.2309 0.2406
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1212 0.1263
Brugia malayi NAD dependent epimerase/dehydratase family protein 0.0012 0.0101 0.0106
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0091 0.0094
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1212 0.1263
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0285 0.0297
Brugia malayi follicle stimulating hormone receptor 0.0224 0.735 0.766
Loa Loa (eye worm) oxidoreductase 0.0012 0.0101 0.0011
Trypanosoma brucei L-threonine 3-dehydrogenase 0.0012 0.0101 0.0101
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1445 0.1506
Echinococcus granulosus GPCR family 2 0.0016 0.0251 0.0261
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1212 0.1263
Trypanosoma brucei NAD dependent epimerase/dehydratase family, putative 0.0012 0.0101 0.0101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0285 0.0297
Brugia malayi TAR-binding protein 0.0076 0.2309 0.2406
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.029 0.9596 1
Trypanosoma cruzi NAD dependent epimerase/dehydratase family, putative 0.0012 0.0101 0.0106
Mycobacterium leprae POSSIBLE UDP-GLUCOSE 4-EPIMERASE GALE2 (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE 4-EPIMERASE 0.0012 0.0101 0.5
Trypanosoma cruzi GDP-L-fucose synthetase, putative 0.0012 0.0101 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1212 0.1263
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 27 0.0012 0.0101 0.0106
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.1183 0.1139
Brugia malayi Cathepsin L-like precursor 0.0017 0.0285 0.0297
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0101 0.0106
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0285 0.0185
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0285 1
Leishmania major cathepsin L-like protease 0.0017 0.0285 0.0185
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1212 0.1263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0285 0.0297
Entamoeba histolytica cysteine protease, putative 0.0017 0.0285 0.0297
Echinococcus multilocularis cysteine protease 0.0017 0.0285 0.0297
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0285 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0251 0.0261
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2309 0.2406
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0285 0.2687
Leishmania major cathepsin L-like protease 0.0066 0.1934 0.1851
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0091 0.0094
Brugia malayi epimerase/reductase 0.0012 0.0101 0.0106
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0251 0.0261
Entamoeba histolytica hypothetical protein, conserved 0.0012 0.0101 0.0106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0285 0.0297
Brugia malayi Cathepsin L-like precursor 0.0017 0.0285 0.0297
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0959 0.0999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0285 0.0297
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0012 0.0101 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0285 0.0297
Trypanosoma cruzi L-threonine 3-dehydrogenase, putative 0.0012 0.0101 0.0106
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.4748 0.4948
Loa Loa (eye worm) hypothetical protein 0.0012 0.0101 0.0011
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0251 0.0168
Brugia malayi Cathepsin L-like precursor 0.0017 0.0285 0.0297
Echinococcus granulosus NADP binding domain 0.0012 0.0101 0.0106
Brugia malayi UDP galactose 4'-epimerase 0.029 0.9596 1
Schistosoma mansoni hypothetical protein 0.0016 0.0251 0.0261
Mycobacterium tuberculosis Possible oxidoreductase 0.0012 0.0101 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2309 0.2406
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0012 0.0101 0.0106
Loa Loa (eye worm) CBP-B 0.0092 0.2849 0.2902
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0012 0.0101 0.0106
Schistosoma mansoni hypothetical protein 0.0035 0.0892 0.093
Onchocerca volvulus 0.0012 0.0101 0.056
Loa Loa (eye worm) hypothetical protein 0.0016 0.0251 0.0168
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0251 0.0261
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.1934 0.2015
Leishmania major cathepsin L-like protease 0.0017 0.0285 0.0185
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0285 0.0297
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1934 0.2015
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0012 0.0101 0.0106
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.1212 0.118
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0012 0.0101 0.0106
Schistosoma mansoni hypothetical protein 0.0016 0.0251 0.0261
Loa Loa (eye worm) TAR-binding protein 0.0076 0.2309 0.2333
Mycobacterium tuberculosis Probable nucleotide-sugar epimerase EpiA 0.0012 0.0101 0.5
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) 1 alpha 0.0012 0.0101 0.0106
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0091 0.0094
Leishmania major cathepsin L-like protease 0.0066 0.1934 0.1851
Mycobacterium ulcerans hypothetical protein 0.0012 0.0101 0.5
Plasmodium vivax GDP-L-fucose synthase, putative 0.0012 0.0101 0.0857
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1934 0.1934
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0285 0.0297
Onchocerca volvulus 0.0017 0.0285 1
Trypanosoma cruzi NAD dependent epimerase/dehydratase family, putative 0.0012 0.0101 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1934 0.1934
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0285 0.0297
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0012 0.0101 0.5
Leishmania major cathepsin L-like protease 0.0017 0.0285 0.0185
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0285 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0285 0.0297
Loa Loa (eye worm) hypothetical protein 0.0017 0.0285 0.0204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0091 0.0094
Echinococcus multilocularis cysteine protease 0.0017 0.0285 0.0297
Toxoplasma gondii cathepsin CPL 0.0017 0.0285 0.0193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1934 0.1934
Brugia malayi GDP-L-fucose synthetase 0.0012 0.0101 0.0106
Mycobacterium ulcerans hypothetical protein 0.0012 0.0101 0.5
Trypanosoma cruzi L-threonine 3-dehydrogenase, putative 0.0012 0.0101 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1934 0.1934
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1934 0.2015
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.029 0.9596 1
Brugia malayi Cytochrome P450 family protein 0.0022 0.0445 0.0464
Onchocerca volvulus 0.0012 0.0101 0.056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1934 0.1934
Trypanosoma brucei UDP-galactose 4-epimerase 0.0302 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0285 0.0297
Plasmodium vivax vivapain-2 0.0017 0.0285 0.2406
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0959 0.0999
Echinococcus multilocularis CREB binding protein 0.0092 0.2849 0.2969

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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