Detailed information for compound 1752175

Basic information

Technical information
  • TDR Targets ID: 1752175
  • Name: N-(furan-2-ylmethyl)-4-[3-(3-methylphenyl)-1, 2,4-oxadiazol-5-yl]butanamide
  • MW: 325.362 | Formula: C18H19N3O3
  • H donors: 1 H acceptors: 3 LogP: 2.66 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccco1)CCCc1onc(n1)c1cccc(c1)C
  • InChi: 1S/C18H19N3O3/c1-13-5-2-6-14(11-13)18-20-17(24-21-18)9-3-8-16(22)19-12-15-7-4-10-23-15/h2,4-7,10-11H,3,8-9,12H2,1H3,(H,19,22)
  • InChiKey: XEFFXQQOARYKPB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-furylmethyl)-4-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]butanamide
  • N-(2-furylmethyl)-4-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]butyramide
  • D134-0147
  • NCGC00116084-01
  • BAS 10848297
  • N-Furan-2-ylmethyl-4-(3-m-tolyl-[1,2,4]oxadiazol-5-yl)-butyramide
  • ST064251
  • ZINC04433704

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum GDP-L-fucose synthase 0.0017 0.0311 0.5
Onchocerca volvulus 0.0017 0.0311 0.5
Brugia malayi GDP-L-fucose synthetase 0.0017 0.0311 0.0324
Echinococcus multilocularis epimerase family protein sdr39u1 0.0017 0.0311 0.0324
Toxoplasma gondii GDP-L-fucose synthetase 0.0017 0.0311 0.0324
Mycobacterium ulcerans oxidoreductase 0.0017 0.0311 1
Trypanosoma cruzi NAD dependent epimerase/dehydratase family, putative 0.0017 0.0311 0.0324
Schistosoma mansoni NAD dependent epimerase/dehydratase 0.0017 0.0311 0.0324
Brugia malayi follicle stimulating hormone receptor 0.0232 0.5435 0.5659
Mycobacterium tuberculosis Possible oxidoreductase 0.0017 0.0311 1
Toxoplasma gondii NAD dependent epimerase/dehydratase family protein 0.0017 0.0311 0.0324
Trypanosoma brucei L-threonine 3-dehydrogenase 0.0017 0.0311 0.0311
Trypanosoma cruzi GDP-mannose 4,6 dehydratase, putative 0.0017 0.0311 0.0324
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0988 0.1029
Brugia malayi Cytochrome P450 family protein 0.0023 0.0455 0.0473
Loa Loa (eye worm) hypothetical protein 0.0017 0.0311 0.0324
Trypanosoma cruzi hypothetical protein 0.0017 0.0311 0.0324
Trypanosoma cruzi UDP-galactose 4-epimerase, putative 0.0406 0.9605 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.5435 0.5659
Mycobacterium tuberculosis Probable UDP-glucose 4-epimerase GalE3 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase 0.0017 0.0311 1
Loa Loa (eye worm) oxidoreductase 0.0017 0.0311 0.0324
Brugia malayi NAD dependent epimerase/dehydratase family protein 0.0017 0.0311 0.0324
Mycobacterium leprae conserved hypothetical protein 0.0017 0.0311 1
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0406 0.9605 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0988 0.1029
Wolbachia endosymbiont of Brugia malayi nucleoside-diphosphate-sugar epimerase 0.0017 0.0311 0.5
Mycobacterium ulcerans hypothetical protein 0.0017 0.0311 1
Trypanosoma cruzi L-threonine 3-dehydrogenase, putative 0.0017 0.0311 0.0324
Onchocerca volvulus 0.0017 0.0311 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0988 0.1029
Trypanosoma cruzi GDP-L-fucose synthetase, putative 0.0017 0.0311 0.0324
Mycobacterium leprae POSSIBLE UDP-GLUCOSE 4-EPIMERASE GALE2 (GALACTOWALDENASE) (UDP-GALACTOSE 4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE 4-EPIMERASE 0.0017 0.0311 1
Mycobacterium ulcerans hypothetical protein 0.0017 0.0311 1
Loa Loa (eye worm) UDP galactose 4'-epimerase 0.0406 0.9605 1
Echinococcus multilocularis NAD(P) binding domain 0.0017 0.0311 0.0324
Echinococcus granulosus NADP binding domain 0.0017 0.0311 0.0324
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0406 0.9605 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0311 0.0324
Plasmodium vivax GDP-L-fucose synthase, putative 0.0017 0.0311 0.5
Toxoplasma gondii UDP-glucose 4-epimerase 0.0406 0.9605 1
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0311 0.0324
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) 1 alpha 0.0017 0.0311 0.0324
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0988 0.1029
Leishmania major udp-glc 4-epimerase, putative 0.0423 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0311 0.0324
Echinococcus granulosus NADH dehydrogenase ubiquinone 1 alpha 0.0017 0.0311 0.0324
Mycobacterium ulcerans UDP-glucose 4-epimerase 0.0017 0.0311 1
Echinococcus multilocularis UDP glucose 4 epimerase 0.0406 0.9605 1
Mycobacterium tuberculosis Possible dTDP-glucose 4,6-dehydratase 0.0017 0.0311 1
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0311 0.0324
Trypanosoma brucei NAD dependent epimerase/dehydratase family, putative 0.0017 0.0311 0.0311
Mycobacterium ulcerans nucleoside-diphosphate-sugar epimerase 0.0017 0.0311 1
Mycobacterium ulcerans oxidoreductase 0.0017 0.0311 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0988 0.1029
Mycobacterium tuberculosis Probable nucleotide-sugar epimerase EpiA 0.0017 0.0311 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0988 0.1029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0988 0.1029
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0455 0.0473
Trypanosoma brucei GDP-L-fucose synthetase 0.0017 0.0311 0.0311
Mycobacterium tuberculosis Conserved protein 0.0017 0.0311 1
Brugia malayi epimerase/reductase 0.0017 0.0311 0.0324
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 27 0.0017 0.0311 0.0324
Trypanosoma cruzi L-threonine 3-dehydrogenase, putative 0.0017 0.0311 0.0324
Mycobacterium ulcerans hypothetical protein 0.0017 0.0311 1
Mycobacterium ulcerans UDP-glucose 4-epimerase 0.0017 0.0311 1
Brugia malayi UDP galactose 4'-epimerase 0.0406 0.9605 1
Echinococcus granulosus GDP L fucose synthase 0.0017 0.0311 0.0324
Echinococcus granulosus epimerase family protein sdr39u1 0.0017 0.0311 0.0324
Schistosoma mansoni UDP-glucose 4-epimerase 0.0406 0.9605 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0988 0.1029
Trypanosoma cruzi UDP-galactose 4-epimerase 0.0406 0.9605 1
Trypanosoma cruzi NAD dependent epimerase/dehydratase family, putative 0.0017 0.0311 0.0324
Entamoeba histolytica UDP-glucose 4-epimerase, putative 0.0406 0.9605 1
Echinococcus multilocularis GDP L fucose synthase 0.0017 0.0311 0.0324
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0017 0.0311 1
Mycobacterium ulcerans UDP-glucose 4-epimerase GalE2 0.0017 0.0311 1
Trypanosoma brucei UDP-galactose 4-epimerase 0.0423 1 1
Leishmania major hypothetical protein, conserved 0.0017 0.0311 0.0311
Mycobacterium tuberculosis Possible oxidoreductase 0.0017 0.0311 1
Onchocerca volvulus 0.0017 0.0311 0.5
Echinococcus granulosus UDP glucose 4 epimerase 0.0406 0.9605 1
Onchocerca volvulus 0.0017 0.0311 0.5
Mycobacterium ulcerans hypothetical protein 0.0017 0.0311 1
Trypanosoma brucei NAD dependent epimerase/dehydratase family, putative 0.0017 0.0311 0.0311
Trichomonas vaginalis UDP-glucose 4-epimerase, putative 0.0406 0.9605 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0988 0.1029

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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