Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0213 | 0.7911 | 0.7911 |
Onchocerca volvulus | 0.0044 | 0.0698 | 1 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.033 | 0.033 |
Brugia malayi | Peroxidasin | 0.0036 | 0.033 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Brugia malayi | Carboxylesterase family protein | 0.0262 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0164 | 0.0164 |
Onchocerca volvulus | 0.0044 | 0.0698 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0164 | 0.0164 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0044 | 0.0698 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0164 | 0.0164 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Echinococcus multilocularis | acetylcholinesterase | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0262 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0044 | 0.0698 | 0.0698 |
Schistosoma mansoni | cell adhesion molecule | 0.0032 | 0.0167 | 0.0167 |
Brugia malayi | Blistered cuticle protein 3 | 0.0032 | 0.0164 | 0.0164 |
Echinococcus granulosus | carboxylesterase 5A | 0.0262 | 1 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0213 | 0.7911 | 0.7911 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0044 | 0.0698 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0044 | 0.0698 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Schistosoma mansoni | acetylcholinesterase | 0.0044 | 0.0698 | 0.0698 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0044 | 0.0698 | 0.5 |
Brugia malayi | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0213 | 0.7911 | 0.7911 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0164 | 0.0164 |
Onchocerca volvulus | 0.0044 | 0.0698 | 1 | |
Schistosoma mansoni | peroxidasin | 0.0032 | 0.0164 | 0.0164 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0032 | 0.0164 | 0.0164 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0044 | 0.0698 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0034 | 0.0275 | 0.0275 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0044 | 0.0698 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0036 | 0.033 | 0.033 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0044 | 0.0698 | 0.0698 |
Echinococcus granulosus | hormone sensitive lipase | 0.0213 | 0.7911 | 0.7911 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0164 | 0.0164 |
Echinococcus granulosus | roundabout 2 | 0.0032 | 0.0167 | 0.0167 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Echinococcus granulosus | acetylcholinesterase | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | carboxylesterase | 0.0044 | 0.0698 | 0.0698 |
Echinococcus granulosus | acetylcholinesterase | 0.0262 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0036 | 0.033 | 0.033 |
Onchocerca volvulus | 0.0044 | 0.0698 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0164 | 0.0164 |
Echinococcus multilocularis | neuroligin | 0.0044 | 0.0698 | 0.0698 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0698 | 0.0698 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0044 | 0.0698 | 0.0698 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0262 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0167 | 0.0167 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0698 | 0.0698 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0213 | 0.7911 | 0.7911 |
Echinococcus multilocularis | acetylcholinesterase | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0032 | 0.0167 | 0.0167 |
Echinococcus granulosus | neuroligin | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0167 | 0.0167 |
Onchocerca volvulus | 0.0044 | 0.0698 | 1 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Schistosoma mansoni | peroxidasin | 0.0036 | 0.033 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | carboxylesterase | 0.0044 | 0.0698 | 0.0698 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0032 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0034 | 0.0275 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.7911 | 0.7911 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log IC50 (binding) | = 0.36 | Inhibitory activity against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383010 |
IC50 (binding) | = 0.36 | Inhibitory activity against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383010 |
IC50 (binding) | = 6.36 | Inhibition of human Prostaglandin G/H synthase 2 | ChEMBL. | 11563921 |
IC50 (binding) | = 0.44 uM | Inhibitory activity against human Prostaglandin G/H synthase 2 | ChEMBL. | 10956225 |
IC50 (binding) | = 0.44 uM | Inhibitory activity against human Prostaglandin G/H synthase 2 | ChEMBL. | 10956225 |
IC50 (binding) | > 1000 uM | Inhibitory activity against Prostaglandin G/H synthase 1 | ChEMBL. | 10956225 |
IC50 (binding) | > 1000 uM | Inhibitory activity against Prostaglandin G/H synthase 1 | ChEMBL. | 10956225 |
Inhibition (functional) | = 100 % | Inhibitory activity against prostaglandin production in rat air-pouch model at 2 mg/kg dose | ChEMBL. | 10956225 |
Log IC50 (binding) | = 6.36 | Inhibition of human Prostaglandin G/H synthase 2 | ChEMBL. | 11563921 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.