Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Echinococcus granulosus | acetylcholinesterase | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0044 | 0.0698 | 0.0698 |
Echinococcus granulosus | acetylcholinesterase | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0164 | 0.0164 |
Echinococcus multilocularis | peroxidasin | 0.0036 | 0.033 | 0.033 |
Echinococcus multilocularis | neuroligin | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0164 | 0.0164 |
Onchocerca volvulus | 0.0044 | 0.0698 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0044 | 0.0698 | 0.0698 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0262 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | carboxylesterase | 0.0262 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0262 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0213 | 0.7911 | 0.7911 |
Echinococcus granulosus | neuroligin | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0167 | 0.0167 |
Echinococcus multilocularis | roundabout 2 | 0.0032 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Onchocerca volvulus | 0.0044 | 0.0698 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0034 | 0.0275 | 0.0275 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0032 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | carboxylesterase | 0.0044 | 0.0698 | 0.0698 |
Schistosoma mansoni | peroxidasin | 0.0036 | 0.033 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.7911 | 0.7911 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.033 | 0.033 |
Onchocerca volvulus | 0.0044 | 0.0698 | 1 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0213 | 0.7911 | 0.7911 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Brugia malayi | Peroxidasin | 0.0036 | 0.033 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0167 | 0.0167 |
Onchocerca volvulus | 0.0044 | 0.0698 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0164 | 0.0164 |
Brugia malayi | Carboxylesterase family protein | 0.0262 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0164 | 0.0164 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0044 | 0.0698 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0262 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0164 | 0.0164 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0698 | 0.0698 |
Echinococcus multilocularis | acetylcholinesterase | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Brugia malayi | Blistered cuticle protein 3 | 0.0032 | 0.0164 | 0.0164 |
Schistosoma mansoni | cell adhesion molecule | 0.0032 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0044 | 0.0698 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0213 | 0.7911 | 0.7911 |
Echinococcus granulosus | carboxylesterase 5A | 0.0262 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0044 | 0.0698 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0164 | 0.0164 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0044 | 0.0698 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Schistosoma mansoni | acetylcholinesterase | 0.0044 | 0.0698 | 0.0698 |
Schistosoma mansoni | gliotactin | 0.0044 | 0.0698 | 0.0698 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0213 | 0.7911 | 0.7911 |
Brugia malayi | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0044 | 0.0698 | 0.0698 |
Schistosoma mansoni | peroxidasin | 0.0032 | 0.0164 | 0.0164 |
Onchocerca volvulus | 0.0044 | 0.0698 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0032 | 0.0164 | 0.0164 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0044 | 0.0698 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0036 | 0.033 | 0.033 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0044 | 0.0698 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0034 | 0.0275 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Echinococcus granulosus | roundabout 2 | 0.0032 | 0.0167 | 0.0167 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0164 | 0.0164 |
Echinococcus granulosus | hormone sensitive lipase | 0.0213 | 0.7911 | 0.7911 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0044 | 0.0698 | 0.0698 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.74 | Inhibition of human Prostaglandin G/H synthase 2 | ChEMBL. | 11563921 |
IC50 (binding) | = 1.83 uM | Inhibitory activity against human Prostaglandin G/H synthase 2 | ChEMBL. | 10956225 |
IC50 (binding) | = 1.83 uM | Inhibitory activity against human Prostaglandin G/H synthase 2 | ChEMBL. | 10956225 |
IC50 (binding) | > 100 uM | Inhibitory activity against Prostaglandin G/H synthase 1 | ChEMBL. | 10956225 |
IC50 (binding) | > 100 uM | Inhibitory activity against Prostaglandin G/H synthase 1 | ChEMBL. | 10956225 |
Inhibition (functional) | = 19 % | Inhibitory activity against prostaglandin production in rat air-pouch model at 2 mg/kg dose | ChEMBL. | 10956225 |
Log IC50 (binding) | = 5.74 | Inhibition of human Prostaglandin G/H synthase 2 | ChEMBL. | 11563921 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.