Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ATP-binding cassette transporter ABC.B1 | 0.0048 | 1 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0041 | 0.7936 | 0.7895 |
Mycobacterium leprae | PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER | 0.0017 | 0.0198 | 0.5 |
Entamoeba histolytica | P-glycoprotein-1 | 0.0048 | 1 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0048 | 1 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0031 | 0.4521 | 0.4521 |
Plasmodium falciparum | multidrug resistance protein 1 | 0.0048 | 1 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0031 | 0.4669 | 0.5777 |
Entamoeba histolytica | P-glycoprotein-2, putative | 0.0048 | 1 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0048 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.4669 | 0.5777 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0041 | 0.7936 | 0.7936 |
Loa Loa (eye worm) | ATP-binding cassette sub-family B member 2 | 0.0048 | 1 | 1 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0041 | 0.7936 | 0.7936 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.003 | 0.4212 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0048 | 1 | 1 |
Leishmania major | p-glycoprotein e | 0.003 | 0.4212 | 0.4095 |
Mycobacterium tuberculosis | Probable transmembrane multidrug efflux pump | 0.0048 | 1 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.003 | 0.4212 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0031 | 0.4669 | 0.5777 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0048 | 1 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.003 | 0.4212 | 0.5187 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.003 | 0.4212 | 0.4095 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.4212 | 0.4212 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.003 | 0.4212 | 0.5187 |
Leishmania major | ABC-thiol transporter | 0.003 | 0.4212 | 0.4095 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0048 | 1 | 1 |
Trypanosoma brucei | trans-sialidase | 0.0031 | 0.4669 | 0.5777 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.4212 | 0.4212 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0017 | 0.0198 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.003 | 0.4212 | 0.4095 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0048 | 1 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0031 | 0.4669 | 0.5777 |
Trypanosoma brucei | multidrug resistance protein E | 0.003 | 0.4212 | 0.5187 |
Echinococcus granulosus | ATP binding cassette sub family B | 0.0017 | 0.0198 | 0.0198 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.003 | 0.4212 | 0.4095 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0048 | 1 | 1 |
Onchocerca volvulus | 0.0048 | 1 | 0.5 | |
Schistosoma mansoni | multidrug resistance protein | 0.0017 | 0.0198 | 0.0198 |
Schistosoma mansoni | multidrug resistance protein | 0.0048 | 1 | 1 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0041 | 0.7936 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.4014 | 0.4014 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.4669 | 0.5777 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0041 | 0.7936 | 0.7936 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0048 | 1 | 1 |
Brugia malayi | ABC transporter family protein | 0.0048 | 1 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0031 | 0.4669 | 0.5777 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0048 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.4669 | 0.5777 |
Loa Loa (eye worm) | multidrug resistance protein 3 | 0.0048 | 1 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0047 | 0.9802 | 0.9798 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.4669 | 0.5777 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0031 | 0.4521 | 0.4411 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.4669 | 0.5777 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0017 | 0.0198 | 0.5 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0041 | 0.7936 | 0.7936 |
Mycobacterium ulcerans | component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD | 0.0017 | 0.0198 | 0.5 |
Brugia malayi | ABC transporter family protein | 0.0017 | 0.0198 | 0.0198 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.4212 | 0.4212 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.003 | 0.4212 | 0.4095 |
Trichomonas vaginalis | abcb9, putative | 0.0048 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0017 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.4212 | 0.4212 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.4669 | 0.5777 |
Entamoeba histolytica | P-glycoprotein 5, putative | 0.0048 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0048 | 1 | 1 |
Loa Loa (eye worm) | ABC transporter | 0.0017 | 0.0198 | 0.0198 |
Echinococcus granulosus | 5'partial|ATP binding cassette sub family B | 0.0047 | 0.9802 | 0.9802 |
Brugia malayi | P-glycoprotein-like protein | 0.0017 | 0.0198 | 0.0198 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.003 | 0.4212 | 0.4095 |
Leishmania major | p-glycoprotein | 0.0048 | 1 | 1 |
Leishmania major | pentamidine resistance protein 1 | 0.003 | 0.4212 | 0.4095 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0048 | 1 | 1 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0017 | 0.0198 | 0.0198 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.4667 | 0.5776 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0048 | 1 | 1 |
Entamoeba histolytica | P-glycoprotein-5 | 0.0048 | 1 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.003 | 0.4212 | 0.5187 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0029 | 0.4014 | 0.953 |
Trichomonas vaginalis | ABC transporter, putative | 0.0048 | 1 | 1 |
Loa Loa (eye worm) | ABC transporter | 0.0017 | 0.0198 | 0.0198 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.4667 | 0.5776 |
Schistosoma mansoni | smdr2 | 0.0048 | 1 | 1 |
Leishmania major | ATP-binding cassette protein subfamily B, member 2, putative | 0.0048 | 1 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0048 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0048 | 1 | 1 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.003 | 0.4212 | 0.4212 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0048 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0198 | 0.0198 |
Mycobacterium leprae | PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER | 0.0017 | 0.0198 | 0.5 |
Trypanosoma brucei | trans-sialidase, putative | 0.0031 | 0.4669 | 0.5777 |
Entamoeba histolytica | P-glycoprotein 6, putative | 0.0017 | 0.0198 | 0.0198 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0048 | 1 | 1 |
Giardia lamblia | ABC transporter, putative | 0.003 | 0.4212 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.4212 | 0.4212 |
Schistosoma mansoni | ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) | 0.0017 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 1 | 1 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0048 | 1 | 1 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.003 | 0.4212 | 0.4095 |
Giardia lamblia | MRP-like ABC transporter | 0.003 | 0.4212 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0048 | 1 | 1 |
Chlamydia trachomatis | ABC transporter ATP binding protein/permease | 0.0048 | 1 | 0.5 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0048 | 1 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0041 | 0.7936 | 0.7936 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.4669 | 0.5777 |
Trichomonas vaginalis | ABC transporter, putative | 0.0048 | 1 | 1 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0041 | 0.7936 | 0.7895 |
Loa Loa (eye worm) | ABC transporter | 0.0017 | 0.0198 | 0.0198 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0048 | 1 | 1 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0041 | 0.7936 | 0.7895 |
Entamoeba histolytica | P-glyco protein 6, putative | 0.0048 | 1 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0048 | 1 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0048 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.4669 | 0.5777 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.4667 | 0.5776 |
Trypanosoma brucei | p-glycoprotein | 0.003 | 0.4212 | 0.5187 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0041 | 0.7936 | 0.7936 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0048 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0041 | 0.7936 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.4669 | 0.5777 |
Wolbachia endosymbiont of Brugia malayi | ABC-type multidrug transport system, ATPase and permease component | 0.0017 | 0.0198 | 0.5 |
Trichomonas vaginalis | abcb9, putative | 0.0048 | 1 | 1 |
Trichomonas vaginalis | abcb9, putative | 0.0048 | 1 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0048 | 1 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.4212 | 0.4212 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.4667 | 0.5776 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.4669 | 0.5777 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0041 | 0.7936 | 0.7936 |
Entamoeba histolytica | P-glycoprotein 6, putative | 0.0017 | 0.0198 | 0.0198 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.003 | 0.4212 | 0.5187 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0031 | 0.4521 | 0.4521 |
Plasmodium vivax | multidrug resistance protein 1, putative | 0.0048 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ABC-type protease secretion system, ATPase and permease component, AprD | 0.0017 | 0.0198 | 0.5 |
Schistosoma mansoni | smdr1 | 0.0017 | 0.0198 | 0.0198 |
Brugia malayi | ABC transporter family protein | 0.0017 | 0.0198 | 0.0198 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0048 | 1 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0048 | 1 | 1 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0041 | 0.7936 | 0.7895 |
Echinococcus granulosus | ATP binding cassette sub family B | 0.0017 | 0.0198 | 0.0198 |
Trichomonas vaginalis | taga, putative | 0.0048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.9802 | 0.9802 |
Schistosoma mansoni | multidrug resistance protein | 0.0048 | 1 | 1 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0017 | 0.0198 | 0.5 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.4669 | 0.5777 |
Brugia malayi | multidrug resistance related protein 1 | 0.003 | 0.4212 | 0.4212 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.4212 | 0.4212 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0048 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0198 | 0.0198 |
Trichomonas vaginalis | ABC transporter, putative | 0.0048 | 1 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0048 | 1 | 1 |
Mycobacterium ulcerans | drugs-transport transmembrane ATP-binding protein ABC transporter | 0.0017 | 0.0198 | 0.5 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.4669 | 0.5777 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 1 | 1 |
Brugia malayi | ABC transporter | 0.0017 | 0.0198 | 0.0198 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.4669 | 0.5777 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0048 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.4212 | 0.4212 |
Entamoeba histolytica | ABC transporter, putative | 0.003 | 0.4212 | 0.4212 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.003 | 0.4212 | 0.4212 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.003 | 0.4212 | 0.4212 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0041 | 0.7936 | 0.7895 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.003 | 0.4212 | 0.4095 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0041 | 0.7936 | 0.7936 |
Brugia malayi | multidrug Resistance Protein family member (mrp-5), putative | 0.0017 | 0.0198 | 0.0198 |
Trichomonas vaginalis | ABC transporter, putative | 0.0048 | 1 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0041 | 0.7936 | 0.7936 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0048 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0048 | 1 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0048 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.4212 | 0.4212 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.003 | 0.4212 | 0.4212 |
Entamoeba histolytica | P-glycoprotein-2 | 0.0048 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.4212 | 0.4212 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.003 | 0.4212 | 0.4212 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.4669 | 0.5777 |
Entamoeba histolytica | P-glycoprotein-2 | 0.0048 | 1 | 1 |
Brugia malayi | ABC transporter family protein | 0.0017 | 0.0198 | 0.0198 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0048 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.4212 | 0.4212 |
Schistosoma mansoni | multidrug resistance protein | 0.0048 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0041 | 0.7936 | 1 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.003 | 0.4212 | 0.5187 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0031 | 0.4521 | 0.4521 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0048 | 1 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0048 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | Growth inhibition of isogenic rad52-deficient Saccharomyces cerevisiae FM588 at 1 to 100 uM after 24 hrs by spectrophotometry | ChEMBL. | 24054489 | |
IC50 (functional) | > 30 uM | Antiproliferative activity against human SKBR3 cells after 48 hrs by MTT assay | ChEMBL. | 24054489 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.