Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | P-glyco protein 6, putative | 0.0059 | 1 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0059 | 1 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0034 | 0.3466 | 0.3339 |
Schistosoma mansoni | multidrug resistance protein | 0.0059 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0034 | 0.3466 | 0.3466 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0059 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0041 | 0.5411 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0041 | 0.5411 | 0.5411 |
Trichomonas vaginalis | ABC transporter, putative | 0.0059 | 1 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0031 | 0.281 | 0.5018 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0041 | 0.5411 | 0.5411 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0059 | 1 | 1 |
Brugia malayi | ABC transporter family protein | 0.0021 | 0.019 | 0.019 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0059 | 1 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0039 | 0.4733 | 0.4631 |
Leishmania major | ATP-binding cassette protein subfamily B, member 2, putative | 0.0059 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0034 | 0.3466 | 0.3466 |
Trypanosoma brucei | trans-sialidase, putative | 0.0031 | 0.281 | 0.5018 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0059 | 1 | 1 |
Trypanosoma brucei | multidrug resistance protein E | 0.0034 | 0.3466 | 0.6274 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0033 | 0.3275 | 0.9451 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0059 | 1 | 1 |
Brugia malayi | multidrug resistance related protein 1 | 0.0034 | 0.3466 | 0.3466 |
Brugia malayi | ABC transporter family protein | 0.0021 | 0.019 | 0.019 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.2809 | 0.5016 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.281 | 0.5018 |
Leishmania major | pentamidine resistance protein 1 | 0.0034 | 0.3466 | 0.3339 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0059 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0034 | 0.3466 | 0.3466 |
Schistosoma mansoni | multidrug resistance protein | 0.0034 | 0.3466 | 0.3466 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.281 | 0.5018 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0059 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0034 | 0.3466 | 0.3466 |
Leishmania major | ABC-thiol transporter | 0.0034 | 0.3466 | 0.3339 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0041 | 0.5411 | 0.5411 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0034 | 0.3466 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0059 | 1 | 1 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0034 | 0.3466 | 0.3466 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0059 | 1 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3466 | 0.3466 |
Mycobacterium leprae | PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER | 0.0021 | 0.019 | 0.5 |
Trichomonas vaginalis | ABC transporter, putative | 0.0059 | 1 | 1 |
Leishmania major | p-glycoprotein | 0.0059 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.281 | 0.5018 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.281 | 0.5018 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0041 | 0.5411 | 0.5322 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0021 | 0.019 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.0059 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.2809 | 0.5016 |
Loa Loa (eye worm) | ABC transporter | 0.0021 | 0.019 | 0.019 |
Giardia lamblia | ABC transporter, putative | 0.0034 | 0.3466 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0034 | 0.3466 | 0.3339 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0039 | 0.4733 | 0.4733 |
Giardia lamblia | MRP-like ABC transporter | 0.0034 | 0.3466 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0058 | 0.981 | 0.9806 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0041 | 0.5411 | 0.5322 |
Mycobacterium leprae | PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER | 0.0021 | 0.019 | 0.5 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0021 | 0.019 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.0034 | 0.3466 | 0.3466 |
Wolbachia endosymbiont of Brugia malayi | ABC-type protease secretion system, ATPase and permease component, AprD | 0.0021 | 0.019 | 0.5 |
Plasmodium vivax | multidrug resistance protein 1, putative | 0.0059 | 1 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0034 | 0.3466 | 0.3466 |
Loa Loa (eye worm) | multidrug resistance protein 3 | 0.0059 | 1 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0034 | 0.3466 | 0.6274 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0059 | 1 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0059 | 1 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0034 | 0.3466 | 0.3339 |
Mycobacterium ulcerans | drugs-transport transmembrane ATP-binding protein ABC transporter | 0.0021 | 0.019 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.981 | 0.981 |
Brugia malayi | ABC transporter family protein | 0.0021 | 0.019 | 0.019 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0059 | 1 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0034 | 0.3466 | 0.6274 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.019 | 0.019 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0059 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ABC-type multidrug transport system, ATPase and permease component | 0.0021 | 0.019 | 0.5 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0059 | 1 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0059 | 1 | 1 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0059 | 1 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0034 | 0.3466 | 0.6274 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.281 | 0.5018 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0034 | 0.3466 | 0.6274 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0059 | 1 | 1 |
Brugia malayi | multidrug Resistance Protein family member (mrp-5), putative | 0.0021 | 0.019 | 0.019 |
Brugia malayi | ABC transporter | 0.0021 | 0.019 | 0.019 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0034 | 0.3466 | 0.3339 |
Entamoeba histolytica | P-glycoprotein-2 | 0.0059 | 1 | 1 |
Plasmodium falciparum | multidrug resistance protein 1 | 0.0059 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.281 | 0.5018 |
Chlamydia trachomatis | ABC transporter ATP binding protein/permease | 0.0059 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane multidrug efflux pump | 0.0059 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0034 | 0.3466 | 0.3466 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0059 | 1 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0059 | 1 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0031 | 0.281 | 0.5018 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0059 | 1 | 1 |
Entamoeba histolytica | P-glycoprotein 6, putative | 0.0021 | 0.019 | 0.019 |
Trypanosoma brucei | trans-sialidase, putative | 0.0031 | 0.281 | 0.5018 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.2809 | 0.5016 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0059 | 1 | 1 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0021 | 0.019 | 0.5 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0059 | 1 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0041 | 0.5411 | 0.5411 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3466 | 0.3466 |
Trypanosoma brucei | p-glycoprotein | 0.0034 | 0.3466 | 0.6274 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0059 | 1 | 1 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0041 | 0.5411 | 0.5322 |
Entamoeba histolytica | P-glycoprotein 5, putative | 0.0059 | 1 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0041 | 0.5411 | 0.5322 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0034 | 0.3466 | 0.3466 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0041 | 0.5411 | 0.5411 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0034 | 0.3466 | 0.3339 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0059 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0059 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0059 | 1 | 1 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0021 | 0.019 | 0.019 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0041 | 0.5411 | 0.5411 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.3466 | 0.3466 |
Loa Loa (eye worm) | ATP-binding cassette sub-family B member 2 | 0.0059 | 1 | 1 |
Trichomonas vaginalis | taga, putative | 0.0059 | 1 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0059 | 1 | 1 |
Trichomonas vaginalis | abcb9, putative | 0.0059 | 1 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0039 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | ABC transporter | 0.0021 | 0.019 | 0.019 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0041 | 0.5411 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.0059 | 1 | 1 |
Schistosoma mansoni | ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) | 0.0021 | 0.019 | 0.019 |
Entamoeba histolytica | P-glycoprotein-5 | 0.0059 | 1 | 1 |
Echinococcus granulosus | 5'partial|ATP binding cassette sub family B | 0.0058 | 0.981 | 0.981 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.281 | 0.5018 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0034 | 0.3466 | 0.3339 |
Schistosoma mansoni | multidrug resistance protein | 0.0021 | 0.019 | 0.019 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0034 | 0.3466 | 0.3466 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0034 | 0.3466 | 0.3339 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0041 | 0.5411 | 0.5322 |
Schistosoma mansoni | smdr1 | 0.0021 | 0.019 | 0.019 |
Leishmania major | p-glycoprotein e | 0.0034 | 0.3466 | 0.3339 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.3275 | 0.3275 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0021 | 0.019 | 0.019 |
Entamoeba histolytica | P-glycoprotein 6, putative | 0.0021 | 0.019 | 0.019 |
Toxoplasma gondii | ATP-binding cassette transporter ABC.B1 | 0.0059 | 1 | 1 |
Echinococcus granulosus | ATP binding cassette sub family B | 0.0021 | 0.019 | 0.019 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0034 | 0.3466 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0059 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0021 | 0.019 | 0.019 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0034 | 0.3466 | 0.3466 |
Mycobacterium ulcerans | component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD | 0.0021 | 0.019 | 0.5 |
Trichomonas vaginalis | abcb9, putative | 0.0059 | 1 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0034 | 0.3466 | 0.6274 |
Trypanosoma brucei | trans-sialidase, putative | 0.0031 | 0.281 | 0.5018 |
Onchocerca volvulus | 0.0059 | 1 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.281 | 0.5018 |
Echinococcus granulosus | ATP binding cassette sub family B | 0.0021 | 0.019 | 0.019 |
Brugia malayi | ABC transporter family protein | 0.0059 | 1 | 1 |
Schistosoma mansoni | smdr2 | 0.0059 | 1 | 1 |
Trichomonas vaginalis | abcb9, putative | 0.0059 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.281 | 0.5018 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.281 | 0.5018 |
Entamoeba histolytica | P-glycoprotein-1 | 0.0059 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.281 | 0.5018 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0034 | 0.3466 | 0.3466 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0041 | 0.5411 | 0.5411 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.281 | 0.5018 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0059 | 1 | 1 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0041 | 0.5411 | 0.5411 |
Brugia malayi | P-glycoprotein-like protein | 0.0021 | 0.019 | 0.019 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0041 | 0.5411 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0059 | 1 | 1 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0059 | 1 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0059 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.2809 | 0.5016 |
Entamoeba histolytica | ABC transporter, putative | 0.0034 | 0.3466 | 0.3466 |
Schistosoma mansoni | multidrug resistance protein | 0.0059 | 1 | 1 |
Trypanosoma brucei | trans-sialidase | 0.0031 | 0.281 | 0.5018 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.281 | 0.5018 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0041 | 0.5411 | 0.5411 |
Entamoeba histolytica | P-glycoprotein-2 | 0.0059 | 1 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0039 | 0.4733 | 0.4733 |
Entamoeba histolytica | P-glycoprotein-2, putative | 0.0059 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.281 | 0.5018 |
Loa Loa (eye worm) | ABC transporter | 0.0021 | 0.019 | 0.019 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0059 | 1 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0059 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antinociceptive activity in Balb/c albino Mus musculus (mouse) assessed as latency time on hot plate at 15 to 45 mg/kg up to 60 min by hot-plate method relative to control | ChEMBL. | No reference | |
Activity (functional) | = 67.62 % | Analgesic activity in Balb/c albino Mus musculus (mouse) assessed as protection against acetic acid-induced writhing at 15 to 45 mg/kg measured up to 20 min relative to control | ChEMBL. | No reference |
Inhibition (functional) | Antipyretic activity in Balb/c albino Mus musculus (mouse) assessed as decrease in Brewer's yeast-induced rectal temperature at 50 to 150 mg/kg, ip measured up to 1.5 hr relative to control | ChEMBL. | No reference | |
Inhibition (functional) | Anti-inflammatory activity in Balb/c albino Mus musculus (mouse) assessed as inhibition of carrageenan-induced paw edema at 50 to 150 mg/kg at 5 hr relative to control | ChEMBL. | No reference | |
Inhibition (functional) | Anti-inflammatory activity in Balb/c albino Mus musculus (mouse) assessed as inhibition of carrageenan-induced paw edema at 50 to 150 mg/kg at 1 hr relative to control | ChEMBL. | No reference | |
T (functional) | = 37.7 degrees C | Antipyretic activity in Balb/c albino Mus musculus (mouse) assessed as Brewer's yeast-induced rectal temperature at 50 to 150 mg/kg, ip measured after 3 hr (Rvb = 38.7 degC) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.