Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | multidrug resistance protein | 0.0034 | 0.3473 | 0.3473 |
Trichomonas vaginalis | abcb9, putative | 0.006 | 1 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.006 | 1 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.006 | 1 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0039 | 0.4731 | 0.4731 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.006 | 1 | 1 |
Entamoeba histolytica | P-glycoprotein 6, putative | 0.0022 | 0.019 | 0.019 |
Entamoeba histolytica | P-glycoprotein 5, putative | 0.006 | 1 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0059 | 0.981 | 0.9806 |
Trypanosoma brucei | trans-sialidase, putative | 0.0031 | 0.2622 | 0.489 |
Giardia lamblia | ABC transporter, putative | 0.0034 | 0.3473 | 1 |
Loa Loa (eye worm) | ABC transporter | 0.0022 | 0.019 | 0.019 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0041 | 0.5163 | 0.5163 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.006 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0022 | 0.019 | 0.019 |
Leishmania major | ABC-thiol transporter | 0.0034 | 0.3473 | 0.3347 |
Schistosoma mansoni | multidrug resistance protein | 0.0034 | 0.3473 | 0.3473 |
Schistosoma mansoni | ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) | 0.0022 | 0.019 | 0.019 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0022 | 0.019 | 0.5 |
Toxoplasma gondii | ATP-binding cassette transporter ABC.B1 | 0.006 | 1 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.006 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Echinococcus granulosus | ATP binding cassette sub family B | 0.0022 | 0.019 | 0.019 |
Schistosoma mansoni | multidrug resistance protein | 0.0034 | 0.3473 | 0.3473 |
Entamoeba histolytica | ABC transporter, putative | 0.0034 | 0.3473 | 0.3473 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0041 | 0.5163 | 0.5069 |
Mycobacterium leprae | PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER | 0.0022 | 0.019 | 0.5 |
Leishmania major | p-glycoprotein e | 0.0034 | 0.3473 | 0.3347 |
Plasmodium falciparum | multidrug resistance protein 1 | 0.006 | 1 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.006 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.2622 | 0.489 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.006 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.2622 | 0.489 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.006 | 1 | 1 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0022 | 0.019 | 0.019 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.2621 | 0.4888 |
Schistosoma mansoni | multidrug resistance protein | 0.0022 | 0.019 | 0.019 |
Trichomonas vaginalis | ABC transporter, putative | 0.006 | 1 | 1 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0034 | 0.3473 | 0.3347 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0034 | 0.3473 | 0.3473 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.006 | 1 | 1 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0041 | 0.5163 | 0.5163 |
Entamoeba histolytica | P-glyco protein 6, putative | 0.006 | 1 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0041 | 0.5163 | 0.5069 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.3473 | 0.3473 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.006 | 1 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.006 | 1 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0041 | 0.5163 | 0.5163 |
Trichomonas vaginalis | abcb9, putative | 0.006 | 1 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.006 | 1 | 1 |
Brugia malayi | ABC transporter | 0.0022 | 0.019 | 0.019 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0041 | 0.5163 | 1 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0041 | 0.5163 | 0.5163 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0034 | 0.3473 | 0.3347 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.006 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.006 | 1 | 1 |
Trypanosoma brucei | trans-sialidase | 0.0031 | 0.2622 | 0.489 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0034 | 0.3473 | 0.3473 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.2622 | 0.489 |
Entamoeba histolytica | P-glycoprotein-2 | 0.006 | 1 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0039 | 0.4731 | 0.4731 |
Entamoeba histolytica | P-glycoprotein-2, putative | 0.006 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.2622 | 0.489 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0041 | 0.5163 | 0.5163 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.006 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.2622 | 0.489 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.006 | 1 | 1 |
Brugia malayi | ABC transporter family protein | 0.0022 | 0.019 | 0.019 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.006 | 1 | 1 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0034 | 0.3473 | 0.6602 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.2622 | 0.489 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.006 | 1 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0034 | 0.3473 | 1 |
Loa Loa (eye worm) | ABC transporter | 0.0022 | 0.019 | 0.019 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0034 | 0.3473 | 0.6602 |
Schistosoma mansoni | smdr1 | 0.0022 | 0.019 | 0.019 |
Schistosoma mansoni | smdr2 | 0.006 | 1 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.006 | 1 | 1 |
Onchocerca volvulus | 0.006 | 1 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.2622 | 0.489 |
Brugia malayi | ABC transporter family protein | 0.006 | 1 | 1 |
Mycobacterium leprae | PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER | 0.0022 | 0.019 | 0.5 |
Trypanosoma brucei | trans-sialidase, putative | 0.0031 | 0.2622 | 0.489 |
Trypanosoma brucei | trans-sialidase, putative | 0.0031 | 0.2622 | 0.489 |
Entamoeba histolytica | P-glycoprotein-5 | 0.006 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0041 | 0.5163 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.006 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ABC-type multidrug transport system, ATPase and permease component | 0.0022 | 0.019 | 0.5 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0041 | 0.5163 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.006 | 1 | 1 |
Trichomonas vaginalis | abcb9, putative | 0.006 | 1 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.006 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.2622 | 0.489 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0041 | 0.5163 | 0.5069 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0034 | 0.3473 | 0.3473 |
Trypanosoma brucei | trans-sialidase, putative | 0.0031 | 0.2622 | 0.489 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0034 | 0.3473 | 0.3347 |
Chlamydia trachomatis | ABC transporter ATP binding protein/permease | 0.006 | 1 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0034 | 0.3473 | 0.3347 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.019 | 0.019 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.2622 | 0.489 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.2622 | 0.489 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.006 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0034 | 0.3473 | 0.3473 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0034 | 0.3473 | 0.3347 |
Leishmania major | pentamidine resistance protein 1 | 0.0034 | 0.3473 | 0.3347 |
Trypanosoma brucei | trans-sialidase, putative | 0.0031 | 0.2622 | 0.489 |
Loa Loa (eye worm) | ATP-binding cassette sub-family B member 2 | 0.006 | 1 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0034 | 0.3473 | 0.3347 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.006 | 1 | 1 |
Trichomonas vaginalis | taga, putative | 0.006 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0034 | 0.3473 | 0.3473 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.006 | 1 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0041 | 0.5163 | 0.5163 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3473 | 0.3473 |
Leishmania major | p-glycoprotein | 0.006 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.006 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.2621 | 0.4888 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0041 | 0.5163 | 0.5069 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.2622 | 0.489 |
Brugia malayi | ABC transporter family protein | 0.0022 | 0.019 | 0.019 |
Schistosoma mansoni | multidrug resistance protein | 0.006 | 1 | 1 |
Mycobacterium ulcerans | component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD | 0.0022 | 0.019 | 0.5 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.006 | 1 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0041 | 0.5163 | 0.5163 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0041 | 0.5163 | 0.5069 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.006 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.2622 | 0.489 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.006 | 1 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.006 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.006 | 1 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0034 | 0.3473 | 0.3347 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3283 | 0.3283 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.006 | 1 | 1 |
Brugia malayi | multidrug Resistance Protein family member (mrp-5), putative | 0.0022 | 0.019 | 0.019 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0039 | 0.4731 | 0.4629 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.006 | 1 | 1 |
Entamoeba histolytica | P-glycoprotein-2 | 0.006 | 1 | 1 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0041 | 0.5163 | 0.5163 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0034 | 0.3473 | 0.6602 |
Trypanosoma brucei | multidrug resistance protein E | 0.0034 | 0.3473 | 0.6602 |
Trypanosoma brucei | p-glycoprotein | 0.0034 | 0.3473 | 0.6602 |
Leishmania major | ATP-binding cassette protein subfamily B, member 2, putative | 0.006 | 1 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0034 | 0.3473 | 0.6602 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.2622 | 0.489 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.006 | 1 | 1 |
Giardia lamblia | MRP-like ABC transporter | 0.0034 | 0.3473 | 1 |
Brugia malayi | P-glycoprotein-like protein | 0.0022 | 0.019 | 0.019 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.006 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.006 | 1 | 1 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.006 | 1 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.006 | 1 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0034 | 0.3473 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.2621 | 0.4888 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0034 | 0.3473 | 0.3473 |
Brugia malayi | ABC transporter family protein | 0.0022 | 0.019 | 0.019 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.006 | 1 | 1 |
Brugia malayi | multidrug resistance related protein 1 | 0.0034 | 0.3473 | 0.3473 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.006 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ABC-type protease secretion system, ATPase and permease component, AprD | 0.0022 | 0.019 | 0.5 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0022 | 0.019 | 0.019 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0031 | 0.2621 | 0.4888 |
Loa Loa (eye worm) | multidrug resistance protein 3 | 0.006 | 1 | 1 |
Mycobacterium tuberculosis | Probable transmembrane multidrug efflux pump | 0.006 | 1 | 1 |
Entamoeba histolytica | P-glycoprotein-1 | 0.006 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0031 | 0.2622 | 0.489 |
Entamoeba histolytica | P-glycoprotein 6, putative | 0.0022 | 0.019 | 0.019 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3473 | 0.3473 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0034 | 0.3473 | 0.3473 |
Loa Loa (eye worm) | ABC transporter | 0.0022 | 0.019 | 0.019 |
Plasmodium vivax | multidrug resistance protein 1, putative | 0.006 | 1 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0034 | 0.3473 | 0.3473 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0039 | 0.4731 | 0.4731 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0034 | 0.3473 | 0.6602 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0034 | 0.3283 | 0.9452 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.981 | 0.981 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0041 | 0.5163 | 0.5163 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0022 | 0.019 | 0.5 |
Mycobacterium ulcerans | drugs-transport transmembrane ATP-binding protein ABC transporter | 0.0022 | 0.019 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0034 | 0.3473 | 0.3473 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0034 | 0.3473 | 0.3473 |
Echinococcus granulosus | ATP binding cassette sub family B | 0.0022 | 0.019 | 0.019 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0022 | 0.019 | 0.5 |
Echinococcus granulosus | 5'partial|ATP binding cassette sub family B | 0.0059 | 0.981 | 0.981 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.006 | 1 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.006 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 24.16 umol/L | Inhibition of electric eel AChE after 30 mins by Ellman's method | ChEMBL. | 23721952 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.