Detailed information for compound 180393

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 719.848 | Formula: C40H41N5O6S
  • H donors: 4 H acceptors: 5 LogP: 6.83 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(NC(=O)C(NC(=O)C(CCc1ccccc1)N/C=C/S(=O)(=O)c1ccc2c(c1)cccc2)Cc1ccc2c(c1)cccc2)NN1CCOCC1
  • InChi: 1S/C40H41N5O6S/c46-38(36(19-15-29-8-2-1-3-9-29)41-20-25-52(49,50)35-18-17-32-11-5-7-13-34(32)28-35)42-37(27-30-14-16-31-10-4-6-12-33(31)26-30)39(47)43-40(48)44-45-21-23-51-24-22-45/h1-14,16-18,20,25-26,28,36-37,41H,15,19,21-24,27H2,(H,42,46)(H2,43,44,47,48)/b25-20+
  • InChiKey: PCJKSKCBOVMYIJ-LKUDQCMESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.7165 1
Echinococcus multilocularis endoplasmin 0.0027 0.1047 0.1047
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Entamoeba histolytica cysteine protease, putative 0.0043 0.1948 0.3723
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.5094 0.7077
Brugia malayi Cyclic-nucleotide gated cation channel 0.0044 0.1977 0.1977
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0014 0.0281 0.0293
Brugia malayi Cathepsin L-like precursor 0.0055 0.2591 0.2591
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0044 0.1977 0.1977
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.1047 0.1364
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0011 0.0146 0.0146
Echinococcus granulosus cathepsin b 0.018 0.9616 0.9616
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.1438 0.1411
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.3969 0.7665
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.007 0.3438 0.6563
Loa Loa (eye worm) hypothetical protein 0.0019 0.0569 0.0578
Entamoeba histolytica cysteine proteinase, putative 0.0043 0.1948 0.3723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.2591 0.4804
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0043 0.1948 0.2635
Brugia malayi voltage-dependent calcium channel 0.0044 0.1977 0.1977
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0569 0.0607
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.7165 0.7429
Echinococcus granulosus voltage gated potassium channel 0.0044 0.1977 0.1977
Brugia malayi hypothetical protein 0.001 0.0082 0.0082
Brugia malayi Protein kinase domain containing protein 0.0011 0.0133 0.0133
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0487 0.0572
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0281 0.0009
Toxoplasma gondii hypothetical protein 0.0044 0.1977 0.1972
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.1047 0.1013
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0281 0.0009
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0014 0.0306 0.0448
Toxoplasma gondii cathepsin CPL 0.0079 0.3969 0.4045
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0014 0.0281 0.0209
Echinococcus granulosus short transient receptor potential channel 6 0.0044 0.1977 0.1977
Giardia lamblia Cathepsin B precursor 0.0019 0.0569 0.0931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.3969 0.7665
Toxoplasma gondii preprocathepsin c precursor, putative 0.0019 0.0569 0.0507
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0305 0.0316
Schistosoma mansoni endoplasmin 0.0034 0.1438 0.1495
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0019 0.0569 0.0607
Echinococcus multilocularis potassium large conductance calcium activated 0.0044 0.1977 0.1977
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0659 0.0685
Echinococcus multilocularis sodium leak channel non selective protein 0.0044 0.1977 0.1977
Plasmodium falciparum serine repeat antigen 2 0.0019 0.0569 0.1202
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0044 0.1977 0.1977
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0079 0.3969 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0569 0.0607
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0044 0.1977 0.2056
Echinococcus multilocularis transient receptor potential cation channel 0.0044 0.1977 0.1977
Brugia malayi Papain family cysteine protease containing protein 0.0043 0.1948 0.1948
Echinococcus granulosus cathepsin l1 0.0079 0.3969 0.3969
Onchocerca volvulus 0.0079 0.3969 0.7756
Plasmodium falciparum sentrin-specific protease 1 0.0014 0.0281 0.0457
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0133 0.0138
Brugia malayi RhoGAP domain containing protein 0.0011 0.0121 0.0121
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.3258 0.3258
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0487 0.0425
Schistosoma mansoni hepatoma derived growth factor 0.001 0.0082 0.0085
Schistosoma mansoni diacylglycerol kinase theta 0.0011 0.0114 0.0119
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0011 0.0121 0.0123
Loa Loa (eye worm) voltage-gated potassium channel 0.0044 0.1977 0.2008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.3969 0.7665
Plasmodium falciparum serine repeat antigen 1 0.0019 0.0569 0.1202
Brugia malayi hypothetical protein 0.001 0.0082 0.0082
Brugia malayi Transient-receptor-potential like protein 0.0044 0.1977 0.1977
Echinococcus multilocularis cathepsin L 0.0019 0.0569 0.0569
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0044 0.1977 0.1977
Entamoeba histolytica cysteine protease, putative 0.0019 0.0569 0.0973
Schistosoma mansoni DNA helicase recq1 0.001 0.0105 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0659 0.0815
Brugia malayi Protein kinase c protein 2 0.0011 0.0133 0.0133
Echinococcus granulosus heat shock protein 90 0.0034 0.1438 0.1438
Brugia malayi Papain family cysteine protease containing protein 0.0043 0.1948 0.1948
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0281 0.0398
Brugia malayi diacylglycerol kinase 0.0011 0.0114 0.0114
Echinococcus granulosus dna polymerase kappa 0.002 0.0659 0.0659
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0659 0.0605
Loa Loa (eye worm) hypothetical protein 0.0011 0.0114 0.0116
Brugia malayi Cathepsin L-like cysteine proteinase 0.0055 0.2591 0.2591
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.018 0.9616 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0277 0.0276
Entamoeba histolytica cysteine protease, putative 0.0043 0.1948 0.3723
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.3969 0.7665
Schistosoma mansoni hepatoma derived growth factor 0.001 0.0082 0.0085
Plasmodium falciparum cysteine protease ATG4, putative 0.0024 0.0877 0.1999
Onchocerca volvulus Cathepsin L homolog 0.0079 0.3969 0.7756
Echinococcus multilocularis short transient receptor potential channel 6 0.0044 0.1977 0.1977
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.7165 0.7429
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.007 0.3438 0.6563
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.5094 0.5297
Echinococcus granulosus hepatoma derived growth factor protein 0.001 0.0082 0.0082
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0133 0.0138
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0569 0.0578
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0105 0.0105
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0019 0.0569 0.0931
Giardia lamblia Cathepsin B precursor 0.0068 0.3367 0.6539
Brugia malayi cathepsin F-like cysteine proteinase 0.0025 0.0898 0.0898
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0044 0.1977 0.2676
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.5094 0.5257
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0659 0.0281
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0659 0.0659
Echinococcus granulosus shaker cognate 0.0044 0.1977 0.1977
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.1977 0.1977
Entamoeba histolytica cysteine protease, putative 0.0019 0.0569 0.0973
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0044 0.1977 0.2056
Onchocerca volvulus 0.0079 0.3969 0.7756
Leishmania major DNA polymerase kappa, putative 0.002 0.0659 0.0815
Giardia lamblia Cathepsin B precursor 0.0019 0.0569 0.0931
Plasmodium vivax glutathione reductase, putative 0.005 0.231 0.5501
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.7165 1
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0569 0.0973
Schistosoma mansoni protein kinase C 0.0011 0.0114 0.0119
Plasmodium vivax endoplasmin, putative 0.0034 0.1438 0.3136
Entamoeba histolytica diacylglycerol kinase, putative 0.0011 0.0114 0.0066
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0659 0.0815
Echinococcus granulosus hyperpolarization activated cyclic 0.0044 0.1977 0.1977
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.5094 0.5094
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.231 0.2338
Echinococcus granulosus cysteine protease atg4b 0.0062 0.3 0.3
Echinococcus multilocularis cathepsin b 0.018 0.9616 0.9616
Plasmodium falciparum cysteine proteinase falcipain 3 0.0079 0.3969 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0281 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0019 0.0569 0.0607
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0659 0.0659
Brugia malayi heat shock protein 90 0.0034 0.1438 0.1438
Loa Loa (eye worm) hypothetical protein 0.018 0.9616 0.9769
Loa Loa (eye worm) hypothetical protein 0.0062 0.3 0.3048
Echinococcus multilocularis conserved hypothetical protein 0.0044 0.1977 0.1977
Echinococcus granulosus voltage dependent calcium channel 0.0044 0.1977 0.1977
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Loa Loa (eye worm) hypothetical protein 0.0011 0.0114 0.0116
Entamoeba histolytica cysteine protease, putative 0.0043 0.1948 0.3723
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0281 0.0398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.7165 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0044 0.1977 0.1977
Echinococcus multilocularis transient receptor potential cation channel 0.0044 0.1977 0.1977
Echinococcus granulosus sodium channel protein 0.0044 0.1977 0.1977
Echinococcus granulosus cathepsin b 0.018 0.9616 0.9616
Echinococcus multilocularis cathepsin L 0.0043 0.1948 0.1948
Echinococcus multilocularis Peptidase C54 0.0062 0.3 0.3
Brugia malayi cation channel family protein 0.0044 0.1977 0.1977
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.007 0.3438 0.6563
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.1438 0.2706
Echinococcus granulosus voltage dependent calcium channel 0.0044 0.1977 0.1977
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0019 0.0569 0.0973
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0044 0.1977 0.1977
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0044 0.1977 0.1977
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Trypanosoma cruzi cruzipain precursor, putative 0.0136 0.7165 0.7429
Loa Loa (eye worm) hypothetical protein 0.0011 0.0114 0.0116
Schistosoma mansoni heat shock protein 0.0034 0.1438 0.1495
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.5885 0.8837
Schistosoma mansoni heat shock protein 0.0034 0.1438 0.1495
Echinococcus multilocularis voltage dependent calcium channel 0.0044 0.1977 0.1977
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.018 0.9616 1
Giardia lamblia Cathepsin L precursor 0.0019 0.0569 0.0931
Schistosoma mansoni cathepsin s 0.0025 0.0898 0.0934
Brugia malayi olfactory channel protein osm-9 0.0044 0.1977 0.1977
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.3969 0.7665
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.2279 0.4157
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0044 0.1977 0.1977
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.1948 0.3469
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.7165 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0487 0.0425
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0659 0.0815
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0044 0.1977 0.1977
Brugia malayi Ras association domain family 1 isoform A 0.0011 0.0114 0.0114
Trypanosoma brucei unspecified product 0.0014 0.0305 0.0316
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0487 0.0572
Loa Loa (eye worm) hypothetical protein 0.0011 0.0114 0.0116
Entamoeba histolytica cysteine protease, putative 0.0019 0.0569 0.0973
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.1977 0.1977
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0044 0.1977 0.1977
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0044 0.1977 0.1977
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0898 0.0857
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0659 0.0281
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0281 0.0281
Echinococcus multilocularis Diacylglycerol kinase theta 0.0011 0.0114 0.0114
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0014 0.0306 0.0448
Loa Loa (eye worm) hypothetical protein 0.0025 0.0898 0.0913
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0487 0.0572
Schistosoma mansoni two-pore calcium channel 0.0044 0.1977 0.2056
Giardia lamblia Cathepsin L precursor 0.0019 0.0569 0.0931
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0487 0.0572
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0044 0.1977 0.1977
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0062 0.3 0.412
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0044 0.1977 0.3781
Loa Loa (eye worm) RNA binding protein 0.0066 0.3258 0.331
Echinococcus multilocularis cathepsin L cysteine protease 0.0079 0.3969 0.3969
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0569 0.0569
Onchocerca volvulus 0.0011 0.0114 0.0066
Echinococcus multilocularis peregrin 0.001 0.0082 0.0082
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.3258 0.331
Echinococcus multilocularis cysteine protease atg4b 0.0062 0.3 0.3
Trypanosoma brucei heat shock protein, putative 0.0034 0.1438 0.1915
Echinococcus multilocularis tar DNA binding protein 0.0066 0.3258 0.3258
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0014 0.0281 0.0208
Trypanosoma brucei heat shock protein, putative 0.0034 0.1438 0.1915
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.3969 0.7665
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0306 0.052
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0659 0.0793
Loa Loa (eye worm) hypothetical protein 0.0019 0.0569 0.0578
Schistosoma mansoni voltage-gated cation channel 0.0044 0.1977 0.2056
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0044 0.1977 0.1977
Echinococcus multilocularis calcium activated potassium channel 0.0044 0.1995 0.1995
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0659 0.0815
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.1977 0.1972
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0019 0.0569 0.0592
Schistosoma mansoni DNA polymerase eta 0.002 0.0659 0.0685
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0044 0.1977 0.1977
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0044 0.1977 0.2056
Leishmania major trypanothione reductase 0.005 0.231 0.3146
Schistosoma mansoni protein kinase C mu 0.0011 0.0114 0.0119
Brugia malayi cathepsin L-like cysteine proteinase 0.0019 0.0569 0.0569
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0079 0.3969 0.4033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0569 0.0607
Echinococcus granulosus traf and tnf receptor associated protein 0.0186 1 1
Echinococcus multilocularis shaker cognate 0.0044 0.1977 0.1977
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Echinococcus multilocularis myotubularin protein 13 0.0011 0.0114 0.0114
Echinococcus granulosus transient receptor potential cation channel 0.0044 0.1977 0.1977
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0019 0.0569 0.0578
Loa Loa (eye worm) hypothetical protein 0.0011 0.0114 0.0116
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0659 0.0793
Echinococcus multilocularis raf serine:threonine protein kinase 0.0011 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.2591 0.4804
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0019 0.0569 0.1202
Toxoplasma gondii cathepsin B 0.0068 0.3367 0.3418
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0011 0.0133 0.0133
Schistosoma mansoni unc-13 (munc13) 0.0011 0.0114 0.0119
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0079 0.3969 0.3969
Plasmodium falciparum thioredoxin reductase 0.005 0.231 0.5707
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0277 0.0389
Brugia malayi Cathepsin L-like precursor 0.0079 0.3969 0.3969
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0659 0.0815
Echinococcus granulosus potassium voltage gated channel protein 0.0044 0.1977 0.1977
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0569 0.0569
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0487 0.0425
Toxoplasma gondii diacylglycerol kinase, putative 0.0011 0.0114 0.0034
Plasmodium vivax vivapain-2 0.0079 0.3969 1
Leishmania major cathepsin L-like protease 0.0136 0.7165 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0075 0.3765 0.3863
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0044 0.1977 0.1977
Schistosoma mansoni voltage-dependent calcium channel 0.0044 0.1977 0.2056
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.5094 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0569 0.0592
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0487 0.0572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.3969 0.7665
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0487 0.0425
Brugia malayi MH2 domain containing protein 0.0125 0.6565 0.6565
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0937 0.137
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0487 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0044 0.1977 0.2056
Entamoeba histolytica cysteine protease, putative 0.0043 0.1948 0.3723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.3969 0.7665
Entamoeba histolytica peptidase, C54 family 0.0024 0.0877 0.1587
Onchocerca volvulus 0.0044 0.1977 0.3781
Echinococcus granulosus sentrin specific protease 7 0.0014 0.0281 0.0281
Plasmodium falciparum serine repeat antigen 5 0.0019 0.0569 0.1202
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0659 0.0815
Giardia lamblia Cathepsin B precursor 0.0019 0.0569 0.0931
Brugia malayi Cathepsin L-like precursor 0.0079 0.3969 0.3969
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0019 0.0569 0.0973
Entamoeba histolytica hypothetical protein 0.0011 0.0114 0.0066
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.1047 0.1013
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Echinococcus multilocularis PWWP domain containing protein 2A 0.001 0.0082 0.0082
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.5094 0.5257
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Entamoeba histolytica cysteine protease, putative 0.0019 0.0569 0.0973
Trypanosoma brucei heat shock protein, putative 0.0034 0.1438 0.1915
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.1438 0.1423
Schistosoma mansoni transient receptor potential channel 0.0044 0.1977 0.2056
Onchocerca volvulus 0.0055 0.2591 0.5006
Echinococcus multilocularis transient receptor potential cation channel 0.0044 0.1977 0.1977
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0044 0.1977 0.1977
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0079 0.3969 0.3969
Loa Loa (eye worm) RasGEF domain-containing protein 0.0011 0.0114 0.0116
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0011 0.0121 0.0125
Entamoeba histolytica peptidase, C54 family 0.0024 0.0877 0.1587
Entamoeba histolytica cysteine protease, putative 0.0079 0.3969 0.7756
Brugia malayi protein kinase C3,putative 0.0011 0.0133 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0068 0.3367 0.6415
Giardia lamblia Kinase, PLK 0.0099 0.5094 1
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0937 0.0937
Echinococcus granulosus protein kinase c iota type 0.0011 0.0133 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0066 0.3258 0.3388
Giardia lamblia DINP protein human, muc B family 0.002 0.0659 0.111
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.3969 0.7756
Echinococcus granulosus cathepsin l cysteine peptidase 0.0079 0.3969 0.3969
Plasmodium vivax vivapain-2 0.0079 0.3969 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.1977 0.1977
Schistosoma mansoni transient receptor potential channel 0.0044 0.1977 0.2056
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0105 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.5094 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0044 0.1977 0.2008
Loa Loa (eye worm) hypothetical protein 0.001 0.0082 0.0083
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0044 0.1977 0.2056
Loa Loa (eye worm) hypothetical protein 0.0019 0.0569 0.0578
Plasmodium vivax unspecified product 0.0025 0.0898 0.1673
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0044 0.1977 0.2676
Loa Loa (eye worm) hypothetical protein 0.0019 0.0569 0.0578
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0659 0.0605
Entamoeba histolytica cysteine protease, putative 0.0043 0.1948 0.3723
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0011 0.0114 0.0114
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0765 0.1707
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0487 0.0558
Brugia malayi TAR-binding protein 0.0066 0.3258 0.3258
Trypanosoma brucei trypanothione reductase 0.005 0.231 0.3146
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0281 0.0009
Echinococcus multilocularis dna polymerase eta 0.002 0.0659 0.0659
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0062 0.3 0.5653
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0044 0.1977 0.1977
Trypanosoma brucei cysteine peptidase C (CPC) 0.0068 0.3367 0.4639
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0659 0.0659
Schistosoma mansoni SET domain protein 0.0011 0.0146 0.0152
Brugia malayi hypothetical protein 0.0044 0.1977 0.1977
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0044 0.1977 0.2056
Trypanosoma brucei heat shock protein, putative 0.0034 0.1438 0.1915
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0105 0.0105
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0487 0.0436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.3969 0.7665
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0044 0.1977 0.1977
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.3969 0.7665
Echinococcus granulosus potassium voltage gated channel protein 0.0044 0.1977 0.1977
Mycobacterium ulcerans heat shock protein 90 0.0027 0.1047 1
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0014 0.0281 0.0208
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0044 0.1977 0.2056
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.5094 1
Echinococcus multilocularis heat shock protein 90 0.0034 0.1438 0.1438
Entamoeba histolytica cysteine protease, putative 0.0043 0.1948 0.3723
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0105 0.0105
Schistosoma mansoni calcium-activated potassium channel 0.0044 0.1977 0.2056
Schistosoma mansoni hypothetical protein 0.001 0.0082 0.0085
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0659 0.0815
Echinococcus granulosus transient receptor potential gamma protein 0.0044 0.1977 0.1977
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0019 0.0569 0.0781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0569 0.0607
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Echinococcus multilocularis transient receptor potential cation channel 0.0044 0.1977 0.1977
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0044 0.1977 0.1977
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0181 0.9694 1
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0044 0.1977 0.1977
Giardia lamblia Cathepsin B precursor 0.0068 0.3367 0.6539
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0043 0.1948 0.1957
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0286
Entamoeba histolytica cysteine protease, putative 0.0043 0.1948 0.3723
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Giardia lamblia Cathepsin B precursor 0.0019 0.0569 0.0931
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0133 0.0138
Echinococcus granulosus short transient receptor potential channel 6 0.0044 0.1977 0.1977
Echinococcus multilocularis cathepsin L cysteine protease 0.0079 0.3969 0.3969
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Brugia malayi Cathepsin L-like precursor 0.0055 0.2591 0.2591
Onchocerca volvulus Cathepsin L homolog 0.0079 0.3969 0.7756
Echinococcus granulosus PWWP domain containing protein 2A 0.001 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0011 0.0114 0.0116
Echinococcus granulosus voltage gated hydrogen channel 1 0.0044 0.1977 0.1977
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.3969 0.7665
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0044 0.1977 0.1977
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.5885 0.8837
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0044 0.1977 0.1977
Brugia malayi diacylglycerol kinase 0.0011 0.0114 0.0114
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Echinococcus granulosus transient receptor potential cation channel 0.0044 0.1977 0.1977
Echinococcus multilocularis heat shock protein 0.0034 0.1438 0.1438
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0011 0.0133 0.0135
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0044 0.1977 0.1977
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0044 0.1977 0.1977
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0044 0.1977 0.1977
Echinococcus granulosus tar DNA binding protein 0.0066 0.3258 0.3258
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.5094 0.5175
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.0569 0.0607
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0024 0.0877 0.1123
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0014 0.0281 0.0209
Schistosoma mansoni cathepsin F (C01 family) 0.0079 0.3969 0.4128
Trypanosoma cruzi cysteine proteinase, putative 0.0043 0.1948 0.1957
Schistosoma mansoni transient receptor potential channel 4 0.0044 0.1977 0.2056
Loa Loa (eye worm) TAR-binding protein 0.0066 0.3258 0.331
Echinococcus multilocularis two pore calcium channel protein 2 0.0044 0.1977 0.1977
Echinococcus multilocularis cysteine protease 0.0079 0.3969 0.3969
Entamoeba histolytica cysteine protease, putative 0.0043 0.1948 0.3723
Loa Loa (eye worm) endoplasmin 0.0034 0.1438 0.1461
Echinococcus multilocularis transient receptor potential gamma protein 0.0044 0.1977 0.1977
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0281 0.0398
Plasmodium falciparum serine repeat antigen 4 0.0019 0.0569 0.1202
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0068 0.3367 0.4639
Echinococcus granulosus hyperpolarization activated cyclic 0.0044 0.1977 0.1977
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.5094 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0019 0.0569 0.0592
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0011 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0019 0.0569 0.0578
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0024 0.0877 0.0834
Echinococcus granulosus transient receptor potential cation channel 0.0044 0.1977 0.1977
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0044 0.1977 0.1977
Leishmania major cathepsin L-like protease 0.0079 0.3969 0.5489
Echinococcus granulosus cysteine protease 0.0043 0.1948 0.1948
Schistosoma mansoni hypothetical protein 0.0178 0.9519 0.9899
Schistosoma mansoni hypothetical protein 0.0178 0.9519 0.9899
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0281 0.0281
Schistosoma mansoni cathepsin C 0.0019 0.0569 0.0592
Schistosoma mansoni autophagin-1 (C54 family) 0.0062 0.3 0.312
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.3969 0.7665
Entamoeba histolytica peptidase, C54 family 0.0062 0.3 0.5823
Echinococcus granulosus cathepsin L 0.0019 0.0569 0.0569
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0068 0.3367 0.3502
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0019 0.0569 0.0781
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.3969 0.4078
Plasmodium vivax vivapain-1 0.0043 0.1948 0.4518
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0062 0.3 0.312
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0044 0.1977 0.1977
Schistosoma mansoni DNA helicase recq5 0.001 0.0105 0.0109
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0044 0.1977 0.1977
Entamoeba histolytica cysteine protease, putative 0.0043 0.1948 0.3723
Giardia lamblia Cathepsin B precursor 0.0068 0.3367 0.6539
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0487 0.0425
Onchocerca volvulus 0.0079 0.3969 0.7756
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.6595 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.018 0.9616 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0898 0.0913
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Entamoeba histolytica cysteine protease, putative 0.0019 0.0569 0.0973
Trypanosoma cruzi cysteine protease, putative 0.0043 0.1948 0.1957
Trypanosoma cruzi cysteine peptidase, putative 0.0043 0.1948 0.1957
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0659 0.0605
Loa Loa (eye worm) hypothetical protein 0.0011 0.0114 0.0116
Loa Loa (eye worm) ctsf protein 0.0079 0.3969 0.4033
Entamoeba histolytica cysteine protease, putative 0.0043 0.1948 0.3723
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0019 0.0569 0.0781
Loa Loa (eye worm) PWWP domain-containing protein 0.001 0.0082 0.0083
Giardia lamblia Grp94/Hsp90 0.0027 0.1047 0.1889
Giardia lamblia Cysteine protease 0.0019 0.0569 0.0931
Giardia lamblia Cysteine protease 0.0019 0.0569 0.0931
Echinococcus granulosus protein kinase c eta type 0.0011 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0114 0.0116
Entamoeba histolytica diacylglycerol kinase, putative 0.0011 0.0114 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.7165 1
Schistosoma mansoni endoplasmin 0.0034 0.1438 0.1495
Toxoplasma gondii cathepsin CPC2 0.0019 0.0569 0.0507
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0019 0.0569 0.0781
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0019 0.0569 0.1202
Plasmodium falciparum serine repeat antigen 8 0.0019 0.0569 0.1202
Echinococcus granulosus transient receptor potential cation channel 0.0044 0.1977 0.1977
Toxoplasma gondii cathepsin CPC1 0.0019 0.0569 0.0507
Loa Loa (eye worm) hypothetical protein 0.001 0.0105 0.0106
Toxoplasma gondii transporter, cation channel family protein 0.0044 0.1977 0.1972
Entamoeba histolytica cysteine protease, putative 0.0043 0.1948 0.3723
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0286
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0044 0.1977 0.2008
Echinococcus granulosus potassium voltage gated channel protein 0.0044 0.1977 0.1977
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.007 0.3438 0.3438
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.5885 0.8837
Leishmania major cathepsin L-like protease 0.0079 0.3969 0.5489
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.7165 0.7429
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0569 0.0607
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0062 0.3 0.3061
Echinococcus granulosus hypothetical protein 0.0044 0.1977 0.1977
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.1977 0.2008
Loa Loa (eye worm) voltage-gated potassium channel 0.0044 0.1977 0.2008
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0306 0.006
Trypanosoma cruzi cruzipain precursor, putative 0.0025 0.0898 0.0857
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0019 0.0569 0.0781
Loa Loa (eye worm) hypothetical protein 0.0077 0.386 0.3921
Giardia lamblia Encystation-specific protease 0.0019 0.0569 0.0931
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.5885 0.8837
Echinococcus granulosus Protein kinase C brain isozyme 0.0011 0.0133 0.0133
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0044 0.1977 0.1977
Schistosoma mansoni hypothetical protein 0.001 0.0082 0.0085
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0569 0.0569
Echinococcus granulosus myotubularin protein 13 0.0011 0.0114 0.0114
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0044 0.1977 0.1977
Leishmania major heat shock protein, putative 0.0014 0.0306 0.0317
Treponema pallidum heat shock protein 90 0.0027 0.1047 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0019 0.0569 0.0931
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0133 0.0138
Toxoplasma gondii heat shock protein 75, putative 0.0014 0.0306 0.0233
Echinococcus multilocularis hepatoma derived growth factor protein 0.001 0.0082 0.0082
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0044 0.1977 0.3529
Brugia malayi RhoGAP domain containing protein 0.0077 0.386 0.386
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Giardia lamblia Cathepsin L-like protease 0.0019 0.0569 0.0931
Entamoeba histolytica cysteine proteinase 1, putative 0.0043 0.1948 0.3723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0569 0.0607
Echinococcus multilocularis hyperpolarization activated cyclic 0.0044 0.1977 0.1977
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.1438 0.1423
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0044 0.1977 0.2056
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0044 0.1977 0.2056
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0044 0.1977 0.1977
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.3969 0.3969
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0044 0.1977 0.2056
Onchocerca volvulus 0.0011 0.0114 0.0066
Loa Loa (eye worm) hypothetical protein 0.0067 0.3265 0.3317
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0044 0.1977 0.1988
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.1438 0.1423
Onchocerca volvulus Cathepsin F homolog 0.0079 0.3969 0.7756
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.007 0.3438 0.3576
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0025 0.0898 0.0898
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0487 0.0425
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0114 0.0119
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Plasmodium vivax vivapain-3 0.0043 0.1948 0.4518
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0014 0.0281 0.0293
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.1438 0.2672
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0044 0.1977 0.1977
Trichomonas vaginalis heat shock protein, putative 0.0027 0.1047 0.16
Schistosoma mansoni vesicular amine transporter 0.0044 0.1977 0.2056
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0305 0.0316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.3969 0.7665
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0011 0.0114 0.0116
Loa Loa (eye worm) hypothetical protein 0.0011 0.0114 0.0116
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.1438 0.1915
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.1977 0.1977
Brugia malayi ion channel NompC 0.0044 0.1977 0.1977
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0044 0.1977 0.1988
Entamoeba histolytica cysteine proteinase 2 0.0043 0.1948 0.3723
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0019 0.0569 0.1202
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0034 0.1454 0.1454
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0011 0.0133 0.0133
Plasmodium falciparum cysteine proteinase falcipain 1 0.0043 0.1948 0.4769
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0019 0.0569 0.0781
Trypanosoma cruzi major cysteine proteinase, putative 0.0019 0.0569 0.0511
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.231 0.231
Brugia malayi Cathepsin L-like precursor 0.0079 0.3969 0.3969
Giardia lamblia Rho GAP, putative 0.0067 0.3265 0.6335
Brugia malayi Cathepsin L-like precursor 0.0079 0.3969 0.3969
Schistosoma mansoni transient receptor potential channel 0.0044 0.1977 0.2056
Echinococcus multilocularis potassium voltage gated channel protein 0.0044 0.1977 0.1977
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0281 0.0009
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Brugia malayi fibroinase precursor 0.0019 0.0569 0.0569
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.3969 0.7665
Schistosoma mansoni ryanodine receptor related 0.0044 0.1977 0.2056
Echinococcus multilocularis traf and tnf receptor associated protein 0.0186 1 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0019 0.0569 0.0781
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0659 0.0815
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0487 0.0487
Echinococcus multilocularis unc 13 (munc13) 0.0011 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0055 0.2591 0.2632
Leishmania major cathepsin L-like protease 0.0079 0.3969 0.5489
Echinococcus granulosus heat shock protein 0.0034 0.1438 0.1438
Giardia lamblia Cathepsin L-like protease 0.0019 0.0569 0.0931
Trichomonas vaginalis heat shock protein, putative 0.0027 0.1047 0.16
Giardia lamblia Cathepsin L precursor 0.0019 0.0569 0.0931
Echinococcus granulosus heat shock protein 90 0.0027 0.1047 0.1047
Echinococcus granulosus two pore calcium channel protein 1 0.0044 0.1977 0.1977
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0044 0.1977 0.1977
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0044 0.1977 0.2056
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0478 0.0533
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.6565 0.6669
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0286
Plasmodium falciparum serine repeat antigen 9 0.0019 0.0569 0.1202
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0659 0.0815
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0044 0.1977 0.1977
Plasmodium vivax thioredoxin reductase, putative 0.005 0.231 0.5501
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.5885 0.8837
Brugia malayi cathepsin Z-like cysteine proteinase 0.0019 0.0569 0.0569
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0044 0.1977 0.1977
Leishmania major hypothetical protein, conserved 0.0044 0.1977 0.2676
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0659 0.3067
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.1438 0.1423
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0659 0.0815
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0044 0.1977 0.1977
Echinococcus granulosus voltage gated potassium channel 0.0044 0.1977 0.1977
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0011 0.0133 0.0135
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0044 0.1977 0.1977
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.3969 0.7665
Giardia lamblia Cathepsin B precursor 0.0019 0.0569 0.0931
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0079 0.3969 0.7665
Loa Loa (eye worm) cysteine protease 0.0079 0.3969 0.4033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.7165 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0569 0.0592
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0105 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.3969 0.7665
Loa Loa (eye worm) Ulp1 protease 0.007 0.3438 0.3493
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0487 0.0422
Plasmodium vivax unspecified product 0.0043 0.1948 0.4518
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0019 0.0569 0.0607
Echinococcus granulosus cathepsin L cysteine protease 0.0043 0.1948 0.1948
Giardia lamblia Cysteine protease 0.0019 0.0569 0.0931
Echinococcus granulosus endoplasmin 0.0027 0.1047 0.1047
Schistosoma mansoni rac gtpase activating protein 0.0077 0.386 0.4014
Trypanosoma brucei heat shock protein, putative 0.0034 0.1438 0.1915
Echinococcus multilocularis Rac GTPase activating protein 1 0.0077 0.386 0.386
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0079 0.3969 0.7665
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.5094 0.5094
Schistosoma mansoni tar DNA-binding protein 0.0066 0.3258 0.3388
Plasmodium vivax heat shock protein, putative 0.0014 0.0306 0.0067
Entamoeba histolytica cysteine proteinase, putative 0.0043 0.1948 0.3723
Echinococcus multilocularis cathepsin b 0.018 0.9616 0.9616
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0011 0.0133 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0659 0.0815
Brugia malayi Peptidase family C54 containing protein 0.0062 0.3 0.3
Entamoeba histolytica cysteine protease, putative 0.0019 0.0569 0.0973
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0466 0.04
Plasmodium falciparum serine repeat antigen 3 0.0019 0.0569 0.1202
Echinococcus granulosus dna polymerase eta 0.002 0.0659 0.0659
Loa Loa (eye worm) hypothetical protein 0.0055 0.2591 0.2632
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.1047 0.1047
Echinococcus multilocularis heat shock protein 90 0.0027 0.1047 0.1047
Plasmodium falciparum serine repeat antigen 7 0.0019 0.0569 0.1202
Giardia lamblia Hypothetical protein 0.0019 0.0569 0.0931
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0044 0.1977 0.3781
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0937 0.0937
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Onchocerca volvulus 0.0019 0.0569 0.0973
Brugia malayi RhoGEF domain containing protein 0.0011 0.0114 0.0114
Trypanosoma brucei heat shock protein, putative 0.0034 0.1438 0.1915
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.5094 1
Echinococcus granulosus potassium large conductance calcium activated 0.0044 0.1977 0.1977
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.023 0.023
Echinococcus granulosus transient receptor potential cation channel 0.0044 0.1977 0.1977
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0011 0.0133 0.0133
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0659 0.1152
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0044 0.1977 0.2056
Plasmodium falciparum serine repeat antigen 6 0.0019 0.0569 0.1202
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.5094 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0487 0.0572
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.0569 0.0607
Plasmodium falciparum glutathione reductase 0.005 0.231 0.5707
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0487 0.0989
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0044 0.1977 0.2056
Entamoeba histolytica peptidase, C54 family 0.0024 0.0877 0.1587
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0281 0.0009
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Brugia malayi protein kinase C II. 0.0011 0.0133 0.0133
Entamoeba histolytica cysteine proteinase, putative 0.0043 0.1948 0.3723
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.6565 0.6669
Trichomonas vaginalis heat shock protein, putative 0.0027 0.1047 0.16
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Brugia malayi cathepsin B-like cysteine proteinase 0.018 0.9616 0.9616
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.3969 0.7665
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0019 0.0569 0.0592
Trypanosoma cruzi cysteine proteinase, putative 0.0043 0.1948 0.1957
Loa Loa (eye worm) hypothetical protein 0.0127 0.665 0.6756
Entamoeba histolytica cysteine protease, putative 0.0043 0.1948 0.3723
Brugia malayi Cathepsin L-like precursor 0.0079 0.3969 0.3969
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0487 0.0989
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0044 0.1977 0.1977
Echinococcus granulosus sodium leak channel non selective protein 0.0044 0.1977 0.1977
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.1047 0.1889
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Trypanosoma brucei heat shock protein 84, putative 0.0014 0.0306 0.0317
Echinococcus multilocularis sentrin specific protease 1 0.0014 0.0281 0.0281
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0024 0.0877 0.0834
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0044 0.1977 0.1977
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.7165 1
Plasmodium vivax heat shock protein 86, putative 0.0034 0.1438 0.3136
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.231 0.231
Brugia malayi Endoplasmin precursor 0.0034 0.1438 0.1438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.7165 1
Brugia malayi cathepsin L precursor 0.0019 0.0569 0.0569
Onchocerca volvulus 0.0011 0.0114 0.0066
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.5094 1
Echinococcus granulosus calcium activated potassium channel 0.0044 0.1995 0.1995
Onchocerca volvulus 0.0079 0.3969 0.7756
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0011 0.0146 0.0146
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0105 0.0106
Giardia lamblia Cysteine protease 0.0019 0.0569 0.0931
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0024 0.0877 0.1123
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0019 0.0569 0.0931
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0487 0.0436
Loa Loa (eye worm) raf kinase 0.0011 0.0114 0.0116
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0569 0.0592
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0027 0.1047 1
Toxoplasma gondii thioredoxin reductase 0.005 0.231 0.2319
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.1438 0.1423
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0281 0.0009
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0696 0.0871
Leishmania major cathepsin L-like protease 0.0136 0.7165 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0044 0.1977 0.1977
Echinococcus multilocularis dna polymerase kappa 0.002 0.0659 0.0659
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Loa Loa (eye worm) hypothetical protein 0.0055 0.2591 0.2632
Schistosoma mansoni cathepsin F (C01 family) 0.0055 0.2591 0.2694
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0043 0.1948 0.2025
Trypanosoma cruzi heat shock protein, putative 0.0014 0.0306 0.0235
Plasmodium falciparum thioredoxin reductase 0.0017 0.0487 0.0989
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0079 0.3969 1
Trypanosoma brucei SUMO1/Ulp2, putative 0.0014 0.0281 0.0282
Loa Loa (eye worm) voltage-gated calcium channel 0.0044 0.1977 0.2008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.3969 0.7665
Echinococcus multilocularis two pore calcium channel protein 1 0.0044 0.1977 0.1977
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Echinococcus multilocularis PWWP domain containing protein 2A 0.001 0.0082 0.0082
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0044 0.1977 0.2056
Schistosoma mansoni heat shock protein 0.0014 0.0306 0.0318
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.018 0.9616 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0569 0.0578
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0659 0.0659
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0105 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.3969 0.7665
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0569 0.0592
Schistosoma mansoni protein kinase C mu 0.0011 0.0133 0.0138
Echinococcus granulosus raf serine:threonine protein kinase 0.0011 0.0114 0.0114
Trichomonas vaginalis heat shock protein, putative 0.0034 0.1438 0.241
Plasmodium vivax unspecified product 0.0019 0.0569 0.0781
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0019 0.0569 0.0781
Echinococcus multilocularis ryanodine receptor 44f 0.0044 0.1977 0.1977
Brugia malayi Cathepsin L-like precursor 0.0025 0.0898 0.0898
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0569 0.0607
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Echinococcus granulosus bloom syndrome protein 0.0025 0.0937 0.0937
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0024 0.0877 0.0828
Echinococcus granulosus peregrin 0.001 0.0082 0.0082
Loa Loa (eye worm) cathepsin B 0.0068 0.3367 0.3421
Echinococcus granulosus two pore calcium channel protein 2 0.0044 0.1977 0.1977
Schistosoma mansoni cathepsin F (C01 family) 0.0079 0.3969 0.4128
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0019 0.0569 0.0607
Echinococcus granulosus transient receptor potential cation channel 0.0044 0.1977 0.1977
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.1438 0.1915
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.3969 0.7665
Echinococcus granulosus cathepsin l1 0.0055 0.2591 0.2591
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0659 0.3067
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.1438 0.2706
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0487 0.0487
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0014 0.0281 0.0293
Echinococcus multilocularis protein kinase c iota type 0.0011 0.0133 0.0133
Echinococcus granulosus cathepsin L 0.0043 0.1948 0.1948
Schistosoma mansoni 60S ribosomal protein L21 0.0044 0.1977 0.2056
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0659 0.0815
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0044 0.1977 0.2676
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0019 0.0569 0.0781
Brugia malayi RNA binding protein 0.0066 0.3258 0.3258
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0305 0.0316
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0487 0.0425
Brugia malayi cathepsin Z-like cysteine proteinase 0.0019 0.0569 0.0569
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0659 0.0605
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.0569 0.0607
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0044 0.1977 0.1977
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0044 0.1977 0.3529
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0937 0.137
Loa Loa (eye worm) hypothetical protein 0.0025 0.0898 0.0913
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.007 0.3438 0.6697
Brugia malayi Pleckstrin Homology Domain 0.0011 0.0114 0.0114
Giardia lamblia Cathepsin L precursor 0.0019 0.0569 0.0931
Brugia malayi Hsp90 protein 0.0014 0.0306 0.0306
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0487 0.0425
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0014 0.0281 0.0009
Schistosoma mansoni unc-13 (munc13) 0.0011 0.0114 0.0119
Trypanosoma brucei polo-like protein kinase 0.0099 0.5094 0.7077
Echinococcus granulosus cathepsin L cysteine proteinase 0.0079 0.3969 0.3969
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0105 0.0105
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.1977 0.1972
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Echinococcus granulosus potassium voltage gated channel protein 0.0044 0.1977 0.1977
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0696 0.0871
Onchocerca volvulus 0.0079 0.3969 0.7756
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.3969 0.7665
Loa Loa (eye worm) hypothetical protein 0.0011 0.0114 0.0116
Brugia malayi RhoGAP domain containing protein 0.0067 0.3265 0.3265
Leishmania major cysteine peptidase A (CPA) 0.0079 0.3969 0.5489
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0043 0.1948 0.2025
Brugia malayi Cathepsin L-like precursor 0.0079 0.3969 0.3969
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0068 0.3367 0.3446
Brugia malayi Thioredoxin reductase 0.005 0.231 0.231
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Echinococcus granulosus N chimaerin 0.0011 0.0121 0.0121
Loa Loa (eye worm) Ulp1 protease 0.0014 0.0281 0.0286
Echinococcus granulosus Diacylglycerol kinase theta 0.0011 0.0114 0.0114
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0487 0.0487
Echinococcus granulosus geminin 0.0178 0.9519 0.9519
Schistosoma mansoni cathepsin B (C01 family) 0.0019 0.0569 0.0592
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0062 0.3 0.312
Plasmodium vivax serine-repeat antigen (SERA) 0.0019 0.0569 0.0781
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0281 0.0398
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0638 0.0664
Giardia lamblia Cathepsin L precursor 0.0019 0.0569 0.0931
Plasmodium falciparum endoplasmin, putative 0.0021 0.0696 0.1531
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0277 0.0276
Echinococcus granulosus potassium voltage gated channel protein 0.0044 0.1977 0.1977
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Mycobacterium tuberculosis Probable reductase 0.0113 0.5885 0.8837
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0014 0.0306 0.0306
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0011 0.0114 0.0114
Loa Loa (eye worm) RecQ helicase 0.0025 0.0937 0.0951
Plasmodium falciparum heat shock protein 90 0.0034 0.1438 0.345
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.5094 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0044 0.1977 0.2056
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0487 0.0766
Echinococcus granulosus ryanodine receptor 44f 0.0044 0.1977 0.1977
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0184 0.9843 1
Schistosoma mansoni voltage-gated ion channel 0.0044 0.1977 0.2056
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.0569 0.0607
Echinococcus multilocularis sentrin specific protease 7 0.0014 0.0281 0.0281
Brugia malayi cathepsin L-like precursor 0.0055 0.2591 0.2591
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Echinococcus granulosus protein kinase c epsilon type 0.0011 0.0133 0.0133
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0569 0.0592
Schistosoma mansoni kinase 0.005 0.2353 0.2447
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0281 0.0281
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.5885 0.872
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0487 0.0572
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0044 0.1977 0.1977
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.7165 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.6595 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0011 0.0114 0.0114
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0019 0.0569 0.0781
Plasmodium falciparum glutathione reductase 0.0017 0.0487 0.0989
Leishmania major DNA polymerase eta, putative 0.002 0.0659 0.0815
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0898 0.0913
Schistosoma mansoni tar DNA-binding protein 0.0066 0.3258 0.3388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.7165 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0044 0.1977 0.2056
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0659 0.0815
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0487 0.0422
Loa Loa (eye worm) glutathione reductase 0.005 0.231 0.2347
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0044 0.1977 0.1977
Echinococcus granulosus unc 13 munc13 0.0011 0.0114 0.0114
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0044 0.1977 0.1977
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0011 0.0121 0.0125
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0652 0.0598
Echinococcus granulosus Rac GTPase activating protein 1 0.0077 0.386 0.386
Echinococcus multilocularis voltage gated potassium channel 0.0044 0.1977 0.1977
Echinococcus multilocularis potassium voltage gated channel protein 0.0044 0.1977 0.1977
Toxoplasma gondii heat shock protein HSP90 0.0034 0.1438 0.1411
Brugia malayi cathepsin F-like cysteine proteinase 0.0019 0.0569 0.0569
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0079 0.3969 0.4033
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0277 0.0205
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0487 0.0425
Giardia lamblia Cathepsin L precursor 0.0019 0.0569 0.0931
Echinococcus multilocularis sodium channel protein 0.0044 0.1977 0.1977
Toxoplasma gondii Hsp90 domain-containing protein 0.0014 0.0306 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0043 0.1948 0.2635
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.2279 0.4157
Echinococcus multilocularis transfer RNA-Gly 0.0044 0.1977 0.1977
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0306 0.052
Loa Loa (eye worm) hypothetical protein 0.0079 0.3969 0.4033
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0044 0.1977 0.2056
Schistosoma mansoni SET domain protein 0.0034 0.1454 0.1512
Brugia malayi glutathione reductase 0.005 0.231 0.231
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Echinococcus multilocularis voltage gated potassium channel 0.0044 0.1977 0.1977
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.1948 0.3469
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Schistosoma mansoni hypothetical protein 0.0011 0.0114 0.0119
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.023 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0569 0.0607
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0034 0.1454 0.1454
Trypanosoma brucei heat shock protein, putative 0.0034 0.1438 0.1915
Toxoplasma gondii transporter, cation channel family protein 0.0044 0.1977 0.1972
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0019 0.0569 0.0931
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.3969 0.7756
Trypanosoma cruzi hypothetical protein 0.007 0.3438 0.3521
Brugia malayi C1-like domain containing protein 0.0011 0.0133 0.0133
Loa Loa (eye worm) voltage-dependent calcium channel 0.0044 0.1977 0.2008
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Entamoeba histolytica hypothetical protein 0.0019 0.0569 0.0973
Loa Loa (eye worm) ion channel NompC 0.0044 0.1977 0.2008
Echinococcus granulosus sentrin specific protease 8 0.007 0.3438 0.3438
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0062 0.3 0.5653
Plasmodium vivax serine-repeat antigen (SERA) 0.0019 0.0569 0.0781
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0044 0.1977 0.1977
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.1047 0.0918
Onchocerca volvulus 0.0079 0.3969 0.7756
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0043 0.1948 0.2025
Echinococcus multilocularis cysteine protease 0.0079 0.3969 0.3969
Loa Loa (eye worm) heat shock protein 75 0.0014 0.0306 0.0311
Echinococcus multilocularis sentrin specific protease 8 0.007 0.3438 0.3438
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.1977 0.2056
Schistosoma mansoni diacylglycerol kinase theta 0.0011 0.0114 0.0119
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.1438 0.1915
Giardia lamblia Sentrin specific protease, putative 0.0014 0.0281 0.0354
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0659 0.0605
Schistosoma mansoni atypical protein kinase C 0.0011 0.0133 0.0138
Leishmania major cathepsin L-like protease 0.0079 0.3969 0.5489
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0062 0.3 0.5653
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0111 0.5786 0.5983
Brugia malayi Variant SH3 domain containing protein 0.0011 0.0114 0.0114
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.6595 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0659 0.0815
Plasmodium vivax heat shock protein 90, putative 0.0014 0.0306 0.0067
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0014 0.0306 0.0306
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0011 0.0114 0.0114
Brugia malayi cation channel family protein 0.0044 0.1977 0.1977
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.6595 1
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0014 0.0281 0.0282
Leishmania major cathepsin L-like protease 0.0079 0.3969 0.5489
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Schistosoma mansoni cathepsin S (C01 family) 0.0019 0.0569 0.0592
Leishmania major hypothetical protein, unknown function 0.0044 0.1977 0.2676
Schistosoma mansoni hypothetical protein 0.0044 0.1977 0.2056
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0019 0.0569 0.0592
Echinococcus multilocularis transient receptor potential cation channel 0.0044 0.1977 0.1977
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0281 0.0398
Onchocerca volvulus 0.0014 0.0281 0.0398
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0044 0.1977 0.1977
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.231 0.2985
Echinococcus multilocularis protein kinase c epsilon type 0.0011 0.0133 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0066 0.3258 0.3388
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0011 0.0114 0.0116
Loa Loa (eye worm) hypothetical protein 0.002 0.0659 0.0669
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0133 0.0138
Loa Loa (eye worm) hypothetical protein 0.0011 0.0114 0.0116
Echinococcus multilocularis N chimaerin 0.0011 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0487 0.0572
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0569 0.0607
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0487 0.0558
Schistosoma mansoni tar DNA-binding protein 0.0066 0.3258 0.3388
Loa Loa (eye worm) heat shock protein 90 0.0034 0.1438 0.1461
Schistosoma mansoni hypothetical protein 0.001 0.0082 0.0085
Schistosoma mansoni phd finger protein 0.001 0.0082 0.0085
Echinococcus granulosus Peptidase C54 0.0062 0.3 0.3
Echinococcus multilocularis geminin 0.0178 0.9519 0.9519
Onchocerca volvulus 0.0079 0.3969 0.7756
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.2591 0.5006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.7165 1
Loa Loa (eye worm) calcium channel 0.0044 0.1977 0.2008
Echinococcus multilocularis potassium voltage gated channel protein 0.0044 0.1977 0.1977
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0062 0.3 0.412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.3969 0.7665
Trypanosoma brucei unspecified product 0.0014 0.0305 0.0316
Loa Loa (eye worm) ryanodine receptor 0.0044 0.1977 0.2008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0569 0.0607
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.5094 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0569 0.0607
Echinococcus granulosus sentrin specific protease 1 0.0014 0.0281 0.0281
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0569 0.0578
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0062 0.3 0.5653
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0659 0.0815
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0014 0.0281 0.0208
Entamoeba histolytica cysteine protease, putative 0.0043 0.1948 0.3723
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0487 0.0506
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.1977 0.1977
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0062 0.3 0.5653
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.018 0.9616 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0659 0.0685
Trypanosoma brucei unspecified product 0.002 0.0659 0.0815
Schistosoma mansoni vav2 0.0011 0.0114 0.0119
Echinococcus granulosus TRP transient receptor potential channel 0.0044 0.1977 0.1977
Echinococcus multilocularis voltage dependent calcium channel 0.0044 0.1977 0.1977
Trichomonas vaginalis Sentrin-specific protease, putative 0.007 0.3438 0.6563
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0044 0.1977 0.1977
Echinococcus multilocularis transient receptor potential cation channel 0.0044 0.1977 0.1977
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.3969 0.7665
Echinococcus multilocularis hyperpolarization activated cyclic 0.0044 0.1977 0.1977
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Entamoeba histolytica cysteine proteinase, putative 0.0043 0.1948 0.3723
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.5094 0.5094
Leishmania major cathepsin L-like protease 0.0136 0.7165 1
Trypanosoma brucei heat shock protein, putative 0.0034 0.1438 0.1915
Brugia malayi PWWP domain containing protein 0.001 0.0082 0.0082
Loa Loa (eye worm) thioredoxin reductase 0.005 0.231 0.2347
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0659 0.0669
Giardia lamblia Hypothetical protein 0.0019 0.0569 0.0931
Echinococcus granulosus PWWP domain containing protein 2A 0.001 0.0082 0.0082
Leishmania major heat shock protein 83-1 0.0034 0.1438 0.1915
Loa Loa (eye worm) fibroinase 0.0079 0.3969 0.4033
Echinococcus multilocularis protein kinase c eta type 0.0011 0.0114 0.0114
Toxoplasma gondii transporter, cation channel family protein 0.0044 0.1977 0.1972
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0019 0.0569 0.0569
Entamoeba histolytica peptidase, C54 family 0.0024 0.0877 0.1587
Loa Loa (eye worm) hypothetical protein 0.0044 0.1977 0.2008
Toxoplasma gondii hypothetical protein 0.0044 0.1977 0.1972

Activities

Activity type Activity value Assay description Source Reference
K inact (binding) 0 s-1 Compound is evaluated for inhibition kinetic constant Kinact for the cathepsin O2; No data ChEMBL. 7650671
K inact (binding) = 0.046 s-1 Compound is evaluated for inhibition kinetic constant Kinact for the Cruzaine ChEMBL. 7650671
K inact (binding) = 0.1 s-1 Compound is evaluated for inhibition kinetic constant Kinact for the cathepsin S ChEMBL. 7650671
K inact (binding) = 0.14 s-1 Compound is evaluated for inhibition kinetic constant Kinact for the cathepsin L ChEMBL. 7650671
Ki (binding) 0 uM Compound is evaluated for inhibitory potency against cathepsin O2; No data ChEMBL. 7650671
Ki (binding) = 0.0018 uM Compound is evaluated for inhibitory potency against cathepsin S ChEMBL. 7650671
Ki (binding) = 0.018 uM Compound is evaluated for inhibitory potency against cathepsin L ChEMBL. 7650671
Ki (binding) = 0.048 uM Compound is evaluated for inhibitory potency against Cruzaine ChEMBL. 7650671
Ki (binding) = 0.15 uM Compound is evaluated for inhibitory potency against cathepsin B ChEMBL. 7650671
kirr (binding) = 0.061 s-1 Compound is evaluated for inhibition kinetic constant Kirr for the cathepsin B ChEMBL. 7650671
Ratio (binding) < 300 Ratio of inhibition kinetic constants kinact and Ki of the compound against Cathepsin O2 ChEMBL. 7650671
Ratio (binding) = 420000 Ratio of inhibition kinetic constants kirr and Ki of the compound against Cathepsin B ChEMBL. 7650671
Ratio (binding) = 1040000 Ratio of inhibition kinetic constants kinact and Ki of the compound against Cruzaine ChEMBL. 7650671
Ratio (binding) = 9200000 Ratio of inhibition kinetic constants kinact and Ki of the compound against Cathepsin L ChEMBL. 7650671
Ratio (binding) = 56000000 Ratio of inhibition kinetic constants kinact and Ki of the compound against Cathepsin S ChEMBL. 7650671

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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