Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GSG2 | 0.049 | 0.991 | 1 |
Brugia malayi | hypothetical protein | 0.049 | 0.991 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0094 | 0.0485 | 0.0324 |
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0088 | 0.0346 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0395 | 0.0395 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0382 | 0.7338 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0132 | 0.1379 | 0.1163 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0382 | 0.7338 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0132 | 0.1379 | 0.1379 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0382 | 0.7338 | 0.7338 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0382 | 0.7338 | 1 |
Onchocerca volvulus | 0.0138 | 0.1517 | 1 | |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0138 | 0.1517 | 0.1306 |
Brugia malayi | endochitinase | 0.0097 | 0.0553 | 0.0259 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0382 | 0.7338 | 1 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0382 | 0.7338 | 0.7323 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0382 | 0.7338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1517 | 0.1517 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0074 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1379 | 0.1379 |
Onchocerca volvulus | Putative endochitinase | 0.0097 | 0.0553 | 0.2052 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0382 | 0.7338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0395 | 0.0395 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0088 | 0.0346 | 0.0346 |
Echinococcus multilocularis | dual specificity | 0.0094 | 0.0485 | 0.0237 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0088 | 0.0346 | 0.0093 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.0088 | 0.0346 | 0.006 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0138 | 0.1517 | 0.1306 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0094 | 0.0485 | 0.0199 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0088 | 0.0346 | 0.0127 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0088 | 0.0346 | 0.0093 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0382 | 0.7338 | 1 |
Echinococcus multilocularis | dual specificity | 0.0382 | 0.7338 | 0.7336 |
Loa Loa (eye worm) | haspin protein kinase | 0.049 | 0.991 | 0.991 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0084 | 0.0249 | 0.0249 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.0088 | 0.0346 | 0.006 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0088 | 0.0346 | 0.0093 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.049 | 0.991 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0138 | 0.1517 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0094 | 0.0485 | 0.0324 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0094 | 0.0485 | 0.0258 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0094 | 0.0485 | 0.0199 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.049 | 0.991 | 1 |
Echinococcus granulosus | dual specificity | 0.0382 | 0.7338 | 0.7336 |
Loa Loa (eye worm) | carboxylesterase | 0.0132 | 0.1379 | 0.1379 |
Loa Loa (eye worm) | CMGC/CDK/CRK7 protein kinase | 0.0088 | 0.0346 | 0.0346 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0088 | 0.0346 | 0.0044 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.049 | 0.991 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0382 | 0.7338 | 1 |
Schistosoma mansoni | hypothetical protein | 0.049 | 0.991 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 0.1379 | 0.1163 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0132 | 0.1379 | 0.1163 |
Echinococcus granulosus | dual specificity | 0.0382 | 0.7338 | 0.7336 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0074 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 0.1379 | 0.1163 |
Loa Loa (eye worm) | haspin protein kinase | 0.049 | 0.991 | 0.991 |
Schistosoma mansoni | protein kinase | 0.0088 | 0.0346 | 0.0093 |
Echinococcus multilocularis | dual specificity | 0.0382 | 0.7338 | 0.7336 |
Echinococcus multilocularis | dual specificity | 0.0382 | 0.7338 | 0.7336 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0088 | 0.0346 | 0.0093 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.049 | 0.991 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0485 | 0.0237 |
Entamoeba histolytica | chitinase, putative | 0.0087 | 0.0304 | 0.0068 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.1517 | 0.1306 |
Brugia malayi | Carboxylesterase family protein | 0.0132 | 0.1379 | 0.1119 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0094 | 0.0485 | 0.0199 |
Onchocerca volvulus | Putative endochitinase | 0.0097 | 0.0553 | 0.2052 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 0.1379 | 0.1163 |
Echinococcus granulosus | carboxylesterase 5A | 0.0132 | 0.1379 | 0.1163 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0138 | 0.1517 | 0.1263 |
Entamoeba histolytica | protein kinase, putative | 0.0094 | 0.0485 | 0.0324 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0088 | 0.0346 | 0.0093 |
Brugia malayi | Carboxylesterase family protein | 0.0132 | 0.1379 | 0.1119 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0088 | 0.0346 | 0.0093 |
Brugia malayi | Endochitinase | 0.0097 | 0.0553 | 0.0259 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0382 | 0.7338 | 0.7336 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0088 | 0.0346 | 0.0127 |
Echinococcus granulosus | dual specificity | 0.0094 | 0.0485 | 0.0237 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 0.1379 | 0.1163 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1517 | 0.1517 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.049 | 0.991 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0088 | 0.0346 | 0.0044 |
Mycobacterium tuberculosis | Possible chitinase | 0.0074 | 0 | 0.5 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0382 | 0.7338 | 1 |
Onchocerca volvulus | 0.0138 | 0.1517 | 1 | |
Loa Loa (eye worm) | chitinase I | 0.0087 | 0.0304 | 0.0304 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0088 | 0.0346 | 0.0093 |
Onchocerca volvulus | Putative endochitinase | 0.0097 | 0.0553 | 0.2052 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0094 | 0.0485 | 0.0324 |
Plasmodium falciparum | conserved protein, unknown function | 0.0138 | 0.1517 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0382 | 0.7338 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0382 | 0.7338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1379 | 0.1379 |
Brugia malayi | Cell division protein kinase 2 | 0.0088 | 0.0346 | 0.0044 |
Brugia malayi | Protein kinase domain containing protein | 0.0094 | 0.0485 | 0.0189 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0382 | 0.7338 | 1 |
Echinococcus granulosus | dual specificity | 0.0382 | 0.7338 | 0.7336 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0382 | 0.7338 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0094 | 0.0485 | 0.0485 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0087 | 0.0304 | 0.0304 |
Schistosoma mansoni | serine/threonine kinase | 0.0088 | 0.0346 | 0.0093 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.