Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0143 | 0.0991 | 1 |
Trypanosoma brucei | Mitogen-activated protein kinase 10, putative | 0.0143 | 0.0991 | 0.0884 |
Loa Loa (eye worm) | haspin protein kinase | 0.0791 | 0.992 | 0.992 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0617 | 0.7516 | 1 |
Trypanosoma cruzi | Mitogen-activated protein kinase 10, putative | 0.0143 | 0.0991 | 0.0884 |
Loa Loa (eye worm) | chitinase I | 0.0083 | 0.0168 | 0.0168 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0791 | 0.992 | 1 |
Echinococcus granulosus | Pfam-B_8186 domain containing protein | 0.0137 | 0.0911 | 0.0578 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0791 | 0.992 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0617 | 0.7516 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0617 | 0.7516 | 1 |
Onchocerca volvulus | 0.0131 | 0.0837 | 1 | |
Onchocerca volvulus | Putative endochitinase | 0.0093 | 0.0305 | 0.2052 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.0143 | 0.0991 | 0.1121 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0143 | 0.0991 | 0.0844 |
Brugia malayi | Endochitinase | 0.0093 | 0.0305 | 0.0141 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0143 | 0.0991 | 0.0991 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0133 | 0.0857 | 0.0857 |
Schistosoma mansoni | protein kinase | 0.0143 | 0.0991 | 0.0661 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0071 | 0 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0143 | 0.0991 | 0.0661 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0131 | 0.0837 | 0.0686 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0837 | 0.0837 |
Brugia malayi | Protein kinase domain containing protein | 0.0097 | 0.0359 | 0.0196 |
Echinococcus granulosus | dual specificity | 0.0617 | 0.7516 | 0.7486 |
Trypanosoma brucei | protein kinase, putative | 0.0143 | 0.0991 | 0.0884 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.0143 | 0.0991 | 0.1121 |
Echinococcus granulosus | carboxylesterase 5A | 0.0133 | 0.0857 | 0.0521 |
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0143 | 0.0991 | 0.0661 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0071 | 0 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0791 | 0.992 | 1 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0083 | 0.0168 | 0.0168 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0133 | 0.0857 | 0.0521 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0143 | 0.0991 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0133 | 0.0857 | 0.0706 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0143 | 0.0991 | 0.0661 |
Echinococcus multilocularis | acetylcholinesterase | 0.0133 | 0.0857 | 0.0521 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0097 | 0.0359 | 0.0359 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0143 | 0.0991 | 0.0661 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0617 | 0.7516 | 0.7486 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0143 | 0.0991 | 0.1121 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0617 | 0.7516 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0093 | 0.0305 | 0.2052 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0143 | 0.0991 | 0.1121 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0097 | 0.0359 | 0.026 |
Plasmodium falciparum | MO15-related protein kinase | 0.0143 | 0.0991 | 1 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0617 | 0.7516 | 1 |
Brugia malayi | endochitinase | 0.0093 | 0.0305 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0279 | 0.0279 |
Echinococcus multilocularis | hypothetical protein | 0.0137 | 0.0911 | 0.0578 |
Entamoeba histolytica | hypothetical protein | 0.0137 | 0.0911 | 0.1012 |
Echinococcus granulosus | dual specificity | 0.0617 | 0.7516 | 0.7486 |
Echinococcus granulosus | dual specificity | 0.0617 | 0.7516 | 0.7486 |
Echinococcus multilocularis | dual specificity | 0.0617 | 0.7516 | 0.7486 |
Brugia malayi | hypothetical protein | 0.0791 | 0.992 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0791 | 0.992 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0097 | 0.0359 | 0.026 |
Loa Loa (eye worm) | carboxylesterase | 0.0133 | 0.0857 | 0.0857 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0143 | 0.0991 | 0.0661 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0617 | 0.7516 | 1 |
Trypanosoma cruzi | serine/threonine protein kinase, putative | 0.0143 | 0.0991 | 0.0884 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0617 | 0.7516 | 0.7535 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0617 | 0.7516 | 0.7516 |
Echinococcus granulosus | acetylcholinesterase | 0.0133 | 0.0857 | 0.0521 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0617 | 0.7516 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0143 | 0.0991 | 0.0661 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0081 | 0.0137 | 0.0137 |
Entamoeba histolytica | protein kinase, putative | 0.0617 | 0.7516 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0143 | 0.0991 | 0.0844 |
Schistosoma mansoni | serine/threonine kinase | 0.0143 | 0.0991 | 0.0661 |
Trypanosoma cruzi | Mitogen-activated protein kinase 10, putative | 0.0143 | 0.0991 | 0.0884 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0143 | 0.0991 | 0.0661 |
Echinococcus multilocularis | dual specificity | 0.0617 | 0.7516 | 0.7486 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0617 | 0.7516 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0097 | 0.0359 | 0.026 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0133 | 0.0857 | 0.0521 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0837 | 0.0837 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0857 | 0.0857 |
Schistosoma mansoni | hypothetical protein | 0.0137 | 0.0911 | 0.0578 |
Echinococcus multilocularis | dual specificity | 0.0617 | 0.7516 | 0.7486 |
Loa Loa (eye worm) | CMGC/CDK/CRK7 protein kinase | 0.0143 | 0.0991 | 0.0991 |
Echinococcus granulosus | acetylcholinesterase | 0.0133 | 0.0857 | 0.0521 |
Onchocerca volvulus | Putative endochitinase | 0.0093 | 0.0305 | 0.2052 |
Brugia malayi | GSG2 | 0.0791 | 0.992 | 1 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0131 | 0.0837 | 0.05 |
Onchocerca volvulus | 0.0131 | 0.0837 | 1 | |
Entamoeba histolytica | protein kinase, putative | 0.0097 | 0.0359 | 0.026 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0617 | 0.7516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0279 | 0.0279 |
Schistosoma mansoni | hypothetical protein | 0.0791 | 0.992 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0617 | 0.7516 | 1 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0131 | 0.0837 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0857 | 0.0857 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0791 | 0.992 | 1 |
Mycobacterium tuberculosis | Possible chitinase | 0.0071 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0133 | 0.0857 | 0.0521 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0143 | 0.0991 | 0.0661 |
Brugia malayi | Carboxylesterase family protein | 0.0133 | 0.0857 | 0.0706 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0617 | 0.7516 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0097 | 0.0359 | 0.026 |
Loa Loa (eye worm) | haspin protein kinase | 0.0791 | 0.992 | 0.992 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0837 | 0.05 |
Brugia malayi | Cell division protein kinase 2 | 0.0143 | 0.0991 | 0.0844 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0617 | 0.7516 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.