Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0133 | 0.1407 | 0.2031 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0888 | 0.1265 |
Schistosoma mansoni | protein kinase | 0.0091 | 0.0805 | 0.1141 |
Schistosoma mansoni | serine/threonine kinase | 0.0091 | 0.0805 | 0.1141 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0144 | 0.1565 | 0.1746 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0102 | 0.096 | 0.0356 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.0091 | 0.0805 | 0.1191 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0091 | 0.0805 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0301 | 0.04 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0091 | 0.0805 | 0.0078 |
Echinococcus multilocularis | dual specificity | 0.0102 | 0.096 | 0.0245 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0133 | 0.1407 | 0.0727 |
Onchocerca volvulus | Putative endochitinase | 0.0081 | 0.0652 | 0.3871 |
Echinococcus granulosus | dual specificity | 0.0391 | 0.5156 | 0.4773 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0069 | 0.0479 | 1 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0091 | 0.0805 | 0.505 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0128 | 0.1342 | 0.0657 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0038 | 0.003 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1342 | 0.1934 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0091 | 0.0805 | 0.1141 |
Loa Loa (eye worm) | chitinase I | 0.0081 | 0.0652 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0479 | 0.0662 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0102 | 0.096 | 0.1505 |
Onchocerca volvulus | 0.0106 | 0.1019 | 0.7125 | |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0091 | 0.0805 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1342 | 0.1934 |
Brugia malayi | AMP-binding enzyme family protein | 0.0051 | 0.0217 | 0.0263 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0091 | 0.0805 | 0.505 |
Leishmania major | protein kinase, putative | 0.0144 | 0.1565 | 0.2729 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0102 | 0.096 | 0.1371 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0051 | 0.0217 | 0.4154 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0144 | 0.1565 | 0.2263 |
Onchocerca volvulus | Putative endochitinase | 0.0091 | 0.0794 | 0.5129 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0133 | 0.1407 | 0.204 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0051 | 0.0217 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0133 | 0.1407 | 0.204 |
Brugia malayi | endochitinase | 0.0091 | 0.0794 | 0.1124 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0051 | 0.0217 | 0.4154 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.05 | 0.674 | 0.6482 |
Entamoeba histolytica | hypothetical protein | 0.0102 | 0.096 | 0.1505 |
Echinococcus granulosus | dual specificity | 0.0391 | 0.5156 | 0.4773 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0051 | 0.0217 | 0.4154 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0041 | 0.0016 |
Brugia malayi | Protein kinase domain containing protein | 0.0144 | 0.1565 | 0.2275 |
Echinococcus multilocularis | 0.0139 | 0.1493 | 0.082 | |
Echinococcus granulosus | dual specificity | 0.0391 | 0.5156 | 0.4773 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0091 | 0.0805 | 0.0078 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.05 | 0.674 | 0.6482 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0081 | 0.0652 | 0.0917 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.0301 | 0.0389 |
Brugia malayi | Endochitinase | 0.0091 | 0.0794 | 0.1124 |
Echinococcus multilocularis | dual specificity | 0.0391 | 0.5156 | 0.4773 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0102 | 0.096 | 0.1372 |
Echinococcus granulosus | acetylcholinesterase | 0.0133 | 0.1407 | 0.0727 |
Plasmodium falciparum | MO15-related protein kinase | 0.0091 | 0.0805 | 0.505 |
Loa Loa (eye worm) | haspin protein kinase | 0.05 | 0.674 | 0.9894 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0217 | 0.0275 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0051 | 0.0217 | 0.4154 |
Plasmodium falciparum | conserved protein, unknown function | 0.0128 | 0.1342 | 0.8548 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0106 | 0.1019 | 0.1459 |
Brugia malayi | AMP-binding enzyme family protein | 0.0051 | 0.0217 | 0.0263 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0051 | 0.0217 | 0.4154 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1019 | 0.1457 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0091 | 0.0805 | 0.0078 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0391 | 0.5156 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0091 | 0.0805 | 0.1191 |
Loa Loa (eye worm) | CMGC/CDK/CRK7 protein kinase | 0.0091 | 0.0805 | 0.1143 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0391 | 0.5156 | 1 |
Onchocerca volvulus | 0.0128 | 0.1342 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0217 | 0.0275 |
Entamoeba histolytica | protein kinase, putative | 0.0102 | 0.096 | 0.1505 |
Brugia malayi | Protein kinase domain containing protein | 0.0091 | 0.0805 | 0.1141 |
Echinococcus multilocularis | acetylcholinesterase | 0.0133 | 0.1407 | 0.0727 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0391 | 0.5156 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0144 | 0.1565 | 0.1746 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0391 | 0.5156 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0391 | 0.5156 | 1 |
Giardia lamblia | Kinase, CMGC CLK | 0.0144 | 0.1565 | 0.1746 |
Echinococcus granulosus | hypothetical protein | 0.0139 | 0.1493 | 0.082 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0038 | 0.003 | 0.0628 |
Mycobacterium tuberculosis | Possible chitinase | 0.0069 | 0.0479 | 1 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0144 | 0.1565 | 0.0897 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0091 | 0.0805 | 0.1191 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0144 | 0.1565 | 0.0584 |
Brugia malayi | hypothetical protein | 0.05 | 0.674 | 1 |
Brugia malayi | Cell division protein kinase 2 | 0.0091 | 0.0805 | 0.1141 |
Loa Loa (eye worm) | haspin protein kinase | 0.0505 | 0.6812 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.05 | 0.674 | 0.6482 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1407 | 0.2031 |
Brugia malayi | Protein kinase domain containing protein | 0.0102 | 0.096 | 0.1372 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0102 | 0.096 | 0.1505 |
Mycobacterium ulcerans | hypothetical protein | 0.0051 | 0.0217 | 0.4154 |
Echinococcus multilocularis | acetylcholinesterase | 0.0133 | 0.1407 | 0.0727 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0069 | 0.0479 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0391 | 0.5156 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0391 | 0.5156 | 0.7635 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0391 | 0.5156 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0391 | 0.5156 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0133 | 0.1407 | 0.0727 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0144 | 0.1565 | 0.1746 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.0301 | 0.04 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0391 | 0.5156 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0144 | 0.1565 | 0.2275 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0888 | 0.1265 |
Schistosoma mansoni | hypothetical protein | 0.05 | 0.674 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0091 | 0.0794 | 0.5129 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0051 | 0.0217 | 0.4521 |
Onchocerca volvulus | Putative endochitinase | 0.0091 | 0.0794 | 0.5129 |
Leishmania major | protein kinase, putative | 0.0144 | 0.1565 | 0.2729 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0144 | 0.1565 | 0.1746 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0144 | 0.1565 | 0.1746 |
Entamoeba histolytica | hypothetical protein | 0.0086 | 0.0733 | 0.1046 |
Echinococcus granulosus | carboxylesterase 5A | 0.0133 | 0.1407 | 0.0727 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.05 | 0.674 | 0.6482 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0102 | 0.096 | 0.0356 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0144 | 0.1565 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0144 | 0.1565 | 0.1746 |
Brugia malayi | AMP-binding enzyme family protein | 0.0051 | 0.0217 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1407 | 0.2031 |
Entamoeba histolytica | chitinase, putative | 0.0081 | 0.0652 | 0.0882 |
Brugia malayi | endochitinase | 0.0081 | 0.0652 | 0.0913 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0217 | 0.0275 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0051 | 0.0217 | 0.4521 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1493 | 0.2157 |
Brugia malayi | GSG2 | 0.05 | 0.674 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0051 | 0.0217 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0128 | 0.1342 | 0.8548 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0391 | 0.5156 | 0.7558 |
Loa Loa (eye worm) | haspin protein kinase | 0.05 | 0.674 | 0.9894 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0091 | 0.0805 | 0.0078 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0144 | 0.1565 | 0.0897 |
Onchocerca volvulus | Putative endochitinase | 0.0081 | 0.0652 | 0.3871 |
Entamoeba histolytica | protein kinase, putative | 0.0102 | 0.096 | 0.1505 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0391 | 0.5156 | 1 |
Leishmania major | chitinase | 0.0081 | 0.0652 | 0.0882 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0144 | 0.1565 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0051 | 0.0217 | 0.4154 |
Brugia malayi | Carboxylesterase family protein | 0.0133 | 0.1407 | 0.204 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0144 | 0.1565 | 0.1746 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0091 | 0.0805 | 0.1141 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0128 | 0.1342 | 0.1942 |
Echinococcus multilocularis | tumor protein p63 | 0.0724 | 1 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0091 | 0.0805 | 0.1143 |
Echinococcus granulosus | dual specificity | 0.0102 | 0.096 | 0.0245 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0391 | 0.5156 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.05 | 0.674 | 0.6482 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0128 | 0.1342 | 0.0657 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0102 | 0.096 | 0.0356 |
Onchocerca volvulus | 0.0128 | 0.1342 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0133 | 0.1407 | 0.2031 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.0733 | 0.1034 |
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0091 | 0.0805 | 0.0078 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0144 | 0.1565 | 0.2275 |
Echinococcus multilocularis | dual specificity | 0.0391 | 0.5156 | 0.4773 |
Echinococcus multilocularis | dual specificity | 0.0391 | 0.5156 | 0.4773 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.0091 | 0.0805 | 0.1191 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0391 | 0.5156 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.0301 | 0.0389 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0051 | 0.0217 | 0.4154 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0079 | 0.0621 | 0.0871 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0391 | 0.5156 | 0.7635 |
Schistosoma mansoni | hypothetical protein | 0.0128 | 0.1342 | 0.1942 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0391 | 0.5156 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
log(1/I50) (binding) | = 7.77 | Inhibition of susceptible Nephotettix cincticeps Ageo (green rice leafhopper) acetylcholinesterase activity | ChEMBL. | No reference |
log(1/I50) (binding) | = 7.8 | Inhibition of susceptible Nephotettix cincticeps Izumi (green rice leafhopper) acetylcholinesterase activity | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.