TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 272.385 | Formula: C17H24N2O
H donors: 0 H acceptors: 1 LogP: 5.06 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCOc1ccc(cc1)n1cncc1
InChi: 1S/C17H24N2O/c1-2-3-4-5-6-7-14-20-17-10-8-16(9-11-17)19-13-12-18-15-19/h8-13,15H,2-7,14H2,1H3
InChiKey: VANOPHPPGSLYDB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0913	0.4036	0.6756
Brugia malayi	cathepsin F-like cysteine proteinase	0.0295	0.1201	0.1193
Brugia malayi	Cathepsin L-like precursor	0.1335	0.597	0.5966
Plasmodium falciparum	serine repeat antigen 9	0.0295	0.1201	0.1834
Loa Loa (eye worm)	hypothetical protein	0.0035	0.001	0.001
Giardia lamblia	Cysteine protease	0.0295	0.1201	0.2824
Toxoplasma gondii	cathepsin B	0.0888	0.3922	0.6565
Trichomonas vaginalis	conserved hypothetical protein	0.0295	0.1201	0.1999
Onchocerca volvulus		0.1335	0.597	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1335	0.597	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0295	0.1201	0.1999
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.001	0.5
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0716	0.3134	0.3128
Echinococcus multilocularis	cysteine protease	0.1335	0.597	0.5966
Leishmania major	cathepsin L-like protease	0.1335	0.597	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0295	0.1201	0.1999
Onchocerca volvulus		0.0913	0.4036	0.6762
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0599	0.2595	0.2588
Brugia malayi	Papain family cysteine protease containing protein	0.0716	0.3134	0.3128
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0055	0.0102	0.0093
Onchocerca volvulus		0.1335	0.597	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0716	0.3134	0.3128
Leishmania major	cathepsin L-like protease	0.1335	0.597	1
Entamoeba histolytica	prefoldin subunit 6, putative	0.0061	0.013	0.0202
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0295	0.1201	0.1193
Brugia malayi	Cathepsin L-like precursor	0.0913	0.4036	0.4031
Brugia malayi	Cathepsin L-like precursor	0.0422	0.1783	0.1775
Onchocerca volvulus		0.1335	0.597	1
Leishmania major	cathepsin L-like protease	0.1335	0.597	1
Plasmodium vivax	prefoldin subunit 6, putative	0.0061	0.013	0.0202
Brugia malayi	Cathepsin L-like precursor	0.1335	0.597	0.5966
Echinococcus multilocularis	cathepsin L cysteine protease	0.1335	0.597	0.5966
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0295	0.1201	0.1193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1335	0.597	1
Brugia malayi	cathepsin L-like precursor	0.0913	0.4036	0.4031
Entamoeba histolytica	cysteine protease, putative	0.0716	0.3134	0.5243
Trypanosoma cruzi	major cysteine proteinase, putative	0.0295	0.1201	0.1193
Loa Loa (eye worm)	hypothetical protein	0.1335	0.597	0.597
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1335	0.597	1
Entamoeba histolytica	cysteine proteinase 2	0.0716	0.3134	0.5243
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1335	0.597	1
Loa Loa (eye worm)	hypothetical protein	0.0913	0.4036	0.4036
Giardia lamblia	Encystation-specific protease	0.0295	0.1201	0.2824
Trypanosoma cruzi	cysteine protease, putative	0.0716	0.3134	0.3128
Onchocerca volvulus	Cathepsin F homolog	0.1335	0.597	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.001	0.5
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0295	0.1201	0.1999
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0888	0.3922	0.6565
Echinococcus multilocularis	geminin	0.0171	0.0631	0.0623
Plasmodium vivax	serine-repeat antigen (SERA)	0.0295	0.1201	0.1999
Entamoeba histolytica	cysteine protease, putative	0.0716	0.3134	0.5243
Schistosoma mansoni	hypothetical protein	0.0061	0.013	0.0121
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0295	0.1201	0.1834
Plasmodium falciparum	serine repeat antigen 4	0.0295	0.1201	0.1834
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0053	0.0091	0.0082
Echinococcus multilocularis	cathepsin b	0.2214	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0295	0.1201	0.1193
Loa Loa (eye worm)	hypothetical protein	0.0422	0.1783	0.1783
Mycobacterium ulcerans	lipase LipD	0.0035	0.001	0.5
Entamoeba histolytica	cysteine protease, putative	0.0716	0.3134	0.5243
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1335	0.597	1
Plasmodium falciparum	serine repeat antigen 7	0.0295	0.1201	0.1834
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1335	0.597	1
Schistosoma mansoni	cathepsin C	0.0295	0.1201	0.1193
Giardia lamblia	Cysteine protease	0.0295	0.1201	0.2824
Schistosoma mansoni	hypothetical protein	0.0171	0.0631	0.0623
Giardia lamblia	Hypothetical protein	0.0295	0.1201	0.2824
Plasmodium vivax	unspecified product	0.0295	0.1201	0.1999
Leishmania major	cysteine peptidase A (CPA)	0.1335	0.597	1
Brugia malayi	Papain family cysteine protease containing protein	0.1335	0.597	0.5966
Giardia lamblia	Cathepsin L precursor	0.0295	0.1201	0.2824
Loa Loa (eye worm)	hypothetical protein	0.0913	0.4036	0.4036
Loa Loa (eye worm)	beta-lactamase	0.0035	0.001	0.001
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1335	0.597	1
Loa Loa (eye worm)	ctsf protein	0.1335	0.597	0.597
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0295	0.1201	0.1999
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.013	0.0202
Schistosoma mansoni	hypothetical protein	0.0171	0.0631	0.0623
Plasmodium vivax	unspecified product	0.0716	0.3134	0.5243
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0295	0.1201	0.1999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1335	0.597	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1335	0.597	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.2214	1	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0295	0.1201	0.1999
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0295	0.1201	0.1193
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0295	0.1201	0.1193
Toxoplasma gondii	cathepsin CPC1	0.0295	0.1201	0.1999
Giardia lamblia	Cathepsin L-like protease	0.0295	0.1201	0.2824
Loa Loa (eye worm)	cysteine protease	0.1335	0.597	0.597
Plasmodium vivax	serine-repeat antigen (SERA)	0.0295	0.1201	0.1999
Plasmodium vivax	vivapain-2	0.1335	0.597	1
Echinococcus granulosus	cathepsin L	0.0716	0.3134	0.3128
Entamoeba histolytica	cysteine protease, putative	0.0295	0.1201	0.1999
Plasmodium vivax	unspecified product	0.0422	0.1783	0.2975
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1335	0.597	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.1201	0.1201
Loa Loa (eye worm)	hypothetical protein	0.0035	0.001	0.001
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0599	0.2595	0.2588
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1335	0.597	1
Brugia malayi	Papain family cysteine protease containing protein	0.0716	0.3134	0.3128
Entamoeba histolytica	cysteine protease, putative	0.1335	0.597	1
Giardia lamblia	Cathepsin B precursor	0.0295	0.1201	0.2824
Brugia malayi	cathepsin L precursor	0.0295	0.1201	0.1193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0295	0.1201	0.1999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1335	0.597	1
Entamoeba histolytica	cysteine protease, putative	0.0716	0.3134	0.5243
Onchocerca volvulus	Cathepsin L homolog	0.1335	0.597	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0888	0.3922	0.6565
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1335	0.597	0.5966
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0295	0.1201	0.1999
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0716	0.3134	0.3128
Loa Loa (eye worm)	calpain family protein 1	0.0039	0.0027	0.0027
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0295	0.1201	0.1201
Entamoeba histolytica	cysteine proteinase, putative	0.0716	0.3134	0.5243
Entamoeba histolytica	cysteine protease, putative	0.0716	0.3134	0.5243
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1335	0.597	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0295	0.1201	0.1999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0716	0.3134	0.5243
Giardia lamblia	Cathepsin L precursor	0.0295	0.1201	0.2824
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1335	0.597	1
Echinococcus granulosus	calpain A	0.0055	0.0102	0.0093
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0295	0.1201	0.2824
Trypanosoma cruzi	cysteine peptidase, putative	0.0716	0.3134	0.3128
Echinococcus granulosus	cathepsin L	0.0295	0.1201	0.1193
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0055	0.0102	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0064	0.0064
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1335	0.597	1
Entamoeba histolytica	cysteine protease, putative	0.0295	0.1201	0.1999
Brugia malayi	Cathepsin L-like precursor	0.1335	0.597	0.5966
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1335	0.597	1
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0295	0.1201	0.1999
Entamoeba histolytica	cysteine protease, putative	0.0716	0.3134	0.5243
Toxoplasma gondii	cathepsin CPL	0.1335	0.597	1
Onchocerca volvulus		0.1335	0.597	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.001	0.001
Echinococcus multilocularis	calpain family protein 1, d	0.0039	0.0027	0.0018
Leishmania major	prefoldin subunit, putative	0.0061	0.013	0.0202
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0913	0.4036	0.4031
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1335	0.597	1
Entamoeba histolytica	cysteine proteinase, putative	0.1335	0.597	1
Loa Loa (eye worm)	calpain family protein 1	0.0053	0.0091	0.0091
Echinococcus granulosus	cysteine protease	0.0716	0.3134	0.3128
Schistosoma mansoni	cathepsin B (C01 family)	0.0295	0.1201	0.1193
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2214	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1335	0.597	0.5966
Plasmodium vivax	vivapain-3	0.0716	0.3134	0.5243
Loa Loa (eye worm)	hypothetical protein	0.0035	0.001	0.001
Trypanosoma cruzi	major cysteine proteinase, putative	0.0295	0.1201	0.1193
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0295	0.1201	0.1999
Loa Loa (eye worm)	hypothetical protein	0.0035	0.001	0.001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1335	0.597	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0295	0.1201	0.1999
Onchocerca volvulus		0.1335	0.597	1
Brugia malayi	Cathepsin L-like precursor	0.1335	0.597	0.5966
Echinococcus granulosus	prefoldin subunit 6	0.0061	0.013	0.0121
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0295	0.1201	0.1999
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0716	0.3134	0.5243
Plasmodium vivax	vivapain-2	0.1335	0.597	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1335	0.597	0.5966
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1335	0.597	1
Giardia lamblia	Cathepsin B precursor	0.0888	0.3922	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.1201	0.1201
Leishmania major	cathepsin L-like protease	0.1335	0.597	1
Onchocerca volvulus		0.0295	0.1201	0.2012
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0295	0.1201	0.1201
Echinococcus multilocularis	cathepsin L	0.0716	0.3134	0.3128
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0295	0.1201	0.1999
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1335	0.597	0.597
Brugia malayi	calpain family protein 1	0.0053	0.0091	0.0082
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0295	0.1201	0.1999
Loa Loa (eye worm)	hypothetical protein	0.0422	0.1783	0.1783
Echinococcus granulosus	cathepsin l1	0.0913	0.4036	0.4031
Giardia lamblia	Cathepsin L-like protease	0.0295	0.1201	0.2824
Trypanosoma cruzi	cysteine peptidase, putative	0.1335	0.597	0.5966
Entamoeba histolytica	cysteine proteinase 1, putative	0.0716	0.3134	0.5243
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0422	0.1783	0.1775
Entamoeba histolytica	cysteine proteinase, putative	0.0913	0.4036	0.6756
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0295	0.1201	0.1193
Schistosoma mansoni	cathepsin s	0.0422	0.1783	0.1775
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0913	0.4036	0.6756
Entamoeba histolytica	cysteine protease, putative	0.0295	0.1201	0.1999
Echinococcus granulosus	geminin	0.0171	0.0631	0.0623
Brugia malayi	KE2 family protein	0.0061	0.013	0.0121
Loa Loa (eye worm)	cathepsin B	0.0888	0.3922	0.3922
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1335	0.597	1
Entamoeba histolytica	cysteine protease, putative	0.0716	0.3134	0.5243
Giardia lamblia	Cathepsin B precursor	0.0295	0.1201	0.2824
Loa Loa (eye worm)	hypothetical protein	0.0913	0.4036	0.4036
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0716	0.3134	0.5243
Plasmodium falciparum	serine repeat antigen 1	0.0295	0.1201	0.1834
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0295	0.1201	0.1193
Loa Loa (eye worm)	hypothetical protein	0.0061	0.013	0.013
Plasmodium falciparum	serine repeat antigen 5	0.0295	0.1201	0.1834
Leishmania major	cathepsin L-like protease	0.1335	0.597	1
Plasmodium falciparum	serine repeat antigen 2	0.0295	0.1201	0.1834
Trypanosoma cruzi	cysteine peptidase, putative	0.0422	0.1783	0.1775
Onchocerca volvulus		0.1335	0.597	1
Toxoplasma gondii	prefoldin subunit 6, putative	0.0061	0.013	0.0202
Entamoeba histolytica	cysteine proteinase, putative	0.0716	0.3134	0.5243
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1335	0.597	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.001	0.001
Giardia lamblia	Cathepsin L precursor	0.0295	0.1201	0.2824
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2214	1	1
Giardia lamblia	Cathepsin B precursor	0.0888	0.3922	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0295	0.1201	0.1999
Trypanosoma cruzi	cysteine proteinase, putative	0.0716	0.3134	0.3128
Loa Loa (eye worm)	hypothetical protein	0.0035	0.001	0.001
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0055	0.0102	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0295	0.1201	0.1201
Brugia malayi	Cathepsin L-like precursor	0.1335	0.597	0.5966
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1335	0.597	1
Echinococcus granulosus	cathepsin l1	0.1335	0.597	0.5966
Entamoeba histolytica	cysteine proteinase, putative	0.0716	0.3134	0.5243
Echinococcus multilocularis	cathepsin L	0.0295	0.1201	0.1193
Brugia malayi	cathepsin L-like cysteine proteinase	0.0295	0.1201	0.1193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1335	0.597	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.1201	0.1201
Entamoeba histolytica	cysteine proteinase, putative	0.0716	0.3134	0.5243
Echinococcus multilocularis	cathepsin b	0.2214	1	1
Entamoeba histolytica	cysteine protease, putative	0.0716	0.3134	0.5243
Entamoeba histolytica	cysteine protease, putative	0.0295	0.1201	0.1999
Leishmania major	cathepsin L-like protease	0.1335	0.597	1
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0295	0.1201	0.1999
Entamoeba histolytica	cysteine protease, putative	0.0716	0.3134	0.5243
Trypanosoma cruzi	cysteine peptidase, putative	0.1335	0.597	0.5966
Loa Loa (eye worm)	hypothetical protein	0.0295	0.1201	0.1201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1335	0.597	1
Plasmodium falciparum	serine repeat antigen 8	0.0295	0.1201	0.1834
Trypanosoma cruzi	cruzipain precursor, putative	0.1335	0.597	0.5966
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1335	0.597	0.5966
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1335	0.597	1
Plasmodium vivax	vivapain-1	0.0716	0.3134	0.5243
Brugia malayi	Papain family cysteine protease containing protein	0.0295	0.1201	0.1193
Plasmodium falciparum	serine repeat antigen 6	0.0295	0.1201	0.1834
Entamoeba histolytica	cysteine protease, putative	0.0716	0.3134	0.5243
Schistosoma mansoni	cathepsin F (C01 family)	0.1335	0.597	0.5966
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0913	0.4036	0.4031
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0295	0.1201	0.1999
Brugia malayi	calpain family protein 1	0.0053	0.0091	0.0082
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0888	0.3922	0.3917
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0716	0.3134	0.3128
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1335	0.597	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0716	0.3134	0.3128
Entamoeba histolytica	cysteine proteinase, putative	0.1335	0.597	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0716	0.3134	0.5243
Giardia lamblia	Cysteine protease	0.0295	0.1201	0.2824
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1335	0.597	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1335	0.597	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0295	0.1201	0.1193
Giardia lamblia	Cathepsin B precursor	0.0888	0.3922	1
Giardia lamblia	Cathepsin L precursor	0.0295	0.1201	0.2824
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0295	0.1201	0.1999
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1335	0.597	1
Giardia lamblia	Cathepsin B precursor	0.0295	0.1201	0.2824
Schistosoma mansoni	cathepsin F (C01 family)	0.0913	0.4036	0.4031
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1335	0.597	1
Onchocerca volvulus	Cathepsin L homolog	0.1335	0.597	1
Trypanosoma cruzi	prefoldin subunit, putative	0.0061	0.013	0.0121
Loa Loa (eye worm)	hypothetical protein	0.2214	1	1
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0295	0.1201	0.1999
Loa Loa (eye worm)	fibroinase	0.1335	0.597	0.597
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1335	0.597	1
Entamoeba histolytica	cysteine protease, putative	0.0716	0.3134	0.5243
Entamoeba histolytica	hypothetical protein	0.0295	0.1201	0.1999
Brugia malayi	Cathepsin L-like precursor	0.1335	0.597	0.5966
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.0871	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0295	0.1201	0.1193
Toxoplasma gondii	cathepsin CPC2	0.0295	0.1201	0.1999
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1335	0.597	0.5966
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0295	0.1201	0.2824
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1335	0.597	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.1335	0.597	0.5966
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0295	0.1201	0.1999
Entamoeba histolytica	cysteine protease, putative	0.0295	0.1201	0.1999
Mycobacterium ulcerans	hypothetical protein	0.0035	0.001	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1335	0.597	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1335	0.597	0.5966
Trypanosoma brucei	prefoldin subunit, putative	0.0061	0.013	0.0202
Brugia malayi	Cathepsin L-like precursor	0.0913	0.4036	0.4031
Echinococcus granulosus	cathepsin b	0.2214	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0295	0.1201	0.2824
Mycobacterium ulcerans	beta-lactamase	0.0035	0.001	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1335	0.597	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1335	0.597	0.5966
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1335	0.597	1
Mycobacterium leprae	Probable lipase LipE	0.0035	0.001	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1335	0.597	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0295	0.1201	0.1999
Giardia lamblia	Cathepsin B precursor	0.0295	0.1201	0.2824
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0295	0.1201	0.1999
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0716	0.3134	0.3128
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1335	0.597	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0295	0.1201	0.1193
Giardia lamblia	Cysteine protease	0.0295	0.1201	0.2824
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1335	0.597	0.597
Onchocerca volvulus		0.0035	0.001	0.0016
Brugia malayi	fibroinase precursor	0.0295	0.1201	0.1193
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0295	0.1201	0.1834
Trypanosoma cruzi	prefoldin subunit, putative	0.0061	0.013	0.0121
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2214	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0295	0.1201	0.1999
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0295	0.1201	0.1999
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0295	0.1201	0.1201
Echinococcus granulosus	cathepsin b	0.2214	1	1
Giardia lamblia	Cathepsin L precursor	0.0295	0.1201	0.2824
Trypanosoma cruzi	cruzipain precursor, putative	0.0422	0.1783	0.1775
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0295	0.1201	0.1999
Brugia malayi	Papain family cysteine protease containing protein	0.0295	0.1201	0.1193
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0716	0.3134	0.5144
Entamoeba histolytica	cysteine protease, putative	0.0295	0.1201	0.1999
Giardia lamblia	Cathepsin L precursor	0.0295	0.1201	0.2824
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0295	0.1201	0.1999
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0422	0.1783	0.1783
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0295	0.1201	0.2824
Schistosoma mansoni	cathepsin S (C01 family)	0.0295	0.1201	0.1193
Onchocerca volvulus		0.1335	0.597	1
Loa Loa (eye worm)	hypothetical protein	0.0422	0.1783	0.1783
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0295	0.1201	0.1193
Brugia malayi	Papain family cysteine protease containing protein	0.0295	0.1201	0.1193
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0888	0.3922	0.3917
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0295	0.1201	0.1999
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.2214	1	1
Leishmania major	cathepsin L-like protease	0.1335	0.597	1
Echinococcus multilocularis	prefoldin subunit 6	0.0061	0.013	0.0121
Onchocerca volvulus		0.0035	0.001	0.0016
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0295	0.1201	0.1201
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0295	0.1201	0.1834
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0091	0.0091
Giardia lamblia	Cathepsin B precursor	0.0295	0.1201	0.2824
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0295	0.1201	0.1999
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1335	0.597	1
Leishmania major	cathepsin L-like protease	0.1335	0.597	1
Entamoeba histolytica	cysteine protease, putative	0.0716	0.3134	0.5243
Entamoeba histolytica	cysteine protease, putative	0.0716	0.3134	0.5243
Echinococcus multilocularis	calpain A	0.0055	0.0102	0.0093
Brugia malayi	cathepsin F-like cysteine proteinase	0.0422	0.1783	0.1775
Giardia lamblia	Hypothetical protein	0.0295	0.1201	0.2824
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0888	0.3922	0.6565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1335	0.597	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0055	0.0102	0.0093
Echinococcus multilocularis	cysteine protease	0.1335	0.597	0.5966
Plasmodium falciparum	serine repeat antigen 3	0.0295	0.1201	0.1834
Onchocerca volvulus	Cathepsin L homolog	0.0295	0.1201	0.2012
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0295	0.1201	0.1193
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0295	0.1201	0.1999
Onchocerca volvulus		0.0035	0.001	0.0016
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0295	0.1201	0.1999

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2285870

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1807114